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Q9GZZ6

- ACH10_HUMAN

UniProt

Q9GZZ6 - ACH10_HUMAN

Protein

Neuronal acetylcholine receptor subunit alpha-10

Gene

CHRNA10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.1 Publication

    GO - Molecular functioni

    1. acetylcholine-activated cation-selective channel activity Source: Ensembl
    2. calcium channel activity Source: UniProtKB-KW
    3. receptor binding Source: UniProtKB

    GO - Biological processi

    1. detection of mechanical stimulus involved in sensory perception of sound Source: Ensembl
    2. inner ear morphogenesis Source: Ensembl
    3. positive regulation of cytosolic calcium ion concentration Source: MGI
    4. regulation of cell proliferation Source: UniProtKB
    5. synaptic transmission, cholinergic Source: UniProtKB

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuronal acetylcholine receptor subunit alpha-10
    Alternative name(s):
    Nicotinic acetylcholine receptor subunit alpha-10
    Short name:
    NACHR alpha-10
    Gene namesi
    Name:CHRNA10
    Synonyms:NACHRA10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:13800. CHRNA10.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cell junction Source: UniProtKB-KW
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane Source: UniProtKB
    5. perikaryon Source: Ensembl
    6. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26488.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 450426Neuronal acetylcholine receptor subunit alpha-10PRO_0000000376Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi154 ↔ 168By similarity
    Disulfide bondi218 ↔ 219Associated with receptor activationBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9GZZ6.
    PRIDEiQ9GZZ6.

    Expressioni

    Tissue specificityi

    Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.2 Publications

    Gene expression databases

    ArrayExpressiQ9GZZ6.
    BgeeiQ9GZZ6.
    CleanExiHS_CHRNA10.
    GenevestigatoriQ9GZZ6.

    Organism-specific databases

    HPAiHPA060919.

    Interactioni

    Subunit structurei

    Forms heterooligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 heterooligomers.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000250699.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GZZ6.
    SMRiQ9GZZ6. Positions 32-328.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 237213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini323 – 428106CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei238 – 25821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei268 – 28821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei302 – 32221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei429 – 44921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG306809.
    HOGENOMiHOG000006756.
    HOVERGENiHBG003756.
    InParanoidiQ9GZZ6.
    KOiK04811.
    OMAiDGAVRWD.
    OrthoDBiEOG72JWGV.
    PhylomeDBiQ9GZZ6.
    TreeFamiTF315605.

    Family and domain databases

    Gene3Di1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProiIPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9GZZ6-1 [UniParc]FASTAAdd to Basket

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    MGLRSHHLSL GLLLLFLLPA ECLGAEGRLA LKLFRDLFAN YTSALRPVAD    50
    TDQTLNVTLE VTLSQIIDMD ERNQVLTLYL WIRQEWTDAY LRWDPNAYGG 100
    LDAIRIPSSL VWRPDIVLYN KADAQPPGSA STNVVLRHDG AVRWDAPAIT 150
    RSSCRVDVAA FPFDAQHCGL TFGSWTHGGH QLDVRPRGAA ASLADFVENV 200
    EWRVLGMPAR RRVLTYGCCS EPYPDVTFTL LLRRRAAAYV CNLLLPCVLI 250
    SLLAPLAFHL PADSGEKVSL GVTVLLALTV FQLLLAESMP PAESVPLIGK 300
    YYMATMTMVT FSTALTILIM NLHYCGPSVR PVPAWARALL LGHLARGLCV 350
    RERGEPCGQS RPPELSPSPQ SPEGGAGPPA GPCHEPRCLC RQEALLHHVA 400
    TIANTFRSHR AAQRCHEDWK RLARVMDRFF LAIFFSMALV MSLLVLVQAL 450
    Length:450
    Mass (Da):49,705
    Last modified:March 1, 2001 - v1
    Checksum:i0A1DAD32D9069870
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti355 – 3551E → A.
    Corresponds to variant rs2231547 [ dbSNP | Ensembl ].
    VAR_048172

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278118 mRNA. Translation: CAC20435.1.
    AF199235 mRNA. Translation: AAG00795.2.
    AF327367 Genomic DNA. Translation: AAK14333.1.
    AJ295237 mRNA. Translation: CAC16144.1.
    CCDSiCCDS7745.1.
    RefSeqiNP_065135.2. NM_020402.2.
    UniGeneiHs.732806.

