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Protein

IQ domain-containing protein N

Gene

IQCN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Names & Taxonomyi

Protein namesi
Recommended name:
IQ domain-containing protein NImported
Gene namesi
Name:IQCNImported
Synonyms:KIAA1683
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000130518.16
HGNCiHGNC:29350 IQCN
neXtProtiNX_Q9H0B3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi80726
OpenTargetsiENSG00000130518
PharmGKBiPA134952902

Polymorphism and mutation databases

BioMutaiKIAA1683
DMDMi73920083

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508011 – 1180IQ domain-containing protein NAdd BLAST1180

Proteomic databases

PaxDbiQ9H0B3
PeptideAtlasiQ9H0B3
PRIDEiQ9H0B3

PTM databases

iPTMnetiQ9H0B3
PhosphoSitePlusiQ9H0B3

Expressioni

Gene expression databases

BgeeiENSG00000130518
CleanExiHS_KIAA1683
ExpressionAtlasiQ9H0B3 baseline and differential
GenevisibleiQ9H0B3 HS

Organism-specific databases

HPAiHPA042409

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi12327664 interactors.
IntActiQ9H0B3 13 interactors.
MINTiQ9H0B3

Structurei

3D structure databases

ProteinModelPortaliQ9H0B3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 132IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini926 – 955IQ 2PROSITE-ProRule annotationAdd BLAST30
Domaini949 – 978IQ 3PROSITE-ProRule annotationAdd BLAST30
Domaini972 – 1001IQ 4PROSITE-ProRule annotationAdd BLAST30
Domaini1113 – 1142IQ 5PROSITE-ProRule annotationAdd BLAST30
Domaini1136 – 1165IQ 6PROSITE-ProRule annotationAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi336 – 424Thr-richAdd BLAST89

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEXS Eukaryota
ENOG41118PW LUCA
GeneTreeiENSGT00390000000311
HOGENOMiHOG000113175
HOVERGENiHBG079541
InParanoidiQ9H0B3
OMAiTLIQANW
OrthoDBiEOG091G00Z4
PhylomeDBiQ9H0B3
TreeFamiTF337595

Family and domain databases

InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00612 IQ, 6 hits
SMARTiView protein in SMART
SM00015 IQ, 6 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50096 IQ, 6 hits

