Q9GZZ8 (LACRT_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Extracellular glycoprotein lacritin

Gene names

Name:

LACRT

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	138 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Modulates secretion by lacrimal acinar cells.
Subcellular location	Secreted.
Tissue specificity	Expressed in secretory granules of many acinar cells in lacrimal gland and in scattered acinar cells of salivary glands.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	calcineurin-NFAT signaling cascade Inferred from direct assay PubMed 16923831. Source: UniProtKB positive regulation of NFAT protein import into nucleus Inferred from direct assay PubMed 16923831. Source: UniProtKB positive regulation of epithelial cell proliferation Inferred from direct assay PubMed 16923831. Source: UniProtKB positive regulation of peptidyl-tyrosine phosphorylation Inferred from direct assay Ref.1. Source: UniProtKB positive regulation of release of sequestered calcium ion into cytosol Inferred from direct assay PubMed 16923831. Source: UniProtKB positive regulation of secretion Inferred from direct assay Ref.1. Source: UniProtKB protein localization to Golgi apparatus Inferred from direct assay PubMed 16923831. Source: UniProtKB tear secretion Non-traceable author statement PubMed 18840430. Source: UniProtKB
Cellular_component	extracellular region Inferred from direct assay PubMed 17850790. Source: UniProtKB secretory granule Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	collagen binding Inferred from direct assay Ref.1. Source: UniProtKB fibronectin binding Inferred from direct assay Ref.1. Source: UniProtKB glycoprotein binding Inferred from direct assay Ref.1. Source: UniProtKB growth factor activity Inferred from direct assay PubMed 16982797. Source: UniProtKB laminin-1 binding Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 138	119	Extracellular glycoprotein lacritin		PRO_0000021574
Amino acid modifications
	Glycosylation	119	1	N-linked (GlcNAc...) Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9GZZ8 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 09910581E650F6FF	FASTA	138	14,246
	10 20 30 40 50 60 MKFTTLLFLA AVAGALVYAE DASSDSTGAD PAQEAGTSKP NEEISGPAEP ASPPETTTTA 70 80 90 100 110 120 QETSAAAVQG TAKVTSSRQE LNPLKSIVEK SILLTEQALA KAGKGMHGGV PGGKQFIENG 130 SEFAQKLLKK FSLLKPWA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland." Sanghi S., Kumar R., Lumsden A., Dickinson D., Klepeis V., Trinkaus-Randall V., Frierson H.F. Jr., Laurie G.W. J. Mol. Biol. 310:127-139(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Lacrimal gland.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thyroid.
[3]	"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry." Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A. J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-119, MASS SPECTROMETRY. Tissue: Saliva.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY005150 Genomic DNA. Translation: AAG32949.1. AF238867 mRNA. Translation: AAG44392.1. BC062217 mRNA. Translation: AAH62217.1. BC069317 mRNA. Translation: AAH69317.1.
IPI	IPI00020487.
RefSeq	NP_150593.1. NM_033277.1.
UniGene	Hs.307096.
3D structure databases
ProteinModelPortal	Q9GZZ8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9GZZ8. 1 interaction.
STRING	9606.ENSP00000257867.
PTM databases
PhosphoSite	Q9GZZ8.
Polymorphism databases
DMDM	33301325.
Proteomic databases
PaxDb	Q9GZZ8.
PeptideAtlas	Q9GZZ8.
PRIDE	Q9GZZ8.
Protocols and materials databases
DNASU	90070.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000257867; ENSP00000257867; ENSG00000135413.
GeneID	90070.
KEGG	hsa:90070.
UCSC	uc001sgi.1. human.
Organism-specific databases
CTD	90070.
GeneCards	GC12M055024.
HGNC	HGNC:16430. LACRT.
MIM	607360. gene.
neXtProt	NX_Q9GZZ8.
PharmGKB	PA30261.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG81831.
HOGENOM	HOG000113273.
HOVERGEN	HBG052295.
InParanoid	Q9GZZ8.
OMA	YAEDASS.
OrthoDB	EOG4QZ7NN.
PhylomeDB	Q9GZZ8.
Gene expression databases
ArrayExpress	Q9GZZ8.
Bgee	Q9GZZ8.
CleanEx	HS_LACRT.
Genevestigator	Q9GZZ8.
GermOnline	ENSG00000135413. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	LACRT. human.
GenomeRNAi	90070.
NextBio	76505.
SOURCE	Search...

Entry information

Entry name

LACRT_HUMAN

Accession

Primary (citable) accession number: Q9GZZ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.