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Q9H014

- Q9H014_HUMAN

UniProt

Q9H014 - Q9H014_HUMAN

Protein
Submitted name:

Cyclin D1

Gene

cyclin D1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: Ensembl
    2. protein kinase activity Source: Ensembl

    GO - Biological processi

    1. canonical Wnt signaling pathway Source: Ensembl
    2. endoplasmic reticulum unfolded protein response Source: Ensembl
    3. fat cell differentiation Source: Ensembl
    4. lactation Source: Ensembl
    5. Leydig cell differentiation Source: Ensembl
    6. liver development Source: Ensembl
    7. mammary gland alveolus development Source: Ensembl
    8. mammary gland epithelial cell proliferation Source: Ensembl
    9. negative regulation of epithelial cell differentiation Source: Ensembl
    10. negative regulation of Wnt signaling pathway Source: Ensembl
    11. organ regeneration Source: Ensembl
    12. positive regulation of mammary gland epithelial cell proliferation Source: Ensembl
    13. re-entry into mitotic cell cycle Source: Ensembl
    14. regulation of G1/S transition of mitotic cell cycle Source: Ensembl
    15. response to calcium ion Source: Ensembl
    16. response to corticosterone Source: Ensembl
    17. response to drug Source: Ensembl
    18. response to estrogen Source: Ensembl
    19. response to ethanol Source: Ensembl
    20. response to iron ion Source: Ensembl
    21. response to magnesium ion Source: Ensembl
    22. response to organonitrogen compound Source: Ensembl
    23. response to vitamin E Source: Ensembl
    24. response to X-ray Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Cyclin D1Imported
    Gene namesi
    Name:cyclin D1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cyclin-dependent protein kinase holoenzyme complex Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. nucleus Source: Ensembl
    4. tight junction Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ9H014.
    BgeeiQ9H014.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ9H014.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG108340.

    Family and domain databases

    Gene3Di1.10.472.10. 1 hit.
    InterProiIPR013763. Cyclin-like.
    IPR004367. Cyclin_C-dom.
    IPR015451. Cyclin_D.
    [Graphical view]
    PANTHERiPTHR10177:SF67. PTHR10177:SF67. 1 hit.
    PfamiPF02984. Cyclin_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q9H014-1 [UniParc]FASTAAdd to Basket

    « Hide

    AEENKQIIRK HAQTFVALCA TDVKFISNPP SMVAAGSVVA AVQGLNLRSP    50
    NNFLSYYRLT RFLSRVIKCD PDCLRACQEQ IEALLESSLR QAQQNMDPKA 100
    AEEEEEEEEE VDLACTPTDV RDVDI 125
    Length:125
    Mass (Da):13,986
    Last modified:March 1, 2001 - v1
    Checksum:iD4630389AF1C89B5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77754 mRNA. Translation: CAA54800.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77754 mRNA. Translation: CAA54800.1 .

    3D structure databases

    ProteinModelPortali Q9H014.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q9H014.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG108340.

    Miscellaneous databases

    ChiTaRSi LMOD1. human.

    Gene expression databases

    ArrayExpressi Q9H014.
    Bgeei Q9H014.

    Family and domain databases

    Gene3Di 1.10.472.10. 1 hit.
    InterProi IPR013763. Cyclin-like.
    IPR004367. Cyclin_C-dom.
    IPR015451. Cyclin_D.
    [Graphical view ]
    PANTHERi PTHR10177:SF67. PTHR10177:SF67. 1 hit.
    Pfami PF02984. Cyclin_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas."
      Fornaro M., Dell'Arciprete R., Stella S., Bucci C., Nutini M., Capri M.G., Alberti S.
      Int. J. Cancer 62:610-618(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9H014_HUMAN
    AccessioniPrimary (citable) accession number: Q9H014
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.