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Q9H0B8

- CRLD2_HUMAN

UniProt

Q9H0B8 - CRLD2_HUMAN

Protein

Cysteine-rich secretory protein LCCL domain-containing 2

Gene

CRISPLD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Promotes matrix assembly.By similarity

    GO - Molecular functioni

    1. heparin binding Source: Ensembl

    GO - Biological processi

    1. extracellular matrix organization Source: Ensembl
    2. face morphogenesis Source: UniProt
    3. lung development Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine-rich secretory protein LCCL domain-containing 2
    Alternative name(s):
    Cysteine-rich secretory protein 11
    Short name:
    CRISP-11
    LCCL domain-containing cysteine-rich secretory protein 2
    Gene namesi
    Name:CRISPLD2
    Synonyms:CRISP11, LCRISP2
    ORF Names:UNQ2914/PRO1156/PRO9783
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:25248. CRISPLD2.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular matrix Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell
    3. transport vesicle Source: LIFEdb

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672077.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 497475Cysteine-rich secretory protein LCCL domain-containing 2PRO_0000248149Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi290 ↔ 308PROSITE-ProRule annotation
    Disulfide bondi312 ↔ 332PROSITE-ProRule annotation
    Disulfide bondi391 ↔ 413PROSITE-ProRule annotation
    Disulfide bondi417 ↔ 440PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9H0B8.
    PaxDbiQ9H0B8.
    PeptideAtlasiQ9H0B8.
    PRIDEiQ9H0B8.

    PTM databases

    PhosphoSiteiQ9H0B8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H0B8.
    BgeeiQ9H0B8.
    CleanExiHS_CRISPLD2.
    GenevestigatoriQ9H0B8.

    Organism-specific databases

    HPAiHPA030055.

    Interactioni

    Subunit structurei

    Binds to heparin, dermatan sulfate and chondroitin sulfate.By similarity

    Protein-protein interaction databases

    BioGridi123739. 1 interaction.
    IntActiQ9H0B8. 1 interaction.
    MINTiMINT-3065575.
    STRINGi9606.ENSP00000262424.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H0B8.
    SMRiQ9H0B8. Positions 53-234, 308-382, 413-481.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini62 – 200139SCPAdd
    BLAST
    Domaini284 – 37996LCCL 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini385 – 488104LCCL 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CRISP family.Curated
    Contains 2 LCCL domains.PROSITE-ProRule annotation
    Contains 1 SCP domain.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG2340.
    HOVERGENiHBG062505.
    InParanoidiQ9H0B8.
    OMAiKDKCKGS.
    OrthoDBiEOG7F7WB4.
    PhylomeDBiQ9H0B8.
    TreeFamiTF316148.

    Family and domain databases

    Gene3Di2.170.130.20. 2 hits.
    3.40.33.10. 1 hit.
    InterProiIPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    IPR004043. LCCL.
    [Graphical view]
    PANTHERiPTHR10334. PTHR10334. 1 hit.
    PfamiPF00188. CAP. 1 hit.
    PF03815. LCCL. 2 hits.
    [Graphical view]
    PRINTSiPR00837. V5TPXLIKE.
    SMARTiSM00603. LCCL. 2 hits.
    SM00198. SCP. 1 hit.
    [Graphical view]
    SUPFAMiSSF55797. SSF55797. 1 hit.
    SSF69848. SSF69848. 2 hits.
    PROSITEiPS01010. CRISP_2. 1 hit.
    PS50820. LCCL. 2 hits.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H0B8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSCVLGGVIP LGLLFLVCGS QGYLLPNVTL LEELLSKYQH NESHSRVRRA    50
    IPREDKEEIL MLHNKLRGQV QPQASNMEYM TWDDELEKSA AAWASQCIWE 100
    HGPTSLLVSI GQNLGAHWGR YRSPGFHVQS WYDEVKDYTY PYPSECNPWC 150
    PERCSGPMCT HYTQIVWATT NKIGCAVNTC RKMTVWGEVW ENAVYFVCNY 200
    SPKGNWIGEA PYKNGRPCSE CPPSYGGSCR NNLCYREETY TPKPETDEMN 250
    EVETAPIPEE NHVWLQPRVM RPTKPKKTSA VNYMTQVVRC DTKMKDRCKG 300
    STCNRYQCPA GCLNHKAKIF GTLFYESSSS ICRAAIHYGI LDDKGGLVDI 350
    TRNGKVPFFV KSERHGVQSL SKYKPSSSFM VSKVKVQDLD CYTTVAQLCP 400
    FEKPATHCPR IHCPAHCKDE PSYWAPVFGT NIYADTSSIC KTAVHAGVIS 450
    NESGGDVDVM PVDKKKTYVG SLRNGVQSES LGTPRDGKAF RIFAVRQ 497
    Length:497
    Mass (Da):55,920
    Last modified:March 1, 2001 - v1
    Checksum:i1E7ADDCAB37CA4ED
    GO
    Isoform 2 (identifier: Q9H0B8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         436-497: TSSICKTAVH...KAFRIFAVRQ → VSRMHFQQLSRKAC

    Note: No experimental confirmation available.

    Show »
    Length:449
    Mass (Da):51,044
    Checksum:i1E597E5C8CA8CD66
    GO
    Isoform 3 (identifier: Q9H0B8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         371-371: S → R
         372-497: Missing.

    Show »
    Length:371
    Mass (Da):42,207
    Checksum:i8D23FBE14F53E85C
    GO
    Isoform 4 (identifier: Q9H0B8-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         81-159: TWDDELEKSA...CPERCSGPMC → VSAGSGRRGW...QWHNRHALKP
         160-497: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:159
    Mass (Da):17,476
    Checksum:iCE3BAAB490465049
    GO
    Isoform 5 (identifier: Q9H0B8-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         121-497: Missing.

    Show »
    Length:120
    Mass (Da):13,497
    Checksum:iD0B40A3149B1099C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti105 – 1051S → G.2 Publications
    Corresponds to variant rs12051468 [ dbSNP | Ensembl ].
    VAR_027256
    Natural varianti322 – 3221T → S.2 Publications
    Corresponds to variant rs721005 [ dbSNP | Ensembl ].
    VAR_027257

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei81 – 15979TWDDE…SGPMC → VSAGSGRRGWHRGWGLGHQP ALFPSQLCSPASACDGWLRV SSGRGGSRLCSVLFVCFETG SHSATDAGVQWHNRHALKP in isoform 4. 1 PublicationVSP_020178Add
    BLAST
    Alternative sequencei121 – 497377Missing in isoform 5. 1 PublicationVSP_020179Add
    BLAST
    Alternative sequencei160 – 497338Missing in isoform 4. 1 PublicationVSP_020180Add
    BLAST
    Alternative sequencei371 – 3711S → R in isoform 3. 1 PublicationVSP_020181
    Alternative sequencei372 – 497126Missing in isoform 3. 1 PublicationVSP_020182Add
    BLAST
    Alternative sequencei436 – 49762TSSIC…FAVRQ → VSRMHFQQLSRKAC in isoform 2. 1 PublicationVSP_020183Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136861 mRNA. Translation: CAB66795.1.
    AY358413 mRNA. Translation: AAQ88779.1.
    AY358790 mRNA. Translation: AAQ89150.1.
    AK027395 mRNA. Translation: BAB55081.1.
    CH471114 Genomic DNA. Translation: EAW95468.1.
    CH471114 Genomic DNA. Translation: EAW95469.1.
    BC007689 mRNA. Translation: AAH07689.1.
    BC063012 mRNA. Translation: AAH63012.1.
    CCDSiCCDS10949.1. [Q9H0B8-1]
    RefSeqiNP_113664.1. NM_031476.3. [Q9H0B8-1]
    XP_005256247.1. XM_005256190.1. [Q9H0B8-1]
    UniGeneiHs.513779.
    Hs.617091.

    Genome annotation databases

    EnsembliENST00000262424; ENSP00000262424; ENSG00000103196. [Q9H0B8-1]
    ENST00000564567; ENSP00000457655; ENSG00000103196. [Q9H0B8-2]
    ENST00000569090; ENSP00000454858; ENSG00000103196. [Q9H0B8-5]
    GeneIDi83716.
    KEGGihsa:83716.
    UCSCiuc002fik.4. human. [Q9H0B8-4]
    uc002fil.2. human. [Q9H0B8-5]
    uc002fim.2. human. [Q9H0B8-3]
    uc002fin.4. human. [Q9H0B8-2]
    uc010voh.1. human. [Q9H0B8-1]

