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Reviewed, UniProtKB/Swiss-Prot Q9H0A9 (CU056_HUMAN)

Last modified November 24, 2009. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Uncharacterized protein C21orf56
Gene names
Name: C21orf56
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Miscellaneous

Highly variable expression among individuals is associated with differential sensitivity to the DNA alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), decreased expression being associated with increased sensitivity.

Sequence caution

The sequence BAA95497.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PARNO954531EBI-372911,EBI-372832

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340Uncharacterized protein C21orf56
PRO_0000079519

Regions

Compositional bias320 – 3234Poly-Leu

Natural variations

Natural variant1131P → L: dbSNP rs884134.
VAR_059639
Natural variant2981S → N: dbSNP rs14378.
VAR_059640

Experimental info

Sequence conflict651G → V in AAH84577. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9H0A9-1 [UniParc].

Last modified October 18, 2001. Version 2.
Checksum: E53EC9F09374B648

FASTA34037,571
        10         20         30         40         50         60 
MAEGGELMSR LLSENADLKK QVRLLKENQM LRRLLSQSCQ EGGGHDLLPP RAHAYPEAGS 

        70         80         90        100        110        120 
PGSGGPDFGR FTSVADTPSQ LQTSSLEDLL CSHAPLSSED DTSPGCAAPS QAPFKAFLSP 

       130        140        150        160        170        180 
PEPHSHRGTD RKLSPLLSPL QDSLVDKTLL EPREMVRPKK VCFSESSLPT GDRTRRSYYL 

       190        200        210        220        230        240 
NEIQSFAGAE KDARVVGEIA FQLDRRILAY VFPGVTRLYG FTVANIPEKI EQTSTKSLDG 

       250        260        270        280        290        300 
SVDERKLREL TQRYLALSAR LEKLGYSRDV HPAFSEFLIN TYGILKQRPD LRANPLHSSP 

       310        320        330        340 
AALRKLVIDV VPPKFLGDSL LLLNCLCELS KEDGKPLFAW 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence of human chromosome 21."
Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. expand/collapse author list , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.
Nature 405:311-319(2000) [PubMed: 10830953] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-340.
Tissue: Brain, Eye, Mammary gland and Ovary.
[3]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 66-340.
Tissue: Testis.
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 155-340.
[5]"Genomic predictors of interindividual differences in response to DNA damaging agents."
Fry R.C., Svensson J.P., Valiathan C., Wang E., Hogan B.J., Bhattacharya S., Bugni J.M., Whittaker C.A., Samson L.D.
Genes Dev. 22:2621-2626(2008) [PubMed: 18805990] [Abstract]
Cited for: ASSOCIATION WITH SENSITIVITY TO ALKYLATING AGENTS.

Cross-references

Sequence databases

AP001759 Genomic DNA. Translation: BAA95497.1. Sequence problems.
BC009497 mRNA. Translation: AAH09497.3. Different initiation.
BC065570 mRNA. Translation: AAH65570.2. Different initiation.
BC084577 mRNA. Translation: AAH84577.1. Different initiation.
BC093804 mRNA. Translation: AAH93804.2. Different initiation.
BC112293 mRNA. Translation: AAI12294.2. Different initiation.
AL136871 mRNA. Translation: CAB66805.1. Different initiation.
CR533451 mRNA. Translation: CAG38482.1.
IPIIPI00031044.
RefSeqNP_115637.3.
UniGeneHs.381214

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ9H0A9. 1 interaction.

Proteomic databases

PRIDEQ9H0A9.

Genome annotation databases

EnsemblENST00000291672; ENSP00000291672; ENSG00000160284; Homo sapiens. [Genome view]
GeneID84221.
UCSCuc002zii.1. human.

Organism-specific databases

CTD84221.
GeneCardsGC21M046405.
HGNCHGNC:1298. C21orf56.
HPAHPA018979.
HPA019165.
MIM612412. gene.
PharmGKBPA25851.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9H0A9.
HOVERGENQ9H0A9.

Gene expression databases

ArrayExpressQ9H0A9.
BgeeQ9H0A9.
CleanExHS_C21orf56.
GenevestigatorQ9H0A9.
GermOnlineENSG00000160284. Homo sapiens.

Family and domain databases

ProtoNetSearch...

Other Resources

NextBio73652.
SOURCESearch...

Entry information

Entry nameCU056_HUMAN
AccessionPrimary (citable) accession number: Q9H0A9
Secondary accession number(s): Q52LS9 expand/collapse secondary AC list , Q6FIH5, Q6P0L3, Q9NSE5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 18, 2001
Last modified: November 24, 2009
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 21

Human chromosome 21: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents