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Q9H0B8

- CRLD2_HUMAN

UniProt

Q9H0B8 - CRLD2_HUMAN

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Protein

Cysteine-rich secretory protein LCCL domain-containing 2

Gene

CRISPLD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Promotes matrix assembly.By similarity

GO - Molecular functioni

  1. heparin binding Source: Ensembl

GO - Biological processi

  1. extracellular matrix organization Source: Ensembl
  2. face morphogenesis Source: UniProt
  3. lung development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich secretory protein LCCL domain-containing 2
Alternative name(s):
Cysteine-rich secretory protein 11
Short name:
CRISP-11
LCCL domain-containing cysteine-rich secretory protein 2
Gene namesi
Name:CRISPLD2
Synonyms:CRISP11, LCRISP2
ORF Names:UNQ2914/PRO1156/PRO9783
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:25248. CRISPLD2.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular matrix Source: Ensembl
  2. extracellular vesicular exosome Source: UniProtKB
  3. transport vesicle Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672077.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 497475Cysteine-rich secretory protein LCCL domain-containing 2PRO_0000248149Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi290 ↔ 308PROSITE-ProRule annotation
Disulfide bondi312 ↔ 332PROSITE-ProRule annotation
Disulfide bondi391 ↔ 413PROSITE-ProRule annotation
Disulfide bondi417 ↔ 440PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9H0B8.
PaxDbiQ9H0B8.
PeptideAtlasiQ9H0B8.
PRIDEiQ9H0B8.

PTM databases

PhosphoSiteiQ9H0B8.

Expressioni

Gene expression databases

BgeeiQ9H0B8.
CleanExiHS_CRISPLD2.
ExpressionAtlasiQ9H0B8. baseline and differential.
GenevestigatoriQ9H0B8.

Organism-specific databases

HPAiHPA030055.

Interactioni

Subunit structurei

Binds to heparin, dermatan sulfate and chondroitin sulfate.By similarity

Protein-protein interaction databases

BioGridi123739. 2 interactions.
IntActiQ9H0B8. 1 interaction.
MINTiMINT-3065575.
STRINGi9606.ENSP00000262424.

Structurei

3D structure databases

ProteinModelPortaliQ9H0B8.
SMRiQ9H0B8. Positions 53-234, 308-382, 413-481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 200139SCPAdd
BLAST
Domaini284 – 37996LCCL 1PROSITE-ProRule annotationAdd
BLAST
Domaini385 – 488104LCCL 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CRISP family.Curated
Contains 2 LCCL domains.PROSITE-ProRule annotation
Contains 1 SCP domain.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2340.
GeneTreeiENSGT00760000119004.
HOVERGENiHBG062505.
InParanoidiQ9H0B8.
OMAiKDKCKGS.
OrthoDBiEOG7F7WB4.
PhylomeDBiQ9H0B8.
TreeFamiTF316148.

Family and domain databases

Gene3Di2.170.130.20. 2 hits.
3.40.33.10. 1 hit.
InterProiIPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR004043. LCCL.
[Graphical view]
PANTHERiPTHR10334. PTHR10334. 1 hit.
PfamiPF00188. CAP. 1 hit.
PF03815. LCCL. 2 hits.
[Graphical view]
PRINTSiPR00837. V5TPXLIKE.
SMARTiSM00603. LCCL. 2 hits.
SM00198. SCP. 1 hit.
[Graphical view]
SUPFAMiSSF55797. SSF55797. 1 hit.
SSF69848. SSF69848. 2 hits.
PROSITEiPS01010. CRISP_2. 1 hit.
PS50820. LCCL. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H0B8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCVLGGVIP LGLLFLVCGS QGYLLPNVTL LEELLSKYQH NESHSRVRRA
60 70 80 90 100
IPREDKEEIL MLHNKLRGQV QPQASNMEYM TWDDELEKSA AAWASQCIWE
110 120 130 140 150
HGPTSLLVSI GQNLGAHWGR YRSPGFHVQS WYDEVKDYTY PYPSECNPWC
160 170 180 190 200
PERCSGPMCT HYTQIVWATT NKIGCAVNTC RKMTVWGEVW ENAVYFVCNY
210 220 230 240 250
SPKGNWIGEA PYKNGRPCSE CPPSYGGSCR NNLCYREETY TPKPETDEMN
260 270 280 290 300
EVETAPIPEE NHVWLQPRVM RPTKPKKTSA VNYMTQVVRC DTKMKDRCKG
310 320 330 340 350
STCNRYQCPA GCLNHKAKIF GTLFYESSSS ICRAAIHYGI LDDKGGLVDI
360 370 380 390 400
TRNGKVPFFV KSERHGVQSL SKYKPSSSFM VSKVKVQDLD CYTTVAQLCP
410 420 430 440 450
FEKPATHCPR IHCPAHCKDE PSYWAPVFGT NIYADTSSIC KTAVHAGVIS
460 470 480 490
NESGGDVDVM PVDKKKTYVG SLRNGVQSES LGTPRDGKAF RIFAVRQ
Length:497
Mass (Da):55,920
Last modified:March 1, 2001 - v1
Checksum:i1E7ADDCAB37CA4ED
GO
Isoform 2 (identifier: Q9H0B8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     436-497: TSSICKTAVH...KAFRIFAVRQ → VSRMHFQQLSRKAC

Note: No experimental confirmation available.

Show »
Length:449
Mass (Da):51,044
Checksum:i1E597E5C8CA8CD66
GO
Isoform 3 (identifier: Q9H0B8-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     371-371: S → R
     372-497: Missing.

Show »
Length:371
Mass (Da):42,207
Checksum:i8D23FBE14F53E85C
GO
Isoform 4 (identifier: Q9H0B8-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-159: TWDDELEKSA...CPERCSGPMC → VSAGSGRRGW...QWHNRHALKP
     160-497: Missing.

Note: No experimental confirmation available.

Show »
Length:159
Mass (Da):17,476
Checksum:iCE3BAAB490465049
GO
Isoform 5 (identifier: Q9H0B8-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-497: Missing.

Show »
Length:120
Mass (Da):13,497
Checksum:iD0B40A3149B1099C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti105 – 1051S → G.2 Publications
Corresponds to variant rs12051468 [ dbSNP | Ensembl ].
VAR_027256
Natural varianti322 – 3221T → S.2 Publications
Corresponds to variant rs721005 [ dbSNP | Ensembl ].
VAR_027257

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei81 – 15979TWDDE…SGPMC → VSAGSGRRGWHRGWGLGHQP ALFPSQLCSPASACDGWLRV SSGRGGSRLCSVLFVCFETG SHSATDAGVQWHNRHALKP in isoform 4. 1 PublicationVSP_020178Add
BLAST
Alternative sequencei121 – 497377Missing in isoform 5. 1 PublicationVSP_020179Add
BLAST
Alternative sequencei160 – 497338Missing in isoform 4. 1 PublicationVSP_020180Add
BLAST
Alternative sequencei371 – 3711S → R in isoform 3. 1 PublicationVSP_020181
Alternative sequencei372 – 497126Missing in isoform 3. 1 PublicationVSP_020182Add
BLAST
Alternative sequencei436 – 49762TSSIC…FAVRQ → VSRMHFQQLSRKAC in isoform 2. 1 PublicationVSP_020183Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136861 mRNA. Translation: CAB66795.1.
AY358413 mRNA. Translation: AAQ88779.1.
AY358790 mRNA. Translation: AAQ89150.1.
AK027395 mRNA. Translation: BAB55081.1.
CH471114 Genomic DNA. Translation: EAW95468.1.
CH471114 Genomic DNA. Translation: EAW95469.1.
BC007689 mRNA. Translation: AAH07689.1.
BC063012 mRNA. Translation: AAH63012.1.
CCDSiCCDS10949.1. [Q9H0B8-1]
RefSeqiNP_113664.1. NM_031476.3. [Q9H0B8-1]
XP_005256247.1. XM_005256190.1. [Q9H0B8-1]
UniGeneiHs.513779.
Hs.617091.

Genome annotation databases

EnsembliENST00000262424; ENSP00000262424; ENSG00000103196. [Q9H0B8-1]
ENST00000564567; ENSP00000457655; ENSG00000103196. [Q9H0B8-2]
ENST00000569090; ENSP00000454858; ENSG00000103196. [Q9H0B8-5]
GeneIDi83716.
KEGGihsa:83716.
UCSCiuc002fik.4. human. [Q9H0B8-4]
uc002fil.2. human. [Q9H0B8-5]
uc002fim.2. human. [Q9H0B8-3]
uc002fin.4. human. [Q9H0B8-2]
uc010voh.1. human. [Q9H0B8-1]

Polymorphism databases

DMDMi74717972.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136861 mRNA. Translation: CAB66795.1 .
AY358413 mRNA. Translation: AAQ88779.1 .
AY358790 mRNA. Translation: AAQ89150.1 .
AK027395 mRNA. Translation: BAB55081.1 .
CH471114 Genomic DNA. Translation: EAW95468.1 .
CH471114 Genomic DNA. Translation: EAW95469.1 .
BC007689 mRNA. Translation: AAH07689.1 .
BC063012 mRNA. Translation: AAH63012.1 .
CCDSi CCDS10949.1. [Q9H0B8-1 ]
RefSeqi NP_113664.1. NM_031476.3. [Q9H0B8-1 ]
XP_005256247.1. XM_005256190.1. [Q9H0B8-1 ]
UniGenei Hs.513779.
Hs.617091.

3D structure databases

ProteinModelPortali Q9H0B8.
SMRi Q9H0B8. Positions 53-234, 308-382, 413-481.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123739. 2 interactions.
IntActi Q9H0B8. 1 interaction.
MINTi MINT-3065575.
STRINGi 9606.ENSP00000262424.

PTM databases

PhosphoSitei Q9H0B8.

Polymorphism databases

DMDMi 74717972.

Proteomic databases

MaxQBi Q9H0B8.
PaxDbi Q9H0B8.
PeptideAtlasi Q9H0B8.
PRIDEi Q9H0B8.

Protocols and materials databases

DNASUi 83716.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262424 ; ENSP00000262424 ; ENSG00000103196 . [Q9H0B8-1 ]
ENST00000564567 ; ENSP00000457655 ; ENSG00000103196 . [Q9H0B8-2 ]
ENST00000569090 ; ENSP00000454858 ; ENSG00000103196 . [Q9H0B8-5 ]
GeneIDi 83716.
KEGGi hsa:83716.
UCSCi uc002fik.4. human. [Q9H0B8-4 ]
uc002fil.2. human. [Q9H0B8-5 ]
uc002fim.2. human. [Q9H0B8-3 ]
uc002fin.4. human. [Q9H0B8-2 ]
uc010voh.1. human. [Q9H0B8-1 ]

Organism-specific databases

CTDi 83716.
GeneCardsi GC16P084853.
HGNCi HGNC:25248. CRISPLD2.
HPAi HPA030055.
MIMi 612434. gene.
neXtProti NX_Q9H0B8.
PharmGKBi PA142672077.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2340.
GeneTreei ENSGT00760000119004.
HOVERGENi HBG062505.
InParanoidi Q9H0B8.
OMAi KDKCKGS.
OrthoDBi EOG7F7WB4.
PhylomeDBi Q9H0B8.
TreeFami TF316148.

Miscellaneous databases

ChiTaRSi CRISPLD2. human.
GeneWikii CRISPLD2.
GenomeRNAii 83716.
NextBioi 72711.
PROi Q9H0B8.
SOURCEi Search...

Gene expression databases

Bgeei Q9H0B8.
CleanExi HS_CRISPLD2.
ExpressionAtlasi Q9H0B8. baseline and differential.
Genevestigatori Q9H0B8.

Family and domain databases

Gene3Di 2.170.130.20. 2 hits.
3.40.33.10. 1 hit.
InterProi IPR001283. Allrgn_V5/Tpx1.
IPR018244. Allrgn_V5/Tpx1_CS.
IPR014044. CAP_domain.
IPR004043. LCCL.
[Graphical view ]
PANTHERi PTHR10334. PTHR10334. 1 hit.
Pfami PF00188. CAP. 1 hit.
PF03815. LCCL. 2 hits.
[Graphical view ]
PRINTSi PR00837. V5TPXLIKE.
SMARTi SM00603. LCCL. 2 hits.
SM00198. SCP. 1 hit.
[Graphical view ]
SUPFAMi SSF55797. SSF55797. 1 hit.
SSF69848. SSF69848. 2 hits.
PROSITEi PS01010. CRISP_2. 1 hit.
PS50820. LCCL. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), VARIANT SER-322.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Mammary gland.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-105.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5), VARIANTS GLY-105 AND SER-322.
    Tissue: Blood and Melanoma.

Entry informationi

Entry nameiCRLD2_HUMAN
AccessioniPrimary (citable) accession number: Q9H0B8
Secondary accession number(s): D3DUM0
, Q6P590, Q6UWH0, Q6UXC6, Q96IB1, Q96K61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3