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Q9H0C3

- TM117_HUMAN

UniProt

Q9H0C3 - TM117_HUMAN

Protein

Transmembrane protein 117

Gene

TMEM117

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 117
    Gene namesi
    Name:TMEM117
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:25308. TMEM117.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: LIFEdb
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485638.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 514514Transmembrane protein 117PRO_0000251204Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9H0C3.
    PRIDEiQ9H0C3.

    PTM databases

    PhosphoSiteiQ9H0C3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H0C3.
    BgeeiQ9H0C3.
    CleanExiHS_TMEM117.
    GenevestigatoriQ9H0C3.

    Organism-specific databases

    HPAiHPA046223.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4722022.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H0C3.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei66 – 8621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei111 – 13121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei155 – 17521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei240 – 26021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei296 – 31621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei395 – 41521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM117 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46585.
    HOGENOMiHOG000294202.
    HOVERGENiHBG066988.
    InParanoidiQ9H0C3.
    OMAiSEYSKEM.
    PhylomeDBiQ9H0C3.
    TreeFamiTF336012.

    Family and domain databases

    InterProiIPR029370. TMEM117.
    [Graphical view]
    PfamiPF15113. TMEM117. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H0C3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKDFRYYFQ HPWSRMIVAY LVIFFNFLIF AEDPVSHSQT EANVIVVGNC    50
    FSFVTNKYPR GVGWRILKVL LWLLAILTGL IAGKFLFHQR LFGQLLRLKM 100
    FREDHGSWMT MFFSTILFLF IFSHIYNTIL LMDGNMGAYI ITDYMGIRNE 150
    SFMKLAAVGT WMGDFVTAWM VTDMMLQDKP YPDWGKSARA FWKKGNVRIT 200
    LFWTVLFTLT SVVVLVITTD WISWDKLNRG FLPSDEVSRA FLASFILVFD 250
    LLIVMQDWEF PHFMGDVDVN LPGLHTPHMQ FKIPFFQKIF KEEYRIHITG 300
    KWFNYGIIFL VLILDLNMWK NQIFYKPHEY GQYIGPGQKI YTVKDSESLK 350
    DLNRTKLSWE WRSNHTNPRT NKTYVEGDMF LHSRFIGASL DVKCLAFVPS 400
    LIAFVWFGFF IWFFGRFLKN EPRMENQDKT YTRMKRKSPS EHSKDMGITR 450
    ENTQASVEDP LNDPSLVCIR SDFNEIVYKS SHLTSENLSS QLNESTSATE 500
    ADQDPTTSKS TPTN 514
    Length:514
    Mass (Da):60,185
    Last modified:March 1, 2001 - v1
    Checksum:i9DBBF7980AAC2246
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti90 – 901R → H.
    Corresponds to variant rs1948516 [ dbSNP | Ensembl ].
    VAR_027660

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136855 mRNA. Translation: CAB66789.1.
    AK057287 mRNA. Translation: BAB71411.1.
    BC060798 mRNA. Translation: AAH60798.1.
    CCDSiCCDS8745.1.
    RefSeqiNP_001273142.1. NM_001286213.1.
    NP_115632.1. NM_032256.2.
    UniGeneiHs.444668.

    Genome annotation databases

    EnsembliENST00000266534; ENSP00000266534; ENSG00000139173.
    GeneIDi84216.
    KEGGihsa:84216.
    UCSCiuc001rod.3. human.

    Polymorphism databases

    DMDMi74733520.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136855 mRNA. Translation: CAB66789.1 .
    AK057287 mRNA. Translation: BAB71411.1 .
    BC060798 mRNA. Translation: AAH60798.1 .
    CCDSi CCDS8745.1.
    RefSeqi NP_001273142.1. NM_001286213.1.
    NP_115632.1. NM_032256.2.
    UniGenei Hs.444668.

    3D structure databases

    ProteinModelPortali Q9H0C3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4722022.

    PTM databases

    PhosphoSitei Q9H0C3.

    Polymorphism databases

    DMDMi 74733520.

    Proteomic databases

    PaxDbi Q9H0C3.
    PRIDEi Q9H0C3.

    Protocols and materials databases

    DNASUi 84216.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266534 ; ENSP00000266534 ; ENSG00000139173 .
    GeneIDi 84216.
    KEGGi hsa:84216.
    UCSCi uc001rod.3. human.

    Organism-specific databases

    CTDi 84216.
    GeneCardsi GC12P044229.
    HGNCi HGNC:25308. TMEM117.
    HPAi HPA046223.
    neXtProti NX_Q9H0C3.
    PharmGKBi PA143485638.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46585.
    HOGENOMi HOG000294202.
    HOVERGENi HBG066988.
    InParanoidi Q9H0C3.
    OMAi SEYSKEM.
    PhylomeDBi Q9H0C3.
    TreeFami TF336012.

    Miscellaneous databases

    GeneWikii TMEM117.
    GenomeRNAii 84216.
    NextBioi 73630.
    PROi Q9H0C3.

    Gene expression databases

    ArrayExpressi Q9H0C3.
    Bgeei Q9H0C3.
    CleanExi HS_TMEM117.
    Genevestigatori Q9H0C3.

    Family and domain databases

    InterProi IPR029370. TMEM117.
    [Graphical view ]
    Pfami PF15113. TMEM117. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiTM117_HUMAN
    AccessioniPrimary (citable) accession number: Q9H0C3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3