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Q9H078 (CLPB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Caseinolytic peptidase B protein homolog
Alternative name(s):
Suppressor of potassium transport defect 3
Gene names
Name:CLPB
Synonyms:HSP78, SKD3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length707 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function as a regulatory ATPase and be related to secretion/protein trafficking process.

Sequence similarities

Belongs to the ClpA/ClpB family.

Contains 4 ANK repeats.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainANK repeat
Repeat
   LigandATP-binding
Nucleotide-binding
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to heat

Inferred from direct assay PubMed 2745427. Source: UniProtKB

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9H078-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9H078-2)

The sequence of this isoform differs from the canonical sequence as follows:
     216-245: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9H078-3)

The sequence of this isoform differs from the canonical sequence as follows:
     152-180: Missing.
     216-245: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q9H078-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: MLGSLVLRRK...ARANNMQEVS → MPRGCHLGTP...TKISSSEWPL
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 707707Caseinolytic peptidase B protein homolog
PRO_0000191239

Regions

Repeat133 – 16230ANK 1
Repeat166 – 19530ANK 2
Repeat265 – 29531ANK 3
Repeat298 – 32730ANK 4
Nucleotide binding381 – 3888ATP Potential

Amino acid modifications

Modified residue5891N6-acetyllysine Ref.5

Natural variations

Alternative sequence1 – 151151MLGSL…MQEVS → MPRGCHLGTPSWSRRNTPRT GQLERGPQQGRTGHVRPGRS AGGSLLQQESVQQGCSPVGS CPCQQYARSQQPQETAKNDA QSRSWAGLNAGVSLKNTKIS SSEWPL in isoform 4.
VSP_044725
Alternative sequence152 – 18029Missing in isoform 3.
VSP_044726
Alternative sequence216 – 24530Missing in isoform 2 and isoform 3.
VSP_001106
Natural variant2951R → T.
Corresponds to variant rs7938203 [ dbSNP | Ensembl ].
VAR_048740

Experimental info

Sequence conflict4131E → K in BAG63459. Ref.2
Sequence conflict5631N → S in BAG63409. Ref.2
Sequence conflict6501R → C in BAG63459. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 0E0F2A244CA20635

FASTA70778,729
        10         20         30         40         50         60 
MLGSLVLRRK ALAPRLLLRL LRSPTLRGHG GASGRNVTTG SLGEPQWLRV ATGGRPGTSP 

        70         80         90        100        110        120 
ALFSGRGAAT GGRQGGRFDT KCLAAATWGR LPGPEETLPG QDSWNGVPSR AGLGMCALAA 

       130        140        150        160        170        180 
ALVVHCYSKS PSNKDAALLE AARANNMQEV SRLLSEGADV NAKHRLGWTA LMVAAINRNN 

       190        200        210        220        230        240 
SVVQVLLAAG ADPNLGDDFS SVYKTAKEQG IHSLEDGGQD GASRHITNQW TSALEFRRWL 

       250        260        270        280        290        300 
GLPAGVLITR EDDFNNRLNN RASFKGCTAL HYAVLADDYR TVKELLDGGA NPLQRNEMGH 

       310        320        330        340        350        360 
TPLDYAREGE VMKLLRTSEA KYQEKQRKRE AEERRRFPLE QRLKEHIIGQ ESAIATVGAA 

       370        380        390        400        410        420 
IRRKENGWYD EEHPLVFLFL GSSGIGKTEL AKQTAKYMHK DAKKGFIRLD MSEFQERHEV 

       430        440        450        460        470        480 
AKFIGSPPGY VGHEEGGQLT KKLKQCPNAV VLFDEVDKAH PDVLTIMLQL FDEGRLTDGK 

       490        500        510        520        530        540 
GKTIDCKDAI FIMTSNVASD EIAQHALQLR QEALEMSRNR IAENLGDVQI SDKITISKNF 

       550        560        570        580        590        600 
KENVIRPILK AHFRRDEFLG RINEIVYFLP FCHSELIQLV NKELNFWAKR AKQRHNITLL 

       610        620        630        640        650        660 
WDREVADVLV DGYNVHYGAR SIKHEVERRV VNQLAAAYEQ DLLPGGCTLR ITVEDSDKQL 

       670        680        690        700 
LKSPELPSPQ AEKRLPKLRL EIIDKDSKTR RLDIRAPLHP EKVCNTI 

« Hide

Isoform 2 [UniParc].

