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Q9H0B8 (CRLD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine-rich secretory protein LCCL domain-containing 2
Alternative name(s):
Cysteine-rich secretory protein 11
Short name=CRISP-11
LCCL domain-containing cysteine-rich secretory protein 2
Gene names
Name:CRISPLD2
Synonyms:CRISP11, LCRISP2
ORF Names:UNQ2914/PRO1156/PRO9783
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Promotes matrix assembly By similarity.

Subunit structure

Binds to heparin, dermatan sulfate and chondroitin sulfate By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the CRISP family.

Contains 2 LCCL domains.

Contains 1 SCP domain.

Ontologies

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H0B8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H0B8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     436-497: TSSICKTAVH...KAFRIFAVRQ → VSRMHFQQLSRKAC
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9H0B8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     371-371: S → R
     372-497: Missing.
Isoform 4 (identifier: Q9H0B8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     81-159: TWDDELEKSA...CPERCSGPMC → VSAGSGRRGW...QWHNRHALKP
     160-497: Missing.
Note: No experimental confirmation available.
Isoform 5 (identifier: Q9H0B8-5)

The sequence of this isoform differs from the canonical sequence as follows:
     121-497: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 497475Cysteine-rich secretory protein LCCL domain-containing 2
PRO_0000248149

Regions

Domain62 – 200139SCP
Domain284 – 37996LCCL 1
Domain385 – 488104LCCL 2

Amino acid modifications

Glycosylation271N-linked (GlcNAc...) Potential
Disulfide bond290 ↔ 308 By similarity
Disulfide bond312 ↔ 332 By similarity
Disulfide bond391 ↔ 413 By similarity
Disulfide bond417 ↔ 440 By similarity

Natural variations

Alternative sequence81 – 15979TWDDE…SGPMC → VSAGSGRRGWHRGWGLGHQP ALFPSQLCSPASACDGWLRV SSGRGGSRLCSVLFVCFETG SHSATDAGVQWHNRHALKP in isoform 4.
VSP_020178
Alternative sequence121 – 497377Missing in isoform 5.
VSP_020179
Alternative sequence160 – 497338Missing in isoform 4.
VSP_020180
Alternative sequence3711S → R in isoform 3.
VSP_020181
Alternative sequence372 – 497126Missing in isoform 3.
VSP_020182
Alternative sequence436 – 49762TSSIC…FAVRQ → VSRMHFQQLSRKAC in isoform 2.
VSP_020183
Natural variant1051S → G. Ref.4 Ref.5
Corresponds to variant rs12051468 [ dbSNP | Ensembl ].
VAR_027256
Natural variant3221T → S. Ref.2 Ref.5
Corresponds to variant rs721005 [ dbSNP | Ensembl ].
VAR_027257

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 1E7ADDCAB37CA4ED

FASTA49755,920
        10         20         30         40         50         60 
MSCVLGGVIP LGLLFLVCGS QGYLLPNVTL LEELLSKYQH NESHSRVRRA IPREDKEEIL 

        70         80         90        100        110        120 
MLHNKLRGQV QPQASNMEYM TWDDELEKSA AAWASQCIWE HGPTSLLVSI GQNLGAHWGR 

       130        140        150        160        170        180 
YRSPGFHVQS WYDEVKDYTY PYPSECNPWC PERCSGPMCT HYTQIVWATT NKIGCAVNTC 

       190        200        210        220        230        240 
RKMTVWGEVW ENAVYFVCNY SPKGNWIGEA PYKNGRPCSE CPPSYGGSCR NNLCYREETY 

       250        260        270        280        290        300 
TPKPETDEMN EVETAPIPEE NHVWLQPRVM RPTKPKKTSA VNYMTQVVRC DTKMKDRCKG 

       310        320        330        340        350        360 
STCNRYQCPA GCLNHKAKIF GTLFYESSSS ICRAAIHYGI LDDKGGLVDI TRNGKVPFFV 

       370        380        390        400        410        420 
KSERHGVQSL SKYKPSSSFM VSKVKVQDLD CYTTVAQLCP FEKPATHCPR IHCPAHCKDE 

       430        440        450        460        470        480 
PSYWAPVFGT NIYADTSSIC KTAVHAGVIS NESGGDVDVM PVDKKKTYVG SLRNGVQSES 

       490 
LGTPRDGKAF RIFAVRQ 

« Hide

Isoform 2 [UniParc].

