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Protein

GDNF family receptor alpha-4

Gene

GFRA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-419037. NCAM1 interactions.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-8853659. RET signaling.
SIGNORiQ9GZZ7.

Names & Taxonomyi

Protein namesi
Recommended name:
GDNF family receptor alpha-4
Short name:
GDNF receptor alpha-4
Short name:
GDNFR-alpha-4
Short name:
GFR-alpha-4
Alternative name(s):
Persephin receptor
Gene namesi
Name:GFRA4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:13821. GFRA4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi64096.
OpenTargetsiENSG00000125861.
PharmGKBiPA28656.

Polymorphism and mutation databases

BioMutaiGFRA4.
DMDMi30173123.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001079321 – 278GDNF family receptor alpha-4Add BLAST258
PropeptideiPRO_0000010794279 – 299Removed in mature formSequence analysisAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1
Lipidationi278GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ9GZZ7.
PeptideAtlasiQ9GZZ7.
PRIDEiQ9GZZ7.

Expressioni

Tissue specificityi

Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.

Gene expression databases

BgeeiENSG00000125861.
CleanExiHS_GFRA4.
GenevisibleiQ9GZZ7. HS.

Interactioni

Protein-protein interaction databases

BioGridi122057. 1 interactor.
STRINGi9606.ENSP00000313423.

Structurei

3D structure databases

ProteinModelPortaliQ9GZZ7.
SMRiQ9GZZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GDNFR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J23G. Eukaryota.
ENOG4111972. LUCA.
GeneTreeiENSGT00550000074579.
HOGENOMiHOG000231728.
HOVERGENiHBG051727.
InParanoidiQ9GZZ7.
OMAiTFVPACA.
OrthoDBiEOG091G0NA3.
PhylomeDBiQ9GZZ7.
TreeFamiTF331647.

Family and domain databases

InterProiIPR016017. GDNF/GAS1.
IPR003438. GDNF_rcpt.
[Graphical view]
PfamiPF02351. GDNF. 2 hits.
[Graphical view]
PRINTSiPR01316. GDNFRECEPTOR.
SMARTiSM00907. GDNF. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform GFRalpha4b (identifier: Q9GZZ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRCLGPALL LLLLLGSASS VGGNRCVDAA EACTADARCQ RLRSEYVAQC
60 70 80 90 100
LGRAAQGGCP RARCRRALRR FFARGPPALT HALLFCPCAG PACAERRRQT
110 120 130 140 150
FVPSCAFSGP GPAPPSCLEP LNFCERSRVC RCARAAAGPW RGWGRGLSPA
160 170 180 190 200
HRPPAAQASP PGLSGLVHPS AQRPRRLPAG PGRPLPARLR GPRGVPAGTA
210 220 230 240 250
VTPNYVDNVS ARVAPWCDCG ASGNRREDCE AFRGLFTRNR CLDGAIQAFA
260 270 280 290
SGWPPVLLDQ LNPQGDPEHS LLQVSSTGRA LERRSLLSIL PVLALPALL
Length:299
Mass (Da):31,670
Last modified:April 23, 2003 - v2
Checksum:i8443B8342FF10801
GO
Isoform GFRalpha4a (identifier: Q9GZZ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-197: CARAAAGPWR...RLRGPRGVPA → PRLLAFQVSC...RCLRAYAGLV

Show »
Length:269
Mass (Da):28,650
Checksum:i09E1DE67073974D1
GO
Isoform GFRalpha4c (identifier: Q9GZZ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-182: CARAAAGPWR...RPRRLPAGPG → PRLLAFQVSC...PPSPLTTWTT
     183-299: Missing.

Show »
Length:182
Mass (Da):19,216
Checksum:iDB837797C0688D5D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007223132 – 197CARAA…RGVPA → PRLLAFQVSCTPAPSAPDGC LLDQGARCLRAYAGLV in isoform GFRalpha4a. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_007224132 – 182CARAA…PAGPG → PRLLAFQVSCTPAPSAPDGC LLDQGARCLRAYAGLVGSPQ APPSPLTTWTT in isoform GFRalpha4c. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_007225183 – 299Missing in isoform GFRalpha4c. 1 PublicationAdd BLAST117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ291673 mRNA. Translation: CAC19690.1.
AJ291674 mRNA. Translation: CAC19691.1.
AJ291675 mRNA. Translation: CAC19692.1.
AF253318 mRNA. Translation: AAG25925.1.
AL356755 Genomic DNA. Translation: CAC16508.2.
AL356755 Genomic DNA. Translation: CAI23466.1.
CCDSiCCDS13055.1. [Q9GZZ7-2]
CCDS13056.1. [Q9GZZ7-1]
RefSeqiNP_071422.1. NM_022139.3. [Q9GZZ7-2]
NP_665705.1. NM_145762.2. [Q9GZZ7-1]
XP_005260850.1. XM_005260793.2. [Q9GZZ7-3]
UniGeneiHs.302025.

Genome annotation databases

EnsembliENST00000290417; ENSP00000290417; ENSG00000125861. [Q9GZZ7-2]
ENST00000319242; ENSP00000313423; ENSG00000125861. [Q9GZZ7-1]
ENST00000477160; ENSP00000435801; ENSG00000125861. [Q9GZZ7-3]
GeneIDi64096.
KEGGihsa:64096.
UCSCiuc002win.3. human. [Q9GZZ7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ291673 mRNA. Translation: CAC19690.1.
AJ291674 mRNA. Translation: CAC19691.1.
AJ291675 mRNA. Translation: CAC19692.1.
AF253318 mRNA. Translation: AAG25925.1.
AL356755 Genomic DNA. Translation: CAC16508.2.
AL356755 Genomic DNA. Translation: CAI23466.1.
CCDSiCCDS13055.1. [Q9GZZ7-2]
CCDS13056.1. [Q9GZZ7-1]
RefSeqiNP_071422.1. NM_022139.3. [Q9GZZ7-2]
NP_665705.1. NM_145762.2. [Q9GZZ7-1]
XP_005260850.1. XM_005260793.2. [Q9GZZ7-3]
UniGeneiHs.302025.

3D structure databases

ProteinModelPortaliQ9GZZ7.
SMRiQ9GZZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122057. 1 interactor.
STRINGi9606.ENSP00000313423.

Polymorphism and mutation databases

BioMutaiGFRA4.
DMDMi30173123.

Proteomic databases

PaxDbiQ9GZZ7.
PeptideAtlasiQ9GZZ7.
PRIDEiQ9GZZ7.

Protocols and materials databases

DNASUi64096.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290417; ENSP00000290417; ENSG00000125861. [Q9GZZ7-2]
ENST00000319242; ENSP00000313423; ENSG00000125861. [Q9GZZ7-1]
ENST00000477160; ENSP00000435801; ENSG00000125861. [Q9GZZ7-3]
GeneIDi64096.
KEGGihsa:64096.
UCSCiuc002win.3. human. [Q9GZZ7-1]

Organism-specific databases

CTDi64096.
DisGeNETi64096.
GeneCardsiGFRA4.
HGNCiHGNC:13821. GFRA4.
neXtProtiNX_Q9GZZ7.
OpenTargetsiENSG00000125861.
PharmGKBiPA28656.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J23G. Eukaryota.
ENOG4111972. LUCA.
GeneTreeiENSGT00550000074579.
HOGENOMiHOG000231728.
HOVERGENiHBG051727.
InParanoidiQ9GZZ7.
OMAiTFVPACA.
OrthoDBiEOG091G0NA3.
PhylomeDBiQ9GZZ7.
TreeFamiTF331647.

Enzyme and pathway databases

ReactomeiR-HSA-419037. NCAM1 interactions.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-8853659. RET signaling.
SIGNORiQ9GZZ7.

Miscellaneous databases

GenomeRNAii64096.
PROiQ9GZZ7.

Gene expression databases

BgeeiENSG00000125861.
CleanExiHS_GFRA4.
GenevisibleiQ9GZZ7. HS.

Family and domain databases

InterProiIPR016017. GDNF/GAS1.
IPR003438. GDNF_rcpt.
[Graphical view]
PfamiPF02351. GDNF. 2 hits.
[Graphical view]
PRINTSiPR01316. GDNFRECEPTOR.
SMARTiSM00907. GDNF. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGFRA4_HUMAN
AccessioniPrimary (citable) accession number: Q9GZZ7
Secondary accession number(s): Q5JT74, Q9H191, Q9H192
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: November 2, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.