    Polymorphism databases

    DMDMi74717972.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136861 mRNA. Translation: CAB66795.1 .
    AY358413 mRNA. Translation: AAQ88779.1 .
    AY358790 mRNA. Translation: AAQ89150.1 .
    AK027395 mRNA. Translation: BAB55081.1 .
    CH471114 Genomic DNA. Translation: EAW95468.1 .
    CH471114 Genomic DNA. Translation: EAW95469.1 .
    BC007689 mRNA. Translation: AAH07689.1 .
    BC063012 mRNA. Translation: AAH63012.1 .
    CCDSi CCDS10949.1. [Q9H0B8-1 ]
    RefSeqi NP_113664.1. NM_031476.3. [Q9H0B8-1 ]
    XP_005256247.1. XM_005256190.1. [Q9H0B8-1 ]
    UniGenei Hs.513779.
    Hs.617091.

    3D structure databases

    ProteinModelPortali Q9H0B8.
    SMRi Q9H0B8. Positions 53-234, 308-382, 413-481.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123739. 1 interaction.
    IntActi Q9H0B8. 1 interaction.
    MINTi MINT-3065575.
    STRINGi 9606.ENSP00000262424.

    PTM databases

    PhosphoSitei Q9H0B8.

    Polymorphism databases

    DMDMi 74717972.

    Proteomic databases

    MaxQBi Q9H0B8.
    PaxDbi Q9H0B8.
    PeptideAtlasi Q9H0B8.
    PRIDEi Q9H0B8.

    Protocols and materials databases

    DNASUi 83716.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262424 ; ENSP00000262424 ; ENSG00000103196 . [Q9H0B8-1 ]
    ENST00000564567 ; ENSP00000457655 ; ENSG00000103196 . [Q9H0B8-2 ]
    ENST00000569090 ; ENSP00000454858 ; ENSG00000103196 . [Q9H0B8-5 ]
    GeneIDi 83716.
    KEGGi hsa:83716.
    UCSCi uc002fik.4. human. [Q9H0B8-4 ]
    uc002fil.2. human. [Q9H0B8-5 ]
    uc002fim.2. human. [Q9H0B8-3 ]
    uc002fin.4. human. [Q9H0B8-2 ]
    uc010voh.1. human. [Q9H0B8-1 ]

    Organism-specific databases

    CTDi 83716.
    GeneCardsi GC16P084853.
    HGNCi HGNC:25248. CRISPLD2.
    HPAi HPA030055.
    MIMi 612434. gene.
    neXtProti NX_Q9H0B8.
    PharmGKBi PA142672077.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2340.
    HOVERGENi HBG062505.
    InParanoidi Q9H0B8.
    OMAi KDKCKGS.
    OrthoDBi EOG7F7WB4.
    PhylomeDBi Q9H0B8.
    TreeFami TF316148.

    Miscellaneous databases

    ChiTaRSi CRISPLD2. human.
    GeneWikii CRISPLD2.
    GenomeRNAii 83716.
    NextBioi 72711.
    PROi Q9H0B8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H0B8.
    Bgeei Q9H0B8.
    CleanExi HS_CRISPLD2.
    Genevestigatori Q9H0B8.

    Family and domain databases

    Gene3Di 2.170.130.20. 2 hits.
    3.40.33.10. 1 hit.
    InterProi IPR001283. Allrgn_V5/Tpx1.
    IPR018244. Allrgn_V5/Tpx1_CS.
    IPR014044. CAP_domain.
    IPR004043. LCCL.
    [Graphical view ]
    PANTHERi PTHR10334. PTHR10334. 1 hit.
    Pfami PF00188. CAP. 1 hit.
    PF03815. LCCL. 2 hits.
    [Graphical view ]
    PRINTSi PR00837. V5TPXLIKE.
    SMARTi SM00603. LCCL. 2 hits.
    SM00198. SCP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55797. SSF55797. 1 hit.
    SSF69848. SSF69848. 2 hits.
    PROSITEi PS01010. CRISP_2. 1 hit.
    PS50820. LCCL. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT SER-322.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Mammary gland.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-105.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5), VARIANTS GLY-105 AND SER-322.
      Tissue: Blood and Melanoma.

    Entry informationi

    Entry nameiCRLD2_HUMAN
    AccessioniPrimary (citable) accession number: Q9H0B8
    Secondary accession number(s): D3DUM0
    , Q6P590, Q6UWH0, Q6UXC6, Q96IB1, Q96K61
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3