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Protein

Extracellular glycoprotein lacritin

Gene

LACRT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Modulates secretion by lacrimal acinar cells.

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • fibronectin binding Source: UniProtKB
  • glycoprotein binding Source: UniProtKB
  • growth factor activity Source: UniProtKB
  • laminin-1 binding Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB

GO - Biological processi

  • calcineurin-NFAT signaling cascade Source: UniProtKB
  • calcium-mediated signaling Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of epithelial cell proliferation Source: UniProtKB
  • positive regulation of NFAT protein import into nucleus Source: UniProtKB
  • positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  • positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  • positive regulation of secretion Source: UniProtKB
  • protein localization to Golgi apparatus Source: UniProtKB
  • tear secretion Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular glycoprotein lacritin
Gene namesi
Name:LACRT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:16430. LACRT.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB
  • secretory granule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30261.

Polymorphism and mutation databases

BioMutaiLACRT.
DMDMi33301325.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 138119Extracellular glycoprotein lacritinPRO_0000021574Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi119 – 1191N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9GZZ8.
PaxDbiQ9GZZ8.
PeptideAtlasiQ9GZZ8.
PRIDEiQ9GZZ8.

PTM databases

PhosphoSiteiQ9GZZ8.

Expressioni

Tissue specificityi

Expressed in secretory granules of many acinar cells in lacrimal gland and in scattered acinar cells of salivary glands.

Gene expression databases

BgeeiQ9GZZ8.
CleanExiHS_LACRT.
ExpressionAtlasiQ9GZZ8. baseline.
GenevisibleiQ9GZZ8. HS.

Interactioni

Protein-protein interaction databases

BioGridi124659. 25 interactions.
IntActiQ9GZZ8. 1 interaction.
STRINGi9606.ENSP00000257867.

Structurei

3D structure databases

ProteinModelPortaliQ9GZZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG81831.
GeneTreeiENSGT00390000008599.
HOGENOMiHOG000113273.
HOVERGENiHBG052295.
InParanoidiQ9GZZ8.
OMAiQELNPLK.
PhylomeDBiQ9GZZ8.
TreeFamiTF340896.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GZZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFTTLLFLA AVAGALVYAE DASSDSTGAD PAQEAGTSKP NEEISGPAEP
60 70 80 90 100
ASPPETTTTA QETSAAAVQG TAKVTSSRQE LNPLKSIVEK SILLTEQALA
110 120 130
KAGKGMHGGV PGGKQFIENG SEFAQKLLKK FSLLKPWA
Length:138
Mass (Da):14,246
Last modified:March 1, 2001 - v1
Checksum:i09910581E650F6FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY005150 Genomic DNA. Translation: AAG32949.1.
AF238867 mRNA. Translation: AAG44392.1.
BC062217 mRNA. Translation: AAH62217.1.
BC069317 mRNA. Translation: AAH69317.1.
CCDSiCCDS8883.1.
RefSeqiNP_150593.1. NM_033277.1.
UniGeneiHs.307096.

Genome annotation databases

EnsembliENST00000257867; ENSP00000257867; ENSG00000135413.
GeneIDi90070.
KEGGihsa:90070.
UCSCiuc001sgi.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY005150 Genomic DNA. Translation: AAG32949.1.
AF238867 mRNA. Translation: AAG44392.1.
BC062217 mRNA. Translation: AAH62217.1.
BC069317 mRNA. Translation: AAH69317.1.
CCDSiCCDS8883.1.
RefSeqiNP_150593.1. NM_033277.1.
UniGeneiHs.307096.

3D structure databases

ProteinModelPortaliQ9GZZ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124659. 25 interactions.
IntActiQ9GZZ8. 1 interaction.
STRINGi9606.ENSP00000257867.

PTM databases

PhosphoSiteiQ9GZZ8.

Polymorphism and mutation databases

BioMutaiLACRT.
DMDMi33301325.

Proteomic databases

MaxQBiQ9GZZ8.
PaxDbiQ9GZZ8.
PeptideAtlasiQ9GZZ8.
PRIDEiQ9GZZ8.

Protocols and materials databases

DNASUi90070.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257867; ENSP00000257867; ENSG00000135413.
GeneIDi90070.
KEGGihsa:90070.
UCSCiuc001sgi.1. human.

Organism-specific databases

CTDi90070.
GeneCardsiGC12M055024.
HGNCiHGNC:16430. LACRT.
MIMi607360. gene.
neXtProtiNX_Q9GZZ8.
PharmGKBiPA30261.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG81831.
GeneTreeiENSGT00390000008599.
HOGENOMiHOG000113273.
HOVERGENiHBG052295.
InParanoidiQ9GZZ8.
OMAiQELNPLK.
PhylomeDBiQ9GZZ8.
TreeFamiTF340896.

Miscellaneous databases

ChiTaRSiLACRT. human.
GeneWikiiLacritin.
GenomeRNAii90070.
NextBioi76505.
PROiQ9GZZ8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9GZZ8.
CleanExiHS_LACRT.
ExpressionAtlasiQ9GZZ8. baseline.
GenevisibleiQ9GZZ8. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland."
    Sanghi S., Kumar R., Lumsden A., Dickinson D., Klepeis V., Trinkaus-Randall V., Frierson H.F. Jr., Laurie G.W.
    J. Mol. Biol. 310:127-139(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Lacrimal gland.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thyroid.
  3. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-119.
    Tissue: Saliva.

Entry informationi

Entry nameiLACRT_HUMAN
AccessioniPrimary (citable) accession number: Q9GZZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: March 1, 2001
Last modified: July 22, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.