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Q9H078

- CLPB_HUMAN

UniProt

Q9H078 - CLPB_HUMAN

Protein

Caseinolytic peptidase B protein homolog

Gene

CLPB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    May function as a regulatory ATPase and be related to secretion/protein trafficking process.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi381 – 3888ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. nucleoside-triphosphatase activity Source: InterPro

    GO - Biological processi

    1. cellular response to heat Source: UniProtKB

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caseinolytic peptidase B protein homolog
    Alternative name(s):
    Suppressor of potassium transport defect 3
    Gene namesi
    Name:CLPB
    Synonyms:HSP78, SKD3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:30664. CLPB.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672092.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 707707Caseinolytic peptidase B protein homologPRO_0000191239Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei589 – 5891N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9H078.
    PaxDbiQ9H078.
    PRIDEiQ9H078.

    PTM databases

    PhosphoSiteiQ9H078.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H078.
    BgeeiQ9H078.
    CleanExiHS_CLPB.
    GenevestigatoriQ9H078.

    Organism-specific databases

    HPAiHPA039005.
    HPA039006.

    Interactioni

    Protein-protein interaction databases

    BioGridi123531. 11 interactions.
    IntActiQ9H078. 15 interactions.
    MINTiMINT-1196059.
    STRINGi9606.ENSP00000294053.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H078.
    SMRiQ9H078. Positions 93-316, 333-657.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati133 – 16230ANK 1Add
    BLAST
    Repeati166 – 19530ANK 2Add
    BLAST
    Repeati265 – 29531ANK 3Add
    BLAST
    Repeati298 – 32730ANK 4Add
    BLAST

    Sequence similaritiesi

    Belongs to the ClpA/ClpB family.Curated
    Contains 4 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG0666.
    HOGENOMiHOG000006543.
    HOVERGENiHBG025978.
    InParanoidiQ9H078.
    KOiK03695.
    OrthoDBiEOG769ZJM.
    PhylomeDBiQ9H078.
    TreeFamiTF328654.

    Family and domain databases

    Gene3Di1.25.40.20. 2 hits.
    3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR001270. ClpA/B.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF07724. AAA_2. 1 hit.
    PF00023. Ank. 1 hit.
    PF12796. Ank_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    [Graphical view]
    PRINTSiPR00300. CLPPROTEASEA.
    SMARTiSM00382. AAA. 1 hit.
    SM00248. ANK. 3 hits.
    SM01086. ClpB_D2-small. 1 hit.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 2 hits.
    SSF52540. SSF52540. 2 hits.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 3 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9H078-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLGSLVLRRK ALAPRLLLRL LRSPTLRGHG GASGRNVTTG SLGEPQWLRV    50
    ATGGRPGTSP ALFSGRGAAT GGRQGGRFDT KCLAAATWGR LPGPEETLPG 100
    QDSWNGVPSR AGLGMCALAA ALVVHCYSKS PSNKDAALLE AARANNMQEV 150
    SRLLSEGADV NAKHRLGWTA LMVAAINRNN SVVQVLLAAG ADPNLGDDFS 200
    SVYKTAKEQG IHSLEDGGQD GASRHITNQW TSALEFRRWL GLPAGVLITR 250
    EDDFNNRLNN RASFKGCTAL HYAVLADDYR TVKELLDGGA NPLQRNEMGH 300
    TPLDYAREGE VMKLLRTSEA KYQEKQRKRE AEERRRFPLE QRLKEHIIGQ 350
    ESAIATVGAA IRRKENGWYD EEHPLVFLFL GSSGIGKTEL AKQTAKYMHK 400
    DAKKGFIRLD MSEFQERHEV AKFIGSPPGY VGHEEGGQLT KKLKQCPNAV 450
    VLFDEVDKAH PDVLTIMLQL FDEGRLTDGK GKTIDCKDAI FIMTSNVASD 500
    EIAQHALQLR QEALEMSRNR IAENLGDVQI SDKITISKNF KENVIRPILK 550
    AHFRRDEFLG RINEIVYFLP FCHSELIQLV NKELNFWAKR AKQRHNITLL 600
    WDREVADVLV DGYNVHYGAR SIKHEVERRV VNQLAAAYEQ DLLPGGCTLR 650
    ITVEDSDKQL LKSPELPSPQ AEKRLPKLRL EIIDKDSKTR RLDIRAPLHP 700
    EKVCNTI 707
    Length:707
    Mass (Da):78,729
    Last modified:March 1, 2001 - v1
    Checksum:i0E0F2A244CA20635
    GO
    Isoform 2 (identifier: Q9H078-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         216-245: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:677
    Mass (Da):75,449
    Checksum:iC03F18C94337B9E4
    GO
    Isoform 3 (identifier: Q9H078-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         152-180: Missing.
         216-245: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:648
    Mass (Da):72,276
    Checksum:i586F3100E877B4D4
    GO
    Isoform 4 (identifier: Q9H078-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-151: MLGSLVLRRK...ARANNMQEVS → MPRGCHLGTP...TKISSSEWPL

