Reviewed, UniProtKB/Swiss-Prot Q9H0A9 (CU056_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C21orf56

Gene names

Name:

C21orf56

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Miscellaneous	Highly variable expression among individuals is associated with differential sensitivity to the DNA alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), decreased expression being associated with increased sensitivity.
Sequence caution	The sequence BAA95497.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PARN	O95453	1	EBI-372911,EBI-372832

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	Uncharacterized protein C21orf56		PRO_0000079519
Regions
	Compositional bias	320 – 323	4	Poly-Leu
Natural variations
	Natural variant	113	1	P → L: dbSNP rs884134.		VAR_059639
	Natural variant	298	1	S → N: dbSNP rs14378.		VAR_059640
Experimental info
	Sequence conflict	65	1	G → V in AAH84577. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9H0A9-1 [UniParc]. Last modified October 18, 2001. Version 2. Checksum: E53EC9F09374B648	FASTA	340	37,571
	10 20 30 40 50 60 MAEGGELMSR LLSENADLKK QVRLLKENQM LRRLLSQSCQ EGGGHDLLPP RAHAYPEAGS 70 80 90 100 110 120 PGSGGPDFGR FTSVADTPSQ LQTSSLEDLL CSHAPLSSED DTSPGCAAPS QAPFKAFLSP 130 140 150 160 170 180 PEPHSHRGTD RKLSPLLSPL QDSLVDKTLL EPREMVRPKK VCFSESSLPT GDRTRRSYYL 190 200 210 220 230 240 NEIQSFAGAE KDARVVGEIA FQLDRRILAY VFPGVTRLYG FTVANIPEKI EQTSTKSLDG 250 260 270 280 290 300 SVDERKLREL TQRYLALSAR LEKLGYSRDV HPAFSEFLIN TYGILKQRPD LRANPLHSSP 310 320 330 340 AALRKLVIDV VPPKFLGDSL LLLNCLCELS KEDGKPLFAW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed: 10830953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-340. Tissue: Brain, Eye, Mammary gland and Ovary.
[3]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 66-340. Tissue: Testis.
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 155-340.
[5]	"Genomic predictors of interindividual differences in response to DNA damaging agents." Fry R.C., Svensson J.P., Valiathan C., Wang E., Hogan B.J., Bhattacharya S., Bugni J.M., Whittaker C.A., Samson L.D. Genes Dev. 22:2621-2626(2008) [PubMed: 18805990] [Abstract] Cited for: ASSOCIATION WITH SENSITIVITY TO ALKYLATING AGENTS.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP001759 Genomic DNA. Translation: BAA95497.1. Sequence problems. BC009497 mRNA. Translation: AAH09497.3. Different initiation. BC065570 mRNA. Translation: AAH65570.2. Different initiation. BC084577 mRNA. Translation: AAH84577.1. Different initiation. BC093804 mRNA. Translation: AAH93804.2. Different initiation. BC112293 mRNA. Translation: AAI12294.2. Different initiation. AL136871 mRNA. Translation: CAB66805.1. Different initiation. CR533451 mRNA. Translation: CAG38482.1.
IPI	IPI00031044.
RefSeq	NP_115637.3.
UniGene	Hs.381214
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H0A9. 1 interaction.
Proteomic databases
PRIDE	Q9H0A9.
Genome annotation databases
Ensembl	ENST00000291672; ENSP00000291672; ENSG00000160284; Homo sapiens. [Genome view]
GeneID	84221.
UCSC	uc002zii.1. human.
Organism-specific databases
CTD	84221.
GeneCards	GC21M046405.
HGNC	HGNC:1298. C21orf56.
HPA	HPA018979. HPA019165.
MIM	612412. gene.
PharmGKB	PA25851.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9H0A9.
HOVERGEN	Q9H0A9.
Gene expression databases
ArrayExpress	Q9H0A9.
Bgee	Q9H0A9.
CleanEx	HS_C21orf56.
Genevestigator	Q9H0A9.
GermOnline	ENSG00000160284. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	73652.
SOURCE	Search...

Entry information

Entry name

CU056_HUMAN

Accession

Primary (citable) accession number: Q9H0A9
Secondary accession number(s): Q52LS9 , Q6FIH5, Q6P0L3, Q9NSE5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	October 18, 2001
Last modified:	November 24, 2009
This is version 65 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.