Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9H0A6

- RNF32_HUMAN

UniProt

Q9H0A6 - RNF32_HUMAN

Protein

RING finger protein 32

Gene

RNF32

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May play a role in sperm formation.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri127 – 16943RING-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri293 – 35260RING-type 2; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RING finger protein 32
    Gene namesi
    Name:RNF32
    ORF Names:FKSG33, HSD15
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:17118. RNF32.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. aggresome Source: MGI
    2. endosome Source: LIFEdb

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34435.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362RING finger protein 32PRO_0000245532Add
    BLAST

    Proteomic databases

    PaxDbiQ9H0A6.
    PRIDEiQ9H0A6.

    Expressioni

    Tissue specificityi

    Highly expressed in testis, less abundant in ovary.1 Publication

    Gene expression databases

    ArrayExpressiQ9H0A6.
    BgeeiQ9H0A6.
    CleanExiHS_RNF32.
    GenevestigatoriQ9H0A6.

    Organism-specific databases

    HPAiHPA019796.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FBXL12Q9NXK82EBI-724829,EBI-719790
    PRAM1Q96QH22EBI-724829,EBI-2860740
    STAMBPL1Q96FJ02EBI-724829,EBI-745021

    Protein-protein interaction databases

    BioGridi126622. 43 interactions.
    IntActiQ9H0A6. 30 interactions.
    MINTiMINT-1376415.
    STRINGi9606.ENSP00000315950.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H0A6.
    SMRiQ9H0A6. Positions 125-172.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini186 – 21530IQPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 IQ domain.PROSITE-ProRule annotation
    Contains 2 RING-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri127 – 16943RING-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri293 – 35260RING-type 2; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG270611.
    HOVERGENiHBG082459.
    InParanoidiQ9H0A6.
    OMAiCSHMFHH.
    PhylomeDBiQ9H0A6.
    TreeFamiTF329796.

    Family and domain databases

    Gene3Di3.30.40.10. 2 hits.
    InterProiIPR000048. IQ_motif_EF-hand-BS.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00612. IQ. 1 hit.
    PF13639. zf-RING_2. 2 hits.
    [Graphical view]
    SMARTiSM00015. IQ. 1 hit.
    SM00184. RING. 2 hits.
    [Graphical view]
    PROSITEiPS50096. IQ. 1 hit.
    PS50089. ZF_RING_2. 2 hits.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Note: Other isoforms seem to exist.

    Isoform 1 (identifier: Q9H0A6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLKNKGHSSK KDNLAVNAVA LQDHILHDLQ LRNLSVADHS KTQVQKKENK    50
    SLKRDTKAII DTGLKKTTQC PKLEDSEKEY VLDPKPPPLT LAQKLGLIGP 100
    PPPPLSSDEW EKVKQRSLLQ GDSVQPCPIC KEEFELRPQV LLSCSHVFHK 150
    ACLQAFEKFT NKKTCPLCRK NQYQTRVIHD GARLFRIKCV TRIQAYWRGC 200
    VVRKWYRNLR KTVPPTDAKL RKKFFEKKFT EISHRILCSY NTNIEELFAE 250
    IDQCLAINRS VLQQLEEKCG HEITEEEWEK IQVQALRRET HECSICLAPL 300
    SAAGGQRVGA GRRSREMALL SCSHVFHHAC LLALEEFSVG DRPPFHACPL 350
    CRSCYQKKIL EC 362
    Length:362
    Mass (Da):41,516
    Last modified:March 1, 2001 - v1
    Checksum:i5C6AF6908FCCA456
    GO
    Isoform 2 (identifier: Q9H0A6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         141-169: LLSCSHVFHKACLQAFEKFTNKKTCPLCR → FSIRG

    Note: Derived from EST data.

    Show »
    Length:338
    Mass (Da):38,741
    Checksum:iCC5A54DB27C34AF3
    GO
    Isoform 3 (identifier: Q9H0A6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         229-235: FTEISHR → TQDWKPA
         236-362: Missing.

    Show »
    Length:235
    Mass (Da):27,131
    Checksum:i2D51EBF78FCCDC65
    GO
    Isoform 4 (identifier: Q9H0A6-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         170-352: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:179
    Mass (Da):20,222
    Checksum:iF1F7344CCBF8B636
    GO
    Isoform 5 (identifier: Q9H0A6-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         92-95: AQKL → GYHS
         96-362: Missing.

    Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:95
    Mass (Da):10,682
    Checksum:i33AD8ABF2FB5FE29
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti97 – 971L → P in CAG38544. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti288 – 2881R → Q.
    Corresponds to variant rs2302148 [ dbSNP | Ensembl ].
    VAR_026982
    Natural varianti291 – 2911H → Q.
    Corresponds to variant rs2302147 [ dbSNP | Ensembl ].
    VAR_026983
    Natural varianti307 – 3071R → C.
    Corresponds to variant rs2302146 [ dbSNP | Ensembl ].
    VAR_026984

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei92 – 954AQKL → GYHS in isoform 5. 1 PublicationVSP_019738
    Alternative sequencei96 – 362267Missing in isoform 5. 1 PublicationVSP_019739Add
    BLAST
    Alternative sequencei141 – 16929LLSCS…CPLCR → FSIRG in isoform 2. CuratedVSP_019740Add
    BLAST
    Alternative sequencei170 – 352183Missing in isoform 4. 1 PublicationVSP_019741Add
    BLAST
    Alternative sequencei229 – 2357FTEISHR → TQDWKPA in isoform 3. 2 PublicationsVSP_019743
    Alternative sequencei236 – 362127Missing in isoform 3. 2 PublicationsVSP_019744Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF441222 mRNA. Translation: AAM18664.1.
    AF441224 mRNA. Translation: AAM18666.1.
    AF325690 mRNA. Translation: AAG50281.1.
    AL136874 mRNA. Translation: CAB66808.1.
    AY251165 mRNA. Translation: AAP20062.1.
    BT007037 mRNA. Translation: AAP35686.1.
    CR533513 mRNA. Translation: CAG38544.1.
    AC005534 Genomic DNA. Translation: AAD43189.1.
    BC015416 mRNA. Translation: AAH15416.1.
    CCDSiCCDS5944.1. [Q9H0A6-1]
    RefSeqiNP_001171925.1. NM_001184996.1. [Q9H0A6-1]
    NP_001171926.1. NM_001184997.1. [Q9H0A6-1]
    NP_112198.1. NM_030936.3. [Q9H0A6-1]
    XP_005249579.1. XM_005249522.2. [Q9H0A6-1]
    XP_006715915.1. XM_006715852.1. [Q9H0A6-4]
    UniGeneiHs.446194.

    Genome annotation databases

    EnsembliENST00000317955; ENSP00000315950; ENSG00000105982. [Q9H0A6-1]
    ENST00000392741; ENSP00000376497; ENSG00000105982. [Q9H0A6-4]
    ENST00000392743; ENSP00000376499; ENSG00000105982. [Q9H0A6-1]
    ENST00000392747; ENSP00000376503; ENSG00000105982. [Q9H0A6-6]
    ENST00000405335; ENSP00000385285; ENSG00000105982. [Q9H0A6-1]
    ENST00000432459; ENSP00000405588; ENSG00000105982. [Q9H0A6-1]
    GeneIDi140545.
    KEGGihsa:140545.
    UCSCiuc003wmo.3. human. [Q9H0A6-1]
    uc003wms.3. human. [Q9H0A6-4]

    Polymorphism databases

    DMDMi74717970.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF441222 mRNA. Translation: AAM18664.1 .
    AF441224 mRNA. Translation: AAM18666.1 .
    AF325690 mRNA. Translation: AAG50281.1 .
    AL136874 mRNA. Translation: CAB66808.1 .
    AY251165 mRNA. Translation: AAP20062.1 .
    BT007037 mRNA. Translation: AAP35686.1 .
    CR533513 mRNA. Translation: CAG38544.1 .
    AC005534 Genomic DNA. Translation: AAD43189.1 .
    BC015416 mRNA. Translation: AAH15416.1 .
    CCDSi CCDS5944.1. [Q9H0A6-1 ]
    RefSeqi NP_001171925.1. NM_001184996.1. [Q9H0A6-1 ]
    NP_001171926.1. NM_001184997.1. [Q9H0A6-1 ]
    NP_112198.1. NM_030936.3. [Q9H0A6-1 ]
    XP_005249579.1. XM_005249522.2. [Q9H0A6-1 ]
    XP_006715915.1. XM_006715852.1. [Q9H0A6-4 ]
    UniGenei Hs.446194.

    3D structure databases

    ProteinModelPortali Q9H0A6.
    SMRi Q9H0A6. Positions 125-172.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126622. 43 interactions.
    IntActi Q9H0A6. 30 interactions.
    MINTi MINT-1376415.
    STRINGi 9606.ENSP00000315950.

    Polymorphism databases

    DMDMi 74717970.

    Proteomic databases

    PaxDbi Q9H0A6.
    PRIDEi Q9H0A6.

    Protocols and materials databases

    DNASUi 140545.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000317955 ; ENSP00000315950 ; ENSG00000105982 . [Q9H0A6-1 ]
    ENST00000392741 ; ENSP00000376497 ; ENSG00000105982 . [Q9H0A6-4 ]
    ENST00000392743 ; ENSP00000376499 ; ENSG00000105982 . [Q9H0A6-1 ]
    ENST00000392747 ; ENSP00000376503 ; ENSG00000105982 . [Q9H0A6-6 ]
    ENST00000405335 ; ENSP00000385285 ; ENSG00000105982 . [Q9H0A6-1 ]
    ENST00000432459 ; ENSP00000405588 ; ENSG00000105982 . [Q9H0A6-1 ]
    GeneIDi 140545.
    KEGGi hsa:140545.
    UCSCi uc003wmo.3. human. [Q9H0A6-1 ]
    uc003wms.3. human. [Q9H0A6-4 ]

    Organism-specific databases

    CTDi 140545.
    GeneCardsi GC07P156433.
    HGNCi HGNC:17118. RNF32.
    HPAi HPA019796.
    MIMi 610241. gene.
    neXtProti NX_Q9H0A6.
    PharmGKBi PA34435.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG270611.
    HOVERGENi HBG082459.
    InParanoidi Q9H0A6.
    OMAi CSHMFHH.
    PhylomeDBi Q9H0A6.
    TreeFami TF329796.

    Miscellaneous databases

    GeneWikii RNF32.
    GenomeRNAii 140545.
    NextBioi 84152.
    PROi Q9H0A6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9H0A6.
    Bgeei Q9H0A6.
    CleanExi HS_RNF32.
    Genevestigatori Q9H0A6.

    Family and domain databases

    Gene3Di 3.30.40.10. 2 hits.
    InterProi IPR000048. IQ_motif_EF-hand-BS.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00612. IQ. 1 hit.
    PF13639. zf-RING_2. 2 hits.
    [Graphical view ]
    SMARTi SM00015. IQ. 1 hit.
    SM00184. RING. 2 hits.
    [Graphical view ]
    PROSITEi PS50096. IQ. 1 hit.
    PS50089. ZF_RING_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 5), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
    2. "Characterization of FKSG33, a novel gene located on human chromosome 7q35-36."
      Wang Y.-G., Gong L.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    4. "A new spermatogenesis-related gene."
      Hu T.H., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Testis.
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    7. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Duodenum.

    Entry informationi

    Entry nameiRNF32_HUMAN
    AccessioniPrimary (citable) accession number: Q9H0A6
    Secondary accession number(s): Q6FIB3
    , Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9Y6U1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3