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Protein

ADP/ATP translocase 4

Gene

SLC25A31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92ADPBy similarity1
Binding sitei104ADPBy similarity1
Binding sitei247ADPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.29.1.8 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 4
Alternative name(s):
ADP,ATP carrier protein 4
Adenine nucleotide translocator 4
Short name:
ANT 4
Solute carrier family 25 member 31
Sperm flagellar energy carrier protein
Gene namesi
Name:SLC25A31
Synonyms:AAC4, ANT4, SFEC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000151475.5
HGNCiHGNC:25319 SLC25A31
MIMi610796 gene
neXtProtiNX_Q9H0C2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 49Helical; Name=1By similarityAdd BLAST30
Transmembranei87 – 111Helical; Name=2By similarityAdd BLAST25
Transmembranei122 – 142Helical; Name=3By similarityAdd BLAST21
Transmembranei191 – 211Helical; Name=4By similarityAdd BLAST21
Transmembranei223 – 243Helical; Name=5By similarityAdd BLAST21
Transmembranei284 – 301Helical; Name=6By similarityAdd BLAST18

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum, Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83447
OpenTargetsiENSG00000151475
PharmGKBiPA142670904

Polymorphism and mutation databases

BioMutaiSLC25A31
DMDMi74752557

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002976241 – 315ADP/ATP translocase 4Add BLAST315

Proteomic databases

EPDiQ9H0C2
MaxQBiQ9H0C2
PaxDbiQ9H0C2
PeptideAtlasiQ9H0C2
PRIDEiQ9H0C2

PTM databases

iPTMnetiQ9H0C2
PhosphoSitePlusiQ9H0C2
SwissPalmiQ9H0C2

Expressioni

Tissue specificityi

Expressed in brain, liver, sperm and testis.2 Publications

Gene expression databases

BgeeiENSG00000151475
CleanExiHS_SLC25A31
GenevisibleiQ9H0C2 HS

Organism-specific databases

HPAiHPA015064
HPA016841
HPA046835
HPA071684

Interactioni

Protein-protein interaction databases

BioGridi123649, 5 interactors
IntActiQ9H0C2, 4 interactors
STRINGi9606.ENSP00000281154

Structurei

3D structure databases

ProteinModelPortaliQ9H0C2
SMRiQ9H0C2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 110Solcar 1Add BLAST93
Repeati123 – 213Solcar 2Add BLAST91
Repeati220 – 307Solcar 3Add BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni247 – 252Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi247 – 252Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
GeneTreeiENSGT00390000011543
HOGENOMiHOG000165727
HOVERGENiHBG108348
InParanoidiQ9H0C2
KOiK05863
OMAiGFFSYWR
OrthoDBiEOG091G0ULB
PhylomeDBiQ9H0C2
TreeFamiTF300743

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q9H0C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHREPAKKKA EKRLFDASSF GKDLLAGGVA AAVSKTAVAP IERVKLLLQV
60 70 80 90 100
QASSKQISPE ARYKGMVDCL VRIPREQGFF SFWRGNLANV IRYFPTQALN
110 120 130 140 150
FAFKDKYKQL FMSGVNKEKQ FWRWFLANLA SGGAAGATSL CVVYPLDFAR
160 170 180 190 200
TRLGVDIGKG PEERQFKGLG DCIMKIAKSD GIAGLYQGFG VSVQGIIVYR
210 220 230 240 250
ASYFGAYDTV KGLLPKPKKT PFLVSFFIAQ VVTTCSGILS YPFDTVRRRM
260 270 280 290 300
MMQSGEAKRQ YKGTLDCFVK IYQHEGISSF FRGAFSNVLR GTGGALVLVL
310
YDKIKEFFHI DIGGR
Length:315
Mass (Da):35,022
Last modified:March 1, 2001 - v1
Checksum:i9ACE26062CCC9675
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_074177303K → E1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ863129 mRNA Translation: CAI05952.1
AY550240 mRNA Translation: AAT42263.1
AL136857 mRNA Translation: CAB66791.1
AC093591 Genomic DNA Translation: AAY40974.1
CH471056 Genomic DNA Translation: EAX05199.1
BC022032 mRNA Translation: AAH22032.1
CCDSiCCDS3733.1
RefSeqiNP_001305396.1, NM_001318467.1
NP_112581.1, NM_031291.3
UniGeneiHs.149030

Genome annotation databases

EnsembliENST00000281154; ENSP00000281154; ENSG00000151475
GeneIDi83447
KEGGihsa:83447
UCSCiuc003ifl.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiADT4_HUMAN
AccessioniPrimary (citable) accession number: Q9H0C2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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