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Protein
Submitted name:

Cyclin D1

Gene

cyclin D1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: Ensembl
  2. protein kinase activity Source: Ensembl

GO - Biological processi

  1. canonical Wnt signaling pathway Source: Ensembl
  2. endoplasmic reticulum unfolded protein response Source: Ensembl
  3. fat cell differentiation Source: Ensembl
  4. lactation Source: Ensembl
  5. Leydig cell differentiation Source: Ensembl
  6. liver development Source: Ensembl
  7. mammary gland alveolus development Source: Ensembl
  8. mammary gland epithelial cell proliferation Source: Ensembl
  9. negative regulation of epithelial cell differentiation Source: Ensembl
  10. negative regulation of Wnt signaling pathway Source: Ensembl
  11. organ regeneration Source: Ensembl
  12. positive regulation of mammary gland epithelial cell proliferation Source: Ensembl
  13. re-entry into mitotic cell cycle Source: Ensembl
  14. regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  15. response to calcium ion Source: Ensembl
  16. response to corticosterone Source: Ensembl
  17. response to drug Source: Ensembl
  18. response to estrogen Source: Ensembl
  19. response to ethanol Source: Ensembl
  20. response to iron ion Source: Ensembl
  21. response to magnesium ion Source: Ensembl
  22. response to organonitrogen compound Source: Ensembl
  23. response to vitamin E Source: Ensembl
  24. response to X-ray Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclin D1Imported
Gene namesi
Name:cyclin D1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cyclin-dependent protein kinase holoenzyme complex Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. nucleus Source: Ensembl
  4. tight junction Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9H014.
ExpressionAtlasiQ9H014. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ9H014.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG108340.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR015451. Cyclin_D.
[Graphical view]
PANTHERiPTHR10177:SF67. PTHR10177:SF67. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q9H014-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
AEENKQIIRK HAQTFVALCA TDVKFISNPP SMVAAGSVVA AVQGLNLRSP
60 70 80 90 100
NNFLSYYRLT RFLSRVIKCD PDCLRACQEQ IEALLESSLR QAQQNMDPKA
110 120
AEEEEEEEEE VDLACTPTDV RDVDI
Length:125
Mass (Da):13,986
Last modified:March 1, 2001 - v1
Checksum:iD4630389AF1C89B5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77754 mRNA. Translation: CAA54800.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77754 mRNA. Translation: CAA54800.1.

3D structure databases

ProteinModelPortaliQ9H014.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ9H014.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG108340.

Miscellaneous databases

ChiTaRSiPCNA. human.

Gene expression databases

BgeeiQ9H014.
ExpressionAtlasiQ9H014. baseline and differential.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR015451. Cyclin_D.
[Graphical view]
PANTHERiPTHR10177:SF67. PTHR10177:SF67. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas."
    Fornaro M., Dell'Arciprete R., Stella S., Bucci C., Nutini M., Capri M.G., Alberti S.
    Int. J. Cancer 62:610-618(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9H014_HUMAN
AccessioniPrimary (citable) accession number: Q9H014
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2001
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.