Checksum: 1E597E5C8CA8CD66
Show »

FASTA44951,044
Isoform 3 [UniParc].

Checksum: 8D23FBE14F53E85C
Show »

FASTA37142,207
Isoform 4 [UniParc].

Checksum: CE3BAAB490465049
Show »

FASTA15917,476
Isoform 5 [UniParc].

Checksum: D0B40A3149B1099C
Show »

FASTA12013,497

References

[1]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT SER-322.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Mammary gland.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-105.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5), VARIANTS GLY-105 AND SER-322.
Tissue: Blood and Melanoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL136861 mRNA. Translation: CAB66795.1.
AY358413 mRNA. Translation: AAQ88779.1.
AY358790 mRNA. Translation: AAQ89150.1.
AK027395 mRNA. Translation: BAB55081.1.
CH471114 Genomic DNA. Translation: EAW95468.1.
CH471114 Genomic DNA. Translation: EAW95469.1.
BC007689 mRNA. Translation: AAH07689.1.
BC063012 mRNA. Translation: AAH63012.1.
RefSeqNP_113664.1. NM_031476.3.
XP_005256247.1. XM_005256190.1.
UniGeneHs.513779.
Hs.617091.

3D structure databases

ProteinModelPortalQ9H0B8.
SMRQ9H0B8. Positions 53-234, 308-382, 386-491.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123739. 1 interaction.
IntActQ9H0B8. 1 interaction.
MINTMINT-3065575.
STRING9606.ENSP00000262424.

PTM databases

PhosphoSiteQ9H0B8.

Polymorphism databases

DMDM74717972.

Proteomic databases

PaxDbQ9H0B8.
PeptideAtlasQ9H0B8.
PRIDEQ9H0B8.

Protocols and materials databases

DNASU83716.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000262424; ENSP00000262424; ENSG00000103196. [Q9H0B8-1]
ENST00000564567; ENSP00000457655; ENSG00000103196. [Q9H0B8-2]
ENST00000569090; ENSP00000454858; ENSG00000103196. [Q9H0B8-5]
GeneID83716.
KEGGhsa:83716.
UCSCuc002fik.4. human. [Q9H0B8-4]
uc002fil.2. human. [Q9H0B8-5]
uc002fim.2. human. [Q9H0B8-3]
uc002fin.4. human. [Q9H0B8-2]
uc010voh.1. human. [Q9H0B8-1]

Organism-specific databases

CTD83716.
GeneCardsGC16P084853.
HGNCHGNC:25248. CRISPLD2.
HPAHPA030055.
MIM612434. gene.
neXtProtNX_Q9H0B8.
PharmGKBPA142672077.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2340.
HOVERGENHBG062505.
InParanoidQ9H0B8.
OMAKDKCKGS.
OrthoDBEOG7F7WB4.
PhylomeDBQ9H0B8.
TreeFamTF316148.

Gene expression databases

ArrayExpressQ9H0B8.
BgeeQ9H0B8.
CleanExHS_CRISPLD2.
GenevestigatorQ9H0B8.

Family and domain databases

Gene3D2.170.130.20. 2 hits.
3.40.33.10. 1 hit.
InterProIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR004043. LCCL.
[Graphical view]
PANTHERPTHR10334. PTHR10334. 1 hit.
PfamPF00188. CAP. 1 hit.
PF03815. LCCL. 2 hits.
[Graphical view]
PRINTSPR00837. V5TPXLIKE.
SMARTSM00603. LCCL. 2 hits.
SM00198. SCP. 1 hit.
[Graphical view]
SUPFAMSSF55797. SSF55797. 1 hit.
SSF69848. SSF69848. 2 hits.
PROSITEPS01010. CRISP_2. 1 hit.
PS50820. LCCL. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCRISPLD2. human.
GeneWikiCRISPLD2.
GenomeRNAi83716.
NextBio72711.
PROQ9H0B8.
SOURCESearch...

Entry information

Entry nameCRLD2_HUMAN
AccessionPrimary (citable) accession number: Q9H0B8
Secondary accession number(s): D3DUM0 expand/collapse secondary AC list , Q6P590, Q6UWH0, Q6UXC6, Q96IB1, Q96K61
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2001
Last modified: March 19, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM