Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

IQ domain-containing protein G

Gene

IQCG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
IQ domain-containing protein G
Gene namesi
Name:IQCG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25251. IQCG.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134919040.

Polymorphism and mutation databases

BioMutaiIQCG.
DMDMi74752551.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443IQ domain-containing protein GPRO_0000282561Add
BLAST

Proteomic databases

EPDiQ9H095.
PaxDbiQ9H095.
PRIDEiQ9H095.

PTM databases

iPTMnetiQ9H095.
PhosphoSiteiQ9H095.

Expressioni

Gene expression databases

BgeeiQ9H095.
CleanExiHS_IQCG.
ExpressionAtlasiQ9H095. baseline and differential.
GenevisibleiQ9H095. HS.

Organism-specific databases

HPAiHPA042787.

Interactioni

Protein-protein interaction databases

BioGridi123957. 2 interactions.
IntActiQ9H095. 2 interactions.
MINTiMINT-4830746.
STRINGi9606.ENSP00000265239.

Structurei

Secondary structure

1
443
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi389 – 41022Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LZXX-ray1.50B389-423[»]
4M1LX-ray2.10B376-435[»]
ProteinModelPortaliQ9H095.
SMRiQ9H095. Positions 389-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini393 – 42230IQPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFH5. Eukaryota.
ENOG410ZKIR. LUCA.
GeneTreeiENSGT00730000111263.
HOGENOMiHOG000007509.
HOVERGENiHBG083921.
InParanoidiQ9H095.
OMAiFDKDTEM.
OrthoDBiEOG761BVW.
PhylomeDBiQ9H095.
TreeFamiTF326203.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
[Graphical view]
PROSITEiPS50096. IQ. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H095-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEDSLEDSN LPPKVWHSEM TVSVTGEPPS TVEEEGIPKE TDIEIIPEIP
60 70 80 90 100
ETLEPLSLPD VLRISAVLED TTDQLSILNY IMPVQYEGRQ SICVKSREMN
110 120 130 140 150
LEGTNLDKLP MASTITKIPS PLITEEGPNL PEIRHRGRFA VEFNKMQDLV
160 170 180 190 200
FKKPTRQTIM TTETLKKIQI DRQFFSDVIA DTIKELQDSA TYNSLLQALS
210 220 230 240 250
KERENKMHFY DIIAREEKGR KQIISLQKQL INVKKEWQFE VQSQNEYIAN
260 270 280 290 300
LKDQLQEMKA KSNLENRYMK TNTELQIAQT QKKCNRTEEL LVEEIEKLRM
310 320 330 340 350
KTEEEARTHT EIEMFLRKEQ QKLEERLEFW MEKYDKDTEM KQNELNALKA
360 370 380 390 400
TKASDLAHLQ DLAKMIREYE QVIIEDRIEK ERSKKKVKQD LLELKSVIKL
410 420 430 440
QAWWRGTMIR REIGGFKMPK DKVDSKDSKG KGKGKDKRRG KKK
Length:443
Mass (Da):51,918
Last modified:March 1, 2001 - v1
Checksum:iF4816EFF3F3386E7
GO
Isoform 2 (identifier: Q9H095-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.

Note: No experimental confirmation available.
Show »
Length:345
Mass (Da):40,927
Checksum:i3287633A2F81EFF1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771D → H in AAH04816 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti112 – 1121A → D.1 Publication
Corresponds to variant rs9880989 [ dbSNP | Ensembl ].
VAR_031415

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9898Missing in isoform 2. 1 PublicationVSP_024187Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136889 mRNA. Translation: CAB66823.1.
CR533515 mRNA. Translation: CAG38546.1.
AK021729 mRNA. Translation: BAB13881.1.
BC004816 mRNA. Translation: AAH04816.2.
CCDSiCCDS3331.1. [Q9H095-1]
RefSeqiNP_001127907.1. NM_001134435.2. [Q9H095-1]
NP_115639.1. NM_032263.4. [Q9H095-1]
UniGeneiHs.591675.

Genome annotation databases

EnsembliENST00000265239; ENSP00000265239; ENSG00000114473. [Q9H095-1]
ENST00000455191; ENSP00000407736; ENSG00000114473. [Q9H095-1]
GeneIDi84223.
KEGGihsa:84223.
UCSCiuc003fyo.4. human. [Q9H095-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136889 mRNA. Translation: CAB66823.1.
CR533515 mRNA. Translation: CAG38546.1.
AK021729 mRNA. Translation: BAB13881.1.
BC004816 mRNA. Translation: AAH04816.2.
CCDSiCCDS3331.1. [Q9H095-1]
RefSeqiNP_001127907.1. NM_001134435.2. [Q9H095-1]
NP_115639.1. NM_032263.4. [Q9H095-1]
UniGeneiHs.591675.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LZXX-ray1.50B389-423[»]
4M1LX-ray2.10B376-435[»]
ProteinModelPortaliQ9H095.
SMRiQ9H095. Positions 389-420.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123957. 2 interactions.
IntActiQ9H095. 2 interactions.
MINTiMINT-4830746.
STRINGi9606.ENSP00000265239.

PTM databases

iPTMnetiQ9H095.
PhosphoSiteiQ9H095.

Polymorphism and mutation databases

BioMutaiIQCG.
DMDMi74752551.

Proteomic databases

EPDiQ9H095.
PaxDbiQ9H095.
PRIDEiQ9H095.

Protocols and materials databases

DNASUi84223.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265239; ENSP00000265239; ENSG00000114473. [Q9H095-1]
ENST00000455191; ENSP00000407736; ENSG00000114473. [Q9H095-1]
GeneIDi84223.
KEGGihsa:84223.
UCSCiuc003fyo.4. human. [Q9H095-1]

Organism-specific databases

CTDi84223.
GeneCardsiIQCG.
HGNCiHGNC:25251. IQCG.
HPAiHPA042787.
MIMi612477. gene.
neXtProtiNX_Q9H095.
PharmGKBiPA134919040.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFH5. Eukaryota.
ENOG410ZKIR. LUCA.
GeneTreeiENSGT00730000111263.
HOGENOMiHOG000007509.
HOVERGENiHBG083921.
InParanoidiQ9H095.
OMAiFDKDTEM.
OrthoDBiEOG761BVW.
PhylomeDBiQ9H095.
TreeFamiTF326203.

Miscellaneous databases

ChiTaRSiIQCG. human.
GenomeRNAii84223.
PROiQ9H095.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H095.
CleanExiHS_IQCG.
ExpressionAtlasiQ9H095. baseline and differential.
GenevisibleiQ9H095. HS.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
[Graphical view]
PROSITEiPS50096. IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryo.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 72-443 (ISOFORM 1), VARIANT ASP-112.
    Tissue: Placenta.

Entry informationi

Entry nameiIQCG_HUMAN
AccessioniPrimary (citable) accession number: Q9H095
Secondary accession number(s): Q9BST2, Q9HAG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.