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Protein

Speriolin-like protein

Gene

SPATC1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Speriolin-like protein
Alternative name(s):
Spermatogenesis and centriole-associated protein 1-like protein
Gene namesi
Name:SPATC1L
Synonyms:C21orf56
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

HGNCiHGNC:1298. SPATC1L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25851.

Polymorphism and mutation databases

BioMutaiSPATC1L.
DMDMi296439382.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Speriolin-like proteinPRO_0000079519Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei60 – 601PhosphoserineBy similarity
Modified residuei134 – 1341PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9H0A9.
PeptideAtlasiQ9H0A9.
PRIDEiQ9H0A9.

PTM databases

iPTMnetiQ9H0A9.
PhosphoSiteiQ9H0A9.

Expressioni

Gene expression databases

BgeeiENSG00000160284.
CleanExiHS_C21orf56.
GenevisibleiQ9H0A9. HS.

Organism-specific databases

HPAiHPA018979.
HPA019165.
HPA029394.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ARL4AP406173EBI-372911,EBI-2875746
ARMC7Q9H6L43EBI-372911,EBI-742909
FSD2A1L4K14EBI-372911,EBI-5661036
IKZF1Q134223EBI-372911,EBI-745305
LZTS2Q9BRK43EBI-372911,EBI-741037
PHC2Q8IXK0-43EBI-372911,EBI-10304199
PNMA1Q8ND903EBI-372911,EBI-302345
SIAH1Q8IUQ43EBI-372911,EBI-747107
TCF4P158843EBI-372911,EBI-533224
TRIM27P143733EBI-372911,EBI-719493

Protein-protein interaction databases

BioGridi123955. 14 interactions.
IntActiQ9H0A9. 12 interactions.
MINTiMINT-4713719.
STRINGi9606.ENSP00000291672.

Structurei

3D structure databases

ProteinModelPortaliQ9H0A9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi320 – 3234Poly-Leu

Sequence similaritiesi

Belongs to the speriolin family.Curated

Phylogenomic databases

eggNOGiENOG410IIK2. Eukaryota.
ENOG410Y05H. LUCA.
GeneTreeiENSGT00520000055666.
HOGENOMiHOG000060272.
HOVERGENiHBG051233.
InParanoidiQ9H0A9.
OMAiKKQVRLM.
OrthoDBiEOG091G0DLF.
PhylomeDBiQ9H0A9.
TreeFamiTF329273.

Family and domain databases

InterProiIPR026715. SPATC1.
IPR029384. Speriolin_C.
IPR029385. Speriolin_N.
[Graphical view]
PANTHERiPTHR22192. PTHR22192. 1 hit.
PfamiPF15059. Speriolin_C. 1 hit.
PF15058. Speriolin_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H0A9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEGGELMSR LLSENADLKK QVRLLKENQM LRRLLSQSCQ EGGGHDLLPP
60 70 80 90 100
RAHAYPEAGS PGSGVPDFGR FTSVADTPSQ LQTSSLEDLL CSHAPLSSED
110 120 130 140 150
DTSPGCAAPS QAPFKAFLSP PEPHSHRGTD RKLSPLLSPL QDSLVDKTLL
160 170 180 190 200
EPREMVRPKK VCFSESSLPT GDRTRRSYYL NEIQSFAGAE KDARVVGEIA
210 220 230 240 250
FQLDRRILAY VFPGVTRLYG FTVANIPEKI EQTSTKSLDG SVDERKLREL
260 270 280 290 300
TQRYLALSAR LEKLGYSRDV HPAFSEFLIN TYGILKQRPD LRANPLHSSP
310 320 330 340
AALRKLVIDV VPPKFLGDSL LLLNCLCELS KEDGKPLFAW
Length:340
Mass (Da):37,613
Last modified:May 18, 2010 - v3
Checksum:iAE8E79F7E5B50644
GO
Isoform 2 (identifier: Q9H0A9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-154: Missing.

Show »
Length:186
Mass (Da):21,049
Checksum:i56342795E99552E8
GO

Sequence cautioni

The sequence BAA95497 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131P → L.
Corresponds to variant rs884134 [ dbSNP | Ensembl ].
VAR_059639
Natural varianti298 – 2981S → N.
Corresponds to variant rs14378 [ dbSNP | Ensembl ].
VAR_059640

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 154154Missing in isoform 2. 3 PublicationsVSP_039151Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136871 mRNA. Translation: CAB66805.1.
CR533451 mRNA. Translation: CAG38482.1.
AK304535 mRNA. Translation: BAG65335.1.
AP001468 Genomic DNA. No translation available.
AP001759 Genomic DNA. Translation: BAA95497.1. Sequence problems.
CH471079 Genomic DNA. Translation: EAX09307.1.
BC009497 mRNA. Translation: AAH09497.3.
BC065570 mRNA. Translation: AAH65570.2.
BC084577 mRNA. Translation: AAH84577.1.
BC093804 mRNA. Translation: AAH93804.2.
BC112293 mRNA. Translation: AAI12294.2.
CCDSiCCDS13732.1. [Q9H0A9-2]
CCDS46653.1. [Q9H0A9-1]
RefSeqiNP_001136326.1. NM_001142854.1. [Q9H0A9-1]
NP_115637.3. NM_032261.4. [Q9H0A9-2]
XP_005261245.1. XM_005261188.4. [Q9H0A9-1]
UniGeneiHs.381214.