    Note: No experimental confirmation available.

    Show »
    Length:662
    Mass (Da):74,543
    Checksum:iF9DE15704672A495
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti413 – 4131E → K in BAG63459. (PubMed:14702039)Curated
    Sequence conflicti563 – 5631N → S in BAG63409. (PubMed:14702039)Curated
    Sequence conflicti650 – 6501R → C in BAG63459. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti295 – 2951R → T.
    Corresponds to variant rs7938203 [ dbSNP | Ensembl ].
    VAR_048740

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 151151MLGSL…MQEVS → MPRGCHLGTPSWSRRNTPRT GQLERGPQQGRTGHVRPGRS AGGSLLQQESVQQGCSPVGS CPCQQYARSQQPQETAKNDA QSRSWAGLNAGVSLKNTKIS SSEWPL in isoform 4. 1 PublicationVSP_044725Add
    BLAST
    Alternative sequencei152 – 18029Missing in isoform 3. 1 PublicationVSP_044726Add
    BLAST
    Alternative sequencei216 – 24530Missing in isoform 2 and isoform 3. 1 PublicationVSP_001106Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136909 mRNA. Translation: CAB66843.1.
    AL834484 mRNA. Translation: CAD39142.1.
    AK023214 mRNA. Translation: BAB14467.1.
    AK302006 mRNA. Translation: BAG63409.1.
    AK302069 mRNA. Translation: BAG63459.1.
    AP000593 Genomic DNA. No translation available.
    AP002892 Genomic DNA. No translation available.
    AP003785 Genomic DNA. No translation available.
    BC006404 mRNA. Translation: AAH06404.1.
    CCDSiCCDS58152.1. [Q9H078-4]
    CCDS58153.1. [Q9H078-3]
    CCDS58154.1. [Q9H078-2]
    CCDS8215.1. [Q9H078-1]
    RefSeqiNP_001245321.1. NM_001258392.1. [Q9H078-2]
    NP_001245322.1. NM_001258393.1. [Q9H078-3]
    NP_001245323.1. NM_001258394.1. [Q9H078-4]
    NP_110440.1. NM_030813.4. [Q9H078-1]
    UniGeneiHs.523877.

    Genome annotation databases

    EnsembliENST00000294053; ENSP00000294053; ENSG00000162129. [Q9H078-1]
    ENST00000340729; ENSP00000340385; ENSG00000162129. [Q9H078-3]
    ENST00000437826; ENSP00000407296; ENSG00000162129. [Q9H078-4]
    ENST00000538039; ENSP00000441518; ENSG00000162129. [Q9H078-2]
    GeneIDi81570.
    KEGGihsa:81570.
    UCSCiuc001osj.4. human. [Q9H078-1]
    uc001osk.4. human. [Q9H078-2]

    Polymorphism databases

    DMDMi25009267.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL136909 mRNA. Translation: CAB66843.1 .
    AL834484 mRNA. Translation: CAD39142.1 .
    AK023214 mRNA. Translation: BAB14467.1 .
    AK302006 mRNA. Translation: BAG63409.1 .
    AK302069 mRNA. Translation: BAG63459.1 .
    AP000593 Genomic DNA. No translation available.
    AP002892 Genomic DNA. No translation available.
    AP003785 Genomic DNA. No translation available.
    BC006404 mRNA. Translation: AAH06404.1 .
    CCDSi CCDS58152.1. [Q9H078-4 ]
    CCDS58153.1. [Q9H078-3 ]
    CCDS58154.1. [Q9H078-2 ]
    CCDS8215.1. [Q9H078-1 ]
    RefSeqi NP_001245321.1. NM_001258392.1. [Q9H078-2 ]
    NP_001245322.1. NM_001258393.1. [Q9H078-3 ]
    NP_001245323.1. NM_001258394.1. [Q9H078-4 ]
    NP_110440.1. NM_030813.4. [Q9H078-1 ]
    UniGenei Hs.523877.

    3D structure databases

    ProteinModelPortali Q9H078.
    SMRi Q9H078. Positions 93-316, 333-657.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123531. 11 interactions.
    IntActi Q9H078. 15 interactions.
    MINTi MINT-1196059.
    STRINGi 9606.ENSP00000294053.

    PTM databases

    PhosphoSitei Q9H078.

    Polymorphism databases

    DMDMi 25009267.

    Proteomic databases

    MaxQBi Q9H078.
    PaxDbi Q9H078.
    PRIDEi Q9H078.

    Protocols and materials databases

    DNASUi 81570.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294053 ; ENSP00000294053 ; ENSG00000162129 . [Q9H078-1 ]
    ENST00000340729 ; ENSP00000340385 ; ENSG00000162129 . [Q9H078-3 ]
    ENST00000437826 ; ENSP00000407296 ; ENSG00000162129 . [Q9H078-4 ]
    ENST00000538039 ; ENSP00000441518 ; ENSG00000162129 . [Q9H078-2 ]
    GeneIDi 81570.
    KEGGi hsa:81570.
    UCSCi uc001osj.4. human. [Q9H078-1 ]
    uc001osk.4. human. [Q9H078-2 ]

    Organism-specific databases

    CTDi 81570.
    GeneCardsi GC11M072008.
    HGNCi HGNC:30664. CLPB.
    HPAi HPA039005.
    HPA039006.
    neXtProti NX_Q9H078.
    PharmGKBi PA142672092.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0666.
    HOGENOMi HOG000006543.
    HOVERGENi HBG025978.
    InParanoidi Q9H078.
    KOi K03695.
    OrthoDBi EOG769ZJM.
    PhylomeDBi Q9H078.
    TreeFami TF328654.

    Miscellaneous databases

    GeneWikii CLPB.
    GenomeRNAii 81570.
    NextBioi 71868.
    PROi Q9H078.

    Gene expression databases

    ArrayExpressi Q9H078.
    Bgeei Q9H078.
    CleanExi HS_CLPB.
    Genevestigatori Q9H078.

    Family and domain databases

    Gene3Di 1.25.40.20. 2 hits.
    3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR001270. ClpA/B.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF07724. AAA_2. 1 hit.
    PF00023. Ank. 1 hit.
    PF12796. Ank_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    [Graphical view ]
    PRINTSi PR00300. CLPPROTEASEA.
    SMARTi SM00382. AAA. 1 hit.
    SM00248. ANK. 3 hits.
    SM01086. ClpB_D2-small. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 2 hits.
    SSF52540. SSF52540. 2 hits.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
      Tissue: Testis.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Uterus.
    5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-589, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCLPB_HUMAN
    AccessioniPrimary (citable) accession number: Q9H078
    Secondary accession number(s): B4DXJ7
    , B4DXP7, E7EWN6, F8W7P6, Q8ND11, Q9H8Y0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3