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Q9H0C2

- ADT4_HUMAN

UniProt

Q9H0C2 - ADT4_HUMAN

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Protein
ADP/ATP translocase 4
Gene
SLC25A31, AAC4, ANT4, SFEC
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility.1 Publication

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.1.8. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 4
Alternative name(s):
ADP,ATP carrier protein 4
Adenine nucleotide translocator 4
Short name:
ANT 4
Solute carrier family 25 member 31
Sperm flagellar energy carrier protein
Gene namesi
Synonyms:AAC4, ANT4, SFEC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:25319. SLC25A31.

Subcellular locationi

Mitochondrion inner membrane; Multi-pass membrane protein. Cell projectionciliumflagellum
Note: In sperm flagellum this protein is located in the fibrous sheath, a non-mitochondrial region.2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4421Helical; Name=1; Reviewed prediction
Add
BLAST
Transmembranei90 – 11021Helical; Name=2; Reviewed prediction
Add
BLAST
Transmembranei124 – 14421Helical; Name=3; Reviewed prediction
Add
BLAST
Transmembranei179 – 19921Helical; Name=4; Reviewed prediction
Add
BLAST
Transmembranei221 – 24121Helical; Name=5; Reviewed prediction
Add
BLAST
Transmembranei285 – 30521Helical; Name=6; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cilium Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrial inner membrane Source: UniProtKB-SubCell
  4. mitochondrion Source: LIFEdb
  5. nucleus Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum, Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670904.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315ADP/ATP translocase 4
PRO_0000297624Add
BLAST

Proteomic databases

MaxQBiQ9H0C2.
PaxDbiQ9H0C2.
PRIDEiQ9H0C2.

PTM databases

PhosphoSiteiQ9H0C2.

Expressioni

Tissue specificityi

Expressed in brain, liver, sperm and testis.2 Publications

Gene expression databases

BgeeiQ9H0C2.
CleanExiHS_SLC25A31.
GenevestigatoriQ9H0C2.

Organism-specific databases

HPAiHPA015064.
HPA016841.

Interactioni

Protein-protein interaction databases

BioGridi123649. 2 interactions.
IntActiQ9H0C2. 2 interactions.
MINTiMINT-4725351.
STRINGi9606.ENSP00000281154.

Structurei

3D structure databases

ProteinModelPortaliQ9H0C2.
SMRiQ9H0C2. Positions 17-304.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati18 – 11093Solcar 1
Add
BLAST
Repeati123 – 21391Solcar 2
Add
BLAST
Repeati220 – 30788Solcar 3
Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238123.
HOGENOMiHOG000165727.
HOVERGENiHBG108348.
InParanoidiQ9H0C2.
KOiK05863.
OMAiRQYKGTI.
OrthoDBiEOG7T1RBR.
PhylomeDBiQ9H0C2.
TreeFamiTF300743.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H0C2-1 [UniParc]FASTAAdd to Basket

« Hide

MHREPAKKKA EKRLFDASSF GKDLLAGGVA AAVSKTAVAP IERVKLLLQV    50
QASSKQISPE ARYKGMVDCL VRIPREQGFF SFWRGNLANV IRYFPTQALN 100
FAFKDKYKQL FMSGVNKEKQ FWRWFLANLA SGGAAGATSL CVVYPLDFAR 150
TRLGVDIGKG PEERQFKGLG DCIMKIAKSD GIAGLYQGFG VSVQGIIVYR 200
ASYFGAYDTV KGLLPKPKKT PFLVSFFIAQ VVTTCSGILS YPFDTVRRRM 250
MMQSGEAKRQ YKGTLDCFVK IYQHEGISSF FRGAFSNVLR GTGGALVLVL 300
YDKIKEFFHI DIGGR 315
Length:315
Mass (Da):35,022
Last modified:March 1, 2001 - v1
Checksum:i9ACE26062CCC9675
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ863129 mRNA. Translation: CAI05952.1.
AY550240 mRNA. Translation: AAT42263.1.
AL136857 mRNA. Translation: CAB66791.1.
AC093591 Genomic DNA. Translation: AAY40974.1.
CH471056 Genomic DNA. Translation: EAX05199.1.
BC022032 mRNA. Translation: AAH22032.1.
CCDSiCCDS3733.1.
RefSeqiNP_112581.1. NM_031291.2.
UniGeneiHs.149030.

Genome annotation databases

EnsembliENST00000281154; ENSP00000281154; ENSG00000151475.
GeneIDi83447.
KEGGihsa:83447.
UCSCiuc003ifl.3. human.

Polymorphism databases

DMDMi74752557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ863129 mRNA. Translation: CAI05952.1 .
AY550240 mRNA. Translation: AAT42263.1 .
AL136857 mRNA. Translation: CAB66791.1 .
AC093591 Genomic DNA. Translation: AAY40974.1 .
CH471056 Genomic DNA. Translation: EAX05199.1 .
BC022032 mRNA. Translation: AAH22032.1 .
CCDSi CCDS3733.1.
RefSeqi NP_112581.1. NM_031291.2.
UniGenei Hs.149030.

3D structure databases

ProteinModelPortali Q9H0C2.
SMRi Q9H0C2. Positions 17-304.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123649. 2 interactions.
IntActi Q9H0C2. 2 interactions.
MINTi MINT-4725351.
STRINGi 9606.ENSP00000281154.

Protein family/group databases

TCDBi 2.A.29.1.8. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSitei Q9H0C2.

Polymorphism databases

DMDMi 74752557.

Proteomic databases

MaxQBi Q9H0C2.
PaxDbi Q9H0C2.
PRIDEi Q9H0C2.

Protocols and materials databases

DNASUi 83447.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000281154 ; ENSP00000281154 ; ENSG00000151475 .
GeneIDi 83447.
KEGGi hsa:83447.
UCSCi uc003ifl.3. human.

Organism-specific databases

CTDi 83447.
GeneCardsi GC04P128651.
HGNCi HGNC:25319. SLC25A31.
HPAi HPA015064.
HPA016841.
MIMi 610796. gene.
neXtProti NX_Q9H0C2.
PharmGKBi PA142670904.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG238123.
HOGENOMi HOG000165727.
HOVERGENi HBG108348.
InParanoidi Q9H0C2.
KOi K05863.
OMAi RQYKGTI.
OrthoDBi EOG7T1RBR.
PhylomeDBi Q9H0C2.
TreeFami TF300743.

Miscellaneous databases

GeneWikii SLC25A31.
GenomeRNAii 83447.
NextBioi 72348.
PROi Q9H0C2.
SOURCEi Search...

Gene expression databases

Bgeei Q9H0C2.
CleanExi HS_SLC25A31.
Genevestigatori Q9H0C2.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution."
    Dolce V., Scarcia P., Iacopetta D., Palmieri F.
    FEBS Lett. 579:633-637(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Liver.
  2. "Compartmentalization of a unique ADP/ATP carrier protein SFEC (sperm flagellar energy carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece."
    Kim Y.-H., Haidl G., Schaefer M., Egner U., Mandal A., Herr J.C.
    Dev. Biol. 302:463-476(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiADT4_HUMAN
AccessioniPrimary (citable) accession number: Q9H0C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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