Checksum: C03F18C94337B9E4
Show »

FASTA67775,449
Isoform 3 [UniParc].

Checksum: 586F3100E877B4D4
Show »

FASTA64872,276
Isoform 4 [UniParc].

Checksum: F9DE15704672A495
Show »

FASTA66274,543

References

[1]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
Tissue: Testis.
[3]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Uterus.
[5]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-589, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL136909 mRNA. Translation: CAB66843.1.
AL834484 mRNA. Translation: CAD39142.1.
AK023214 mRNA. Translation: BAB14467.1.
AK302006 mRNA. Translation: BAG63409.1.
AK302069 mRNA. Translation: BAG63459.1.
AP000593 Genomic DNA. No translation available.
AP002892 Genomic DNA. No translation available.
AP003785 Genomic DNA. No translation available.
BC006404 mRNA. Translation: AAH06404.1.
CCDSCCDS58152.1. [Q9H078-4]
CCDS58153.1. [Q9H078-3]
CCDS58154.1. [Q9H078-2]
CCDS8215.1. [Q9H078-1]
RefSeqNP_001245321.1. NM_001258392.1. [Q9H078-2]
NP_001245322.1. NM_001258393.1. [Q9H078-3]
NP_001245323.1. NM_001258394.1. [Q9H078-4]
NP_110440.1. NM_030813.4. [Q9H078-1]
UniGeneHs.523877.

3D structure databases

ProteinModelPortalQ9H078.
SMRQ9H078. Positions 93-316, 333-657.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123531. 10 interactions.
IntActQ9H078. 14 interactions.
MINTMINT-1196059.
STRING9606.ENSP00000294053.

PTM databases

PhosphoSiteQ9H078.

Polymorphism databases

DMDM25009267.

Proteomic databases

MaxQBQ9H078.
PaxDbQ9H078.
PRIDEQ9H078.

Protocols and materials databases

DNASU81570.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000294053; ENSP00000294053; ENSG00000162129. [Q9H078-1]
ENST00000340729; ENSP00000340385; ENSG00000162129. [Q9H078-3]
ENST00000437826; ENSP00000407296; ENSG00000162129. [Q9H078-4]
ENST00000538039; ENSP00000441518; ENSG00000162129. [Q9H078-2]
GeneID81570.
KEGGhsa:81570.
UCSCuc001osj.4. human. [Q9H078-1]
uc001osk.4. human. [Q9H078-2]

Organism-specific databases

CTD81570.
GeneCardsGC11M072008.
HGNCHGNC:30664. CLPB.
HPAHPA039005.
HPA039006.
neXtProtNX_Q9H078.
PharmGKBPA142672092.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0666.
HOGENOMHOG000006543.
HOVERGENHBG025978.
InParanoidQ9H078.
KOK03695.
OrthoDBEOG769ZJM.
PhylomeDBQ9H078.
TreeFamTF328654.

Gene expression databases

ArrayExpressQ9H078.
BgeeQ9H078.
CleanExHS_CLPB.
GenevestigatorQ9H078.

Family and domain databases

Gene3D1.25.40.20. 2 hits.
3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR001270. ClpA/B.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF07724. AAA_2. 1 hit.
PF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view]
PRINTSPR00300. CLPPROTEASEA.
SMARTSM00382. AAA. 1 hit.
SM00248. ANK. 3 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMSSF48403. SSF48403. 2 hits.
SSF52540. SSF52540. 2 hits.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCLPB.
GenomeRNAi81570.
NextBio71868.
PROQ9H078.

Entry information

Entry nameCLPB_HUMAN
AccessionPrimary (citable) accession number: Q9H078
Secondary accession number(s): B4DXJ7 expand/collapse secondary AC list , B4DXP7, E7EWN6, F8W7P6, Q8ND11, Q9H8Y0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM