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Q9H0C2

- ADT4_HUMAN

UniProt

Q9H0C2 - ADT4_HUMAN

Protein

ADP/ATP translocase 4

Gene

SLC25A31

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility.1 Publication

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    GO - Biological processi

    1. transmembrane transport Source: InterPro

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.29.1.8. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP/ATP translocase 4
    Alternative name(s):
    ADP,ATP carrier protein 4
    Adenine nucleotide translocator 4
    Short name:
    ANT 4
    Solute carrier family 25 member 31
    Sperm flagellar energy carrier protein
    Gene namesi
    Name:SLC25A31
    Synonyms:AAC4, ANT4, SFEC
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:25319. SLC25A31.

    Subcellular locationi

    Mitochondrion inner membrane; Multi-pass membrane protein. Cell projectionciliumflagellum
    Note: In sperm flagellum this protein is located in the fibrous sheath, a non-mitochondrial region.

    GO - Cellular componenti

    1. cilium Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. mitochondrial inner membrane Source: UniProtKB-SubCell
    4. mitochondrion Source: LIFEdb
    5. nucleus Source: UniProt

    Keywords - Cellular componenti

    Cell projection, Cilium, Flagellum, Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670904.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315ADP/ATP translocase 4PRO_0000297624Add
    BLAST

    Proteomic databases

    MaxQBiQ9H0C2.
    PaxDbiQ9H0C2.
    PRIDEiQ9H0C2.

    PTM databases

    PhosphoSiteiQ9H0C2.

    Expressioni

    Tissue specificityi

    Expressed in brain, liver, sperm and testis.2 Publications

    Gene expression databases

    BgeeiQ9H0C2.
    CleanExiHS_SLC25A31.
    GenevestigatoriQ9H0C2.

    Organism-specific databases

    HPAiHPA015064.
    HPA016841.

    Interactioni

    Protein-protein interaction databases

    BioGridi123649. 2 interactions.
    IntActiQ9H0C2. 2 interactions.
    MINTiMINT-4725351.
    STRINGi9606.ENSP00000281154.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H0C2.
    SMRiQ9H0C2. Positions 17-304.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei285 – 30521Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati18 – 11093Solcar 1Add
    BLAST
    Repeati123 – 21391Solcar 2Add
    BLAST
    Repeati220 – 30788Solcar 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238123.
    HOGENOMiHOG000165727.
    HOVERGENiHBG108348.
    InParanoidiQ9H0C2.
    KOiK05863.
    OMAiRQYKGTI.
    OrthoDBiEOG7T1RBR.
    PhylomeDBiQ9H0C2.
    TreeFamiTF300743.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002113. Aden_trnslctor.
    IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00927. ADPTRNSLCASE.
    PR00926. MITOCARRIER.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9H0C2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHREPAKKKA EKRLFDASSF GKDLLAGGVA AAVSKTAVAP IERVKLLLQV    50
    QASSKQISPE ARYKGMVDCL VRIPREQGFF SFWRGNLANV IRYFPTQALN 100
    FAFKDKYKQL FMSGVNKEKQ FWRWFLANLA SGGAAGATSL CVVYPLDFAR 150
    TRLGVDIGKG PEERQFKGLG DCIMKIAKSD GIAGLYQGFG VSVQGIIVYR 200
    ASYFGAYDTV KGLLPKPKKT PFLVSFFIAQ VVTTCSGILS YPFDTVRRRM 250
    MMQSGEAKRQ YKGTLDCFVK IYQHEGISSF FRGAFSNVLR GTGGALVLVL 300
    YDKIKEFFHI DIGGR 315
    Length:315
    Mass (Da):35,022
    Last modified:March 1, 2001 - v1
    Checksum:i9ACE26062CCC9675
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ863129 mRNA. Translation: CAI05952.1.
    AY550240 mRNA. Translation: AAT42263.1.
    AL136857 mRNA. Translation: CAB66791.1.
    AC093591 Genomic DNA. Translation: AAY40974.1.
    CH471056 Genomic DNA. Translation: EAX05199.1.
    BC022032 mRNA. Translation: AAH22032.1.
    CCDSiCCDS3733.1.
    RefSeqiNP_112581.1. NM_031291.2.
    UniGeneiHs.149030.

    Genome annotation databases

    EnsembliENST00000281154; ENSP00000281154; ENSG00000151475.
    GeneIDi83447.
    KEGGihsa:83447.
    UCSCiuc003ifl.3. human.

    Polymorphism databases

    DMDMi74752557.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ863129 mRNA. Translation: CAI05952.1 .
    AY550240 mRNA. Translation: AAT42263.1 .
    AL136857 mRNA. Translation: CAB66791.1 .
    AC093591 Genomic DNA. Translation: AAY40974.1 .
    CH471056 Genomic DNA. Translation: EAX05199.1 .
    BC022032 mRNA. Translation: AAH22032.1 .
    CCDSi CCDS3733.1.
    RefSeqi NP_112581.1. NM_031291.2.
    UniGenei Hs.149030.

    3D structure databases

    ProteinModelPortali Q9H0C2.
    SMRi Q9H0C2. Positions 17-304.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123649. 2 interactions.
    IntActi Q9H0C2. 2 interactions.
    MINTi MINT-4725351.
    STRINGi 9606.ENSP00000281154.

    Protein family/group databases

    TCDBi 2.A.29.1.8. the mitochondrial carrier (mc) family.

    PTM databases

    PhosphoSitei Q9H0C2.

    Polymorphism databases

    DMDMi 74752557.

    Proteomic databases

    MaxQBi Q9H0C2.
    PaxDbi Q9H0C2.
    PRIDEi Q9H0C2.

    Protocols and materials databases

    DNASUi 83447.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000281154 ; ENSP00000281154 ; ENSG00000151475 .
    GeneIDi 83447.
    KEGGi hsa:83447.
    UCSCi uc003ifl.3. human.

    Organism-specific databases

    CTDi 83447.
    GeneCardsi GC04P128651.
    HGNCi HGNC:25319. SLC25A31.
    HPAi HPA015064.
    HPA016841.
    MIMi 610796. gene.
    neXtProti NX_Q9H0C2.
    PharmGKBi PA142670904.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG238123.
    HOGENOMi HOG000165727.
    HOVERGENi HBG108348.
    InParanoidi Q9H0C2.
    KOi K05863.
    OMAi RQYKGTI.
    OrthoDBi EOG7T1RBR.
    PhylomeDBi Q9H0C2.
    TreeFami TF300743.

    Miscellaneous databases

    GeneWikii SLC25A31.
    GenomeRNAii 83447.
    NextBioi 72348.
    PROi Q9H0C2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9H0C2.
    CleanExi HS_SLC25A31.
    Genevestigatori Q9H0C2.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002113. Aden_trnslctor.
    IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00927. ADPTRNSLCASE.
    PR00926. MITOCARRIER.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution."
      Dolce V., Scarcia P., Iacopetta D., Palmieri F.
      FEBS Lett. 579:633-637(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Liver.
    2. "Compartmentalization of a unique ADP/ATP carrier protein SFEC (sperm flagellar energy carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece."
      Kim Y.-H., Haidl G., Schaefer M., Egner U., Mandal A., Herr J.C.
      Dev. Biol. 302:463-476(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiADT4_HUMAN
    AccessioniPrimary (citable) accession number: Q9H0C2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 21, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3