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1 to 25 of 33  Show
  1. 1
    "cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland."
    Sanghi S., Kumar R., Lumsden A., Dickinson D., Klepeis V., Trinkaus-Randall V., Frierson H.F. Jr., Laurie G.W.
    J. Mol. Biol. 310:127-139(2001) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Tissue: Lacrimal gland.
    Source: UniProtKB/Swiss-Prot (reviewed).
  2. 2
    "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Tissue: Thyroid.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 50486 other entries.

  3. 3
    "Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification."
    Azkargorta M., Soria J., Ojeda C., Guzman F., Acera A., Iloro I., Suarez T., Elortza F.
    J. Proteome Res. 14:2649-2658(2015) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Tissue: Tear.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 24 other entries.

  4. 4
    "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Category: PTM / Processing.
    Tissue: Saliva.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 41 other entries.

  5. 5
    "Genetic separation of the human lacritin gene ("LACRT") and triple A (Allgrove) syndrome on 12q13."
    Kumar R., Huebner A., Laurie G.W.
    Adv. Exp. Med. Biol. 506:167-174(2002) [PubMed] [Europe PMC] [Abstract]
    Annotation: Lacritin gene maps near but not within triple A syndome region. Alacrimia in triple a syndrome not due to mutation in lacritin gene.Imported.
    Source: GeneRIF:90070.
  6. 6
    "Expression of a novel lacrimal gland gene lacritin in human breast tissues."
    Weigelt B., Bosma A.J., van 't Veer L.J.
    J. Cancer Res. Clin. Oncol. 129:735-736(2003) [PubMed] [Europe PMC] [Abstract]
    Annotation: expressed in human breast tumors breast cancer cell lines and normal breastImported.
    Source: GeneRIF:90070.
  7. 7
    "The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts."
    Ozyildirim A.M., Wistow G.J., Gao J., Wang J., Dickinson D.P., Frierson H.F. Jr., Laurie G.W.
    Invest. Ophthalmol. Vis. Sci. 46:1572-1580(2005) [PubMed] [Europe PMC] [Abstract]
    Annotation: Lacritin is the sixth most common transcript in the human lacrimal gland based on EST sequencing and is one of twenty-nine 'lacrimal preferred' genes.Imported.
    Source: GeneRIF:90070.

    This publication is mapped to 3 other entries.

  8. 8
    "Comparative analysis of the tear protein expression in blepharitis patients using two-dimensional electrophoresis."
    Koo B.S., Lee D.Y., Ha H.S., Kim J.C., Kim C.W.
    J. Proteome Res. 4:719-724(2005) [PubMed] [Europe PMC] [Abstract]
    Annotation: Lacritin is one of nine tear proteins downregulated in patients suffering from blepharitis or inflammation of the eyelid often associated with dry eye.Imported.
    Source: GeneRIF:90070.
  9. 9
    "Proteomic analysis of human meibomian gland secretions."
    Tsai P.S., Evans J.E., Green K.M., Sullivan R.M., Schaumberg D.A., Richards S.M., Dana M.R., Sullivan D.A.
    Br J Ophthalmol 90:372-377(2006) [PubMed] [Europe PMC] [Abstract]
    Annotation: Lacritin is detected by MS in meibomian gland secretions.Imported.
    Source: GeneRIF:90070.
  10. 10
    "Characterisation of human tear proteins using high-resolution mass spectrometry."
    Zhou L., Beuerman R.W., Foo Y., Liu S., Ang L.P., Tan D.T.
    Ann. Acad. Med. Singap. 35:400-407(2006) [PubMed] [Europe PMC] [Abstract]
    Annotation: Lacritin is detected in human tears by mass spectometry from patients with pterygium.Imported.
    Source: GeneRIF:90070.
  11. 11
    "Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways."
    Wang J., Wang N., Xie J., Walton S.C., McKown R.L., Raab R.W., Ma P., Beck S.L., Coffman G.L., Hussaini I.M., Laurie G.W.
    J. Cell Biol. 174:689-700(2006) [PubMed] [Europe PMC] [Abstract]
    Annotation: Lacritin signaling drives the formation of a Golgi PKCalpha/PLD1/PLCgamma2 complex; Lacritin calcium signaling is inhibited by pertussis toxin U73122 and Go 6976; Lacritin displays restricted cell target specificity in a screen of 17 different cell types. It targets rat lacrimal acinar human corneal epithelial (HCE-T) human salivary ductal (HSG) and human embryonal kidney cells (HEK293); Lacritin's signaling and mitogenic responses are biphasic (1- 10 nM dose optimum). Its biphasic signaling includes rapid PKCalpha dephosphorylation and PLD1 calcineurin and NFATC1 activation; Lacritin's C-terminus is required for mitogenesis. C-10 is fully active C-15 has approximately half the activity and C-20 is inactive; Lacritin-dependent mitogenesis is abrogated by siRNA depletion of NFATC1 mTOR and STIM1 but not TRPC1. Also cyclosporin and rapamycin inhibit. This same pattern is observed in affect on lacritin-stimulated COX2 mRNA expression.Imported.
    Source: GeneRIF:90070.
  12. 12
    "Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin."
    Ma P., Beck S.L., Raab R.W., McKown R.L., Coffman G.L., Utani A., Chirico W.J., Rapraeger A.C., Laurie G.W.
    J. Cell Biol. 174:1097-1106(2006) [PubMed] [Europe PMC] [Abstract]
    Annotation: Heparanase cleavage of SDC1 heparan sulfate chains is required for lacritin binding. This mechanism therefore forms a novel off/on switch for lacritin-dependent mitogenesis; Lacritin mitogenesis and COX2 expression is abrogated when SDC1 (but not SDC2) is depleted by siRNA. Similarly siRNA depletion of HPSE1 (but not HPSE2) knocks out lacritin mitogenesis and can be rescued by exogenous HPSE1; Lacritin binds a form of SDC1 that lacks or contains short heparan sulfate chains as revealed by gel filtration of chemically cleaved chains. Also by binding studies with FGF2 purified SDC1 with or without heparitinase digestion; Lacritin binds human SDC1 but not human SDC2 or SDC4. Lacritin C-5 C-10 N-15 N-24 but not C-25 binds SDC1. C-15 weakly binds. Thus the C-terminal mitogenic and SDC1 binding domains appear to be the same.Imported.
    Source: GeneRIF:90070.

    This publication is mapped to 8 other entries.

  13. 13
    "Establishment of an appropriate animal model for lacritin studies: cloning and characterization of lacritin in monkey eyes."
    Nakajima T., Walkup R.D., Tochigi A., Shearer T.R., Azuma M.
    Exp. Eye Res. 85:651-658(2007) [PubMed] [Europe PMC] [Abstract]
    Annotation: Lacritin was detected in monkey tear fluid. Among monkey ocular tissues lacritin mRNA is highly expressed highly in lacrimal gland somewhat less so in conjunctiva and meibomian gland and slightly in corneal epithelium.Imported.
    Source: GeneRIF:90070.

    This publication is cited by 2 other entries.

  14. 14
    "Mass spectrometry-based proteomic analyses of contact lens deposition."
    Green-Church K.B., Nichols J.J.
    Mol. Vis. 14:291-297(2008) [PubMed] [Europe PMC] [Abstract]
    Annotation: Lacritin from tears is deposited on all contact lenses tested and one of 19 tear proteins identified.Imported.
    Source: GeneRIF:90070.
  15. 15
    "Mass spectrometry-based proteomic analyses in contact lens-related dry eye."
    Nichols J.J., Green-Church K.B.
    Cornea 28:1109-1117(2009) [PubMed] [Europe PMC] [Abstract]
    Annotation: Lacritin was found to be decreased in tears of patients with contact lens related dry eye.Imported.
    Source: GeneRIF:90070.
  16. 16
    "Mechanism for carbachol-induced secretion of lacritin in cultured monkey lacrimal acinar cells."
    Morimoto-Tochigi A., Walkup R.D., Nakajima E., Shearer T.R., Azuma M.
    Invest. Ophthalmol. Vis. Sci. 51:4395-4406(2010) [PubMed] [Europe PMC] [Abstract]
    Annotation: Monkey lacrimal acinar cells release lacritin upon carbachol stimulation. Pro-secretory signaling involves PKC and calcium but not MAPK.Imported.
    Source: GeneRIF:90070.
  17. 17
    "Network organization of the human autophagy system."
    Behrends C., Sowa M.E., Gygi S.P., Harper J.W.
    Nature 466:68-76(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Source: IntAct:Q9GZZ8.

    This publication is cited by 6 and mapped to 1204 other entries.

