SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9H009

- NACA2_HUMAN

UniProt

Q9H009 - NACA2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Nascent polypeptide-associated complex subunit alpha-2

Gene
NACA2, NACAL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) By similarity.

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nascent polypeptide-associated complex subunit alpha-2
Alternative name(s):
Alpha-NAC-like
Hom s 2.01
Nascent polypeptide-associated complex subunit alpha-like
Short name:
NAC-alpha-like
Gene namesi
Name:NACA2
Synonyms:NACAL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:23290. NACA2.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162396699.

Protein family/group databases

Allergomei412. Hom s 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Nascent polypeptide-associated complex subunit alpha-2PRO_0000280746Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei214 – 2141Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9H009.
PeptideAtlasiQ9H009.
PRIDEiQ9H009.

PTM databases

PhosphoSiteiQ9H009.

Expressioni

Tissue specificityi

Expressed specifically in testis and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9H009.
CleanExiHS_NACA2.
GenevestigatoriQ9H009.

Interactioni

Subunit structurei

Part of the nascent polypeptide-associated complex (NAC), consisting of NACA and BTF3. NAC associates with ribosomes through the BTF3 subunit. Both subunits can contact nascent polypeptide chains By similarity.

Protein-protein interaction databases

BioGridi131183. 14 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9H009.
SMRiQ9H009. Positions 79-132.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 13566NAC-A/BAdd
BLAST
Domaini176 – 21338UBAAdd
BLAST

Sequence similaritiesi

Belongs to the NAC-alpha family.
Contains 1 UBA domain.

Phylogenomic databases

eggNOGiCOG1308.
HOGENOMiHOG000239674.
HOVERGENiHBG082004.
InParanoidiQ9H009.
OMAiDAYIVFG.
OrthoDBiEOG7RNK24.
PhylomeDBiQ9H009.
TreeFamiTF313348.

Family and domain databases

InterProiIPR016641. EGD2/NACA.
IPR002715. Nas_poly-pep-assoc_cplx_dom.
[Graphical view]
PANTHERiPTHR21713. PTHR21713. 1 hit.
PfamiPF01849. NAC. 1 hit.
[Graphical view]
PIRSFiPIRSF015901. NAC_alpha. 1 hit.
PROSITEiPS51151. NAC_AB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9H009-1 [UniParc]FASTAAdd to Basket

« Hide

MPGEATETVP ATEQELPQSQ AETGSGTASD SGESVPGIEE QDSTQTTTQK    50
AWLVAAAEID EEPVGKAKQS RSEKRARKAM SKLGLLQVTG VTRVTIWKSK 100
NILFVITKLD VYKSPASDAY IVFGEAKIQD LSQQAQLAAA EKFRVQGEAV 150
GNIQENTQTP TVQEESEEEE VDETGVEVKD VKLVMSQANV SRAKAVRALK 200
NNSNDIVNAI MELTV 215
Length:215
Mass (Da):23,223
Last modified:March 1, 2001 - v1
Checksum:iC6B96A8370E9B24E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641V → I.
Corresponds to variant rs17531723 [ dbSNP | Ensembl ].
VAR_050218

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ278883 Genomic DNA. Translation: CAC06614.1.
BC062710 mRNA. Translation: AAH62710.1.
DQ120612 Genomic DNA. Translation: ABB92399.1.
CCDSiCCDS11630.1.
RefSeqiNP_954984.1. NM_199290.3.
UniGeneiHs.591178.

Genome annotation databases

EnsembliENST00000521764; ENSP00000427802; ENSG00000253506.
GeneIDi342538.
KEGGihsa:342538.
UCSCiuc002izj.2. human.

Polymorphism databases

DMDMi74733511.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ278883 Genomic DNA. Translation: CAC06614.1 .
BC062710 mRNA. Translation: AAH62710.1 .
DQ120612 Genomic DNA. Translation: ABB92399.1 .
CCDSi CCDS11630.1.
RefSeqi NP_954984.1. NM_199290.3.
UniGenei Hs.591178.

3D structure databases

ProteinModelPortali Q9H009.
SMRi Q9H009. Positions 79-132.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131183. 14 interactions.

Protein family/group databases

Allergomei 412. Hom s 2.

PTM databases

PhosphoSitei Q9H009.

Polymorphism databases

DMDMi 74733511.

Proteomic databases

PaxDbi Q9H009.
PeptideAtlasi Q9H009.
PRIDEi Q9H009.

Protocols and materials databases

DNASUi 342538.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000521764 ; ENSP00000427802 ; ENSG00000253506 .
GeneIDi 342538.
KEGGi hsa:342538.
UCSCi uc002izj.2. human.

Organism-specific databases

CTDi 342538.
GeneCardsi GC17M059668.
HGNCi HGNC:23290. NACA2.
MIMi 609274. gene.
neXtProti NX_Q9H009.
PharmGKBi PA162396699.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1308.
HOGENOMi HOG000239674.
HOVERGENi HBG082004.
InParanoidi Q9H009.
OMAi DAYIVFG.
OrthoDBi EOG7RNK24.
PhylomeDBi Q9H009.
TreeFami TF313348.

Miscellaneous databases

GenomeRNAii 342538.
NextBioi 98309.
PROi Q9H009.
SOURCEi Search...

Gene expression databases

Bgeei Q9H009.
CleanExi HS_NACA2.
Genevestigatori Q9H009.

Family and domain databases

InterProi IPR016641. EGD2/NACA.
IPR002715. Nas_poly-pep-assoc_cplx_dom.
[Graphical view ]
PANTHERi PTHR21713. PTHR21713. 1 hit.
Pfami PF01849. NAC. 1 hit.
[Graphical view ]
PIRSFi PIRSF015901. NAC_alpha. 1 hit.
PROSITEi PS51151. NAC_AB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen."
    Mossabeb R., Seiberler S., Mittermann I., Reininger R., Spitzauer S., Natter S., Verdino P., Keller W., Kraft D., Valenta R.
    J. Invest. Dermatol. 119:820-829(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Epithelium.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Emergence of young human genes after a burst of retroposition in primates."
    Marques A.C., Dupanloup I., Vinckenbosch N., Reymond A., Kaessmann H.
    PLoS Biol. 3:E357-E357(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-210, TISSUE SPECIFICITY.
  4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-214, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiNACA2_HUMAN
AccessioniPrimary (citable) accession number: Q9H009
Secondary accession number(s): Q2VIR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

NACAL arose from a recent (40-63 million-year-old), anthropoid primate-specific retroduplication of NACA.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi