Q9H0C5 (BTBD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
BTB/POZ domain-containing protein 1

Alternative name(s):
Hepatitis C virus NS5A-transactivated protein 8
Short name=HCV NS5A-transactivated protein 8

Gene names

Name:	BTBD1
Synonyms:	C15orf1, NS5ATP8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	482 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ref.8
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Interacts with topoisomerase 1 and with TRIM5 isoform Delta. Interacts with CUL3. Ref.7 Ref.8
Subcellular location	Cytoplasm › P-body. Note: Cytoplasmic bodies. Ref.7
Tissue specificity	Ubiquitous; higher levels in heart and skeletal muscle. Ref.1
Sequence similarities	Contains 1 BTB (POZ) domain.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein ubiquitination Inferred from electronic annotation. Source: UniProtKB-UniPathway regulation of protein binding Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	cytoplasmic mRNA processing body Inferred from direct assay Ref.7. Source: UniProtKB protein complex Inferred from direct assay. Source: LIFEdb
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 482	482	BTB/POZ domain-containing protein 1		PRO_0000186208
Regions
	Domain	69 – 145	77	BTB
	Compositional bias	25 – 31	7	Poly-Pro
Experimental info
	Sequence conflict	406	1	T → A in BAA91345. Ref.5
	Sequence conflict	422	1	C → G in AAK25825. Ref.2
	Sequence conflict	429	1	L → P in BAA91345. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Q9H0C5 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 525A49E01728AFF0	FASTA	482	52,771
	10 20 30 40 50 60 MASLGPAAAG EQASGAEAEP GPAGPPPPPS PSSLGPLLPL QREPLYNWQA TKASLKERFA 70 80 90 100 110 120 FLFNSELLSD VRFVLGKGRG AAAAGGPQRI PAHRFVLAAG SAVFDAMFNG GMATTSAEIE 130 140 150 160 170 180 LPDVEPAAFL ALLRFLYSDE VQIGPETVMT TLYTAKKYAV PALEAHCVEF LTKHLRADNA 190 200 210 220 230 240 FMLLTQARLF DEPQLASLCL DTIDKSTMDA ISAEGFTDID IDTLCAVLER DTLSIRESRL 250 260 270 280 290 300 FGAVVRWAEA ECQRQQLPVT FGNKQKVLGK ALSLIRFPLM TIEEFAAGPA QSGILSDREV 310 320 330 340 350 360 VNLFLHFTVN PKPRVEYIDR PRCCLRGKEC CINRFQQVES RWGYSGTSDR IRFTVNRRIS 370 380 390 400 410 420 IVGFGLYGSI HGPTDYQVNI QIIEYEKKQT LGQNDTGFSC DGTANTFRVM FKEPIEILPN 430 440 450 460 470 480 VCYTACATLK GPDSHYGTKG LKKVVHETPA ASKTVFFFFS SPGNNNGTSI EDGQIPEIIF YT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24." Carim-Todd L., Sumoy L., Andreu N., Estivill X., Escarceller M. Gene 262:275-281(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with topoisomerase I." Xu L., Yang L., Hashimoto K., Anderson M., Kohlhagen G., Pommier Y., D'Arpa P. BMC Genomics 3:1-1(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning and identification of human gene 8 transactivated by hepatitis C virus NS5A protein." Liu Y., Cheng J., Wang G., Wang J., Zhang L., Chen J., Li L. Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[7]	"BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta." Xu L., Yang L., Moitra P.K., Hashimoto K., Rallabhandi P., Kaul S., Meroni G., Jensen J.P., Weissman A.M., D'Arpa P. Exp. Cell Res. 288:84-93(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TRIM5.
[8]	"Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases." Furukawa M., He Y.J., Borchers C., Xiong Y. Nat. Cell Biol. 5:1001-1007(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION AS AN E3 UBIQUITIN-PROTEIN LIGASE, INTERACTION WITH CUL3.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL136853 mRNA. Translation: CAB66787.1. AF355402 mRNA. Translation: AAK25825.1. AF257241 mRNA. Translation: AAK17068.1. AK000731 mRNA. Translation: BAA91345.1. AF529369 mRNA. Translation: AAQ09603.1. BC028097 mRNA. Translation: AAH28097.1.
IPI	IPI00033866.
RefSeq	NP_001011885.1. NM_001011885.1. NP_079514.1. NM_025238.3.
UniGene	Hs.459149.
3D structure databases
ProteinModelPortal	Q9H0C5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H0C5. 5 interactions.
STRING	9606.ENSP00000261721.
PTM databases
PhosphoSite	Q9H0C5.
Polymorphism databases
DMDM	20137477.
Proteomic databases
PaxDb	Q9H0C5.
PRIDE	Q9H0C5.
Protocols and materials databases
DNASU	53339.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000261721; ENSP00000261721; ENSG00000064726.
GeneID	53339.
KEGG	hsa:53339.
UCSC	uc002bjn.3. human.
Organism-specific databases
CTD	53339.
GeneCards	GC15M083685.
HGNC	HGNC:1120. BTBD1.
MIM	608530. gene.
neXtProt	NX_Q9H0C5.
PharmGKB	PA25438.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG308618.
HOGENOM	HOG000293364.
HOVERGEN	HBG050743.
InParanoid	Q9H0C5.
KO	K10477.
OMA	SRFLYSD.
OrthoDB	EOG480HWK.
PhylomeDB	Q9H0C5.
Enzyme and pathway databases
UniPathway	UPA00143.
Gene expression databases
ArrayExpress	Q9H0C5.
Bgee	Q9H0C5.
CleanEx	HS_BTBD1.
Genevestigator	Q9H0C5.
GermOnline	ENSG00000064726. Homo sapiens.
Family and domain databases
Gene3D	3.30.710.10. 1 hit.
InterPro	IPR011705. BACK. IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR012983. PHR. [Graphical view]
Pfam	PF07707. BACK. 1 hit. PF00651. BTB. 1 hit. PF08005. PHR. 1 hit. [Graphical view]
SMART	SM00875. BACK. 1 hit. SM00225. BTB. 1 hit. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	53339.
NextBio	55964.
SOURCE	Search...

Entry information

Entry name

BTBD1_HUMAN

Accession

Primary (citable) accession number: Q9H0C5
Secondary accession number(s): Q9BX71, Q9NWN4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.