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Protein

Prostate and breast cancer overexpressed gene 1 protein

Gene

PBOV1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Prostate and breast cancer overexpressed gene 1 protein
Alternative name(s):
Protein UROC28
Short name:
UC28
Gene namesi
Name:PBOV1
Synonyms:UROC28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21079. PBOV1.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134869958.

Polymorphism and mutation databases

BioMutaiPBOV1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 135135Prostate and breast cancer overexpressed gene 1 proteinPRO_0000076285Add
BLAST

Proteomic databases

PaxDbiQ9GZY1.
PRIDEiQ9GZY1.

Expressioni

Tissue specificityi

Expressed in colon, prostate, small intestine, testis and spleen, with lower expression in thymus, ovary, and peripheral blood leukocytes. Up-regulated expression in prostate, breast, and bladder cancer, but not in lung and colon cancer.1 Publication

Gene expression databases

BgeeiQ9GZY1.
CleanExiHS_PBOV1.
GenevisibleiQ9GZY1. HS.

Organism-specific databases

HPAiHPA063021.

Structurei

3D structure databases

ProteinModelPortaliQ9GZY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410JMBJ. Eukaryota.
ENOG41118T1. LUCA.
GeneTreeiENSGT00390000009242.
OMAiQSHHAIL.
OrthoDBiEOG7WX0CH.

Sequencei

Sequence statusi: Complete.

Q9GZY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAFLRNQKY EDMHNIIHIL QIRKLRHRLS NFPRLPGILA PETVLLPFCY
60 70 80 90 100
KVFRKKEKVK RSQKATEFID YSIEQSHHAI LTPLQTHLTM KGSSMKCSSL
110 120 130
SSEAILFTLT LQLTQTLGLE CCLLYLSKTI HPQII
Length:135
Mass (Da):15,722
Last modified:March 1, 2001 - v1
Checksum:i2B7DB8B1983705D0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti73 – 731I → T.
Corresponds to variant rs6927706 [ dbSNP | Ensembl ].
VAR_059707

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189269 mRNA. Translation: AAG17117.1.
AF189270 mRNA. Translation: AAG17118.1.
AL031433 Genomic DNA. No translation available.
BC069109 mRNA. Translation: AAH69109.1.
CCDSiCCDS5190.1.
RefSeqiNP_067648.1. NM_021635.2.
UniGeneiHs.302016.

Genome annotation databases

EnsembliENST00000527246; ENSP00000432353; ENSG00000254440.
GeneIDi59351.
KEGGihsa:59351.
UCSCiuc003qhv.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189269 mRNA. Translation: AAG17117.1.
AF189270 mRNA. Translation: AAG17118.1.
AL031433 Genomic DNA. No translation available.
BC069109 mRNA. Translation: AAH69109.1.
CCDSiCCDS5190.1.
RefSeqiNP_067648.1. NM_021635.2.
UniGeneiHs.302016.

3D structure databases

ProteinModelPortaliQ9GZY1.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiPBOV1.

Proteomic databases

PaxDbiQ9GZY1.
PRIDEiQ9GZY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000527246; ENSP00000432353; ENSG00000254440.
GeneIDi59351.
KEGGihsa:59351.
UCSCiuc003qhv.5. human.

Organism-specific databases

CTDi59351.
GeneCardsiPBOV1.
HGNCiHGNC:21079. PBOV1.
HPAiHPA063021.
MIMi605669. gene.
neXtProtiNX_Q9GZY1.
PharmGKBiPA134869958.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JMBJ. Eukaryota.
ENOG41118T1. LUCA.
GeneTreeiENSGT00390000009242.
OMAiQSHHAIL.
OrthoDBiEOG7WX0CH.

Miscellaneous databases

GenomeRNAii59351.
NextBioi65265.
PROiQ9GZY1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9GZY1.
CleanExiHS_PBOV1.
GenevisibleiQ9GZY1. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of UROC28, a novel gene overexpressed in prostate, breast, and bladder cancers."
    An G., Ng A.Y., Meka C.S.R., Luo G., Bright S.P., Cazares L., Wright G.L. Jr., Veltri R.W.
    Cancer Res. 60:7014-7020(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Prostatic carcinoma.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiPBOV1_HUMAN
AccessioniPrimary (citable) accession number: Q9GZY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 1, 2001
Last modified: March 16, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.