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Protein

Nascent polypeptide-associated complex subunit alpha-2

Gene

NACA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nascent polypeptide-associated complex subunit alpha-2
Alternative name(s):
Alpha-NAC-like
Hom s 2.01
Nascent polypeptide-associated complex subunit alpha-like
Short name:
NAC-alpha-like
Gene namesi
Name:NACA2
Synonyms:NACAL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:23290. NACA2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162396699.

Protein family/group databases

Allergomei412. Hom s 2.

Polymorphism and mutation databases

BioMutaiNACA2.
DMDMi74733511.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Nascent polypeptide-associated complex subunit alpha-2PRO_0000280746Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei214 – 2141Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9H009.
PaxDbiQ9H009.
PeptideAtlasiQ9H009.
PRIDEiQ9H009.

PTM databases

PhosphoSiteiQ9H009.

Expressioni

Tissue specificityi

Expressed specifically in testis and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9H009.
CleanExiHS_NACA2.
GenevisibleiQ9H009. HS.

Interactioni

Subunit structurei

Part of the nascent polypeptide-associated complex (NAC), consisting of NACA and BTF3. NAC associates with ribosomes through the BTF3 subunit. Both subunits can contact nascent polypeptide chains (By similarity).By similarity

Protein-protein interaction databases

BioGridi131183. 12 interactions.
STRINGi9606.ENSP00000427802.

Structurei

3D structure databases

ProteinModelPortaliQ9H009.
SMRiQ9H009. Positions 79-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 13566NAC-A/BPROSITE-ProRule annotationAdd
BLAST
Domaini176 – 21338UBAAdd
BLAST

Sequence similaritiesi

Belongs to the NAC-alpha family.Curated
Contains 1 NAC-A/B (NAC-alpha/beta) domain.PROSITE-ProRule annotation
Contains 1 UBA domain.Curated

Phylogenomic databases

eggNOGiCOG1308.
GeneTreeiENSGT00440000033468.
HOGENOMiHOG000239674.
HOVERGENiHBG082004.
InParanoidiQ9H009.
OMAiTTTQKAW.
OrthoDBiEOG7RNK24.
PhylomeDBiQ9H009.
TreeFamiTF313348.

Family and domain databases

InterProiIPR016641. EGD2/NACA.
IPR002715. Nas_poly-pep-assoc_cplx_dom.
[Graphical view]
PANTHERiPTHR21713. PTHR21713. 1 hit.
PfamiPF01849. NAC. 1 hit.
[Graphical view]
PIRSFiPIRSF015901. NAC_alpha. 1 hit.
PROSITEiPS51151. NAC_AB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H009-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGEATETVP ATEQELPQSQ AETGSGTASD SGESVPGIEE QDSTQTTTQK
60 70 80 90 100
AWLVAAAEID EEPVGKAKQS RSEKRARKAM SKLGLLQVTG VTRVTIWKSK
110 120 130 140 150
NILFVITKLD VYKSPASDAY IVFGEAKIQD LSQQAQLAAA EKFRVQGEAV
160 170 180 190 200
GNIQENTQTP TVQEESEEEE VDETGVEVKD VKLVMSQANV SRAKAVRALK
210
NNSNDIVNAI MELTV
Length:215
Mass (Da):23,223
Last modified:March 1, 2001 - v1
Checksum:iC6B96A8370E9B24E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641V → I.
Corresponds to variant rs17531723 [ dbSNP | Ensembl ].
VAR_050218

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278883 Genomic DNA. Translation: CAC06614.1.
BC062710 mRNA. Translation: AAH62710.1.
DQ120612 Genomic DNA. Translation: ABB92399.1.
CCDSiCCDS11630.1.
RefSeqiNP_954984.1. NM_199290.3.
UniGeneiHs.591178.

Genome annotation databases

EnsembliENST00000521764; ENSP00000427802; ENSG00000253506.
GeneIDi342538.
KEGGihsa:342538.
UCSCiuc002izj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278883 Genomic DNA. Translation: CAC06614.1.
BC062710 mRNA. Translation: AAH62710.1.
DQ120612 Genomic DNA. Translation: ABB92399.1.
CCDSiCCDS11630.1.
RefSeqiNP_954984.1. NM_199290.3.
UniGeneiHs.591178.

3D structure databases

ProteinModelPortaliQ9H009.
SMRiQ9H009. Positions 79-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131183. 12 interactions.
STRINGi9606.ENSP00000427802.

Protein family/group databases

Allergomei412. Hom s 2.

PTM databases

PhosphoSiteiQ9H009.

Polymorphism and mutation databases

BioMutaiNACA2.
DMDMi74733511.

Proteomic databases

MaxQBiQ9H009.
PaxDbiQ9H009.
PeptideAtlasiQ9H009.
PRIDEiQ9H009.

Protocols and materials databases

DNASUi342538.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000521764; ENSP00000427802; ENSG00000253506.
GeneIDi342538.
KEGGihsa:342538.
UCSCiuc002izj.2. human.

Organism-specific databases

CTDi342538.
GeneCardsiGC17M059668.
HGNCiHGNC:23290. NACA2.
MIMi609274. gene.
neXtProtiNX_Q9H009.
PharmGKBiPA162396699.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1308.
GeneTreeiENSGT00440000033468.
HOGENOMiHOG000239674.
HOVERGENiHBG082004.
InParanoidiQ9H009.
OMAiTTTQKAW.
OrthoDBiEOG7RNK24.
PhylomeDBiQ9H009.
TreeFamiTF313348.

Miscellaneous databases

GenomeRNAii342538.
NextBioi98309.
PROiQ9H009.
SOURCEiSearch...

Gene expression databases

BgeeiQ9H009.
CleanExiHS_NACA2.
GenevisibleiQ9H009. HS.

Family and domain databases

InterProiIPR016641. EGD2/NACA.
IPR002715. Nas_poly-pep-assoc_cplx_dom.
[Graphical view]
PANTHERiPTHR21713. PTHR21713. 1 hit.
PfamiPF01849. NAC. 1 hit.
[Graphical view]
PIRSFiPIRSF015901. NAC_alpha. 1 hit.
PROSITEiPS51151. NAC_AB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen."
    Mossabeb R., Seiberler S., Mittermann I., Reininger R., Spitzauer S., Natter S., Verdino P., Keller W., Kraft D., Valenta R.
    J. Invest. Dermatol. 119:820-829(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Epithelium.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Emergence of young human genes after a burst of retroposition in primates."
    Marques A.C., Dupanloup I., Vinckenbosch N., Reymond A., Kaessmann H.
    PLoS Biol. 3:E357-E357(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-210, TISSUE SPECIFICITY.
  4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-214, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiNACA2_HUMAN
AccessioniPrimary (citable) accession number: Q9H009
Secondary accession number(s): Q2VIR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2001
Last modified: July 22, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

NACAL arose from a recent (40-63 million-year-old), anthropoid primate-specific retroduplication of NACA.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.