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Protein

ADP/ATP translocase 4

Gene

SLC25A31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility.1 Publication

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.1.8. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 4
Alternative name(s):
ADP,ATP carrier protein 4
Adenine nucleotide translocator 4
Short name:
ANT 4
Solute carrier family 25 member 31
Sperm flagellar energy carrier protein
Cleaved into the following chain:
Gene namesi
Name:SLC25A31
Synonyms:AAC4, ANT4, SFEC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:25319. SLC25A31.

Subcellular locationi

Mitochondrion inner membrane; Multi-pass membrane protein. Cell projectionciliumflagellum
Note: In sperm flagellum this protein is located in the fibrous sheath, a non-mitochondrial region.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei90 – 11021Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei124 – 14421Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei179 – 19921Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei221 – 24121Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei285 – 30521Helical; Name=6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: LIFEdb
  4. motile cilium Source: UniProtKB-KW
  5. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum, Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670904.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315ADP/ATP translocase 4PRO_0000297624Add
BLAST
Initiator methioninei1 – 11Removed; alternateBy similarity
Chaini2 – 315314ADP/ATP translocase 4, N-terminally processedPRO_0000432196Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei64 – 641N6,N6-dimethyllysine; alternateBy similarity
Modified residuei64 – 641N6-methyllysine; alternateBy similarity
Modified residuei117 – 1171N6-acetyllysineBy similarity
Modified residuei175 – 1751N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

MaxQBiQ9H0C2.
PaxDbiQ9H0C2.
PRIDEiQ9H0C2.

PTM databases

PhosphoSiteiQ9H0C2.

Expressioni

Tissue specificityi

Expressed in brain, liver, sperm and testis.2 Publications

Gene expression databases

BgeeiQ9H0C2.
CleanExiHS_SLC25A31.
GenevestigatoriQ9H0C2.

Organism-specific databases

HPAiHPA015064.
HPA016841.

Interactioni

Protein-protein interaction databases

BioGridi123649. 3 interactions.
IntActiQ9H0C2. 2 interactions.
MINTiMINT-4725351.
STRINGi9606.ENSP00000281154.

Structurei

3D structure databases

ProteinModelPortaliQ9H0C2.
SMRiQ9H0C2. Positions 17-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati18 – 11093Solcar 1Add
BLAST
Repeati123 – 21391Solcar 2Add
BLAST
Repeati220 – 30788Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238123.
GeneTreeiENSGT00390000011543.
HOGENOMiHOG000165727.
HOVERGENiHBG108348.
InParanoidiQ9H0C2.
KOiK05863.
OMAiRQYKGTI.
OrthoDBiEOG7T1RBR.
PhylomeDBiQ9H0C2.
TreeFamiTF300743.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H0C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHREPAKKKA EKRLFDASSF GKDLLAGGVA AAVSKTAVAP IERVKLLLQV
60 70 80 90 100
QASSKQISPE ARYKGMVDCL VRIPREQGFF SFWRGNLANV IRYFPTQALN
110 120 130 140 150
FAFKDKYKQL FMSGVNKEKQ FWRWFLANLA SGGAAGATSL CVVYPLDFAR
160 170 180 190 200
TRLGVDIGKG PEERQFKGLG DCIMKIAKSD GIAGLYQGFG VSVQGIIVYR
210 220 230 240 250
ASYFGAYDTV KGLLPKPKKT PFLVSFFIAQ VVTTCSGILS YPFDTVRRRM
260 270 280 290 300
MMQSGEAKRQ YKGTLDCFVK IYQHEGISSF FRGAFSNVLR GTGGALVLVL
310
YDKIKEFFHI DIGGR
Length:315
Mass (Da):35,022
Last modified:March 1, 2001 - v1
Checksum:i9ACE26062CCC9675
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ863129 mRNA. Translation: CAI05952.1.
AY550240 mRNA. Translation: AAT42263.1.
AL136857 mRNA. Translation: CAB66791.1.
AC093591 Genomic DNA. Translation: AAY40974.1.
CH471056 Genomic DNA. Translation: EAX05199.1.
BC022032 mRNA. Translation: AAH22032.1.
CCDSiCCDS3733.1.
RefSeqiNP_112581.1. NM_031291.2.
UniGeneiHs.149030.

Genome annotation databases

EnsembliENST00000281154; ENSP00000281154; ENSG00000151475.
GeneIDi83447.
KEGGihsa:83447.
UCSCiuc003ifl.3. human.

Polymorphism databases

DMDMi74752557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ863129 mRNA. Translation: CAI05952.1.
AY550240 mRNA. Translation: AAT42263.1.
AL136857 mRNA. Translation: CAB66791.1.
AC093591 Genomic DNA. Translation: AAY40974.1.
CH471056 Genomic DNA. Translation: EAX05199.1.
BC022032 mRNA. Translation: AAH22032.1.
CCDSiCCDS3733.1.
RefSeqiNP_112581.1. NM_031291.2.
UniGeneiHs.149030.

3D structure databases

ProteinModelPortaliQ9H0C2.
SMRiQ9H0C2. Positions 17-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123649. 3 interactions.
IntActiQ9H0C2. 2 interactions.
MINTiMINT-4725351.
STRINGi9606.ENSP00000281154.

Protein family/group databases

TCDBi2.A.29.1.8. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSiteiQ9H0C2.

Polymorphism databases

DMDMi74752557.

Proteomic databases

MaxQBiQ9H0C2.
PaxDbiQ9H0C2.
PRIDEiQ9H0C2.

Protocols and materials databases

DNASUi83447.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281154; ENSP00000281154; ENSG00000151475.
GeneIDi83447.
KEGGihsa:83447.
UCSCiuc003ifl.3. human.

Organism-specific databases

CTDi83447.
GeneCardsiGC04P128651.
HGNCiHGNC:25319. SLC25A31.
HPAiHPA015064.
HPA016841.
MIMi610796. gene.
neXtProtiNX_Q9H0C2.
PharmGKBiPA142670904.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG238123.
GeneTreeiENSGT00390000011543.
HOGENOMiHOG000165727.
HOVERGENiHBG108348.
InParanoidiQ9H0C2.
KOiK05863.
OMAiRQYKGTI.
OrthoDBiEOG7T1RBR.
PhylomeDBiQ9H0C2.
TreeFamiTF300743.

Miscellaneous databases

GeneWikiiSLC25A31.
GenomeRNAii83447.
NextBioi72348.
PROiQ9H0C2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H0C2.
CleanExiHS_SLC25A31.
GenevestigatoriQ9H0C2.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution."
    Dolce V., Scarcia P., Iacopetta D., Palmieri F.
    FEBS Lett. 579:633-637(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Liver.
  2. "Compartmentalization of a unique ADP/ATP carrier protein SFEC (sperm flagellar energy carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece."
    Kim Y.-H., Haidl G., Schaefer M., Egner U., Mandal A., Herr J.C.
    Dev. Biol. 302:463-476(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiADT4_HUMAN
AccessioniPrimary (citable) accession number: Q9H0C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2001
Last modified: March 4, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.