Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9H009 (NACA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nascent polypeptide-associated complex subunit alpha-2
Alternative name(s):
Alpha-NAC-like
Hom s 2.01
Nascent polypeptide-associated complex subunit alpha-like
Short name=NAC-alpha-like
Gene names
Name:NACA2
Synonyms:NACAL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length215 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) By similarity.

Subunit structure

Part of the nascent polypeptide-associated complex (NAC), consisting of NACA and BTF3. NAC associates with ribosomes through the BTF3 subunit. Both subunits can contact nascent polypeptide chains By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Tissue specificity

Expressed specifically in testis and skeletal muscle. Ref.3

Miscellaneous

NACAL arose from a recent (40-63 million-year-old), anthropoid primate-specific retroduplication of NACA.

Sequence similarities

Belongs to the NAC-alpha family.

Contains 1 NAC-A/B (NAC-alpha/beta) domain.

Contains 1 UBA domain.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityPolymorphism
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 215215Nascent polypeptide-associated complex subunit alpha-2
PRO_0000280746

Regions

Domain70 – 13566NAC-A/B
Domain176 – 21338UBA

Amino acid modifications

Modified residue2141Phosphothreonine Ref.4

Natural variations

Natural variant641V → I.
Corresponds to variant rs17531723 [ dbSNP | Ensembl ].
VAR_050218

Sequences

Sequence LengthMass (Da)Tools
Q9H009 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: C6B96A8370E9B24E

FASTA21523,223
        10         20         30         40         50         60 
MPGEATETVP ATEQELPQSQ AETGSGTASD SGESVPGIEE QDSTQTTTQK AWLVAAAEID 

        70         80         90        100        110        120 
EEPVGKAKQS RSEKRARKAM SKLGLLQVTG VTRVTIWKSK NILFVITKLD VYKSPASDAY 

       130        140        150        160        170        180 
IVFGEAKIQD LSQQAQLAAA EKFRVQGEAV GNIQENTQTP TVQEESEEEE VDETGVEVKD 

       190        200        210 
VKLVMSQANV SRAKAVRALK NNSNDIVNAI MELTV 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen."
Mossabeb R., Seiberler S., Mittermann I., Reininger R., Spitzauer S., Natter S., Verdino P., Keller W., Kraft D., Valenta R.
J. Invest. Dermatol. 119:820-829(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Epithelium.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"Emergence of young human genes after a burst of retroposition in primates."
Marques A.C., Dupanloup I., Vinckenbosch N., Reymond A., Kaessmann H.
PLoS Biol. 3:E357-E357(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-210, TISSUE SPECIFICITY.
[4]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-214, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ278883 Genomic DNA. Translation: CAC06614.1.
BC062710 mRNA. Translation: AAH62710.1.
DQ120612 Genomic DNA. Translation: ABB92399.1.
RefSeqNP_954984.1. NM_199290.3.
UniGeneHs.591178.

3D structure databases

ProteinModelPortalQ9H009.
SMRQ9H009. Positions 79-213.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid131183. 14 interactions.

Protein family/group databases

Allergome412. Hom s 2.

PTM databases

PhosphoSiteQ9H009.

Polymorphism databases

DMDM74733511.

Proteomic databases

PaxDbQ9H009.
PeptideAtlasQ9H009.
PRIDEQ9H009.

Protocols and materials databases

DNASU342538.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000521764; ENSP00000427802; ENSG00000253506.
GeneID342538.
KEGGhsa:342538.
UCSCuc002izj.2. human.

Organism-specific databases

CTD342538.
GeneCardsGC17M059668.
HGNCHGNC:23290. NACA2.
MIM609274. gene.
neXtProtNX_Q9H009.
PharmGKBPA162396699.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1308.
HOGENOMHOG000239674.
HOVERGENHBG082004.
InParanoidQ9H009.
OMAVGNIQEN.
OrthoDBEOG7RNK24.
PhylomeDBQ9H009.
TreeFamTF313348.

Gene expression databases

BgeeQ9H009.
CleanExHS_NACA2.
GenevestigatorQ9H009.

Family and domain databases

InterProIPR016641. EGD2/NACA.
IPR002715. Nas_poly-pep-assoc_cplx_dom.
[Graphical view]
PANTHERPTHR21713. PTHR21713. 1 hit.
PfamPF01849. NAC. 1 hit.
[Graphical view]
PIRSFPIRSF015901. NAC_alpha. 1 hit.
PROSITEPS51151. NAC_AB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi342538.
NextBio98309.
PROQ9H009.
SOURCESearch...

Entry information

Entry nameNACA2_HUMAN
AccessionPrimary (citable) accession number: Q9H009
Secondary accession number(s): Q2VIR9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2001
Last modified: March 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM