Q9H0B3 (K1683_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein KIAA1683

Gene names

Name:

KIAA1683

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1180 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 6 IQ domains.
Sequence caution	The sequence BAB21774.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	mitochondrion Inferred from direct assay. Source: LIFEdb
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H0B3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H0B3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     440-1053: Missing.
     1148-1180: RGHHTRSCLKNTEALLGPADPSASSRHMHWPGI → HLGPWLPAVGTSWEALMALWV

Isoform 3 (identifier: Q9H0B3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-736: Missing.
     737-872: TCLTKTQSRG...GQAVPCQEDT → MAPSSRWDAM...KASLNSTILQ

Isoform 4 (identifier: Q9H0B3-4)

The sequence of this isoform differs from the canonical sequence as follows:
     872-872: T → TVGSLLASLC...LGPVRPQTSK

Note: No experimental confirmation available.

Isoform 5 (identifier: Q9H0B3-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1180	1180	Uncharacterized protein KIAA1683		PRO_0000050801
Regions
	Domain	103 – 132	30	IQ 1
	Domain	926 – 955	30	IQ 2
	Domain	949 – 978	30	IQ 3
	Domain	972 – 1001	30	IQ 4
	Domain	1113 – 1142	30	IQ 5
	Domain	1136 – 1165	30	IQ 6
	Compositional bias	336 – 424	89	Thr-rich
Natural variations
	Alternative sequence	1 – 736	736	Missing in isoform 3.		VSP_015473
	Alternative sequence	1 – 46	46	Missing in isoform 5.		VSP_045713
	Alternative sequence	440 – 1053	614	Missing in isoform 2.		VSP_015474
	Alternative sequence	737 – 872	136	TCLTK…CQEDT → MAPSSRWDAMGPKNSYRSVH GRIVPELLESSVARVRPLQY VQRQPSQASARSGANPTHRP SAEVRPVIRTGEMTHSSVIP PLAPGVRRVSLGYESSPSGS LPPLFNQESPWRRQDSYSPQ NPAVSHKASLNSTILQ in isoform 3.		VSP_015475
	Alternative sequence	872	1	T → TVGSLLASLCAEVAGVLASQ EDLRTLLAKALSQGEVWAAL NQALSKEVLGATVTKALPQS MLSMALVKALSWSELRLTLS RALSRGELRAELTKVMQGKL AEVLSKALTEEEWVALSQAL CQGELGALLSQSWCRVALRT GTILPKAASKSTGSGVTKTP ALVKVACRRSPSAAWGPSLG PVRPQTSK in isoform 4.		VSP_045714
	Alternative sequence	1148 – 1180	33	RGHHT…HWPGI → HLGPWLPAVGTSWEALMALW V in isoform 2.		VSP_015476
	Natural variant	44	1	L → P. Ref.2 Ref.4 Corresponds to variant rs1469023 [ dbSNP | Ensembl ].		VAR_023418
	Natural variant	50	1	A → V. Corresponds to variant rs3810431 [ dbSNP | Ensembl ].		VAR_049520
	Natural variant	197	1	C → R. Ref.4 Corresponds to variant rs12609001 [ dbSNP | Ensembl ].		VAR_049521
	Natural variant	235	1	L → V. Ref.2 Ref.4 Corresponds to variant rs8103906 [ dbSNP | Ensembl ].		VAR_023419
	Natural variant	285	1	S → T. Ref.2 Ref.4 Corresponds to variant rs8104533 [ dbSNP | Ensembl ].		VAR_023420
	Natural variant	359	1	M → T. Ref.2 Ref.4 Corresponds to variant rs3746186 [ dbSNP | Ensembl ].		VAR_023421
	Natural variant	524	1	T → A. Corresponds to variant rs12462974 [ dbSNP | Ensembl ].		VAR_049522
	Natural variant	610	1	T → P. Ref.2 Ref.4 Corresponds to variant rs2277922 [ dbSNP | Ensembl ].		VAR_049523
	Natural variant	614	1	A → V. Corresponds to variant rs16982285 [ dbSNP | Ensembl ].		VAR_049524
	Natural variant	648	1	Y → F. Ref.2 Ref.4 Corresponds to variant rs8110972 [ dbSNP | Ensembl ].		VAR_034042
	Natural variant	823	1	P → R. Ref.4 Corresponds to variant rs12608777 [ dbSNP | Ensembl ].		VAR_034043
	Natural variant	835	1	P → L. Ref.4 Corresponds to variant rs2277921 [ dbSNP | Ensembl ].		VAR_049525
	Natural variant	908	1	P → H. Ref.2 Ref.4 Ref.5 Corresponds to variant rs999813 [ dbSNP | Ensembl ].		VAR_023422
Experimental info
	Sequence conflict	381	1	M → V in BAB71500. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: A81A2824C2794AC3	FASTA	1,180	127,693
	10 20 30 40 50 60 MTLQGRADLS GNQGNAAGRL ATVHEPVVTQ WAVHPPAPAH PSLLDKMEKA PPQPQHEGLK 70 80 90 100 110 120 SKEHLPQQPA EGKTASRRVP RLRAVVESQA FKNILVDEMD MMHARAATLI QANWRGYWLR 130 140 150 160 170 180 QKLISQMMAA KAIQEAWRRF NKRHILHSSK SLVKKTRAEE GDIPYHAPQQ VRFQHPEENR 190 200 210 220 230 240 LLSPPIMVNK ETQFPSCDNL VLCRPQSSPL LQPPAAQGTP EPCVQGPHAA RVRGLAFLPH 250 260 270 280 290 300 QTVTIRFPCP VSLDAKCQPC LLTRTIRSTC LVHIEGDSVK TKRVSARTNK ARAPETPLSR 310 320 330 340 350 360 RYDQAVTRPS RAQTQGPVKA ETPKAPFQIC PGPMITKTLL QTYPVVSVTL PQTYPASTMT 370 380 390 400 410 420 TTPPKTSPVP KVTIIKTPAQ MYPGPTVTKT APHTCPMPTM TKIQVHPTAS RTGTPRQTCP 430 440 450 460 470 480 ATITAKNRPQ VSLLASIMKS LPQVCPGPAM AKTPPQMHPV TTPAKNPLQT CLSATMSKTS 490 500 510 520 530 540 SQRSPVGVTK PSPQTRLPAM ITKTPAQLRS VATILKTLCL ASPTVANVKA PPQVAVAAGT 550 560 570 580 590 600 PNTSGSIHEN PPKAKATVNV KQAAKVVKAS SPSYLAEGKI RCLAQPHPGT GVPRAAAELP 610 620 630 640 650 660 LEAEKIKTGT QKQAKTDMAF KTSVAVEMAG APSWTKVAEE GDKPPHVYVP VDMAVTLPRG 670 680 690 700 710 720 QLAAPLTNAS SQRHPPCLSQ RPLAAPLTKA SSQGHLPTEL TKTPSLAHLD TCLSKMHSQT 730 740 750 760 770 780 HLATGAVKVQ SQAPLATCLT KTQSRGQPIT DITTCLIPAH QAADLSSNTH SQVLLTGSKV 790 800 810 820 830 840 SNHACQRLGG LSAPPWAKPE DRQTQPQPHG HVPGKTTQGG PCPAACEVQG MLVPPMAPTG 850 860 870 880 890 900 HSTCNVESWG DNGATRAQPS MPGQAVPCQE DTGPADAGVV GGQSWNRAWE PARGAASWDT 910 920 930 940 950 960 WRNKAVVPPR RSGEPMVSMQ AAEEIRILAV ITIQAGVRGY LARRRIRLWH RGAMVIQATW 970 980 990 1000 1010 1020 RGYRVRRNLA HLCRATTTIQ SAWRGYSTRR DQARHWQMLH PVTWVELGSR AGVMSDRSWF 1030 1040 1050 1060 1070 1080 QDGRARTVSD HRCFQSCQAH ACSVCHSLSS RIGSPPSVVM LVGSSPRTCH TCGRTQPTRV 1090 1100 1110 1120 1130 1140 VQGMGQGTEG PGAVSWASAY QLAALSPRQP HRQDKAATAI QSAWRGFKIR QQMRQQQMAA 1150 1160 1170 1180 KIVQATWRGH HTRSCLKNTE ALLGPADPSA SSRHMHWPGI
	Isoform 2 [UniParc]. Checksum: 40386EC8A196A156	FASTA	554	60,963
	10 20 30 40 50 60 MTLQGRADLS GNQGNAAGRL ATVHEPVVTQ WAVHPPAPAH PSLLDKMEKA PPQPQHEGLK 70 80 90 100 110 120 SKEHLPQQPA EGKTASRRVP RLRAVVESQA FKNILVDEMD MMHARAATLI QANWRGYWLR 130 140 150 160 170 180 QKLISQMMAA KAIQEAWRRF NKRHILHSSK SLVKKTRAEE GDIPYHAPQQ VRFQHPEENR 190 200 210 220 230 240 LLSPPIMVNK ETQFPSCDNL VLCRPQSSPL LQPPAAQGTP EPCVQGPHAA RVRGLAFLPH 250 260 270 280 290 300 QTVTIRFPCP VSLDAKCQPC LLTRTIRSTC LVHIEGDSVK TKRVSARTNK ARAPETPLSR 310 320 330 340 350 360 RYDQAVTRPS RAQTQGPVKA ETPKAPFQIC PGPMITKTLL QTYPVVSVTL PQTYPASTMT 370 380 390 400 410 420 TTPPKTSPVP KVTIIKTPAQ MYPGPTVTKT APHTCPMPTM TKIQVHPTAS RTGTPRQTCP 430 440 450 460 470 480 ATITAKNRPQ VSLLASIMKS PPSVVMLVGS SPRTCHTCGR TQPTRVVQGM GQGTEGPGAV 490 500 510 520 530 540 SWASAYQLAA LSPRQPHRQD KAATAIQSAW RGFKIRQQMR QQQMAAKIVQ ATWHLGPWLP 550 AVGTSWEALM ALWV
	Isoform 3 [UniParc]. Checksum: 1F32C281B6FCEEEB	FASTA	444	49,193
	10 20 30 40 50 60 MAPSSRWDAM GPKNSYRSVH GRIVPELLES SVARVRPLQY VQRQPSQASA RSGANPTHRP 70 80 90 100 110 120 SAEVRPVIRT GEMTHSSVIP PLAPGVRRVS LGYESSPSGS LPPLFNQESP WRRQDSYSPQ 130 140 150 160 170 180 NPAVSHKASL NSTILQGPAD AGVVGGQSWN RAWEPARGAA SWDTWRNKAV VPPRRSGEPM 190 200 210 220 230 240 VSMQAAEEIR ILAVITIQAG VRGYLARRRI RLWHRGAMVI QATWRGYRVR RNLAHLCRAT 250 260 270 280 290 300 TTIQSAWRGY STRRDQARHW QMLHPVTWVE LGSRAGVMSD RSWFQDGRAR TVSDHRCFQS 310 320 330 340 350 360 CQAHACSVCH SLSSRIGSPP SVVMLVGSSP RTCHTCGRTQ PTRVVQGMGQ GTEGPGAVSW 370 380 390 400 410 420 ASAYQLAALS PRQPHRQDKA ATAIQSAWRG FKIRQQMRQQ QMAAKIVQAT WRGHHTRSCL 430 440 KNTEALLGPA DPSASSRHMH WPGI
	Isoform 4 [UniParc]. Checksum: DA1B0ADE754F8578	FASTA	1,367	147,266
	10 20 30 40 50 60 MTLQGRADLS GNQGNAAGRL ATVHEPVVTQ WAVHPPAPAH PSLLDKMEKA PPQPQHEGLK 70 80 90 100 110 120 SKEHLPQQPA EGKTASRRVP RLRAVVESQA FKNILVDEMD MMHARAATLI QANWRGYWLR 130 140 150 160 170 180 QKLISQMMAA KAIQEAWRRF NKRHILHSSK SLVKKTRAEE GDIPYHAPQQ VRFQHPEENR 190 200 210 220 230 240 LLSPPIMVNK ETQFPSCDNL VLCRPQSSPL LQPPAAQGTP EPCVQGPHAA RVRGLAFLPH 250 260 270 280 290 300 QTVTIRFPCP VSLDAKCQPC LLTRTIRSTC LVHIEGDSVK TKRVSARTNK ARAPETPLSR 310 320 330 340 350 360 RYDQAVTRPS RAQTQGPVKA ETPKAPFQIC PGPMITKTLL QTYPVVSVTL PQTYPASTMT 370 380 390 400 410 420 TTPPKTSPVP KVTIIKTPAQ MYPGPTVTKT APHTCPMPTM TKIQVHPTAS RTGTPRQTCP 430 440 450 460 470 480 ATITAKNRPQ VSLLASIMKS LPQVCPGPAM AKTPPQMHPV TTPAKNPLQT CLSATMSKTS 490 500 510 520 530 540 SQRSPVGVTK PSPQTRLPAM ITKTPAQLRS VATILKTLCL ASPTVANVKA PPQVAVAAGT 550 560 570 580 590 600 PNTSGSIHEN PPKAKATVNV KQAAKVVKAS SPSYLAEGKI RCLAQPHPGT GVPRAAAELP 610 620 630 640 650 660 LEAEKIKTGT QKQAKTDMAF KTSVAVEMAG APSWTKVAEE GDKPPHVYVP VDMAVTLPRG 670 680 690 700 710 720 QLAAPLTNAS SQRHPPCLSQ RPLAAPLTKA SSQGHLPTEL TKTPSLAHLD TCLSKMHSQT 730 740 750 760 770 780 HLATGAVKVQ SQAPLATCLT KTQSRGQPIT DITTCLIPAH QAADLSSNTH SQVLLTGSKV 790 800 810 820 830 840 SNHACQRLGG LSAPPWAKPE DRQTQPQPHG HVPGKTTQGG PCPAACEVQG MLVPPMAPTG 850 860 870 880 890 900 HSTCNVESWG DNGATRAQPS MPGQAVPCQE DTVGSLLASL CAEVAGVLAS QEDLRTLLAK 910 920 930 940 950 960 ALSQGEVWAA LNQALSKEVL GATVTKALPQ SMLSMALVKA LSWSELRLTL SRALSRGELR 970 980 990 1000 1010 1020 AELTKVMQGK LAEVLSKALT EEEWVALSQA LCQGELGALL SQSWCRVALR TGTILPKAAS 1030 1040 1050 1060 1070 1080 KSTGSGVTKT PALVKVACRR SPSAAWGPSL GPVRPQTSKG PADAGVVGGQ SWNRAWEPAR 1090 1100 1110 1120 1130 1140 GAASWDTWRN KAVVPPRRSG EPMVSMQAAE EIRILAVITI QAGVRGYLAR RRIRLWHRGA 1150 1160 1170 1180 1190 1200 MVIQATWRGY RVRRNLAHLC RATTTIQSAW RGYSTRRDQA RHWQMLHPVT WVELGSRAGV 1210 1220 1230 1240 1250 1260 MSDRSWFQDG RARTVSDHRC FQSCQAHACS VCHSLSSRIG SPPSVVMLVG SSPRTCHTCG 1270 1280 1290 1300 1310 1320 RTQPTRVVQG MGQGTEGPGA VSWASAYQLA ALSPRQPHRQ DKAATAIQSA WRGFKIRQQM 1330 1340 1350 1360 RQQQMAAKIV QATWRGHHTR SCLKNTEALL GPADPSASSR HMHWPGI
	Isoform 5 [UniParc]. Checksum: 9DD6A52B63131CD9	FASTA	1,134	122,901
	10 20 30 40 50 60 MEKAPPQPQH EGLKSKEHLP QQPAEGKTAS RRVPRLRAVV ESQAFKNILV DEMDMMHARA 70 80 90 100 110 120 ATLIQANWRG YWLRQKLISQ MMAAKAIQEA WRRFNKRHIL HSSKSLVKKT RAEEGDIPYH 130 140 150 160 170 180 APQQVRFQHP EENRLLSPPI MVNKETQFPS CDNLVLCRPQ SSPLLQPPAA QGTPEPCVQG 190 200 210 220 230 240 PHAARVRGLA FLPHQTVTIR FPCPVSLDAK CQPCLLTRTI RSTCLVHIEG DSVKTKRVSA 250 260 270 280 290 300 RTNKARAPET PLSRRYDQAV TRPSRAQTQG PVKAETPKAP FQICPGPMIT KTLLQTYPVV 310 320 330 340 350 360 SVTLPQTYPA STMTTTPPKT SPVPKVTIIK TPAQMYPGPT VTKTAPHTCP MPTMTKIQVH 370 380 390 400 410 420 PTASRTGTPR QTCPATITAK NRPQVSLLAS IMKSLPQVCP GPAMAKTPPQ MHPVTTPAKN 430 440 450 460 470 480 PLQTCLSATM SKTSSQRSPV GVTKPSPQTR LPAMITKTPA QLRSVATILK TLCLASPTVA 490 500 510 520 530 540 NVKAPPQVAV AAGTPNTSGS IHENPPKAKA TVNVKQAAKV VKASSPSYLA EGKIRCLAQP 550 560 570 580 590 600 HPGTGVPRAA AELPLEAEKI KTGTQKQAKT DMAFKTSVAV EMAGAPSWTK VAEEGDKPPH 610 620 630 640 650 660 VYVPVDMAVT LPRGQLAAPL TNASSQRHPP CLSQRPLAAP LTKASSQGHL PTELTKTPSL 670 680 690 700 710 720 AHLDTCLSKM HSQTHLATGA VKVQSQAPLA TCLTKTQSRG QPITDITTCL IPAHQAADLS 730 740 750 760 770 780 SNTHSQVLLT GSKVSNHACQ RLGGLSAPPW AKPEDRQTQP QPHGHVPGKT TQGGPCPAAC 790 800 810 820 830 840 EVQGMLVPPM APTGHSTCNV ESWGDNGATR AQPSMPGQAV PCQEDTGPAD AGVVGGQSWN 850 860 870 880 890 900 RAWEPARGAA SWDTWRNKAV VPPRRSGEPM VSMQAAEEIR ILAVITIQAG VRGYLARRRI 910 920 930 940 950 960 RLWHRGAMVI QATWRGYRVR RNLAHLCRAT TTIQSAWRGY STRRDQARHW QMLHPVTWVE 970 980 990 1000 1010 1020 LGSRAGVMSD RSWFQDGRAR TVSDHRCFQS CQAHACSVCH SLSSRIGSPP SVVMLVGSSP 1030 1040 1050 1060 1070 1080 RTCHTCGRTQ PTRVVQGMGQ GTEGPGAVSW ASAYQLAALS PRQPHRQDKA ATAIQSAWRG 1090 1100 1110 1120 1130 FKIRQQMRQQ QMAAKIVQAT WRGHHTRSCL KNTEALLGPA DPSASSRHMH WPGI

References

[1]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5), VARIANTS PRO-44; VAL-235; THR-285; THR-359; PRO-610; PHE-648 AND HIS-908. Tissue: Testis.
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANTS PRO-44; ARG-197; VAL-235; THR-285; THR-359; PRO-610; PHE-648; ARG-823; LEU-835 AND HIS-908. Tissue: Brain and Skin.
[5]	"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O. DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 873-1180, VARIANT HIS-908. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL136867 mRNA. Translation: CAB66801.1. AK057466 mRNA. Translation: BAB71500.1. AK302431 mRNA. Translation: BAG63734.1. AC008397 Genomic DNA. No translation available. BC034327 mRNA. Translation: AAH34327.1. BC112932 mRNA. Translation: AAI12933.1. AB051470 mRNA. Translation: BAB21774.1. Sequence problems.
IPI	IPI00031282. IPI00384249. IPI00874228. IPI00923466. IPI01010920.
RefSeq	NP_001138776.1. NM_001145304.1. NP_001138777.1. NM_001145305.1. NP_079525.1. NM_025249.3.
UniGene	Hs.732366.
3D structure databases
ProteinModelPortal	Q9H0B3.
SMR	Q9H0B3. Positions 100-151, 931-967, 1111-1157.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H0B3. 4 interactions.
MINT	MINT-1439991.
STRING	9606.ENSP00000376213.
PTM databases
PhosphoSite	Q9H0B3.
Polymorphism databases
DMDM	73920083.
Proteomic databases
PaxDb	Q9H0B3.
PRIDE	Q9H0B3.
Protocols and materials databases
DNASU	80726.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359737; ENSP00000352774; ENSG00000130518. ENST00000392413; ENSP00000376213; ENSG00000130518. ENST00000427634; ENSP00000404501; ENSG00000130518. ENST00000600328; ENSP00000470780; ENSG00000130518. ENST00000600359; ENSP00000472912; ENSG00000130518.
GeneID	80726.
KEGG	hsa:80726.
UCSC	uc002nin.2. human. uc010ebn.2. human.
Organism-specific databases
CTD	80726.
GeneCards	GC19M018367.
HGNC	HGNC:29350. KIAA1683.
HPA	HPA042409.
neXtProt	NX_Q9H0B3.
PharmGKB	PA134952902.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG29346.
HOGENOM	HOG000113175.
HOVERGEN	HBG079541.
PhylomeDB	Q9H0B3.
Gene expression databases
ArrayExpress	Q9H0B3.
Bgee	Q9H0B3.
CleanEx	HS_KIAA1683.
Genevestigator	Q9H0B3.
GermOnline	ENSG00000130518. Homo sapiens.
Family and domain databases
InterPro	IPR000048. IQ_motif_EF-hand-BS. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF00612. IQ. 6 hits. [Graphical view]
SMART	SM00015. IQ. 6 hits. [Graphical view]
SUPFAM	SSF52540. SSF52540. 3 hits.
PROSITE	PS50096. IQ. 6 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	80726.
NextBio	71038.

Entry information

Entry name

K1683_HUMAN

Accession

Primary (citable) accession number: Q9H0B3
Secondary accession number(s): B4DYH2 , E9PDE0, E9PH54, Q2KHR5, Q8N4G8, Q96M14, Q9C0I0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	March 1, 2001
Last modified:	May 29, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.