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Protein

N-alpha-acetyltransferase 50

Gene

NAA50

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable catalytic component of the NAA11-NAA15 complex which displays alpha (N-terminal) acetyltransferase activity.1 Publication

GO - Molecular functioni

  • H4 histone acetyltransferase activity Source: UniProtKB
  • peptide alpha-N-acetyltransferase activity Source: UniProtKB
  • peptidyl-lysine acetyltransferase activity Source: UniProtKB

GO - Biological processi

  • mitotic sister chromatid cohesion, centromeric Source: UniProtKB
  • N-terminal protein amino acid acetylation Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121579-MONOMER.
BRENDAi2.3.1.88. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 50 (EC:2.3.1.-)
Alternative name(s):
N-acetyltransferase 13
N-acetyltransferase 5
Short name:
hNAT5
N-acetyltransferase san homolog
Short name:
hSAN
NatE catalytic subunit
Gene namesi
Name:NAA50
Synonyms:MAK3, NAT13, NAT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:29533. NAA50.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HGNC
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi80218.
OpenTargetsiENSG00000121579.
PharmGKBiPA165697846.

Polymorphism and mutation databases

BioMutaiNAA50.
DMDMi74733509.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002849021 – 169N-alpha-acetyltransferase 50Add BLAST169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphothreonineCombined sources1
Modified residuei34N6-acetyllysineCombined sources1
Modified residuei37N6-acetyllysineCombined sources1
Modified residuei110PhosphotyrosineCombined sources1
Isoform 2 (identifier: Q9GZZ1-2)
Modified residuei34N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9GZZ1.
MaxQBiQ9GZZ1.
PaxDbiQ9GZZ1.
PeptideAtlasiQ9GZZ1.
PRIDEiQ9GZZ1.

PTM databases

iPTMnetiQ9GZZ1.
PhosphoSitePlusiQ9GZZ1.

Expressioni

Gene expression databases

BgeeiENSG00000121579.
CleanExiHS_NAT13.
HS_NAT5.
ExpressionAtlasiQ9GZZ1. baseline and differential.
GenevisibleiQ9GZZ1. HS.

Interactioni

Subunit structurei

Interacts with NAA35 (By similarity). Interacts with NAA15 and NAA11.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BHLHE40O145033EBI-1052523,EBI-711810
JMJD6Q6NYC13EBI-1052523,EBI-8464037
NAA10P412272EBI-1052523,EBI-747693
NAA15Q9BXJ92EBI-1052523,EBI-1042540

Protein-protein interaction databases

BioGridi123185. 36 interactors.
IntActiQ9GZZ1. 9 interactors.
STRINGi9606.ENSP00000240922.

Structurei

Secondary structure

1169
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 10Combined sources6
Turni13 – 15Combined sources3
Helixi16 – 26Combined sources11
Helixi33 – 39Combined sources7
Helixi43 – 45Combined sources3
Beta strandi46 – 51Combined sources6
Beta strandi54 – 66Combined sources13
Beta strandi69 – 79Combined sources11
Helixi81 – 83Combined sources3
Beta strandi85 – 87Combined sources3
Helixi88 – 103Combined sources16
Beta strandi107 – 114Combined sources8
Helixi118 – 126Combined sources9
Beta strandi130 – 135Combined sources6
Beta strandi140 – 144Combined sources5
Beta strandi147 – 153Combined sources7
Helixi162 – 164Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OB0X-ray1.80A/B/C2-169[»]
2PSWX-ray2.10A/B/C2-169[»]
3TFYX-ray2.75A/B/C1-169[»]
4X5KX-ray2.49A1-169[»]
ProteinModelPortaliQ9GZZ1.
SMRiQ9GZZ1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9GZZ1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 155N-acetyltransferasePROSITE-ProRule annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni79 – 90Coenzyme A bindingAdd BLAST12

