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Q9H0A6

- RNF32_HUMAN

UniProt

Q9H0A6 - RNF32_HUMAN

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Protein

RING finger protein 32

Gene
RNF32, FKSG33, HSD15
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in sperm formation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri127 – 16943RING-type 1; atypicalAdd
BLAST
Zinc fingeri293 – 35260RING-type 2; atypicalAdd
BLAST

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 32
Gene namesi
Name:RNF32
ORF Names:FKSG33, HSD15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:17118. RNF32.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. aggresome Source: MGI
  2. endosome Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34435.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362RING finger protein 32PRO_0000245532Add
BLAST

Proteomic databases

PaxDbiQ9H0A6.
PRIDEiQ9H0A6.

Expressioni

Tissue specificityi

Highly expressed in testis, less abundant in ovary.1 Publication

Gene expression databases

ArrayExpressiQ9H0A6.
BgeeiQ9H0A6.
CleanExiHS_RNF32.
GenevestigatoriQ9H0A6.

Organism-specific databases

HPAiHPA019796.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FBXL12Q9NXK82EBI-724829,EBI-719790
PRAM1Q96QH22EBI-724829,EBI-2860740
STAMBPL1Q96FJ02EBI-724829,EBI-745021

Protein-protein interaction databases

BioGridi126622. 43 interactions.
IntActiQ9H0A6. 30 interactions.
MINTiMINT-1376415.
STRINGi9606.ENSP00000315950.

Structurei

3D structure databases

ProteinModelPortaliQ9H0A6.
SMRiQ9H0A6. Positions 125-172.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini186 – 21530IQAdd
BLAST

Sequence similaritiesi

Contains 1 IQ domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri127 – 16943RING-type 1; atypicalAdd
BLAST
Zinc fingeri293 – 35260RING-type 2; atypicalAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG270611.
HOVERGENiHBG082459.
InParanoidiQ9H0A6.
OMAiCSHMFHH.
PhylomeDBiQ9H0A6.
TreeFamiTF329796.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF13639. zf-RING_2. 2 hits.
[Graphical view]
SMARTiSM00015. IQ. 1 hit.
SM00184. RING. 2 hits.
[Graphical view]
PROSITEiPS50096. IQ. 1 hit.
PS50089. ZF_RING_2. 2 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Note: Other isoforms seem to exist.

Isoform 1 (identifier: Q9H0A6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLKNKGHSSK KDNLAVNAVA LQDHILHDLQ LRNLSVADHS KTQVQKKENK    50
SLKRDTKAII DTGLKKTTQC PKLEDSEKEY VLDPKPPPLT LAQKLGLIGP 100
PPPPLSSDEW EKVKQRSLLQ GDSVQPCPIC KEEFELRPQV LLSCSHVFHK 150
ACLQAFEKFT NKKTCPLCRK NQYQTRVIHD GARLFRIKCV TRIQAYWRGC 200
VVRKWYRNLR KTVPPTDAKL RKKFFEKKFT EISHRILCSY NTNIEELFAE 250
IDQCLAINRS VLQQLEEKCG HEITEEEWEK IQVQALRRET HECSICLAPL 300
SAAGGQRVGA GRRSREMALL SCSHVFHHAC LLALEEFSVG DRPPFHACPL 350
CRSCYQKKIL EC 362
Length:362
Mass (Da):41,516
Last modified:March 1, 2001 - v1
Checksum:i5C6AF6908FCCA456
GO
Isoform 2 (identifier: Q9H0A6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-169: LLSCSHVFHKACLQAFEKFTNKKTCPLCR → FSIRG

Note: Derived from EST data.

Show »
Length:338
Mass (Da):38,741
Checksum:iCC5A54DB27C34AF3
GO
Isoform 3 (identifier: Q9H0A6-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-235: FTEISHR → TQDWKPA
     236-362: Missing.

Show »
Length:235
Mass (Da):27,131
Checksum:i2D51EBF78FCCDC65
GO
Isoform 4 (identifier: Q9H0A6-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     170-352: Missing.

Note: No experimental confirmation available.

Show »
Length:179
Mass (Da):20,222
Checksum:iF1F7344CCBF8B636
GO
Isoform 5 (identifier: Q9H0A6-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-95: AQKL → GYHS
     96-362: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:95
Mass (Da):10,682
Checksum:i33AD8ABF2FB5FE29
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti288 – 2881R → Q.
Corresponds to variant rs2302148 [ dbSNP | Ensembl ].
VAR_026982
Natural varianti291 – 2911H → Q.
Corresponds to variant rs2302147 [ dbSNP | Ensembl ].
VAR_026983
Natural varianti307 – 3071R → C.
Corresponds to variant rs2302146 [ dbSNP | Ensembl ].
VAR_026984

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei92 – 954AQKL → GYHS in isoform 5. VSP_019738
Alternative sequencei96 – 362267Missing in isoform 5. VSP_019739Add
BLAST
Alternative sequencei141 – 16929LLSCS…CPLCR → FSIRG in isoform 2. VSP_019740Add
BLAST
Alternative sequencei170 – 352183Missing in isoform 4. VSP_019741Add
BLAST
Alternative sequencei229 – 2357FTEISHR → TQDWKPA in isoform 3. VSP_019743
Alternative sequencei236 – 362127Missing in isoform 3. VSP_019744Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971L → P in CAG38544. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF441222 mRNA. Translation: AAM18664.1.
AF441224 mRNA. Translation: AAM18666.1.
AF325690 mRNA. Translation: AAG50281.1.
AL136874 mRNA. Translation: CAB66808.1.
AY251165 mRNA. Translation: AAP20062.1.
BT007037 mRNA. Translation: AAP35686.1.
CR533513 mRNA. Translation: CAG38544.1.
AC005534 Genomic DNA. Translation: AAD43189.1.
BC015416 mRNA. Translation: AAH15416.1.
CCDSiCCDS5944.1. [Q9H0A6-1]
RefSeqiNP_001171925.1. NM_001184996.1. [Q9H0A6-1]
NP_001171926.1. NM_001184997.1. [Q9H0A6-1]
NP_112198.1. NM_030936.3. [Q9H0A6-1]
XP_005249579.1. XM_005249522.2. [Q9H0A6-1]
XP_006715915.1. XM_006715852.1. [Q9H0A6-4]
UniGeneiHs.446194.

Genome annotation databases

EnsembliENST00000317955; ENSP00000315950; ENSG00000105982. [Q9H0A6-1]
ENST00000343665; ENSP00000341185; ENSG00000105982. [Q9H0A6-2]
ENST00000392740; ENSP00000376496; ENSG00000105982. [Q9H0A6-6]
ENST00000392741; ENSP00000376497; ENSG00000105982. [Q9H0A6-4]
ENST00000392743; ENSP00000376499; ENSG00000105982. [Q9H0A6-1]
ENST00000392747; ENSP00000376503; ENSG00000105982. [Q9H0A6-6]
ENST00000405335; ENSP00000385285; ENSG00000105982. [Q9H0A6-1]
ENST00000432459; ENSP00000405588; ENSG00000105982. [Q9H0A6-1]
GeneIDi140545.
KEGGihsa:140545.
UCSCiuc003wmo.3. human. [Q9H0A6-1]
uc003wms.3. human. [Q9H0A6-4]

Polymorphism databases

DMDMi74717970.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF441222 mRNA. Translation: AAM18664.1 .
AF441224 mRNA. Translation: AAM18666.1 .
AF325690 mRNA. Translation: AAG50281.1 .
AL136874 mRNA. Translation: CAB66808.1 .
AY251165 mRNA. Translation: AAP20062.1 .
BT007037 mRNA. Translation: AAP35686.1 .
CR533513 mRNA. Translation: CAG38544.1 .
AC005534 Genomic DNA. Translation: AAD43189.1 .
BC015416 mRNA. Translation: AAH15416.1 .
CCDSi CCDS5944.1. [Q9H0A6-1 ]
RefSeqi NP_001171925.1. NM_001184996.1. [Q9H0A6-1 ]
NP_001171926.1. NM_001184997.1. [Q9H0A6-1 ]
NP_112198.1. NM_030936.3. [Q9H0A6-1 ]
XP_005249579.1. XM_005249522.2. [Q9H0A6-1 ]
XP_006715915.1. XM_006715852.1. [Q9H0A6-4 ]
UniGenei Hs.446194.

3D structure databases

ProteinModelPortali Q9H0A6.
SMRi Q9H0A6. Positions 125-172.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126622. 43 interactions.
IntActi Q9H0A6. 30 interactions.
MINTi MINT-1376415.
STRINGi 9606.ENSP00000315950.

Polymorphism databases

DMDMi 74717970.

Proteomic databases

PaxDbi Q9H0A6.
PRIDEi Q9H0A6.

Protocols and materials databases

DNASUi 140545.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000317955 ; ENSP00000315950 ; ENSG00000105982 . [Q9H0A6-1 ]
ENST00000343665 ; ENSP00000341185 ; ENSG00000105982 . [Q9H0A6-2 ]
ENST00000392740 ; ENSP00000376496 ; ENSG00000105982 . [Q9H0A6-6 ]
ENST00000392741 ; ENSP00000376497 ; ENSG00000105982 . [Q9H0A6-4 ]
ENST00000392743 ; ENSP00000376499 ; ENSG00000105982 . [Q9H0A6-1 ]
ENST00000392747 ; ENSP00000376503 ; ENSG00000105982 . [Q9H0A6-6 ]
ENST00000405335 ; ENSP00000385285 ; ENSG00000105982 . [Q9H0A6-1 ]
ENST00000432459 ; ENSP00000405588 ; ENSG00000105982 . [Q9H0A6-1 ]
GeneIDi 140545.
KEGGi hsa:140545.
UCSCi uc003wmo.3. human. [Q9H0A6-1 ]
uc003wms.3. human. [Q9H0A6-4 ]

Organism-specific databases

CTDi 140545.
GeneCardsi GC07P156433.
HGNCi HGNC:17118. RNF32.
HPAi HPA019796.
MIMi 610241. gene.
neXtProti NX_Q9H0A6.
PharmGKBi PA34435.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG270611.
HOVERGENi HBG082459.
InParanoidi Q9H0A6.
OMAi CSHMFHH.
PhylomeDBi Q9H0A6.
TreeFami TF329796.

Miscellaneous databases

GeneWikii RNF32.
GenomeRNAii 140545.
NextBioi 84152.
PROi Q9H0A6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9H0A6.
Bgeei Q9H0A6.
CleanExi HS_RNF32.
Genevestigatori Q9H0A6.

Family and domain databases

Gene3Di 3.30.40.10. 2 hits.
InterProi IPR000048. IQ_motif_EF-hand-BS.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF00612. IQ. 1 hit.
PF13639. zf-RING_2. 2 hits.
[Graphical view ]
SMARTi SM00015. IQ. 1 hit.
SM00184. RING. 2 hits.
[Graphical view ]
PROSITEi PS50096. IQ. 1 hit.
PS50089. ZF_RING_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 5), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
  2. "Characterization of FKSG33, a novel gene located on human chromosome 7q35-36."
    Wang Y.-G., Gong L.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. "A new spermatogenesis-related gene."
    Hu T.H., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Testis.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  7. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Duodenum.

Entry informationi

Entry nameiRNF32_HUMAN
AccessioniPrimary (citable) accession number: Q9H0A6
Secondary accession number(s): Q6FIB3
, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9Y6U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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