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Protein

GDNF family receptor alpha-4

Gene

GFRA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-419037 NCAM1 interactions
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8853659 RET signaling
SIGNORiQ9GZZ7

Names & Taxonomyi

Protein namesi
Recommended name:
GDNF family receptor alpha-4
Short name:
GDNF receptor alpha-4
Short name:
GDNFR-alpha-4
Short name:
GFR-alpha-4
Alternative name(s):
Persephin receptor
Gene namesi
Name:GFRA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125861.14
HGNCiHGNC:13821 GFRA4
neXtProtiNX_Q9GZZ7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi64096
OpenTargetsiENSG00000125861
PharmGKBiPA28656

Polymorphism and mutation databases

BioMutaiGFRA4
DMDMi30173123

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001079321 – 278GDNF family receptor alpha-4Add BLAST258
PropeptideiPRO_0000010794279 – 299Removed in mature formSequence analysisAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi278GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9GZZ7
PeptideAtlasiQ9GZZ7
PRIDEiQ9GZZ7

Expressioni

Tissue specificityi

Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.

Gene expression databases

BgeeiENSG00000125861
CleanExiHS_GFRA4
GenevisibleiQ9GZZ7 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1220571 interactor.
STRINGi9606.ENSP00000313423

Structurei

3D structure databases

ProteinModelPortaliQ9GZZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GDNFR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J23G Eukaryota
ENOG4111972 LUCA
GeneTreeiENSGT00550000074579
HOGENOMiHOG000231728
HOVERGENiHBG051727
InParanoidiQ9GZZ7
OMAiTFVPACA
OrthoDBiEOG091G0NA3
PhylomeDBiQ9GZZ7
TreeFamiTF331647

Family and domain databases

InterProiView protein in InterPro
IPR016017 GDNF/GAS1
IPR037193 GDNF_alpha
IPR003438 GDNF_rcpt
PANTHERiPTHR10269 PTHR10269, 1 hit
PfamiView protein in Pfam
PF02351 GDNF, 2 hits
PRINTSiPR01316 GDNFRECEPTOR
SMARTiView protein in SMART
SM00907 GDNF, 2 hits
SUPFAMiSSF110035 SSF110035, 2 hits

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform GFRalpha4b (identifier: Q9GZZ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRCLGPALL LLLLLGSASS VGGNRCVDAA EACTADARCQ RLRSEYVAQC
60 70 80 90 100
LGRAAQGGCP RARCRRALRR FFARGPPALT HALLFCPCAG PACAERRRQT
110 120 130 140 150
FVPSCAFSGP GPAPPSCLEP LNFCERSRVC RCARAAAGPW RGWGRGLSPA
160 170 180 190 200
HRPPAAQASP PGLSGLVHPS AQRPRRLPAG PGRPLPARLR GPRGVPAGTA
210 220 230 240 250
VTPNYVDNVS ARVAPWCDCG ASGNRREDCE AFRGLFTRNR CLDGAIQAFA
260 270 280 290
SGWPPVLLDQ LNPQGDPEHS LLQVSSTGRA LERRSLLSIL PVLALPALL
Length:299
Mass (Da):31,670
Last modified:April 23, 2003 - v2
Checksum:i8443B8342FF10801
GO
Isoform GFRalpha4a (identifier: Q9GZZ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-197: CARAAAGPWR...RLRGPRGVPA → PRLLAFQVSC...RCLRAYAGLV

Show »
Length:269
Mass (Da):28,650
Checksum:i09E1DE67073974D1
GO
Isoform GFRalpha4c (identifier: Q9GZZ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-182: CARAAAGPWR...RPRRLPAGPG → PRLLAFQVSC...PPSPLTTWTT
     183-299: Missing.

Show »
Length:182
Mass (Da):19,216
Checksum:iDB837797C0688D5D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007223132 – 197CARAA…RGVPA → PRLLAFQVSCTPAPSAPDGC LLDQGARCLRAYAGLV in isoform GFRalpha4a. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_007224132 – 182CARAA…PAGPG → PRLLAFQVSCTPAPSAPDGC LLDQGARCLRAYAGLVGSPQ APPSPLTTWTT in isoform GFRalpha4c. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_007225183 – 299Missing in isoform GFRalpha4c. 1 PublicationAdd BLAST117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ291673 mRNA Translation: CAC19690.1
AJ291674 mRNA Translation: CAC19691.1
AJ291675 mRNA Translation: CAC19692.1
AF253318 mRNA Translation: AAG25925.1
AL356755 Genomic DNA No translation available.
CCDSiCCDS13055.1 [Q9GZZ7-2]
CCDS13056.1 [Q9GZZ7-1]
RefSeqiNP_071422.1, NM_022139.3 [Q9GZZ7-2]
NP_665705.1, NM_145762.2 [Q9GZZ7-1]
XP_005260850.1, XM_005260793.2 [Q9GZZ7-3]
UniGeneiHs.302025

Genome annotation databases

EnsembliENST00000290417; ENSP00000290417; ENSG00000125861 [Q9GZZ7-2]
ENST00000319242; ENSP00000313423; ENSG00000125861 [Q9GZZ7-1]
ENST00000477160; ENSP00000435801; ENSG00000125861 [Q9GZZ7-3]
GeneIDi64096
KEGGihsa:64096
UCSCiuc002win.3 human [Q9GZZ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGFRA4_HUMAN
AccessioniPrimary (citable) accession number: Q9GZZ7
Secondary accession number(s): Q5JT74, Q9H191, Q9H192
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: April 25, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome