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Protein

Zinc finger MYND domain-containing protein 12

Gene

ZMYND12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri17 – 5438MYND-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MYND domain-containing protein 12
Gene namesi
Name:ZMYND12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:21192. ZMYND12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134993145.

Polymorphism and mutation databases

BioMutaiZMYND12.
DMDMi322510090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Zinc finger MYND domain-containing protein 12PRO_0000218316Add
BLAST

Proteomic databases

PaxDbiQ9H0C1.
PRIDEiQ9H0C1.

PTM databases

PhosphoSiteiQ9H0C1.

Expressioni

Gene expression databases

BgeeiQ9H0C1.
CleanExiHS_ZMYND12.
ExpressionAtlasiQ9H0C1. baseline and differential.
GenevisibleiQ9H0C1. HS.

Interactioni

Protein-protein interaction databases

MINTiMINT-4714146.
STRINGi9606.ENSP00000361646.

Structurei

3D structure databases

ProteinModelPortaliQ9H0C1.
SMRiQ9H0C1. Positions 210-243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati172 – 20534TPR 1Add
BLAST
Repeati214 – 24734TPR 2Add
BLAST

Sequence similaritiesi

Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation
Contains 2 TPR repeats.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri17 – 5438MYND-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, TPR repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IFR5. Eukaryota.
ENOG410ZNR5. LUCA.
GeneTreeiENSGT00390000004248.
HOGENOMiHOG000232150.
HOVERGENiHBG054572.
InParanoidiQ9H0C1.
OMAiWGSIHEK.
PhylomeDBiQ9H0C1.
TreeFamiTF328348.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR011990. TPR-like_helical_dom.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF01753. zf-MYND. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H0C1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVIYPLAVP KGRRLCCEVC EAPAERVCAA CTVTYYCGVV HQKADWDSIH
60 70 80 90 100
EKICQLLIPL RTSMPFYNSE EERQHGLQQL QQRQKYLIEF CYTIAQKYLF
110 120 130 140 150
EGKHEDAVPA ALQSLRFRVK LYGLSSVELV PAYLLLAEAS LGLGRIVQAE
160 170 180 190 200
EYLFQAQWTV LKSTDCSNAT HSLLHRNLGL LYIAKKNYEE ARYHLANDIY
210 220 230 240 250
FASCAFGTED IRTSGGYFHL ANIFYDLKKL DLADTLYTKV SEIWHAYLNN
260 270 280 290 300
HYQVLSQAHI QQMDLLGKLF ENDTGLDEAQ EAEAIRILTS ILNIRESTSD
310 320 330 340 350
KAPQKTIFVL KILVMFYYLM MNSSKAQEYG MRALSLAKEQ QLDVHEQSTI
360
QELLSLISTE DHPIT
Length:365
Mass (Da):41,818
Last modified:February 8, 2011 - v3
Checksum:i3974C5C55D0A2302
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti134 – 1341L → P in CAB66792 (PubMed:11230166).Curated
Sequence conflicti166 – 1661C → Y in BAB71461 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti316 – 3161F → L.3 Publications
Corresponds to variant rs1034268 [ dbSNP | Ensembl ].
VAR_018425

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136858 mRNA. Translation: CAB66792.1.
AK057384 mRNA. Translation: BAB71461.1.
AL513331, AL445669 Genomic DNA. Translation: CAH70660.1.
AL445669, AL513331 Genomic DNA. Translation: CAH70745.1.
BC024186 mRNA. Translation: AAH24186.1.
CCDSiCCDS467.1.
RefSeqiNP_001139664.1. NM_001146192.1.
NP_115633.3. NM_032257.4.
UniGeneiHs.294009.

Genome annotation databases

EnsembliENST00000372565; ENSP00000361646; ENSG00000066185.
GeneIDi84217.
KEGGihsa:84217.
UCSCiuc001chj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136858 mRNA. Translation: CAB66792.1.
AK057384 mRNA. Translation: BAB71461.1.
AL513331, AL445669 Genomic DNA. Translation: CAH70660.1.
AL445669, AL513331 Genomic DNA. Translation: CAH70745.1.
BC024186 mRNA. Translation: AAH24186.1.
CCDSiCCDS467.1.
RefSeqiNP_001139664.1. NM_001146192.1.
NP_115633.3. NM_032257.4.
UniGeneiHs.294009.

3D structure databases

ProteinModelPortaliQ9H0C1.
SMRiQ9H0C1. Positions 210-243.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4714146.
STRINGi9606.ENSP00000361646.

PTM databases

PhosphoSiteiQ9H0C1.

Polymorphism and mutation databases

BioMutaiZMYND12.
DMDMi322510090.

Proteomic databases

PaxDbiQ9H0C1.
PRIDEiQ9H0C1.

Protocols and materials databases

DNASUi84217.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372565; ENSP00000361646; ENSG00000066185.
GeneIDi84217.
KEGGihsa:84217.
UCSCiuc001chj.4. human.

Organism-specific databases

CTDi84217.
GeneCardsiZMYND12.
HGNCiHGNC:21192. ZMYND12.
neXtProtiNX_Q9H0C1.
PharmGKBiPA134993145.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFR5. Eukaryota.
ENOG410ZNR5. LUCA.
GeneTreeiENSGT00390000004248.
HOGENOMiHOG000232150.
HOVERGENiHBG054572.
InParanoidiQ9H0C1.
OMAiWGSIHEK.
PhylomeDBiQ9H0C1.
TreeFamiTF328348.

Miscellaneous databases

GenomeRNAii84217.
NextBioi73634.
PROiQ9H0C1.

Gene expression databases

BgeeiQ9H0C1.
CleanExiHS_ZMYND12.
ExpressionAtlasiQ9H0C1. baseline and differential.
GenevisibleiQ9H0C1. HS.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR011990. TPR-like_helical_dom.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF01753. zf-MYND. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-316.
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-316.
    Tissue: Testis.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-316.
    Tissue: Testis.

Entry informationi

Entry nameiZMY12_HUMAN
AccessioniPrimary (citable) accession number: Q9H0C1
Secondary accession number(s): Q5VUS6, Q8TC87, Q96M51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: February 8, 2011
Last modified: May 11, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.