    Genome annotation databases

    EnsembliENST00000250699; ENSP00000250699; ENSG00000129749.
    GeneIDi57053.
    KEGGihsa:57053.
    UCSCiuc001lyf.3. human.

    Polymorphism databases

    DMDMi14916526.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278118 mRNA. Translation: CAC20435.1 .
    AF199235 mRNA. Translation: AAG00795.2 .
    AF327367 Genomic DNA. Translation: AAK14333.1 .
    AJ295237 mRNA. Translation: CAC16144.1 .
    CCDSi CCDS7745.1.
    RefSeqi NP_065135.2. NM_020402.2.
    UniGenei Hs.732806.

    3D structure databases

    ProteinModelPortali Q9GZZ6.
    SMRi Q9GZZ6. Positions 32-328.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000250699.

    Chemistry

    BindingDBi Q9GZZ6.
    ChEMBLi CHEMBL2109238.
    DrugBanki DB01161. Chloroprocaine.
    DB00674. Galantamine.
    DB00333. Methadone.
    DB00184. Nicotine.
    DB01090. Pentolinium.
    DB00202. Succinylcholine.
    DB01116. Trimethaphan.
    GuidetoPHARMACOLOGYi 470.

    Polymorphism databases

    DMDMi 14916526.

    Proteomic databases

    PaxDbi Q9GZZ6.
    PRIDEi Q9GZZ6.

    Protocols and materials databases

    DNASUi 57053.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000250699 ; ENSP00000250699 ; ENSG00000129749 .
    GeneIDi 57053.
    KEGGi hsa:57053.
    UCSCi uc001lyf.3. human.

    Organism-specific databases

    CTDi 57053.
    GeneCardsi GC11M003691.
    HGNCi HGNC:13800. CHRNA10.
    HPAi HPA060919.
    MIMi 606372. gene.
    neXtProti NX_Q9GZZ6.
    PharmGKBi PA26488.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG306809.
    HOGENOMi HOG000006756.
    HOVERGENi HBG003756.
    InParanoidi Q9GZZ6.
    KOi K04811.
    OMAi DGAVRWD.
    OrthoDBi EOG72JWGV.
    PhylomeDBi Q9GZZ6.
    TreeFami TF315605.

    Miscellaneous databases

    GeneWikii CHRNA10.
    GenomeRNAii 57053.
    NextBioi 62824.
    PROi Q9GZZ6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9GZZ6.
    Bgeei Q9GZZ6.
    CleanExi HS_CHRNA10.
    Genevestigatori Q9GZZ6.

    Family and domain databases

    Gene3Di 1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProi IPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit."
      Sgard F., Charpantier E., Bertrand S., Walker N., Caput D., Graham D., Bertrand D., Besnard F.
      Mol. Pharmacol. 61:150-159(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CHRNA9, TISSUE SPECIFICITY.
      Tissue: Skeletal muscle.
    2. "Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10)."
      Lustig L.R., Peng H., Hiel H., Yamamoto T., Fuchs P.A.
      Genomics 73:272-283(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Inner ear and Tonsil.
    3. "Identification and functional characterisation of a novel human neuronal nicotinic acetylcholine receptor subunit alpha 10."
      Vandenberk I., van der Helm L., Nieuwstraten D.M., Verfaille C., Kremer A., van der Spek P., Masure S., Hoefnagel E., Yon J., Groot Kormelink P.J., Luyten W.H., Grantham C.J.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes."
      Peng H., Ferris R.L., Matthews T., Hiel H., Lopez-Albaitero A., Lustig L.R.
      Life Sci. 76:263-280(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiACH10_HUMAN
    AccessioniPrimary (citable) accession number: Q9GZZ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The heterooligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3