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H0B3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTLQGRADLS GNQGNAAGRL ATVHEPVVTQ WAVHPPAPAH PSLLDKMEKA
60 70 80 90 100
PPQPQHEGLK SKEHLPQQPA EGKTASRRVP RLRAVVESQA FKNILVDEMD
110 120 130 140 150
MMHARAATLI QANWRGYWLR QKLISQMMAA KAIQEAWRRF NKRHILHSSK
160 170 180 190 200
SLVKKTRAEE GDIPYHAPQQ VRFQHPEENR LLSPPIMVNK ETQFPSCDNL
210 220 230 240 250
VLCRPQSSPL LQPPAAQGTP EPCVQGPHAA RVRGLAFLPH QTVTIRFPCP
260 270 280 290 300
VSLDAKCQPC LLTRTIRSTC LVHIEGDSVK TKRVSARTNK ARAPETPLSR
310 320 330 340 350
RYDQAVTRPS RAQTQGPVKA ETPKAPFQIC PGPMITKTLL QTYPVVSVTL
360 370 380 390 400
PQTYPASTMT TTPPKTSPVP KVTIIKTPAQ MYPGPTVTKT APHTCPMPTM
410 420 430 440 450
TKIQVHPTAS RTGTPRQTCP ATITAKNRPQ VSLLASIMKS LPQVCPGPAM
460 470 480 490 500
AKTPPQMHPV TTPAKNPLQT CLSATMSKTS SQRSPVGVTK PSPQTRLPAM
510 520 530 540 550
ITKTPAQLRS VATILKTLCL ASPTVANVKA PPQVAVAAGT PNTSGSIHEN
560 570 580 590 600
PPKAKATVNV KQAAKVVKAS SPSYLAEGKI RCLAQPHPGT GVPRAAAELP
610 620 630 640 650
LEAEKIKTGT QKQAKTDMAF KTSVAVEMAG APSWTKVAEE GDKPPHVYVP
660 670 680 690 700
VDMAVTLPRG QLAAPLTNAS SQRHPPCLSQ RPLAAPLTKA SSQGHLPTEL
710 720 730 740 750
TKTPSLAHLD TCLSKMHSQT HLATGAVKVQ SQAPLATCLT KTQSRGQPIT
760 770 780 790 800
DITTCLIPAH QAADLSSNTH SQVLLTGSKV SNHACQRLGG LSAPPWAKPE
810 820 830 840 850
DRQTQPQPHG HVPGKTTQGG PCPAACEVQG MLVPPMAPTG HSTCNVESWG
860 870 880 890 900
DNGATRAQPS MPGQAVPCQE DTGPADAGVV GGQSWNRAWE PARGAASWDT
910 920 930 940 950
WRNKAVVPPR RSGEPMVSMQ AAEEIRILAV ITIQAGVRGY LARRRIRLWH
960 970 980 990 1000
RGAMVIQATW RGYRVRRNLA HLCRATTTIQ SAWRGYSTRR DQARHWQMLH
1010 1020 1030 1040 1050
PVTWVELGSR AGVMSDRSWF QDGRARTVSD HRCFQSCQAH ACSVCHSLSS
1060 1070 1080 1090 1100
RIGSPPSVVM LVGSSPRTCH TCGRTQPTRV VQGMGQGTEG PGAVSWASAY
1110 1120 1130 1140 1150
QLAALSPRQP HRQDKAATAI QSAWRGFKIR QQMRQQQMAA KIVQATWRGH
1160 1170 1180
HTRSCLKNTE ALLGPADPSA SSRHMHWPGI
Length:1,180
Mass (Da):127,693
Last modified:March 1, 2001 - v1
Checksum:iA81A2824C2794AC3
GO
Isoform 2 (identifier: Q9H0B3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     440-1053: Missing.
     1148-1180: RGHHTRSCLKNTEALLGPADPSASSRHMHWPGI → HLGPWLPAVGTSWEALMALWV

Show »
Length:554
Mass (Da):60,963
Checksum:i40386EC8A196A156
GO
Isoform 3 (identifier: Q9H0B3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-736: Missing.
     737-872: TCLTKTQSRG...GQAVPCQEDT → MAPSSRWDAM...KASLNSTILQ

Show »
Length:444
Mass (Da):49,193
Checksum:i1F32C281B6FCEEEB
GO
Isoform 4 (identifier: Q9H0B3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     872-872: T → TVGSLLASLC...LGPVRPQTSK

Note: No experimental confirmation available.
Show »
Length:1,367
Mass (Da):147,266
Checksum:iDA1B0ADE754F8578
GO
Isoform 5 (identifier: Q9H0B3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Note: No experimental confirmation available.
Show »
Length:1,134
Mass (Da):122,901
Checksum:i9DD6A52B63131CD9
GO