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3138. Eukaryota.
COG0456. LUCA.
GeneTreeiENSGT00390000009110.
HOGENOMiHOG000238056.
HOVERGENiHBG060820.
InParanoidiQ9GZZ1.
KOiK20793.
OMAiPIKYSEK.
OrthoDBiEOG091G0PAG.
PhylomeDBiQ9GZZ1.
TreeFamiTF314841.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9GZZ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGSRIELGD VTPHNIKQLK RLNQVIFPVS YNDKFYKDVL EVGELAKLAY
60 70 80 90 100
FNDIAVGAVC CRVDHSQNQK RLYIMTLGCL APYRRLGIGT KMLNHVLNIC
110 120 130 140 150
EKDGTFDNIY LHVQISNESA IDFYRKFGFE IIETKKNYYK RIEPADAHVL
160
QKNLKVPSGQ NADVQKTDN
Length:169
Mass (Da):19,398
Last modified:March 1, 2001 - v1
Checksum:i153A8021B74655CC
GO
Isoform 2 (identifier: Q9GZZ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-122: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:81
Mass (Da):9,465
Checksum:i72B366F6387B4FC5
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02474735 – 122Missing in isoform 2. 1 PublicationAdd BLAST88

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023090 mRNA. Translation: BAB14397.1.
AK023256 mRNA. Translation: BAB14490.1.
CR749314 mRNA. Translation: CAH18169.1.
CH471052 Genomic DNA. Translation: EAW79629.1.
CH471052 Genomic DNA. Translation: EAW79630.1.
BC012731 mRNA. Translation: AAH12731.1.
CCDSiCCDS2975.1. [Q9GZZ1-1]
RefSeqiNP_079422.1. NM_025146.3. [Q9GZZ1-1]
UniGeneiHs.372378.

Genome annotation databases

EnsembliENST00000240922; ENSP00000240922; ENSG00000121579. [Q9GZZ1-1]
GeneIDi80218.
KEGGihsa:80218.
UCSCiuc003ean.3. human. [Q9GZZ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023090 mRNA. Translation: BAB14397.1.
AK023256 mRNA. Translation: BAB14490.1.
CR749314 mRNA. Translation: CAH18169.1.
CH471052 Genomic DNA. Translation: EAW79629.1.
CH471052 Genomic DNA. Translation: EAW79630.1.
BC012731 mRNA. Translation: AAH12731.1.
CCDSiCCDS2975.1. [Q9GZZ1-1]
RefSeqiNP_079422.1. NM_025146.3. [Q9GZZ1-1]
UniGeneiHs.372378.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OB0X-ray1.80A/B/C2-169[»]
2PSWX-ray2.10A/B/C2-169[»]
3TFYX-ray2.75A/B/C1-169[»]
4X5KX-ray2.49A1-169[»]
ProteinModelPortaliQ9GZZ1.
SMRiQ9GZZ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123185. 36 interactors.
IntActiQ9GZZ1. 9 interactors.
STRINGi9606.ENSP00000240922.

PTM databases

iPTMnetiQ9GZZ1.
PhosphoSitePlusiQ9GZZ1.

Polymorphism and mutation databases

BioMutaiNAA50.
DMDMi74733509.

Proteomic databases

EPDiQ9GZZ1.
MaxQBiQ9GZZ1.
PaxDbiQ9GZZ1.
PeptideAtlasiQ9GZZ1.
PRIDEiQ9GZZ1.

Protocols and materials databases

DNASUi80218.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240922; ENSP00000240922; ENSG00000121579. [Q9GZZ1-1]
GeneIDi80218.
KEGGihsa:80218.
UCSCiuc003ean.3. human. [Q9GZZ1-1]

Organism-specific databases

CTDi80218.
DisGeNETi80218.
GeneCardsiNAA50.
HGNCiHGNC:29533. NAA50.
MIMi610834. gene.
neXtProtiNX_Q9GZZ1.
OpenTargetsiENSG00000121579.
PharmGKBiPA165697846.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3138. Eukaryota.
COG0456. LUCA.
GeneTreeiENSGT00390000009110.
HOGENOMiHOG000238056.
HOVERGENiHBG060820.
InParanoidiQ9GZZ1.
KOiK20793.
OMAiPIKYSEK.
OrthoDBiEOG091G0PAG.
PhylomeDBiQ9GZZ1.
TreeFamiTF314841.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000121579-MONOMER.
BRENDAi2.3.1.88. 2681.

Miscellaneous databases

ChiTaRSiNAA50. human.
EvolutionaryTraceiQ9GZZ1.
GenomeRNAii80218.
PROiQ9GZZ1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121579.
CleanExiHS_NAT13.
HS_NAT5.
ExpressionAtlasiQ9GZZ1. baseline and differential.
GenevisibleiQ9GZZ1. HS.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAA50_HUMAN
AccessioniPrimary (citable) accession number: Q9GZZ1
Secondary accession number(s): D3DN74, Q68DQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.