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Protein

Large subunit GTPase 1 homolog

Gene

LSG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable).1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi212 – 2154GTPSequence analysis
Nucleotide bindingi393 – 4008GTPSequence analysis
Nucleotide bindingi437 – 4404GTPSequence analysis

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB

GO - Biological processi

  • nuclear export Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • ribosome biogenesis Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Large subunit GTPase 1 homolog (EC:3.6.1.-)
Short name:
hLsg1
Gene namesi
Name:LSG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25652. LSG1.

Subcellular locationi

GO - Cellular componenti

  • Cajal body Source: UniProtKB
  • cytoplasm Source: HPA
  • cytosol Source: GO_Central
  • endoplasmic reticulum Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671501.

Polymorphism and mutation databases

BioMutaiLSG1.
DMDMi172045910.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 658658Large subunit GTPase 1 homologPRO_0000324553Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei252 – 2521PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H089.
MaxQBiQ9H089.
PaxDbiQ9H089.
PRIDEiQ9H089.

PTM databases

iPTMnetiQ9H089.
PhosphoSiteiQ9H089.

Expressioni

Gene expression databases

BgeeiQ9H089.
CleanExiHS_LSG1.
ExpressionAtlasiQ9H089. baseline and differential.
GenevisibleiQ9H089. HS.

Organism-specific databases

HPAiHPA037704.
HPA037705.

Interactioni

Protein-protein interaction databases

BioGridi120622. 18 interactions.
IntActiQ9H089. 9 interactions.
MINTiMINT-3065471.
STRINGi9606.ENSP00000265245.

Structurei

3D structure databases

ProteinModelPortaliQ9H089.
SMRiQ9H089. Positions 165-218, 387-442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini164 – 444281CP-type GPROSITE-ProRule annotationAdd
BLAST

Domaini

In contrast to other GTP-binding proteins, this family is characterized by a circular permutation of the GTPase motifs described by a G4-G1-G3 pattern.

Sequence similaritiesi

Belongs to the TRAFAC class YlqF/YawG GTPase family. LSG1 subfamily.PROSITE-ProRule annotation
Contains 1 CP-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1424. Eukaryota.
COG1161. LUCA.
GeneTreeiENSGT00530000063453.
HOGENOMiHOG000172552.
HOVERGENiHBG097657.
InParanoidiQ9H089.
KOiK14539.
OMAiDAAWVKM.
OrthoDBiEOG78H3SQ.
PhylomeDBiQ9H089.
TreeFamiTF105747.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR030378. G_CP_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRRAPAGG SLGRALMRHQ TQRSRSHRHT DSWLHTSELN DGYDWGRLNL
60 70 80 90 100
QSVTEQSSLD DFLATAELAG TEFVAEKLNI KFVPAEARTG LLSFEESQRI
110 120 130 140 150
KKLHEENKQF LCIPRRPNWN QNTTPEELKQ AEKDNFLEWR RQLVRLEEEQ
160 170 180 190 200
KLILTPFERN LDFWRQLWRV IERSDIVVQI VDARNPLLFR CEDLECYVKE
210 220 230 240 250
MDANKENVIL INKADLLTAE QRSAWAMYFE KEDVKVIFWS ALAGAIPLNG
260 270 280 290 300
DSEEEANRDD RQSNTTKFGH SSFDQAEISH SESEHLPARD SPSLSENPTT
310 320 330 340 350
DEDDSEYEDC PEEEEDDWQT CSEEDGPKEE DCSQDWKESS TADSEARSRK
360 370 380 390 400
TPQKRQIHNF SHLVSKQELL ELFKELHTGR KVKDGQLTVG LVGYPNVGKS
410 420 430 440 450
STINTIMGNK KVSVSATPGH TKHFQTLYVE PGLCLCDCPG LVMPSFVSTK
460 470 480 490 500
AEMTCSGILP IDQMRDHVPP VSLVCQNIPR HVLEATYGIN IITPREDEDP
510 520 530 540 550
HRPPTSEELL TAYGYMRGFM TAHGQPDQPR SARYILKDYV SGKLLYCHPP
560 570 580 590 600
PGRDPVTFQH QHQRLLENKM NSDEIKMQLG RNKKAKQIEN IVDKTFFHQE
610 620 630 640 650
NVRALTKGVQ AVMGYKPGSG VVTASTASSE NGAGKPWKKH GNRNKKEKSR

RLYKHLDM
Length:658
Mass (Da):75,225
Last modified:March 18, 2008 - v2
Checksum:i7C1B0AEF1C960E78
GO

Sequence cautioni

The sequence AAH15042.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH40119.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921L → P.
Corresponds to variant rs34423045 [ dbSNP | Ensembl ].
VAR_039826
Natural varianti267 – 2671K → E.3 Publications
Corresponds to variant rs1675953 [ dbSNP | Ensembl ].
VAR_039827

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136897 mRNA. Translation: CAB66831.1.
AC046143 Genomic DNA. No translation available.
BC015042 mRNA. Translation: AAH15042.1. Sequence problems.
BC040119 mRNA. Translation: AAH40119.1. Sequence problems.
BC068500 mRNA. Translation: AAH68500.1.
AK002163 mRNA. Translation: BAA92116.1.
CCDSiCCDS33922.1.
RefSeqiNP_060855.2. NM_018385.2.
UniGeneiHs.744061.

Genome annotation databases

EnsembliENST00000265245; ENSP00000265245; ENSG00000041802.
GeneIDi55341.
KEGGihsa:55341.
UCSCiuc003fui.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136897 mRNA. Translation: CAB66831.1.
AC046143 Genomic DNA. No translation available.
BC015042 mRNA. Translation: AAH15042.1. Sequence problems.
BC040119 mRNA. Translation: AAH40119.1. Sequence problems.
BC068500 mRNA. Translation: AAH68500.1.
AK002163 mRNA. Translation: BAA92116.1.
CCDSiCCDS33922.1.
RefSeqiNP_060855.2. NM_018385.2.
UniGeneiHs.744061.

3D structure databases

ProteinModelPortaliQ9H089.
SMRiQ9H089. Positions 165-218, 387-442.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120622. 18 interactions.
IntActiQ9H089. 9 interactions.
MINTiMINT-3065471.
STRINGi9606.ENSP00000265245.

PTM databases

iPTMnetiQ9H089.
PhosphoSiteiQ9H089.

Polymorphism and mutation databases

BioMutaiLSG1.
DMDMi172045910.

Proteomic databases

EPDiQ9H089.
MaxQBiQ9H089.
PaxDbiQ9H089.
PRIDEiQ9H089.

Protocols and materials databases

DNASUi55341.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265245; ENSP00000265245; ENSG00000041802.
GeneIDi55341.
KEGGihsa:55341.
UCSCiuc003fui.3. human.

Organism-specific databases

CTDi55341.
GeneCardsiLSG1.
H-InvDBHIX0200488.
HGNCiHGNC:25652. LSG1.
HPAiHPA037704.
HPA037705.
MIMi610780. gene.
neXtProtiNX_Q9H089.
PharmGKBiPA142671501.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1424. Eukaryota.
COG1161. LUCA.
GeneTreeiENSGT00530000063453.
HOGENOMiHOG000172552.
HOVERGENiHBG097657.
InParanoidiQ9H089.
KOiK14539.
OMAiDAAWVKM.
OrthoDBiEOG78H3SQ.
PhylomeDBiQ9H089.
TreeFamiTF105747.

Miscellaneous databases

ChiTaRSiLSG1. human.
GeneWikiiLSG1.
GenomeRNAii55341.
PROiQ9H089.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H089.
CleanExiHS_LSG1.
ExpressionAtlasiQ9H089. baseline and differential.
GenevisibleiQ9H089. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR030378. G_CP_dom.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51721. G_CP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-267.
    Tissue: Testis.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-267.
    Tissue: Duodenum, Placenta and Skin.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-642, VARIANT GLU-267.
    Tissue: Placenta.
  5. "Human Lsg1 defines a family of essential GTPases that correlates with the evolution of compartmentalization."
    Reynaud E.G., Andrade M.A., Bonneau F., Ly T.B., Knop M., Scheffzek K., Pepperkok R.
    BMC Biol. 3:21-21(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, GTP-BINDING, SUBCELLULAR LOCATION.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiLSG1_HUMAN
AccessioniPrimary (citable) accession number: Q9H089
Secondary accession number(s): A0JLT4
, A0PJK3, A6NI18, Q7L9H8, Q9NUK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: June 8, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.