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Protein

Neuronal acetylcholine receptor subunit alpha-10

Gene

CHRNA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.1 Publication

GO - Molecular functioni

GO - Biological processi

  • detection of mechanical stimulus involved in sensory perception of sound Source: Ensembl
  • inner ear morphogenesis Source: Ensembl
  • positive regulation of cytosolic calcium ion concentration Source: MGI
  • regulation of cell proliferation Source: UniProtKB
  • synaptic transmission, cholinergic Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-10
Alternative name(s):
Nicotinic acetylcholine receptor subunit alpha-10
Short name:
NACHR alpha-10
Gene namesi
Name:CHRNA10
Synonyms:NACHRA10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:13800. CHRNA10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 237213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence AnalysisAdd
BLAST
Transmembranei268 – 28821HelicalSequence AnalysisAdd
BLAST
Transmembranei302 – 32221HelicalSequence AnalysisAdd
BLAST
Topological domaini323 – 428106CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei429 – 44921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • acetylcholine-gated channel complex Source: Ensembl
  • axon Source: Ensembl
  • cell junction Source: UniProtKB-KW
  • cytosol Source: GOC
  • membrane Source: UniProtKB
  • perikaryon Source: Ensembl
  • postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26488.

Chemistry

DrugBankiDB01161. Chloroprocaine.
DB00674. Galantamine.
DB00333. Methadone.
DB00184. Nicotine.
DB01090. Pentolinium.
DB00202. Succinylcholine.
DB01116. Trimethaphan.

Polymorphism and mutation databases

BioMutaiCHRNA10.
DMDMi14916526.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 450426Neuronal acetylcholine receptor subunit alpha-10PRO_0000000376Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi154 ↔ 168By similarity
Disulfide bondi218 ↔ 219Associated with receptor activationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZZ6.
PRIDEiQ9GZZ6.

Expressioni

Tissue specificityi

Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.2 Publications

Gene expression databases

BgeeiQ9GZZ6.
CleanExiHS_CHRNA10.
ExpressionAtlasiQ9GZZ6. baseline.
GenevisibleiQ9GZZ6. HS.

Organism-specific databases

HPAiHPA060919.

Interactioni

Subunit structurei

Forms heterooligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 heterooligomers.

Protein-protein interaction databases

STRINGi9606.ENSP00000250699.

Structurei

3D structure databases

ProteinModelPortaliQ9GZZ6.
SMRiQ9GZZ6. Positions 26-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG306809.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiQ9GZZ6.
KOiK04811.
OMAiCHQEALL.
OrthoDBiEOG72JWGV.
PhylomeDBiQ9GZZ6.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GZZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLRSHHLSL GLLLLFLLPA ECLGAEGRLA LKLFRDLFAN YTSALRPVAD
60 70 80 90 100
TDQTLNVTLE VTLSQIIDMD ERNQVLTLYL WIRQEWTDAY LRWDPNAYGG
110 120 130 140 150
LDAIRIPSSL VWRPDIVLYN KADAQPPGSA STNVVLRHDG AVRWDAPAIT
160 170 180 190 200
RSSCRVDVAA FPFDAQHCGL TFGSWTHGGH QLDVRPRGAA ASLADFVENV
210 220 230 240 250
EWRVLGMPAR RRVLTYGCCS EPYPDVTFTL LLRRRAAAYV CNLLLPCVLI
260 270 280 290 300
SLLAPLAFHL PADSGEKVSL GVTVLLALTV FQLLLAESMP PAESVPLIGK
310 320 330 340 350
YYMATMTMVT FSTALTILIM NLHYCGPSVR PVPAWARALL LGHLARGLCV
360 370 380 390 400
RERGEPCGQS RPPELSPSPQ SPEGGAGPPA GPCHEPRCLC RQEALLHHVA
410 420 430 440 450
TIANTFRSHR AAQRCHEDWK RLARVMDRFF LAIFFSMALV MSLLVLVQAL
Length:450
Mass (Da):49,705
Last modified:March 1, 2001 - v1
Checksum:i0A1DAD32D9069870
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti355 – 3551E → A.
Corresponds to variant rs2231547 [ dbSNP | Ensembl ].
VAR_048172

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278118 mRNA. Translation: CAC20435.1.
AF199235 mRNA. Translation: AAG00795.2.
AF327367 Genomic DNA. Translation: AAK14333.1.
AJ295237 mRNA. Translation: CAC16144.1.
CCDSiCCDS7745.1.
RefSeqiNP_001289963.1. NM_001303034.1.
NP_001289964.1. NM_001303035.1.
NP_065135.2. NM_020402.3.
UniGeneiHs.732806.

Genome annotation databases

EnsembliENST00000250699; ENSP00000250699; ENSG00000129749.
GeneIDi57053.
KEGGihsa:57053.
UCSCiuc001lyf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278118 mRNA. Translation: CAC20435.1.
AF199235 mRNA. Translation: AAG00795.2.
AF327367 Genomic DNA. Translation: AAK14333.1.
AJ295237 mRNA. Translation: CAC16144.1.
CCDSiCCDS7745.1.
RefSeqiNP_001289963.1. NM_001303034.1.
NP_001289964.1. NM_001303035.1.
NP_065135.2. NM_020402.3.
UniGeneiHs.732806.

3D structure databases

ProteinModelPortaliQ9GZZ6.
SMRiQ9GZZ6. Positions 26-446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000250699.

Chemistry

BindingDBiQ9GZZ6.
ChEMBLiCHEMBL2109238.
DrugBankiDB01161. Chloroprocaine.
DB00674. Galantamine.
DB00333. Methadone.
DB00184. Nicotine.
DB01090. Pentolinium.
DB00202. Succinylcholine.
DB01116. Trimethaphan.
GuidetoPHARMACOLOGYi470.

Polymorphism and mutation databases

BioMutaiCHRNA10.
DMDMi14916526.

Proteomic databases

PaxDbiQ9GZZ6.
PRIDEiQ9GZZ6.

Protocols and materials databases

DNASUi57053.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250699; ENSP00000250699; ENSG00000129749.
GeneIDi57053.
KEGGihsa:57053.
UCSCiuc001lyf.3. human.

Organism-specific databases

CTDi57053.
GeneCardsiGC11M003699.
HGNCiHGNC:13800. CHRNA10.
HPAiHPA060919.
MIMi606372. gene.
neXtProtiNX_Q9GZZ6.
PharmGKBiPA26488.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG306809.
GeneTreeiENSGT00790000122957.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiQ9GZZ6.
KOiK04811.
OMAiCHQEALL.
OrthoDBiEOG72JWGV.
PhylomeDBiQ9GZZ6.
TreeFamiTF315605.

Miscellaneous databases

GeneWikiiCHRNA10.
GenomeRNAii57053.
NextBioi62824.
PROiQ9GZZ6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9GZZ6.
CleanExiHS_CHRNA10.
ExpressionAtlasiQ9GZZ6. baseline.
GenevisibleiQ9GZZ6. HS.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit."
    Sgard F., Charpantier E., Bertrand S., Walker N., Caput D., Graham D., Bertrand D., Besnard F.
    Mol. Pharmacol. 61:150-159(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CHRNA9, TISSUE SPECIFICITY.
    Tissue: Skeletal muscle.
  2. "Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10)."
    Lustig L.R., Peng H., Hiel H., Yamamoto T., Fuchs P.A.
    Genomics 73:272-283(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Inner ear and Tonsil.
  3. "Identification and functional characterisation of a novel human neuronal nicotinic acetylcholine receptor subunit alpha 10."
    Vandenberk I., van der Helm L., Nieuwstraten D.M., Verfaille C., Kremer A., van der Spek P., Masure S., Hoefnagel E., Yon J., Groot Kormelink P.J., Luyten W.H., Grantham C.J.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes."
    Peng H., Ferris R.L., Matthews T., Hiel H., Lopez-Albaitero A., Lustig L.R.
    Life Sci. 76:263-280(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiACH10_HUMAN
AccessioniPrimary (citable) accession number: Q9GZZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: March 1, 2001
Last modified: June 24, 2015
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The heterooligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.