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Q9H0C3

- TM117_HUMAN

UniProt

Q9H0C3 - TM117_HUMAN

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Protein

Transmembrane protein 117

Gene

TMEM117

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 117
Gene namesi
Name:TMEM117
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:25308. TMEM117.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: LIFEdb
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485638.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Transmembrane protein 117PRO_0000251204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9H0C3.
PaxDbiQ9H0C3.
PRIDEiQ9H0C3.

PTM databases

PhosphoSiteiQ9H0C3.

Expressioni

Gene expression databases

BgeeiQ9H0C3.
CleanExiHS_TMEM117.
ExpressionAtlasiQ9H0C3. baseline and differential.
GenevestigatoriQ9H0C3.

Organism-specific databases

HPAiHPA046223.

Interactioni

Protein-protein interaction databases

MINTiMINT-4722022.

Structurei

3D structure databases

ProteinModelPortaliQ9H0C3.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Transmembranei66 – 8621HelicalSequence AnalysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence AnalysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence AnalysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence AnalysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence AnalysisAdd
BLAST
Transmembranei296 – 31621HelicalSequence AnalysisAdd
BLAST
Transmembranei395 – 41521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM117 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46585.
GeneTreeiENSGT00390000013052.
HOGENOMiHOG000294202.
HOVERGENiHBG066988.
InParanoidiQ9H0C3.
OMAiSEYSKEM.
PhylomeDBiQ9H0C3.
TreeFamiTF336012.

Family and domain databases

InterProiIPR029370. TMEM117.
[Graphical view]
PfamiPF15113. TMEM117. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H0C3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKDFRYYFQ HPWSRMIVAY LVIFFNFLIF AEDPVSHSQT EANVIVVGNC
60 70 80 90 100
FSFVTNKYPR GVGWRILKVL LWLLAILTGL IAGKFLFHQR LFGQLLRLKM
110 120 130 140 150
FREDHGSWMT MFFSTILFLF IFSHIYNTIL LMDGNMGAYI ITDYMGIRNE
160 170 180 190 200
SFMKLAAVGT WMGDFVTAWM VTDMMLQDKP YPDWGKSARA FWKKGNVRIT
210 220 230 240 250
LFWTVLFTLT SVVVLVITTD WISWDKLNRG FLPSDEVSRA FLASFILVFD
260 270 280 290 300
LLIVMQDWEF PHFMGDVDVN LPGLHTPHMQ FKIPFFQKIF KEEYRIHITG
310 320 330 340 350
KWFNYGIIFL VLILDLNMWK NQIFYKPHEY GQYIGPGQKI YTVKDSESLK
360 370 380 390 400
DLNRTKLSWE WRSNHTNPRT NKTYVEGDMF LHSRFIGASL DVKCLAFVPS
410 420 430 440 450
LIAFVWFGFF IWFFGRFLKN EPRMENQDKT YTRMKRKSPS EHSKDMGITR
460 470 480 490 500
ENTQASVEDP LNDPSLVCIR SDFNEIVYKS SHLTSENLSS QLNESTSATE
510
ADQDPTTSKS TPTN
Length:514
Mass (Da):60,185
Last modified:March 1, 2001 - v1
Checksum:i9DBBF7980AAC2246
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti90 – 901R → H.
Corresponds to variant rs1948516 [ dbSNP | Ensembl ].
VAR_027660

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136855 mRNA. Translation: CAB66789.1.
AK057287 mRNA. Translation: BAB71411.1.
BC060798 mRNA. Translation: AAH60798.1.
CCDSiCCDS8745.1.
RefSeqiNP_001273142.1. NM_001286213.1.
NP_115632.1. NM_032256.2.
UniGeneiHs.444668.

Genome annotation databases

EnsembliENST00000266534; ENSP00000266534; ENSG00000139173.
GeneIDi84216.
KEGGihsa:84216.
UCSCiuc001rod.3. human.

Polymorphism databases

DMDMi74733520.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136855 mRNA. Translation: CAB66789.1 .
AK057287 mRNA. Translation: BAB71411.1 .
BC060798 mRNA. Translation: AAH60798.1 .
CCDSi CCDS8745.1.
RefSeqi NP_001273142.1. NM_001286213.1.
NP_115632.1. NM_032256.2.
UniGenei Hs.444668.

3D structure databases

ProteinModelPortali Q9H0C3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4722022.

PTM databases

PhosphoSitei Q9H0C3.

Polymorphism databases

DMDMi 74733520.

Proteomic databases

MaxQBi Q9H0C3.
PaxDbi Q9H0C3.
PRIDEi Q9H0C3.

Protocols and materials databases

DNASUi 84216.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266534 ; ENSP00000266534 ; ENSG00000139173 .
GeneIDi 84216.
KEGGi hsa:84216.
UCSCi uc001rod.3. human.

Organism-specific databases

CTDi 84216.
GeneCardsi GC12P044229.
HGNCi HGNC:25308. TMEM117.
HPAi HPA046223.
neXtProti NX_Q9H0C3.
PharmGKBi PA143485638.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46585.
GeneTreei ENSGT00390000013052.
HOGENOMi HOG000294202.
HOVERGENi HBG066988.
InParanoidi Q9H0C3.
OMAi SEYSKEM.
PhylomeDBi Q9H0C3.
TreeFami TF336012.

Miscellaneous databases

GeneWikii TMEM117.
GenomeRNAii 84216.
NextBioi 73630.
PROi Q9H0C3.

Gene expression databases

Bgeei Q9H0C3.
CleanExi HS_TMEM117.
ExpressionAtlasi Q9H0C3. baseline and differential.
Genevestigatori Q9H0C3.

Family and domain databases

InterProi IPR029370. TMEM117.
[Graphical view ]
Pfami PF15113. TMEM117. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiTM117_HUMAN
AccessioniPrimary (citable) accession number: Q9H0C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3