Sequence cautioni

The sequence BAB21774 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti381M → V in BAB71500 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02341844L → P2 PublicationsCorresponds to variant dbSNP:rs1469023Ensembl.1
Natural variantiVAR_04952050A → V. Corresponds to variant dbSNP:rs3810431Ensembl.1
Natural variantiVAR_049521197C → R1 PublicationCorresponds to variant dbSNP:rs12609001Ensembl.1
Natural variantiVAR_023419235L → V2 PublicationsCorresponds to variant dbSNP:rs8103906Ensembl.1
Natural variantiVAR_023420285S → T2 PublicationsCorresponds to variant dbSNP:rs8104533Ensembl.1
Natural variantiVAR_023421359M → T2 PublicationsCorresponds to variant dbSNP:rs3746186Ensembl.1
Natural variantiVAR_049522524T → A. Corresponds to variant dbSNP:rs12462974Ensembl.1
Natural variantiVAR_049523610T → P2 PublicationsCorresponds to variant dbSNP:rs2277922Ensembl.1
Natural variantiVAR_049524614A → V. Corresponds to variant dbSNP:rs16982285Ensembl.1
Natural variantiVAR_034042648Y → F2 PublicationsCorresponds to variant dbSNP:rs8110972Ensembl.1
Natural variantiVAR_034043823P → R1 PublicationCorresponds to variant dbSNP:rs12608777Ensembl.1
Natural variantiVAR_049525835P → L1 PublicationCorresponds to variant dbSNP:rs2277921Ensembl.1
Natural variantiVAR_023422908P → H3 PublicationsCorresponds to variant dbSNP:rs999813Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0154731 – 736Missing in isoform 3. 1 PublicationAdd BLAST736
Alternative sequenceiVSP_0457131 – 46Missing in isoform 5. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_015474440 – 1053Missing in isoform 2. 1 PublicationAdd BLAST614
Alternative sequenceiVSP_015475737 – 872TCLTK…CQEDT → MAPSSRWDAMGPKNSYRSVH GRIVPELLESSVARVRPLQY VQRQPSQASARSGANPTHRP SAEVRPVIRTGEMTHSSVIP PLAPGVRRVSLGYESSPSGS LPPLFNQESPWRRQDSYSPQ NPAVSHKASLNSTILQ in isoform 3. 1 PublicationAdd BLAST136
Alternative sequenceiVSP_045714872T → TVGSLLASLCAEVAGVLASQ EDLRTLLAKALSQGEVWAAL NQALSKEVLGATVTKALPQS MLSMALVKALSWSELRLTLS RALSRGELRAELTKVMQGKL AEVLSKALTEEEWVALSQAL CQGELGALLSQSWCRVALRT GTILPKAASKSTGSGVTKTP ALVKVACRRSPSAAWGPSLG PVRPQTSK in isoform 4. 1 Publication1
Alternative sequenceiVSP_0154761148 – 1180RGHHT…HWPGI → HLGPWLPAVGTSWEALMALW V in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136867 mRNA Translation: CAB66801.1
AK057466 mRNA Translation: BAB71500.1
AK302431 mRNA Translation: BAG63734.1
AC008397 Genomic DNA No translation available.
BC034327 mRNA Translation: AAH34327.1
BC112932 mRNA Translation: AAI12933.1
AB051470 mRNA Translation: BAB21774.1 Sequence problems.
CCDSiCCDS32958.1 [Q9H0B3-1]
CCDS46017.1 [Q9H0B3-4]
CCDS46018.1 [Q9H0B3-5]
RefSeqiNP_001138776.1, NM_001145304.1 [Q9H0B3-4]
NP_001138777.1, NM_001145305.1 [Q9H0B3-5]
NP_079525.1, NM_025249.3 [Q9H0B3-1]
XP_005260141.1, XM_005260084.1 [Q9H0B3-4]
UniGeneiHs.732366

Genome annotation databases

EnsembliENST00000392413; ENSP00000376213; ENSG00000130518 [Q9H0B3-4]
ENST00000600328; ENSP00000470780; ENSG00000130518 [Q9H0B3-1]
ENST00000600359; ENSP00000472912; ENSG00000130518 [Q9H0B3-5]
GeneIDi80726
KEGGihsa:80726
UCSCiuc002nin.3 human [Q9H0B3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIQCN_HUMAN
AccessioniPrimary (citable) accession number: Q9H0B3
Secondary accession number(s): B4DYH2
, E9PDE0, E9PH54, Q2KHR5, Q8N4G8, Q96M14, Q9C0I0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome