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Protein

ADP/ATP translocase 4

Gene

SLC25A31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151475-MONOMER.

Protein family/group databases

TCDBi2.A.29.1.8. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 4
Alternative name(s):
ADP,ATP carrier protein 4
Adenine nucleotide translocator 4
Short name:
ANT 4
Solute carrier family 25 member 31
Sperm flagellar energy carrier protein
Gene namesi
Name:SLC25A31
Synonyms:AAC4, ANT4, SFEC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:25319. SLC25A31.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei90 – 110Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei124 – 144Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei179 – 199Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei221 – 241Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei285 – 305Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum, Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi83447.
OpenTargetsiENSG00000151475.
PharmGKBiPA142670904.

Polymorphism and mutation databases

BioMutaiSLC25A31.
DMDMi74752557.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002976241 – 315ADP/ATP translocase 4Add BLAST315

Proteomic databases

EPDiQ9H0C2.
MaxQBiQ9H0C2.
PaxDbiQ9H0C2.
PeptideAtlasiQ9H0C2.
PRIDEiQ9H0C2.

PTM databases

iPTMnetiQ9H0C2.
PhosphoSitePlusiQ9H0C2.
SwissPalmiQ9H0C2.

Expressioni

Tissue specificityi

Expressed in brain, liver, sperm and testis.2 Publications

Gene expression databases

BgeeiENSG00000151475.
CleanExiHS_SLC25A31.
GenevisibleiQ9H0C2. HS.

Organism-specific databases

HPAiHPA015064.
HPA016841.

Interactioni

Protein-protein interaction databases

BioGridi123649. 2 interactors.
IntActiQ9H0C2. 4 interactors.
MINTiMINT-4725351.
STRINGi9606.ENSP00000281154.

Structurei

3D structure databases

ProteinModelPortaliQ9H0C2.
SMRiQ9H0C2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 110Solcar 1Add BLAST93
Repeati123 – 213Solcar 2Add BLAST91
Repeati220 – 307Solcar 3Add BLAST88

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
GeneTreeiENSGT00390000011543.
HOGENOMiHOG000165727.
HOVERGENiHBG108348.
InParanoidiQ9H0C2.
KOiK05863.
OMAiQHEGINA.
OrthoDBiEOG091G0ULB.
PhylomeDBiQ9H0C2.
TreeFamiTF300743.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H0C2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHREPAKKKA EKRLFDASSF GKDLLAGGVA AAVSKTAVAP IERVKLLLQV
60 70 80 90 100
QASSKQISPE ARYKGMVDCL VRIPREQGFF SFWRGNLANV IRYFPTQALN
110 120 130 140 150
FAFKDKYKQL FMSGVNKEKQ FWRWFLANLA SGGAAGATSL CVVYPLDFAR
160 170 180 190 200
TRLGVDIGKG PEERQFKGLG DCIMKIAKSD GIAGLYQGFG VSVQGIIVYR
210 220 230 240 250
ASYFGAYDTV KGLLPKPKKT PFLVSFFIAQ VVTTCSGILS YPFDTVRRRM
260 270 280 290 300
MMQSGEAKRQ YKGTLDCFVK IYQHEGISSF FRGAFSNVLR GTGGALVLVL
310
YDKIKEFFHI DIGGR
Length:315
Mass (Da):35,022
Last modified:March 1, 2001 - v1
Checksum:i9ACE26062CCC9675
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_074177303K → E.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ863129 mRNA. Translation: CAI05952.1.
AY550240 mRNA. Translation: AAT42263.1.
AL136857 mRNA. Translation: CAB66791.1.
AC093591 Genomic DNA. Translation: AAY40974.1.
CH471056 Genomic DNA. Translation: EAX05199.1.
BC022032 mRNA. Translation: AAH22032.1.
CCDSiCCDS3733.1.
RefSeqiNP_001305396.1. NM_001318467.1.
NP_112581.1. NM_031291.3.
UniGeneiHs.149030.

Genome annotation databases

EnsembliENST00000281154; ENSP00000281154; ENSG00000151475.
GeneIDi83447.
KEGGihsa:83447.
UCSCiuc003ifl.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ863129 mRNA. Translation: CAI05952.1.
AY550240 mRNA. Translation: AAT42263.1.
AL136857 mRNA. Translation: CAB66791.1.
AC093591 Genomic DNA. Translation: AAY40974.1.
CH471056 Genomic DNA. Translation: EAX05199.1.
BC022032 mRNA. Translation: AAH22032.1.
CCDSiCCDS3733.1.
RefSeqiNP_001305396.1. NM_001318467.1.
NP_112581.1. NM_031291.3.
UniGeneiHs.149030.

3D structure databases

ProteinModelPortaliQ9H0C2.
SMRiQ9H0C2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123649. 2 interactors.
IntActiQ9H0C2. 4 interactors.
MINTiMINT-4725351.
STRINGi9606.ENSP00000281154.

Protein family/group databases

TCDBi2.A.29.1.8. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiQ9H0C2.
PhosphoSitePlusiQ9H0C2.
SwissPalmiQ9H0C2.

Polymorphism and mutation databases

BioMutaiSLC25A31.
DMDMi74752557.

Proteomic databases

EPDiQ9H0C2.
MaxQBiQ9H0C2.
PaxDbiQ9H0C2.
PeptideAtlasiQ9H0C2.
PRIDEiQ9H0C2.

Protocols and materials databases

DNASUi83447.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281154; ENSP00000281154; ENSG00000151475.
GeneIDi83447.
KEGGihsa:83447.
UCSCiuc003ifl.4. human.

Organism-specific databases

CTDi83447.
DisGeNETi83447.
GeneCardsiSLC25A31.
HGNCiHGNC:25319. SLC25A31.
HPAiHPA015064.
HPA016841.
MIMi610796. gene.
neXtProtiNX_Q9H0C2.
OpenTargetsiENSG00000151475.
PharmGKBiPA142670904.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
GeneTreeiENSGT00390000011543.
HOGENOMiHOG000165727.
HOVERGENiHBG108348.
InParanoidiQ9H0C2.
KOiK05863.
OMAiQHEGINA.
OrthoDBiEOG091G0ULB.
PhylomeDBiQ9H0C2.
TreeFamiTF300743.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151475-MONOMER.

Miscellaneous databases

GeneWikiiSLC25A31.
GenomeRNAii83447.
PROiQ9H0C2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151475.
CleanExiHS_SLC25A31.
GenevisibleiQ9H0C2. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADT4_HUMAN
AccessioniPrimary (citable) accession number: Q9H0C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.