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Q9H078

- CLPB_HUMAN

UniProt

Q9H078 - CLPB_HUMAN

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Protein
Caseinolytic peptidase B protein homolog
Gene
CLPB, HSP78, SKD3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May function as a regulatory ATPase and be related to secretion/protein trafficking process.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi381 – 3888ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. nucleoside-triphosphatase activity Source: InterPro

GO - Biological processi

  1. cellular response to heat Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Caseinolytic peptidase B protein homolog
Alternative name(s):
Suppressor of potassium transport defect 3
Gene namesi
Name:CLPB
Synonyms:HSP78, SKD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:30664. CLPB.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672092.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 707707Caseinolytic peptidase B protein homolog
PRO_0000191239Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei589 – 5891N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9H078.
PaxDbiQ9H078.
PRIDEiQ9H078.

PTM databases

PhosphoSiteiQ9H078.

Expressioni

Gene expression databases

ArrayExpressiQ9H078.
BgeeiQ9H078.
CleanExiHS_CLPB.
GenevestigatoriQ9H078.

Organism-specific databases

HPAiHPA039005.
HPA039006.

Interactioni

Protein-protein interaction databases

BioGridi123531. 10 interactions.
IntActiQ9H078. 14 interactions.
MINTiMINT-1196059.
STRINGi9606.ENSP00000294053.

Structurei

3D structure databases

ProteinModelPortaliQ9H078.
SMRiQ9H078. Positions 93-316, 333-657.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati133 – 16230ANK 1
Add
BLAST
Repeati166 – 19530ANK 2
Add
BLAST
Repeati265 – 29531ANK 3
Add
BLAST
Repeati298 – 32730ANK 4
Add
BLAST

Sequence similaritiesi

Belongs to the ClpA/ClpB family.
Contains 4 ANK repeats.

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiCOG0666.
HOGENOMiHOG000006543.
HOVERGENiHBG025978.
InParanoidiQ9H078.
KOiK03695.
OrthoDBiEOG769ZJM.
PhylomeDBiQ9H078.
TreeFamiTF328654.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR001270. ClpA/B.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF07724. AAA_2. 1 hit.
PF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view]
PRINTSiPR00300. CLPPROTEASEA.
SMARTiSM00382. AAA. 1 hit.
SM00248. ANK. 3 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 2 hits.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9H078-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLGSLVLRRK ALAPRLLLRL LRSPTLRGHG GASGRNVTTG SLGEPQWLRV    50
ATGGRPGTSP ALFSGRGAAT GGRQGGRFDT KCLAAATWGR LPGPEETLPG 100
QDSWNGVPSR AGLGMCALAA ALVVHCYSKS PSNKDAALLE AARANNMQEV 150
SRLLSEGADV NAKHRLGWTA LMVAAINRNN SVVQVLLAAG ADPNLGDDFS 200
SVYKTAKEQG IHSLEDGGQD GASRHITNQW TSALEFRRWL GLPAGVLITR 250
EDDFNNRLNN RASFKGCTAL HYAVLADDYR TVKELLDGGA NPLQRNEMGH 300
TPLDYAREGE VMKLLRTSEA KYQEKQRKRE AEERRRFPLE QRLKEHIIGQ 350
ESAIATVGAA IRRKENGWYD EEHPLVFLFL GSSGIGKTEL AKQTAKYMHK 400
DAKKGFIRLD MSEFQERHEV AKFIGSPPGY VGHEEGGQLT KKLKQCPNAV 450
VLFDEVDKAH PDVLTIMLQL FDEGRLTDGK GKTIDCKDAI FIMTSNVASD 500
EIAQHALQLR QEALEMSRNR IAENLGDVQI SDKITISKNF KENVIRPILK 550
AHFRRDEFLG RINEIVYFLP FCHSELIQLV NKELNFWAKR AKQRHNITLL 600
WDREVADVLV DGYNVHYGAR SIKHEVERRV VNQLAAAYEQ DLLPGGCTLR 650
ITVEDSDKQL LKSPELPSPQ AEKRLPKLRL EIIDKDSKTR RLDIRAPLHP 700
EKVCNTI 707
Length:707
Mass (Da):78,729
Last modified:March 1, 2001 - v1
Checksum:i0E0F2A244CA20635
GO
Isoform 2 (identifier: Q9H078-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-245: Missing.

Note: No experimental confirmation available.

Show »
Length:677
Mass (Da):75,449
Checksum:iC03F18C94337B9E4
GO
Isoform 3 (identifier: Q9H078-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-180: Missing.
     216-245: Missing.

Note: No experimental confirmation available.

Show »
Length:648
Mass (Da):72,276
Checksum:i586F3100E877B4D4
GO
Isoform 4 (identifier: Q9H078-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: MLGSLVLRRK...ARANNMQEVS → MPRGCHLGTP...TKISSSEWPL

Note: No experimental confirmation available.

