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Q9GZZ6

- ACH10_HUMAN

UniProt

Q9GZZ6 - ACH10_HUMAN

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Protein
Neuronal acetylcholine receptor subunit alpha-10
Gene
CHRNA10, NACHRA10
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.1 Publication

GO - Molecular functioni

  1. acetylcholine-activated cation-selective channel activity Source: Ensembl
  2. calcium channel activity Source: UniProtKB-KW
  3. receptor binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. detection of mechanical stimulus involved in sensory perception of sound Source: Ensembl
  2. inner ear morphogenesis Source: Ensembl
  3. positive regulation of cytosolic calcium ion concentration Source: MGI
  4. regulation of cell proliferation Source: UniProtKB
  5. synaptic transmission, cholinergic Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-10
Alternative name(s):
Nicotinic acetylcholine receptor subunit alpha-10
Short name:
NACHR alpha-10
Gene namesi
Name:CHRNA10
Synonyms:NACHRA10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:13800. CHRNA10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 237213Extracellular Reviewed prediction
Add
BLAST
Transmembranei238 – 25821Helical; Reviewed prediction
Add
BLAST
Transmembranei268 – 28821Helical; Reviewed prediction
Add
BLAST
Transmembranei302 – 32221Helical; Reviewed prediction
Add
BLAST
Topological domaini323 – 428106Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei429 – 44921Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cell junction Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane Source: UniProtKB
  5. perikaryon Source: Ensembl
  6. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26488.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 450426Neuronal acetylcholine receptor subunit alpha-10
PRO_0000000376Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi56 – 561N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi154 ↔ 168 By similarity
Disulfide bondi218 ↔ 219Associated with receptor activation By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZZ6.
PRIDEiQ9GZZ6.

Expressioni

Tissue specificityi

Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.2 Publications

Gene expression databases

ArrayExpressiQ9GZZ6.
BgeeiQ9GZZ6.
CleanExiHS_CHRNA10.
GenevestigatoriQ9GZZ6.

Organism-specific databases

HPAiHPA060919.

Interactioni

Subunit structurei

Forms heterooligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 heterooligomers.

Protein-protein interaction databases

STRINGi9606.ENSP00000250699.

Structurei

3D structure databases

ProteinModelPortaliQ9GZZ6.
SMRiQ9GZZ6. Positions 32-328.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG306809.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiQ9GZZ6.
KOiK04811.
OMAiDGAVRWD.
OrthoDBiEOG72JWGV.
PhylomeDBiQ9GZZ6.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GZZ6-1 [UniParc]FASTAAdd to Basket

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MGLRSHHLSL GLLLLFLLPA ECLGAEGRLA LKLFRDLFAN YTSALRPVAD    50
TDQTLNVTLE VTLSQIIDMD ERNQVLTLYL WIRQEWTDAY LRWDPNAYGG 100
LDAIRIPSSL VWRPDIVLYN KADAQPPGSA STNVVLRHDG AVRWDAPAIT 150
RSSCRVDVAA FPFDAQHCGL TFGSWTHGGH QLDVRPRGAA ASLADFVENV 200
EWRVLGMPAR RRVLTYGCCS EPYPDVTFTL LLRRRAAAYV CNLLLPCVLI 250
SLLAPLAFHL PADSGEKVSL GVTVLLALTV FQLLLAESMP PAESVPLIGK 300
YYMATMTMVT FSTALTILIM NLHYCGPSVR PVPAWARALL LGHLARGLCV 350
RERGEPCGQS RPPELSPSPQ SPEGGAGPPA GPCHEPRCLC RQEALLHHVA 400
TIANTFRSHR AAQRCHEDWK RLARVMDRFF LAIFFSMALV MSLLVLVQAL 450
Length:450
Mass (Da):49,705
Last modified:March 1, 2001 - v1
Checksum:i0A1DAD32D9069870
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti355 – 3551E → A.
Corresponds to variant rs2231547 [ dbSNP | Ensembl ].
VAR_048172

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ278118 mRNA. Translation: CAC20435.1.
AF199235 mRNA. Translation: AAG00795.2.
AF327367 Genomic DNA. Translation: AAK14333.1.
AJ295237 mRNA. Translation: CAC16144.1.
CCDSiCCDS7745.1.
RefSeqiNP_065135.2. NM_020402.2.
UniGeneiHs.732806.

