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Protein

Neuronal acetylcholine receptor subunit alpha-10

Gene

CHRNA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.1 Publication

Miscellaneous

The heterooligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).

GO - Molecular functioni

GO - Biological processi

  • detection of mechanical stimulus involved in sensory perception of sound Source: Ensembl
  • inner ear morphogenesis Source: Ensembl
  • positive regulation of cytosolic calcium ion concentration Source: MGI
  • regulation of cell proliferation Source: UniProtKB
  • synaptic transmission, cholinergic Source: UniProtKB

Keywordsi

Molecular functionCalcium channel, Ion channel, Ligand-gated ion channel, Receptor
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-10
Alternative name(s):
Nicotinic acetylcholine receptor subunit alpha-10
Short name:
NACHR alpha-10
Gene namesi
Name:CHRNA10
Synonyms:NACHRA10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000129749.3
HGNCiHGNC:13800 CHRNA10
MIMi606372 gene
neXtProtiNX_Q9GZZ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 237ExtracellularSequence analysisAdd BLAST213
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Topological domaini323 – 428CytoplasmicSequence analysisAdd BLAST106
Transmembranei429 – 449HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31L → H: 11-fold increase in inhibition of the AChR composed of subunits CHRNA9 and CHRNA10 by the conotoxin GEXXA, and no change in activity on mAChR composed of subunits CHRNA9 and CHRNA10 by the competitive conotoxin Vc1A. 1 Publication1

Organism-specific databases

DisGeNETi57053
OpenTargetsiENSG00000129749
PharmGKBiPA26488

Chemistry databases

ChEMBLiCHEMBL2109238
DrugBankiDB05069 ATG003
DB01161 Chloroprocaine
DB00898 Ethanol
DB00674 Galantamine
DB05137 Lobeline
DB00333 Methadone
DB00184 Nicotine
DB01090 Pentolinium
DB05740 RPI-78M
DB00202 Succinylcholine
DB01116 Trimethaphan
GuidetoPHARMACOLOGYi470

Polymorphism and mutation databases

BioMutaiCHRNA10
DMDMi14916526

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000000037625 – 450Neuronal acetylcholine receptor subunit alpha-10Add BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi56N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi154 ↔ 168By similarity
Disulfide bondi218 ↔ 219Associated with receptor activationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZZ6
PRIDEiQ9GZZ6

PTM databases

iPTMnetiQ9GZZ6
PhosphoSitePlusiQ9GZZ6

Expressioni

Tissue specificityi

Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.2 Publications

Gene expression databases

BgeeiENSG00000129749
CleanExiHS_CHRNA10
ExpressionAtlasiQ9GZZ6 baseline and differential
GenevisibleiQ9GZZ6 HS

Interactioni

Subunit structurei

Forms heterooligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 heterooligomers. Interacts with the conotoxin GeXXA (PubMed:26395518). Interacts with the alpha-conotoxin RgIA (By similarity).By similarity1 Publication

GO - Molecular functioni

  • signaling receptor binding Source: UniProtKB

Protein-protein interaction databases

CORUMiQ9GZZ6
STRINGi9606.ENSP00000250699

Chemistry databases

BindingDBiQ9GZZ6

Structurei

3D structure databases

ProteinModelPortaliQ9GZZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00760000118930
HOGENOMiHOG000006756
HOVERGENiHBG003756
InParanoidiQ9GZZ6
KOiK04811
OMAiAQRCHED
OrthoDBiEOG091G0R20
PhylomeDBiQ9GZZ6
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 2 hits
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 2 hits
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GZZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLRSHHLSL GLLLLFLLPA ECLGAEGRLA LKLFRDLFAN YTSALRPVAD
60 70 80 90 100
TDQTLNVTLE VTLSQIIDMD ERNQVLTLYL WIRQEWTDAY LRWDPNAYGG
110 120 130 140 150
LDAIRIPSSL VWRPDIVLYN KADAQPPGSA STNVVLRHDG AVRWDAPAIT
160 170 180 190 200
RSSCRVDVAA FPFDAQHCGL TFGSWTHGGH QLDVRPRGAA ASLADFVENV
210 220 230 240 250
EWRVLGMPAR RRVLTYGCCS EPYPDVTFTL LLRRRAAAYV CNLLLPCVLI
260 270 280 290 300
SLLAPLAFHL PADSGEKVSL GVTVLLALTV FQLLLAESMP PAESVPLIGK
310 320 330 340 350
YYMATMTMVT FSTALTILIM NLHYCGPSVR PVPAWARALL LGHLARGLCV
360 370 380 390 400
RERGEPCGQS RPPELSPSPQ SPEGGAGPPA GPCHEPRCLC RQEALLHHVA
410 420 430 440 450
TIANTFRSHR AAQRCHEDWK RLARVMDRFF LAIFFSMALV MSLLVLVQAL
Length:450
Mass (Da):49,705
Last modified:March 1, 2001 - v1
Checksum:i0A1DAD32D9069870
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048172355E → A. Corresponds to variant dbSNP:rs2231547Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278118 mRNA Translation: CAC20435.1
AF199235 mRNA Translation: AAG00795.2
AF327367 Genomic DNA Translation: AAK14333.1
AJ295237 mRNA Translation: CAC16144.1
CCDSiCCDS7745.1
RefSeqiNP_001289963.1, NM_001303034.1
NP_001289964.1, NM_001303035.1
NP_065135.2, NM_020402.3
UniGeneiHs.732806

Genome annotation databases

EnsembliENST00000250699; ENSP00000250699; ENSG00000129749
GeneIDi57053
KEGGihsa:57053
UCSCiuc001lyf.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiACH10_HUMAN
AccessioniPrimary (citable) accession number: Q9GZZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health