Genome annotation databases

EnsembliENST00000291672; ENSP00000291672; ENSG00000160284. [Q9H0A9-1]
ENST00000330205; ENSP00000333869; ENSG00000160284. [Q9H0A9-2]
ENST00000618495; ENSP00000478124; ENSG00000274679. [Q9H0A9-2]
ENST00000621926; ENSP00000483544; ENSG00000274679. [Q9H0A9-1]
GeneIDi84221.
KEGGihsa:84221.
UCSCiuc002zii.4. human. [Q9H0A9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136871 mRNA. Translation: CAB66805.1.
CR533451 mRNA. Translation: CAG38482.1.
AK304535 mRNA. Translation: BAG65335.1.
AP001468 Genomic DNA. No translation available.
AP001759 Genomic DNA. Translation: BAA95497.1. Sequence problems.
CH471079 Genomic DNA. Translation: EAX09307.1.
BC009497 mRNA. Translation: AAH09497.3.
BC065570 mRNA. Translation: AAH65570.2.
BC084577 mRNA. Translation: AAH84577.1.
BC093804 mRNA. Translation: AAH93804.2.
BC112293 mRNA. Translation: AAI12294.2.
CCDSiCCDS13732.1. [Q9H0A9-2]
CCDS46653.1. [Q9H0A9-1]
RefSeqiNP_001136326.1. NM_001142854.1. [Q9H0A9-1]
NP_115637.3. NM_032261.4. [Q9H0A9-2]
XP_005261245.1. XM_005261188.4. [Q9H0A9-1]
UniGeneiHs.381214.

3D structure databases

ProteinModelPortaliQ9H0A9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123955. 14 interactions.
IntActiQ9H0A9. 12 interactions.
MINTiMINT-4713719.
STRINGi9606.ENSP00000291672.

PTM databases

iPTMnetiQ9H0A9.
PhosphoSiteiQ9H0A9.

Polymorphism and mutation databases

BioMutaiSPATC1L.
DMDMi296439382.

Proteomic databases

PaxDbiQ9H0A9.
PeptideAtlasiQ9H0A9.
PRIDEiQ9H0A9.

Protocols and materials databases

DNASUi84221.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291672; ENSP00000291672; ENSG00000160284. [Q9H0A9-1]
ENST00000330205; ENSP00000333869; ENSG00000160284. [Q9H0A9-2]
ENST00000618495; ENSP00000478124; ENSG00000274679. [Q9H0A9-2]
ENST00000621926; ENSP00000483544; ENSG00000274679. [Q9H0A9-1]
GeneIDi84221.
KEGGihsa:84221.
UCSCiuc002zii.4. human. [Q9H0A9-1]

Organism-specific databases

CTDi84221.
GeneCardsiSPATC1L.
H-InvDBHIX0203124.
HGNCiHGNC:1298. SPATC1L.
HPAiHPA018979.
HPA019165.
HPA029394.
MIMi612412. gene.
neXtProtiNX_Q9H0A9.
PharmGKBiPA25851.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIK2. Eukaryota.
ENOG410Y05H. LUCA.
GeneTreeiENSGT00520000055666.
HOGENOMiHOG000060272.
HOVERGENiHBG051233.
InParanoidiQ9H0A9.
OMAiKKQVRLM.
OrthoDBiEOG091G0DLF.
PhylomeDBiQ9H0A9.
TreeFamiTF329273.

Miscellaneous databases

GeneWikiiC21orf56.
GenomeRNAii84221.
PROiQ9H0A9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160284.
CleanExiHS_C21orf56.
GenevisibleiQ9H0A9. HS.

Family and domain databases

InterProiIPR026715. SPATC1.
IPR029384. Speriolin_C.
IPR029385. Speriolin_N.
[Graphical view]
PANTHERiPTHR22192. PTHR22192. 1 hit.
PfamiPF15059. Speriolin_C. 1 hit.
PF15058. Speriolin_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPC1L_HUMAN
AccessioniPrimary (citable) accession number: Q9H0A9
Secondary accession number(s): B4E323
, Q52LS9, Q6FIH5, Q6P0L3, Q9NSE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Highly variable expression among individuals is associated with differential sensitivity to the DNA alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), decreased expression being associated with increased sensitivity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.