Show »
Length:662
Mass (Da):74,543
Checksum:iF9DE15704672A495
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti295 – 2951R → T.
Corresponds to variant rs7938203 [ dbSNP | Ensembl ].
VAR_048740

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 151151MLGSL…MQEVS → MPRGCHLGTPSWSRRNTPRT GQLERGPQQGRTGHVRPGRS AGGSLLQQESVQQGCSPVGS CPCQQYARSQQPQETAKNDA QSRSWAGLNAGVSLKNTKIS SSEWPL in isoform 4.
VSP_044725Add
BLAST
Alternative sequencei152 – 18029Missing in isoform 3.
VSP_044726Add
BLAST
Alternative sequencei216 – 24530Missing in isoform 2 and isoform 3.
VSP_001106Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti413 – 4131E → K in BAG63459. 1 Publication
Sequence conflicti563 – 5631N → S in BAG63409. 1 Publication
Sequence conflicti650 – 6501R → C in BAG63459. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136909 mRNA. Translation: CAB66843.1.
AL834484 mRNA. Translation: CAD39142.1.
AK023214 mRNA. Translation: BAB14467.1.
AK302006 mRNA. Translation: BAG63409.1.
AK302069 mRNA. Translation: BAG63459.1.
AP000593 Genomic DNA. No translation available.
AP002892 Genomic DNA. No translation available.
AP003785 Genomic DNA. No translation available.
BC006404 mRNA. Translation: AAH06404.1.
CCDSiCCDS58152.1. [Q9H078-4]
CCDS58153.1. [Q9H078-3]
CCDS58154.1. [Q9H078-2]
CCDS8215.1. [Q9H078-1]
RefSeqiNP_001245321.1. NM_001258392.1. [Q9H078-2]
NP_001245322.1. NM_001258393.1. [Q9H078-3]
NP_001245323.1. NM_001258394.1. [Q9H078-4]
NP_110440.1. NM_030813.4. [Q9H078-1]
UniGeneiHs.523877.

Genome annotation databases

EnsembliENST00000294053; ENSP00000294053; ENSG00000162129. [Q9H078-1]
ENST00000340729; ENSP00000340385; ENSG00000162129. [Q9H078-3]
ENST00000437826; ENSP00000407296; ENSG00000162129. [Q9H078-4]
ENST00000538039; ENSP00000441518; ENSG00000162129. [Q9H078-2]
GeneIDi81570.
KEGGihsa:81570.
UCSCiuc001osj.4. human. [Q9H078-1]
uc001osk.4. human. [Q9H078-2]

Polymorphism databases

DMDMi25009267.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL136909 mRNA. Translation: CAB66843.1 .
AL834484 mRNA. Translation: CAD39142.1 .
AK023214 mRNA. Translation: BAB14467.1 .
AK302006 mRNA. Translation: BAG63409.1 .
AK302069 mRNA. Translation: BAG63459.1 .
AP000593 Genomic DNA. No translation available.
AP002892 Genomic DNA. No translation available.
AP003785 Genomic DNA. No translation available.
BC006404 mRNA. Translation: AAH06404.1 .
CCDSi CCDS58152.1. [Q9H078-4 ]
CCDS58153.1. [Q9H078-3 ]
CCDS58154.1. [Q9H078-2 ]
CCDS8215.1. [Q9H078-1 ]
RefSeqi NP_001245321.1. NM_001258392.1. [Q9H078-2 ]
NP_001245322.1. NM_001258393.1. [Q9H078-3 ]
NP_001245323.1. NM_001258394.1. [Q9H078-4 ]
NP_110440.1. NM_030813.4. [Q9H078-1 ]
UniGenei Hs.523877.

3D structure databases

ProteinModelPortali Q9H078.
SMRi Q9H078. Positions 93-316, 333-657.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123531. 10 interactions.
IntActi Q9H078. 14 interactions.
MINTi MINT-1196059.
STRINGi 9606.ENSP00000294053.

PTM databases

PhosphoSitei Q9H078.

Polymorphism databases

DMDMi 25009267.

Proteomic databases

MaxQBi Q9H078.
PaxDbi Q9H078.
PRIDEi Q9H078.

Protocols and materials databases

DNASUi 81570.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000294053 ; ENSP00000294053 ; ENSG00000162129 . [Q9H078-1 ]
ENST00000340729 ; ENSP00000340385 ; ENSG00000162129 . [Q9H078-3 ]
ENST00000437826 ; ENSP00000407296 ; ENSG00000162129 . [Q9H078-4 ]
ENST00000538039 ; ENSP00000441518 ; ENSG00000162129 . [Q9H078-2 ]
GeneIDi 81570.
KEGGi hsa:81570.
UCSCi uc001osj.4. human. [Q9H078-1 ]
uc001osk.4. human. [Q9H078-2 ]

Organism-specific databases

CTDi 81570.
GeneCardsi GC11M072008.
HGNCi HGNC:30664. CLPB.
HPAi HPA039005.
HPA039006.
neXtProti NX_Q9H078.
PharmGKBi PA142672092.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0666.
HOGENOMi HOG000006543.
HOVERGENi HBG025978.
InParanoidi Q9H078.
KOi K03695.
OrthoDBi EOG769ZJM.
PhylomeDBi Q9H078.
TreeFami TF328654.

Miscellaneous databases

GeneWikii CLPB.
GenomeRNAii 81570.
NextBioi 71868.
PROi Q9H078.

Gene expression databases

ArrayExpressi Q9H078.
Bgeei Q9H078.
CleanExi HS_CLPB.
Genevestigatori Q9H078.

Family and domain databases

Gene3Di 1.25.40.20. 2 hits.
3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR001270. ClpA/B.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF07724. AAA_2. 1 hit.
PF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
[Graphical view ]
PRINTSi PR00300. CLPPROTEASEA.
SMARTi SM00382. AAA. 1 hit.
SM00248. ANK. 3 hits.
SM01086. ClpB_D2-small. 1 hit.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 2 hits.
SSF52540. SSF52540. 2 hits.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-589, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCLPB_HUMAN
AccessioniPrimary (citable) accession number: Q9H078
Secondary accession number(s): B4DXJ7
, B4DXP7, E7EWN6, F8W7P6, Q8ND11, Q9H8Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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