Genome annotation databases

EnsembliENST00000250699; ENSP00000250699; ENSG00000129749.
GeneIDi57053.
KEGGihsa:57053.
UCSCiuc001lyf.3. human.

Polymorphism databases

DMDMi14916526.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ278118 mRNA. Translation: CAC20435.1 .
AF199235 mRNA. Translation: AAG00795.2 .
AF327367 Genomic DNA. Translation: AAK14333.1 .
AJ295237 mRNA. Translation: CAC16144.1 .
CCDSi CCDS7745.1.
RefSeqi NP_065135.2. NM_020402.2.
UniGenei Hs.732806.

3D structure databases

ProteinModelPortali Q9GZZ6.
SMRi Q9GZZ6. Positions 32-328.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000250699.

Chemistry

BindingDBi Q9GZZ6.
ChEMBLi CHEMBL2109238.
DrugBanki DB01161. Chloroprocaine.
DB00333. Methadone.
DB00184. Nicotine.
DB01090. Pentolinium.
DB00721. Procaine.
DB01116. Trimethaphan.
GuidetoPHARMACOLOGYi 470.

Polymorphism databases

DMDMi 14916526.

Proteomic databases

PaxDbi Q9GZZ6.
PRIDEi Q9GZZ6.

Protocols and materials databases

DNASUi 57053.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000250699 ; ENSP00000250699 ; ENSG00000129749 .
GeneIDi 57053.
KEGGi hsa:57053.
UCSCi uc001lyf.3. human.

Organism-specific databases

CTDi 57053.
GeneCardsi GC11M003691.
HGNCi HGNC:13800. CHRNA10.
HPAi HPA060919.
MIMi 606372. gene.
neXtProti NX_Q9GZZ6.
PharmGKBi PA26488.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG306809.
HOGENOMi HOG000006756.
HOVERGENi HBG003756.
InParanoidi Q9GZZ6.
KOi K04811.
OMAi DGAVRWD.
OrthoDBi EOG72JWGV.
PhylomeDBi Q9GZZ6.
TreeFami TF315605.

Miscellaneous databases

GeneWikii CHRNA10.
GenomeRNAii 57053.
NextBioi 62824.
PROi Q9GZZ6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9GZZ6.
Bgeei Q9GZZ6.
CleanExi HS_CHRNA10.
Genevestigatori Q9GZZ6.

Family and domain databases

Gene3Di 1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProi IPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view ]
PANTHERi PTHR18945. PTHR18945. 1 hit.
Pfami PF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view ]
PRINTSi PR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMi SSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsi TIGR00860. LIC. 1 hit.
PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit."
    Sgard F., Charpantier E., Bertrand S., Walker N., Caput D., Graham D., Bertrand D., Besnard F.
    Mol. Pharmacol. 61:150-159(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CHRNA9, TISSUE SPECIFICITY.
    Tissue: Skeletal muscle.
  2. "Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10)."
    Lustig L.R., Peng H., Hiel H., Yamamoto T., Fuchs P.A.
    Genomics 73:272-283(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Inner ear and Tonsil.
  3. "Identification and functional characterisation of a novel human neuronal nicotinic acetylcholine receptor subunit alpha 10."
    Vandenberk I., van der Helm L., Nieuwstraten D.M., Verfaille C., Kremer A., van der Spek P., Masure S., Hoefnagel E., Yon J., Groot Kormelink P.J., Luyten W.H., Grantham C.J.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes."
    Peng H., Ferris R.L., Matthews T., Hiel H., Lopez-Albaitero A., Lustig L.R.
    Life Sci. 76:263-280(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiACH10_HUMAN
AccessioniPrimary (citable) accession number: Q9GZZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The heterooligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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