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Q9GZZ8 (LACRT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Extracellular glycoprotein lacritin
Gene names
Name:LACRT
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length138 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Modulates secretion by lacrimal acinar cells.

Subcellular location

Secreted.

Tissue specificity

Expressed in secretory granules of many acinar cells in lacrimal gland and in scattered acinar cells of salivary glands.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcalcineurin-NFAT signaling cascade

Inferred from direct assay PubMed 16923831. Source: UniProtKB

calcium-mediated signaling

Inferred from direct assay Ref.1PubMed 16923831. Source: UniProtKB

positive regulation of NFAT protein import into nucleus

Inferred from direct assay PubMed 16923831. Source: UniProtKB

positive regulation of cell proliferation

Inferred from direct assay Ref.1PubMed 16982797. Source: UniProtKB

positive regulation of epithelial cell proliferation

Inferred from direct assay PubMed 16923831. Source: UniProtKB

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from direct assay Ref.1. Source: UniProtKB

positive regulation of release of sequestered calcium ion into cytosol

Inferred from direct assay PubMed 16923831. Source: UniProtKB

positive regulation of secretion

Inferred from direct assay Ref.1. Source: UniProtKB

protein localization to Golgi apparatus

Inferred from direct assay PubMed 16923831. Source: UniProtKB

tear secretion

Non-traceable author statement PubMed 18840430. Source: UniProtKB

   Cellular_componentextracellular region

Inferred from direct assay PubMed 17850790. Source: UniProtKB

extracellular space

Inferred from direct assay PubMed 22664934PubMed 23580065. Source: UniProt

secretory granule

Inferred from direct assay Ref.1. Source: UniProtKB

   Molecular_functioncollagen binding

Inferred from direct assay Ref.1. Source: UniProtKB

fibronectin binding

Inferred from direct assay Ref.1. Source: UniProtKB

glycoprotein binding

Inferred from direct assay Ref.1. Source: UniProtKB

growth factor activity

Inferred from direct assay PubMed 16982797. Source: UniProtKB

laminin-1 binding

Inferred from direct assay Ref.1. Source: UniProtKB

protein N-terminus binding

Inferred from physical interaction PubMed 16982797. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 138119Extracellular glycoprotein lacritin
PRO_0000021574

Amino acid modifications

Glycosylation1191N-linked (GlcNAc...) Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9GZZ8 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 09910581E650F6FF

FASTA13814,246
        10         20         30         40         50         60 
MKFTTLLFLA AVAGALVYAE DASSDSTGAD PAQEAGTSKP NEEISGPAEP ASPPETTTTA 

        70         80         90        100        110        120 
QETSAAAVQG TAKVTSSRQE LNPLKSIVEK SILLTEQALA KAGKGMHGGV PGGKQFIENG 

       130 
SEFAQKLLKK FSLLKPWA 

« Hide

References

« Hide 'large scale' references
[1]"cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland."
Sanghi S., Kumar R., Lumsden A., Dickinson D., Klepeis V., Trinkaus-Randall V., Frierson H.F. Jr., Laurie G.W.
J. Mol. Biol. 310:127-139(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Tissue: Lacrimal gland.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thyroid.
[3]"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-119.
Tissue: Saliva.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY005150 Genomic DNA. Translation: AAG32949.1.
AF238867 mRNA. Translation: AAG44392.1.
BC062217 mRNA. Translation: AAH62217.1.
BC069317 mRNA. Translation: AAH69317.1.
CCDSCCDS8883.1.
RefSeqNP_150593.1. NM_033277.1.
UniGeneHs.307096.

3D structure databases

ProteinModelPortalQ9GZZ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124659. 8 interactions.
IntActQ9GZZ8. 1 interaction.
STRING9606.ENSP00000257867.

PTM databases

PhosphoSiteQ9GZZ8.

Polymorphism databases

DMDM33301325.

Proteomic databases

MaxQBQ9GZZ8.
PaxDbQ9GZZ8.
PeptideAtlasQ9GZZ8.
PRIDEQ9GZZ8.

Protocols and materials databases

DNASU90070.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000257867; ENSP00000257867; ENSG00000135413.
GeneID90070.
KEGGhsa:90070.
UCSCuc001sgi.1. human.

Organism-specific databases

CTD90070.
GeneCardsGC12M055024.
HGNCHGNC:16430. LACRT.
MIM607360. gene.
neXtProtNX_Q9GZZ8.
PharmGKBPA30261.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG81831.
HOGENOMHOG000113273.
HOVERGENHBG052295.
InParanoidQ9GZZ8.
OMAYAEDASS.
PhylomeDBQ9GZZ8.
TreeFamTF340896.

Gene expression databases

ArrayExpressQ9GZZ8.
BgeeQ9GZZ8.
CleanExHS_LACRT.
GenevestigatorQ9GZZ8.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSLACRT. human.
GeneWikiLacritin.
GenomeRNAi90070.
NextBio76505.
PROQ9GZZ8.
SOURCESearch...

Entry information

Entry nameLACRT_HUMAN
AccessionPrimary (citable) accession number: Q9GZZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM