Q9H098 (F107B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM107B

Gene names

Name:	FAM107B
Synonyms:	C10orf45

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the FAM107 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9H098-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9H098-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSTWKARLTK...DSYLITRSIM

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 131	130	Protein FAM107B		PRO_0000230774
Regions
	Coiled coil	61 – 112	52	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.7
Natural variations
	Alternative sequence	1	1	M → MSTWKARLTKRLKSPSRSMH PFPCSALLACFGNTRESASF NQSGVADTHSTVRVQPVAKA GRQPRHPSAEGAPEKRQDSS THAERNGSANRNSSHRTAAQ PAETPEDVPGSLDDGADCEA VVFHASIPRPSIIDTPKEEE FREEPKCLELEQKMTSDSPP EDIDHKDSYLITRSIM in isoform 2.		VSP_037527

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 6BEC6C5F02F679D4	FASTA	131	15,558
	10 20 30 40 50 60 MAEPDYIEDD NPELIRPQKL INPVKTSRNH QDLHRELLMN QKRGLAPQNK PELQKVMEKR 70 80 90 100 110 120 KRDQVIKQKE EEAQKKKSDL EIELLKRQQK LEQLELEKQK LQEEQENAPE FVKVKGNLRR 130 TGQEVAQAQE S
	Isoform 2 [UniParc]. Checksum: 4AD303B43DCE2E40	FASTA	306	34,759
	10 20 30 40 50 60 MSTWKARLTK RLKSPSRSMH PFPCSALLAC FGNTRESASF NQSGVADTHS TVRVQPVAKA 70 80 90 100 110 120 GRQPRHPSAE GAPEKRQDSS THAERNGSAN RNSSHRTAAQ PAETPEDVPG SLDDGADCEA 130 140 150 160 170 180 VVFHASIPRP SIIDTPKEEE FREEPKCLEL EQKMTSDSPP EDIDHKDSYL ITRSIMAEPD 190 200 210 220 230 240 YIEDDNPELI RPQKLINPVK TSRNHQDLHR ELLMNQKRGL APQNKPELQK VMEKRKRDQV 250 260 270 280 290 300 IKQKEEEAQK KKSDLEIELL KRQQKLEQLE LEKQKLQEEQ ENAPEFVKVK GNLRRTGQEV AQAQES

References

[1]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Hippocampus and Thalamus.
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lymph, PNS and Testis.
[7]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, MASS SPECTROMETRY. Tissue: Embryonic kidney.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL136885 mRNA. Translation: CAB66819.1. CR533466 mRNA. Translation: CAG38497.1. AK127413 mRNA. Translation: BAC86966.1. AK289959 mRNA. Translation: BAF82648.1. AL158168 Genomic DNA. No translation available. AC069544 Genomic DNA. No translation available. AL157706 Genomic DNA. Translation: CAI12270.1. AL157706 Genomic DNA. Translation: CAI12271.1. AL157706 Genomic DNA. Translation: CAI12272.1. CH471072 Genomic DNA. Translation: EAW86268.1. CH471072 Genomic DNA. Translation: EAW86269.1. CH471072 Genomic DNA. Translation: EAW86270.1. BC004872 mRNA. Translation: AAH04872.1. BC064407 mRNA. Translation: AAH64407.1. BC072452 mRNA. Translation: AAH72452.1.
IPI	IPI00027799. IPI00871831.
RefSeq	NP_113641.2. NM_031453.2.
UniGene	Hs.446315.
3D structure databases
ProteinModelPortal	Q9H098.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9H098. 2 interactions.
MINT	MINT-4712674.
STRING	Q9H098.
PTM databases
PhosphoSite	Q9H098.
Polymorphism databases
DMDM	74752552.
Proteomic databases
PRIDE	Q9H098.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000181796; ENSP00000181796; ENSG00000065809. ENST00000378458; ENSP00000367719; ENSG00000065809. ENST00000378461; ENSP00000367722; ENSG00000065809. ENST00000378462; ENSP00000367723; ENSG00000065809. ENST00000378465; ENSP00000367726; ENSG00000065809. ENST00000378467; ENSP00000367728; ENSG00000065809. ENST00000378470; ENSP00000367731; ENSG00000065809. ENST00000468492; ENSP00000420444; ENSG00000065809. ENST00000468747; ENSP00000418120; ENSG00000065809. ENST00000478076; ENSP00000417782; ENSG00000065809. ENST00000479731; ENSP00000419603; ENSG00000065809. ENST00000496330; ENSP00000418330; ENSG00000065809.
GeneID	83641.
KEGG	hsa:83641.
UCSC	uc001imx.1. human.
Organism-specific databases
CTD	83641.
GeneCards	GC10M014471.
HGNC	HGNC:23726. FAM107B.
HPA	HPA039661.
neXtProt	NX_Q9H098.
PharmGKB	PA134902915.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000011228.
HOVERGEN	HBG002824.
InParanoid	Q9H098.
OMA	PRPSIID.
OrthoDB	EOG4KSPM9.
Gene expression databases
ArrayExpress	Q9H098.
Bgee	Q9H098.
CleanEx	HS_FAM107B.
Genevestigator	Q9H098.
GermOnline	ENSG00000065809. Homo sapiens.
Family and domain databases
InterPro	IPR009533. DUF1151. [Graphical view]
PANTHER	PTHR16768. DUF1151. 1 hit.
Pfam	PF06625. DUF1151. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F107B_HUMAN

Accession

Primary (citable) accession number: Q9H098
Secondary accession number(s): A8K1P4 , D3DRT2, Q5T9K7, Q5T9K8, Q6ZSI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	March 1, 2001
Last modified:	December 14, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.