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Q9H098 (F107B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM107B
Gene names
Name:FAM107B
Synonyms:C10orf45
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length131 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the FAM107 family.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainCoiled coil
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H098-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H098-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSTWKARLTK...DSYLITRSIM
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.7
Chain2 – 131130Protein FAM107B
PRO_0000230774

Regions

Coiled coil61 – 11252 Potential

Amino acid modifications

Modified residue21N-acetylalanine Ref.7
Modified residue501N6-acetyllysine By similarity

Natural variations

Alternative sequence11M → MSTWKARLTKRLKSPSRSMH PFPCSALLACFGNTRESASF NQSGVADTHSTVRVQPVAKA GRQPRHPSAEGAPEKRQDSS THAERNGSANRNSSHRTAAQ PAETPEDVPGSLDDGADCEA VVFHASIPRPSIIDTPKEEE FREEPKCLELEQKMTSDSPP EDIDHKDSYLITRSIM in isoform 2.
VSP_037527

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 6BEC6C5F02F679D4

FASTA13115,558
        10         20         30         40         50         60 
MAEPDYIEDD NPELIRPQKL INPVKTSRNH QDLHRELLMN QKRGLAPQNK PELQKVMEKR 

        70         80         90        100        110        120 
KRDQVIKQKE EEAQKKKSDL EIELLKRQQK LEQLELEKQK LQEEQENAPE FVKVKGNLRR 

       130 
TGQEVAQAQE S 

« Hide

Isoform 2 [UniParc].

Checksum: 4AD303B43DCE2E40
Show »

FASTA30634,759

References

[1]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Hippocampus and Thalamus.
[4]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Lymph, PNS and Testis.
[7]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL136885 mRNA. Translation: CAB66819.1.
CR533466 mRNA. Translation: CAG38497.1.
AK127413 mRNA. Translation: BAC86966.1.
AK289959 mRNA. Translation: BAF82648.1.
AL158168 Genomic DNA. No translation available.
AC069544 Genomic DNA. No translation available.
AL157706 Genomic DNA. Translation: CAI12270.1.
AL157706 Genomic DNA. Translation: CAI12271.1.
AL157706 Genomic DNA. Translation: CAI12272.1.
CH471072 Genomic DNA. Translation: EAW86268.1.
CH471072 Genomic DNA. Translation: EAW86269.1.
CH471072 Genomic DNA. Translation: EAW86270.1.
BC004872 mRNA. Translation: AAH04872.1.
BC064407 mRNA. Translation: AAH64407.1.
BC072452 mRNA. Translation: AAH72452.1.
RefSeqNP_001269624.1. NM_001282695.1.
NP_001269625.1. NM_001282696.1.
NP_001269626.1. NM_001282697.1.
NP_001269627.1. NM_001282698.1.
NP_001269628.1. NM_001282699.1.
NP_001269629.1. NM_001282700.1.
NP_001269630.1. NM_001282701.1.
NP_001269631.1. NM_001282702.1.
NP_001269632.1. NM_001282703.1.
NP_113641.2. NM_031453.3.
XP_005252673.1. XM_005252616.1.
UniGeneHs.446315.

3D structure databases

ProteinModelPortalQ9H098.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123705. 3 interactions.
IntActQ9H098. 2 interactions.
MINTMINT-4712674.
STRING9606.ENSP00000181796.

Polymorphism databases

DMDM74752552.

Proteomic databases

PaxDbQ9H098.
PRIDEQ9H098.

Protocols and materials databases

DNASU83641.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000181796; ENSP00000181796; ENSG00000065809. [Q9H098-2]
ENST00000378458; ENSP00000367719; ENSG00000065809. [Q9H098-1]
ENST00000378462; ENSP00000367723; ENSG00000065809. [Q9H098-1]
ENST00000378465; ENSP00000367726; ENSG00000065809. [Q9H098-1]
ENST00000378467; ENSP00000367728; ENSG00000065809. [Q9H098-1]
ENST00000378470; ENSP00000367731; ENSG00000065809. [Q9H098-1]
ENST00000468492; ENSP00000420444; ENSG00000065809. [Q9H098-1]
ENST00000468747; ENSP00000418120; ENSG00000065809. [Q9H098-1]
ENST00000478076; ENSP00000417782; ENSG00000065809. [Q9H098-1]
ENST00000479731; ENSP00000419603; ENSG00000065809. [Q9H098-1]
ENST00000496330; ENSP00000418330; ENSG00000065809. [Q9H098-1]
GeneID83641.
KEGGhsa:83641.
UCSCuc001imx.1. human. [Q9H098-1]
uc001ina.1. human. [Q9H098-2]

Organism-specific databases

CTD83641.
GeneCardsGC10M014471.
H-InvDBHIX0008665.
HGNCHGNC:23726. FAM107B.
HPAHPA039661.
neXtProtNX_Q9H098.
PharmGKBPA134902915.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG75700.
HOGENOMHOG000048230.
HOVERGENHBG002824.
InParanoidQ9H098.
OMAERNGSAN.
OrthoDBEOG7P02MP.
PhylomeDBQ9H098.
TreeFamTF325943.

Gene expression databases

ArrayExpressQ9H098.
BgeeQ9H098.
CleanExHS_FAM107B.
GenevestigatorQ9H098.

Family and domain databases

InterProIPR009533. DUF1151.
[Graphical view]
PANTHERPTHR16768. PTHR16768. 1 hit.
PfamPF06625. DUF1151. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFAM107B. human.
GenomeRNAi83641.
NextBio72591.
PROQ9H098.

Entry information

Entry nameF107B_HUMAN
AccessionPrimary (citable) accession number: Q9H098
Secondary accession number(s): A8K1P4 expand/collapse secondary AC list , D3DRT2, Q5T9K7, Q5T9K8, Q6ZSI4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM