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Protein

Transmembrane protein 117

Gene

TMEM117

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139173-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 117
Gene namesi
Name:TMEM117
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25308. TMEM117.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84216.
OpenTargetsiENSG00000139173.
PharmGKBiPA143485638.

Polymorphism and mutation databases

DMDMi74733520.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002512041 – 514Transmembrane protein 117Add BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi353N-linked (GlcNAc...)Sequence analysis1
Glycosylationi371N-linked (GlcNAc...)Sequence analysis1
Modified residuei453PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9H0C3.
PaxDbiQ9H0C3.
PeptideAtlasiQ9H0C3.
PRIDEiQ9H0C3.

PTM databases

iPTMnetiQ9H0C3.
PhosphoSitePlusiQ9H0C3.

Expressioni

Gene expression databases

BgeeiENSG00000139173.
CleanExiHS_TMEM117.
ExpressionAtlasiQ9H0C3. baseline and differential.
GenevisibleiQ9H0C3. HS.

Organism-specific databases

HPAiHPA046223.

Interactioni

Protein-protein interaction databases

MINTiMINT-4722022.
STRINGi9606.ENSP00000266534.

Structurei

3D structure databases

ProteinModelPortaliQ9H0C3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM117 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFTG. Eukaryota.
ENOG410Z7KD. LUCA.
GeneTreeiENSGT00390000013052.
HOGENOMiHOG000294202.
HOVERGENiHBG066988.
InParanoidiQ9H0C3.
OMAiEYSKEMG.
OrthoDBiEOG091G0786.
PhylomeDBiQ9H0C3.
TreeFamiTF336012.

Family and domain databases

InterProiIPR029370. TMEM117.
[Graphical view]
PfamiPF15113. TMEM117. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H0C3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKDFRYYFQ HPWSRMIVAY LVIFFNFLIF AEDPVSHSQT EANVIVVGNC
60 70 80 90 100
FSFVTNKYPR GVGWRILKVL LWLLAILTGL IAGKFLFHQR LFGQLLRLKM
110 120 130 140 150
FREDHGSWMT MFFSTILFLF IFSHIYNTIL LMDGNMGAYI ITDYMGIRNE
160 170 180 190 200
SFMKLAAVGT WMGDFVTAWM VTDMMLQDKP YPDWGKSARA FWKKGNVRIT
210 220 230 240 250
LFWTVLFTLT SVVVLVITTD WISWDKLNRG FLPSDEVSRA FLASFILVFD
260 270 280 290 300
LLIVMQDWEF PHFMGDVDVN LPGLHTPHMQ FKIPFFQKIF KEEYRIHITG
310 320 330 340 350
KWFNYGIIFL VLILDLNMWK NQIFYKPHEY GQYIGPGQKI YTVKDSESLK
360 370 380 390 400
DLNRTKLSWE WRSNHTNPRT NKTYVEGDMF LHSRFIGASL DVKCLAFVPS
410 420 430 440 450
LIAFVWFGFF IWFFGRFLKN EPRMENQDKT YTRMKRKSPS EHSKDMGITR
460 470 480 490 500
ENTQASVEDP LNDPSLVCIR SDFNEIVYKS SHLTSENLSS QLNESTSATE
510
ADQDPTTSKS TPTN
Length:514
Mass (Da):60,185
Last modified:March 1, 2001 - v1
Checksum:i9DBBF7980AAC2246
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02766090R → H.Corresponds to variant rs1948516dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136855 mRNA. Translation: CAB66789.1.
AK057287 mRNA. Translation: BAB71411.1.
BC060798 mRNA. Translation: AAH60798.1.
CCDSiCCDS8745.1.
RefSeqiNP_001273142.1. NM_001286213.1.
NP_115632.1. NM_032256.2.
XP_011537133.1. XM_011538831.2.
XP_011537134.1. XM_011538832.2.
UniGeneiHs.444668.

Genome annotation databases

EnsembliENST00000266534; ENSP00000266534; ENSG00000139173.
GeneIDi84216.
KEGGihsa:84216.
UCSCiuc001rod.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136855 mRNA. Translation: CAB66789.1.
AK057287 mRNA. Translation: BAB71411.1.
BC060798 mRNA. Translation: AAH60798.1.
CCDSiCCDS8745.1.
RefSeqiNP_001273142.1. NM_001286213.1.
NP_115632.1. NM_032256.2.
XP_011537133.1. XM_011538831.2.
XP_011537134.1. XM_011538832.2.
UniGeneiHs.444668.

3D structure databases

ProteinModelPortaliQ9H0C3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4722022.
STRINGi9606.ENSP00000266534.

PTM databases

iPTMnetiQ9H0C3.
PhosphoSitePlusiQ9H0C3.

Polymorphism and mutation databases

DMDMi74733520.

Proteomic databases

MaxQBiQ9H0C3.
PaxDbiQ9H0C3.
PeptideAtlasiQ9H0C3.
PRIDEiQ9H0C3.

Protocols and materials databases

DNASUi84216.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266534; ENSP00000266534; ENSG00000139173.
GeneIDi84216.
KEGGihsa:84216.
UCSCiuc001rod.5. human.

Organism-specific databases

CTDi84216.
DisGeNETi84216.
GeneCardsiTMEM117.
HGNCiHGNC:25308. TMEM117.
HPAiHPA046223.
neXtProtiNX_Q9H0C3.
OpenTargetsiENSG00000139173.
PharmGKBiPA143485638.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFTG. Eukaryota.
ENOG410Z7KD. LUCA.
GeneTreeiENSGT00390000013052.
HOGENOMiHOG000294202.
HOVERGENiHBG066988.
InParanoidiQ9H0C3.
OMAiEYSKEMG.
OrthoDBiEOG091G0786.
PhylomeDBiQ9H0C3.
TreeFamiTF336012.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139173-MONOMER.

Miscellaneous databases

ChiTaRSiTMEM117. human.
GeneWikiiTMEM117.
GenomeRNAii84216.
PROiQ9H0C3.

Gene expression databases

BgeeiENSG00000139173.
CleanExiHS_TMEM117.
ExpressionAtlasiQ9H0C3. baseline and differential.
GenevisibleiQ9H0C3. HS.

Family and domain databases

InterProiIPR029370. TMEM117.
[Graphical view]
PfamiPF15113. TMEM117. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM117_HUMAN
AccessioniPrimary (citable) accession number: Q9H0C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.