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Q9GZZ8

- LACRT_HUMAN

UniProt

Q9GZZ8 - LACRT_HUMAN

Protein

Extracellular glycoprotein lacritin

Gene

LACRT

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Modulates secretion by lacrimal acinar cells.

    GO - Molecular functioni

    1. collagen binding Source: UniProtKB
    2. fibronectin binding Source: UniProtKB
    3. glycoprotein binding Source: UniProtKB
    4. growth factor activity Source: UniProtKB
    5. laminin-1 binding Source: UniProtKB
    6. protein N-terminus binding Source: UniProtKB

    GO - Biological processi

    1. calcineurin-NFAT signaling cascade Source: UniProtKB
    2. calcium-mediated signaling Source: UniProtKB
    3. positive regulation of cell proliferation Source: UniProtKB
    4. positive regulation of epithelial cell proliferation Source: UniProtKB
    5. positive regulation of NFAT protein import into nucleus Source: UniProtKB
    6. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
    7. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
    8. positive regulation of secretion Source: UniProtKB
    9. protein localization to Golgi apparatus Source: UniProtKB
    10. tear secretion Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Extracellular glycoprotein lacritin
    Gene namesi
    Name:LACRT
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:16430. LACRT.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: UniProt
    3. secretory granule Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30261.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 138119Extracellular glycoprotein lacritinPRO_0000021574Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi119 – 1191N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9GZZ8.
    PaxDbiQ9GZZ8.
    PeptideAtlasiQ9GZZ8.
    PRIDEiQ9GZZ8.

    PTM databases

    PhosphoSiteiQ9GZZ8.

    Expressioni

    Tissue specificityi

    Expressed in secretory granules of many acinar cells in lacrimal gland and in scattered acinar cells of salivary glands.

    Gene expression databases

    ArrayExpressiQ9GZZ8.
    BgeeiQ9GZZ8.
    CleanExiHS_LACRT.
    GenevestigatoriQ9GZZ8.

    Interactioni

    Protein-protein interaction databases

    BioGridi124659. 8 interactions.
    IntActiQ9GZZ8. 1 interaction.
    STRINGi9606.ENSP00000257867.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GZZ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG81831.
    HOGENOMiHOG000113273.
    HOVERGENiHBG052295.
    InParanoidiQ9GZZ8.
    OMAiYAEDASS.
    PhylomeDBiQ9GZZ8.
    TreeFamiTF340896.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9GZZ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFTTLLFLA AVAGALVYAE DASSDSTGAD PAQEAGTSKP NEEISGPAEP    50
    ASPPETTTTA QETSAAAVQG TAKVTSSRQE LNPLKSIVEK SILLTEQALA 100
    KAGKGMHGGV PGGKQFIENG SEFAQKLLKK FSLLKPWA 138
    Length:138
    Mass (Da):14,246
    Last modified:March 1, 2001 - v1
    Checksum:i09910581E650F6FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY005150 Genomic DNA. Translation: AAG32949.1.
    AF238867 mRNA. Translation: AAG44392.1.
    BC062217 mRNA. Translation: AAH62217.1.
    BC069317 mRNA. Translation: AAH69317.1.
    CCDSiCCDS8883.1.
    RefSeqiNP_150593.1. NM_033277.1.
    UniGeneiHs.307096.

    Genome annotation databases

    GeneIDi90070.
    KEGGihsa:90070.
    UCSCiuc001sgi.1. human.

    Polymorphism databases

    DMDMi33301325.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY005150 Genomic DNA. Translation: AAG32949.1 .
    AF238867 mRNA. Translation: AAG44392.1 .
    BC062217 mRNA. Translation: AAH62217.1 .
    BC069317 mRNA. Translation: AAH69317.1 .
    CCDSi CCDS8883.1.
    RefSeqi NP_150593.1. NM_033277.1.
    UniGenei Hs.307096.

    3D structure databases

    ProteinModelPortali Q9GZZ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124659. 8 interactions.
    IntActi Q9GZZ8. 1 interaction.
    STRINGi 9606.ENSP00000257867.

    PTM databases

    PhosphoSitei Q9GZZ8.

    Polymorphism databases

    DMDMi 33301325.

    Proteomic databases

    MaxQBi Q9GZZ8.
    PaxDbi Q9GZZ8.
    PeptideAtlasi Q9GZZ8.
    PRIDEi Q9GZZ8.

    Protocols and materials databases

    DNASUi 90070.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 90070.
    KEGGi hsa:90070.
    UCSCi uc001sgi.1. human.

    Organism-specific databases

    CTDi 90070.
    GeneCardsi GC12M055024.
    HGNCi HGNC:16430. LACRT.
    MIMi 607360. gene.
    neXtProti NX_Q9GZZ8.
    PharmGKBi PA30261.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG81831.
    HOGENOMi HOG000113273.
    HOVERGENi HBG052295.
    InParanoidi Q9GZZ8.
    OMAi YAEDASS.
    PhylomeDBi Q9GZZ8.
    TreeFami TF340896.

    Miscellaneous databases

    ChiTaRSi LACRT. human.
    GeneWikii Lacritin.
    GenomeRNAii 90070.
    NextBioi 76505.
    PROi Q9GZZ8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9GZZ8.
    Bgeei Q9GZZ8.
    CleanExi HS_LACRT.
    Genevestigatori Q9GZZ8.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland."
      Sanghi S., Kumar R., Lumsden A., Dickinson D., Klepeis V., Trinkaus-Randall V., Frierson H.F. Jr., Laurie G.W.
      J. Mol. Biol. 310:127-139(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Lacrimal gland.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thyroid.
    3. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
      Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
      J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-119.
      Tissue: Saliva.

    Entry informationi

    Entry nameiLACRT_HUMAN
    AccessioniPrimary (citable) accession number: Q9GZZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3