  18. 18
    "iTRAQ quantitative proteomics in the analysis of tears in dry eye patients."
    Srinivasan S., Thangavelu M., Zhang L., Green K.B., Nichols K.K.
    Invest. Ophthalmol. Vis. Sci. 53:5052-5059(2012) [PubMed] [Europe PMC] [Abstract]
    Annotation: iTRAQ analysis suggests that lacritin is selectively deficient in tears of patients with aqueous deficient dry eye.Imported.
    Source: GeneRIF:90070.
  19. 19
    "Detection of prosecretory mitogen lacritin in nonprimate tears primarily as a C-terminal-like fragment."
    Laurie D.E., Splan R.K., Green K., Still K.M., McKown R.L., Laurie G.W.
    Invest. Ophthalmol. Vis. Sci. 53:6130-6136(2012) [PubMed] [Europe PMC] [Abstract]
    Annotation: Horse lacritin is 45% identical to human and shares a predicted amphipathic alpha helix important for cell targeting.Imported.
    Source: GeneRIF:90070.
  20. 20
    "Tear lacritin levels by age, sex, and time of day in healthy adults."
    Seifert K., Gandia N.C., Wilburn J.K., Bower K.S., Sia R.K., Ryan D.S., Deaton M.L., Still K.M., Vassilev V.C., Laurie G.W., McKown R.L.
    Invest. Ophthalmol. Vis. Sci. 53:6610-6616(2012) [PubMed] [Europe PMC] [Abstract]
    Annotation: A direct ELISA was established to estimate lacritin levels in tears. An ELISA estimate of 4.2 ng lacritin per 100 ng total tear protein did not vary significantly among individuals of different ages (18 - 52 years) or gender.Imported.
    Source: GeneRIF:90070.
  21. 21
    "Gene expression in human accessory lacrimal glands of Wolfring."
    Ubels J.L., Gipson I.K., Spurr-Michaud S.J., Tisdale A.S., Van Dyken R.E., Hatton M.P.
    Invest. Ophthalmol. Vis. Sci. 53:6738-6747(2012) [PubMed] [Europe PMC] [Abstract]
    Annotation: Lacritin mRNA is the 24st most abundant in the lacrimal gland of Wolfring. Lacritin protein is detected by immunofluorescence.Imported.
    Source: GeneRIF:90070.
  22. 22
    "Lacrimal proline rich 4 (LPRR4) protein in the tear fluid is a potential biomarker of dry eye syndrome."
    Aluru S.V., Agarwal S., Srinivasan B., Iyer G.K., Rajappa S.M., Tatu U., Padmanabhan P., Subramanian N., Narayanasamy A.
    PLoS ONE 7:e51979-e51979(2012) [PubMed] [Europe PMC] [Abstract]
    Annotation: Study involving 129 dry eye disease patients and 73 healthy controls revealing significantly less tear lacritin in 95% of patients. Lacritin was one of seven proteins downregulatedImported.
    Source: GeneRIF:90070.

    This publication is mapped to 2 other entries.

  23. 23
    "Pathogen induced changes in the protein profile of human tears from Fusarium keratitis patients."
    Ananthi S., Venkatesh Prajna N., Lalitha P., Valarnila M., Dharmalingam K.
    PLoS ONE 8:e53018-e53018(2013) [PubMed] [Europe PMC] [Abstract]
    Annotation: Lacritin is 10-fold less in tears from individuals suffering from fungal keratitis and is barely detectable in the initial stage of infection by Fusarium solani. Fungal keratitis accounts for half of all corneal ulcers in Africa and India.Imported.
    Source: GeneRIF:90070.
  24. 24
    "Conserved regional 3' grouping of rare codons in the coding sequence of ocular prosecretory mitogen lacritin."
    McKown R.L., Raab R.W., Kachelries P., Caldwell S., Laurie G.W.
    Invest. Ophthalmol. Vis. Sci. 54:1979-1987(2013) [PubMed] [Europe PMC] [Abstract]
    Annotation: Lacritin protein yields were improved primarily by hydrophobic or salt bridge mutagenesis and less so by elimination of rare codons.Imported.
    Source: GeneRIF:90070.
  25. 25
    "Tissue transglutaminase is a negative regulator of monomeric lacritin bioactivity."
    Velez V F., Romano J.A., McKown R.L., Green K., Zhang L., Raab R.W., Ryan D.S., Hutnik C.M., Frierson H.F. Jr., Laurie G.W.
    Invest. Ophthalmol. Vis. Sci. 54:2123-2132(2013) [PubMed] [Europe PMC] [Abstract]
    Annotation: Tissue transglutaminase promotes crosslinking of lacritin between K82 or K85 and Q106 - the latter residing in the SDC1 binding domain of lacritin necessary for cell targeting thus inactivating lacritin. Tissue transglutaminase is thought to be upregulated in dry eye the most common eye disease.Imported.
    Source: GeneRIF:90070.
1 to 25 of 33  Show

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