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Q9H0C2 (ADT4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ADP/ATP translocase 4
Alternative name(s):
ADP,ATP carrier protein 4
Adenine nucleotide translocator 4
Short name=ANT 4
Solute carrier family 25 member 31
Sperm flagellar energy carrier protein
Gene names
Name:SLC25A31
Synonyms:AAC4, ANT4, SFEC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility. Ref.2

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein. Cell projectionciliumflagellum. Note: In sperm flagellum this protein is located in the fibrous sheath, a non-mitochondrial region. Ref.1 Ref.2

Tissue specificity

Expressed in brain, liver, sperm and testis. Ref.1 Ref.2

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315ADP/ATP translocase 4
PRO_0000297624

Regions

Transmembrane24 – 4421Helical; Name=1; Potential
Transmembrane90 – 11021Helical; Name=2; Potential
Transmembrane124 – 14421Helical; Name=3; Potential
Transmembrane179 – 19921Helical; Name=4; Potential
Transmembrane221 – 24121Helical; Name=5; Potential
Transmembrane285 – 30521Helical; Name=6; Potential
Repeat18 – 11093Solcar 1
Repeat123 – 21391Solcar 2
Repeat220 – 30788Solcar 3

Sequences

Sequence LengthMass (Da)Tools
Q9H0C2 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 9ACE26062CCC9675

FASTA31535,022
        10         20         30         40         50         60 
MHREPAKKKA EKRLFDASSF GKDLLAGGVA AAVSKTAVAP IERVKLLLQV QASSKQISPE 

        70         80         90        100        110        120 
ARYKGMVDCL VRIPREQGFF SFWRGNLANV IRYFPTQALN FAFKDKYKQL FMSGVNKEKQ 

       130        140        150        160        170        180 
FWRWFLANLA SGGAAGATSL CVVYPLDFAR TRLGVDIGKG PEERQFKGLG DCIMKIAKSD 

       190        200        210        220        230        240 
GIAGLYQGFG VSVQGIIVYR ASYFGAYDTV KGLLPKPKKT PFLVSFFIAQ VVTTCSGILS 

       250        260        270        280        290        300 
YPFDTVRRRM MMQSGEAKRQ YKGTLDCFVK IYQHEGISSF FRGAFSNVLR GTGGALVLVL 

       310 
YDKIKEFFHI DIGGR 

« Hide

References

« Hide 'large scale' references
[1]"A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution."
Dolce V., Scarcia P., Iacopetta D., Palmieri F.
FEBS Lett. 579:633-637(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Liver.
[2]"Compartmentalization of a unique ADP/ATP carrier protein SFEC (sperm flagellar energy carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece."
Kim Y.-H., Haidl G., Schaefer M., Egner U., Mandal A., Herr J.C.
Dev. Biol. 302:463-476(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[3]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ863129 mRNA. Translation: CAI05952.1.
AY550240 mRNA. Translation: AAT42263.1.
AL136857 mRNA. Translation: CAB66791.1.
AC093591 Genomic DNA. Translation: AAY40974.1.
CH471056 Genomic DNA. Translation: EAX05199.1.
BC022032 mRNA. Translation: AAH22032.1.
RefSeqNP_112581.1. NM_031291.2.
UniGeneHs.149030.

3D structure databases

ProteinModelPortalQ9H0C2.
SMRQ9H0C2. Positions 17-304.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123649. 2 interactions.
IntActQ9H0C2. 1 interaction.
MINTMINT-4725351.
STRING9606.ENSP00000281154.

Protein family/group databases

TCDB2.A.29.1.8. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSiteQ9H0C2.

Polymorphism databases

DMDM74752557.

Proteomic databases

PaxDbQ9H0C2.
PRIDEQ9H0C2.

Protocols and materials databases

DNASU83447.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000281154; ENSP00000281154; ENSG00000151475.
GeneID83447.
KEGGhsa:83447.
UCSCuc003ifl.3. human.

Organism-specific databases

CTD83447.
GeneCardsGC04P128651.
HGNCHGNC:25319. SLC25A31.
HPAHPA015064.
HPA016841.
MIM610796. gene.
neXtProtNX_Q9H0C2.
PharmGKBPA142670904.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG238123.
HOGENOMHOG000165727.
HOVERGENHBG108348.
InParanoidQ9H0C2.
KOK05863.
OMARQYKGTI.
OrthoDBEOG7T1RBR.
PhylomeDBQ9H0C2.
TreeFamTF300743.

Gene expression databases

BgeeQ9H0C2.
CleanExHS_SLC25A31.
GenevestigatorQ9H0C2.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLC25A31.
GenomeRNAi83447.
NextBio72348.
PROQ9H0C2.
SOURCESearch...

Entry information

Entry nameADT4_HUMAN
AccessionPrimary (citable) accession number: Q9H0C2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2001
Last modified: February 19, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM