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Q9H0C3 (TM117_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 117
Gene names
Name:TMEM117
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TMEM117 family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum

Inferred from direct assay. Source: LIFEdb

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 514514Transmembrane protein 117
PRO_0000251204

Regions

Transmembrane16 – 3621Helical; Potential
Transmembrane66 – 8621Helical; Potential
Transmembrane111 – 13121Helical; Potential
Transmembrane155 – 17521Helical; Potential
Transmembrane199 – 21921Helical; Potential
Transmembrane240 – 26021Helical; Potential
Transmembrane296 – 31621Helical; Potential
Transmembrane395 – 41521Helical; Potential

Amino acid modifications

Glycosylation3531N-linked (GlcNAc...) Potential
Glycosylation3711N-linked (GlcNAc...) Potential

Natural variations

Natural variant901R → H.
Corresponds to variant rs1948516 [ dbSNP | Ensembl ].
VAR_027660

Sequences

Sequence LengthMass (Da)Tools
Q9H0C3 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 9DBBF7980AAC2246

FASTA51460,185
        10         20         30         40         50         60 
MGKDFRYYFQ HPWSRMIVAY LVIFFNFLIF AEDPVSHSQT EANVIVVGNC FSFVTNKYPR 

        70         80         90        100        110        120 
GVGWRILKVL LWLLAILTGL IAGKFLFHQR LFGQLLRLKM FREDHGSWMT MFFSTILFLF 

       130        140        150        160        170        180 
IFSHIYNTIL LMDGNMGAYI ITDYMGIRNE SFMKLAAVGT WMGDFVTAWM VTDMMLQDKP 

       190        200        210        220        230        240 
YPDWGKSARA FWKKGNVRIT LFWTVLFTLT SVVVLVITTD WISWDKLNRG FLPSDEVSRA 

       250        260        270        280        290        300 
FLASFILVFD LLIVMQDWEF PHFMGDVDVN LPGLHTPHMQ FKIPFFQKIF KEEYRIHITG 

       310        320        330        340        350        360 
KWFNYGIIFL VLILDLNMWK NQIFYKPHEY GQYIGPGQKI YTVKDSESLK DLNRTKLSWE 

       370        380        390        400        410        420 
WRSNHTNPRT NKTYVEGDMF LHSRFIGASL DVKCLAFVPS LIAFVWFGFF IWFFGRFLKN 

       430        440        450        460        470        480 
EPRMENQDKT YTRMKRKSPS EHSKDMGITR ENTQASVEDP LNDPSLVCIR SDFNEIVYKS 

       490        500        510 
SHLTSENLSS QLNESTSATE ADQDPTTSKS TPTN 

« Hide

References

[1]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL136855 mRNA. Translation: CAB66789.1.
AK057287 mRNA. Translation: BAB71411.1.
BC060798 mRNA. Translation: AAH60798.1.
CCDSCCDS8745.1.
RefSeqNP_001273142.1. NM_001286213.1.
NP_115632.1. NM_032256.2.
UniGeneHs.444668.

3D structure databases

ProteinModelPortalQ9H0C3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4722022.

PTM databases

PhosphoSiteQ9H0C3.

Polymorphism databases

DMDM74733520.

Proteomic databases

PaxDbQ9H0C3.
PRIDEQ9H0C3.

Protocols and materials databases

DNASU84216.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000266534; ENSP00000266534; ENSG00000139173.
GeneID84216.
KEGGhsa:84216.
UCSCuc001rod.3. human.

Organism-specific databases

CTD84216.
GeneCardsGC12P044229.
HGNCHGNC:25308. TMEM117.
HPAHPA046223.
neXtProtNX_Q9H0C3.
PharmGKBPA143485638.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46585.
HOGENOMHOG000294202.
HOVERGENHBG066988.
InParanoidQ9H0C3.
OMASEYSKEM.
PhylomeDBQ9H0C3.
TreeFamTF336012.

Gene expression databases

ArrayExpressQ9H0C3.
BgeeQ9H0C3.
CleanExHS_TMEM117.
GenevestigatorQ9H0C3.

Family and domain databases

InterProIPR029370. TMEM117.
[Graphical view]
PfamPF15113. TMEM117. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiTMEM117.
GenomeRNAi84216.
NextBio73630.
PROQ9H0C3.

Entry information

Entry nameTM117_HUMAN
AccessionPrimary (citable) accession number: Q9H0C3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM