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Protein

Nuclear RNA export factor 2

Gene

NXF2

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the export of mRNA from the nucleus to the cytoplasm.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear RNA export factor 2
Alternative name(s):
Cancer/testis antigen 39
Short name:
CT39
TAP-like protein 2
Short name:
TAPL-2
Gene namesi
Name:NXF2
Synonyms:TAPL2
AND
Name:NXF2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000269405.6
HostDB:ENSG00000269437.6
HGNCiHGNC:8072 NXF2
HGNC:23984 NXF2B
MIMi300315 gene
neXtProtiNX_Q9GZY0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi598E → A: Has no effect on FG-nucleoporin binding. 1 Publication1
Mutagenesisi599W → A: Suppresses FG-nucleoporin binding. 1 Publication1
Mutagenesisi600N → A: Has no effect on FG-nucleoporin binding. 1 Publication1

Organism-specific databases

DisGeNETi56001
OpenTargetsiENSG00000269405
ENSG00000269437
PharmGKBiPA162398310

Polymorphism and mutation databases

BioMutaiNXF2
DMDMi20978536

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002205331 – 626Nuclear RNA export factor 2Add BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9GZY0
PaxDbiQ9GZY0
PeptideAtlasiQ9GZY0
PRIDEiQ9GZY0
ProteomicsDBi80171

PTM databases

iPTMnetiQ9GZY0
PhosphoSitePlusiQ9GZY0

Expressioni

Tissue specificityi

Expressed almost exclusively in testis. Also expressed in several cancers.1 Publication

Gene expression databases

BgeeiENSG00000269405
CleanExiHS_NXF2
HS_NXF2B
ExpressionAtlasiQ9GZY0 baseline and differential
GenevisibleiQ9GZY0 HS

Organism-specific databases

HPAiHPA002079

Interactioni

Subunit structurei

Interacts with NXT1, NXT2, E1B-AP5, the REF proteins and with nucleoporins, Nup62, Nup153 and Nup214. Interacts with LUZP4.2 Publications

Protein-protein interaction databases

BioGridi121026, 65 interactors
608771, 3 interactors
IntActiQ9GZY0, 1 interactor
STRINGi9606.ENSP00000361835

Structurei

3D structure databases

ProteinModelPortaliQ9GZY0
SMRiQ9GZY0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 203RRMAdd BLAST80
Repeati271 – 296LRR 1Add BLAST26
Repeati297 – 320LRR 2Add BLAST24
Repeati321 – 348LRR 3Add BLAST28
Repeati349 – 376LRR 4Add BLAST28
Domaini391 – 541NTF2PROSITE-ProRule annotationAdd BLAST151
Domaini570 – 625TAP-CPROSITE-ProRule annotationAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi528 – 531Poly-Ser4
Compositional biasi561 – 564Poly-Ser4

Domaini

The NTF2 domain heterodimerizes with NXT1 and NXT2. The formation of NXF1/NXT1 heterodimers is required for NXF2-mediated nuclear mRNA export.
The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus.
The C-terminal fragment, containing the TAP domain (also called UBA-like domain) and part of the NTF2-like domain, named the NPC-binding domain, mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF2 to the nuclear rim.
The RNA-binding domain is a non-canonical RNP-type domain.

Sequence similaritiesi

Belongs to the NXF family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG3763 Eukaryota
ENOG410XR55 LUCA
GeneTreeiENSGT00390000007539
HOGENOMiHOG000236269
HOVERGENiHBG013199
InParanoidiQ9GZY0
KOiK14284
OMAiVELMNIN
OrthoDBiEOG091G04QA
PhylomeDBiQ9GZY0
TreeFamiTF314566

Family and domain databases

CDDicd00780 NTF2, 1 hit
cd14342 UBA_TAP-C, 1 hit
Gene3Di3.30.70.330, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR002075 NTF2
IPR032710 NTF2-like_dom_sf
IPR018222 Nuclear_transport_factor_2_euk
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR030218 NXF5
IPR030217 NXF_fam
IPR035979 RBD_domain_sf
IPR005637 TAP_C_dom
IPR015245 Tap_RNA-bd
IPR009060 UBA-like_sf
PANTHERiPTHR10662 PTHR10662, 1 hit
PTHR10662:SF15 PTHR10662:SF15, 1 hit
PfamiView protein in Pfam
PF02136 NTF2, 1 hit
PF09162 Tap-RNA_bind, 1 hit
PF03943 TAP_C, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD043466 Tap_RNA_bd, 1 hit
SMARTiView protein in SMART
SM00804 TAP_C, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF54427 SSF54427, 1 hit
SSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 3 hits
PS50177 NTF2_DOMAIN, 1 hit
PS51281 TAP_C, 1 hit

Sequencei

Sequence statusi: Complete.

Q9GZY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSTLKKCGT YRTEVAECHD HGSTFQGRKK GGSSFRDNFD KRSCHYEHGG
60 70 80 90 100
YERPPSHCQE NDGSVEMRDV HKDQQLRHTP YSIRCERRMK WHSEDEIRIT
110 120 130 140 150
TWRNRKPPER KMSQNTQDGY TRNWFKVTIP YGIKYDKAWL MNSIQSHCSD
160 170 180 190 200
RFTPVDFHYV RNRACFFVQD ASAASALKDV SYKIYDDENQ KICIFVNHST
210 220 230 240 250
APYSVKNKLK PGQMEMLKLT MNKRYNVSQQ ALDLQNLRFD PDLMGRDIDI
260 270 280 290 300
ILNRRNCMAA TLKIIERNFP ELLSLNLCNN KLYQLDGLSD ITEKAPKVKT
310 320 330 340 350
LNLSKNKLES AWELGKVKGL KLEELWLEGN PLCSTFSDQS AYVSAIRDCF
360 370 380 390 400
PKLLRLDGRE LSAPVIVDID SSETMKPCKE NFTGSETLKH LVLQFLQQYY
410 420 430 440 450
SIYDSGDRQG LLGAYHDEAC FSLAIPFDPK DSAPSSLCKY FEDSRNMKTL
460 470 480 490 500
KDPYLKGELL RRTKRDIVDS LSALPKTQHD LSSILVDVWC QTERMLCFSV
510 520 530 540 550
NGVFKEVEGQ SQGSVLAFTR TFIATPGSSS SLCIVNDELF VRDASPQETQ
560 570 580 590 600
SAFSIPVSTL SSSSEPSLSQ EQQEMVQAFS AQSGMKLEWS QKCLQDNEWN
610 620
YTRAGQAFTM LQTEGKIPAE AFKQIS
Length:626
Mass (Da):71,627
Last modified:March 1, 2001 - v1
Checksum:i319CFEDF3E67A163
GO

Sequence cautioni

The sequence AAK31975 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91154 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB75659 differs from that shown. The sequence differs from that shown due to either intron retention or a splicing event.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277526 mRNA Translation: CAC16588.1
AJ277659 mRNA Translation: CAC20433.1
AL157436 mRNA Translation: CAB75659.1 Sequence problems.
Z81367 Genomic DNA Translation: CAI42026.1
AL590069 Genomic DNA Translation: CAD13494.1
BC015020 mRNA Translation: AAH15020.1
AF285596 mRNA Translation: AAK31975.1 Different initiation.
AK000423 mRNA Translation: BAA91154.1 Different initiation.
CCDSiCCDS14497.1
CCDS43979.1
RefSeqiNP_001093156.1, NM_001099686.2
NP_071336.1, NM_022053.3
UniGeneiHs.530358
Hs.648337
Hs.689668
Hs.737538

Genome annotation databases

EnsembliENST00000602195; ENSP00000472530; ENSG00000269437
ENST00000604395; ENSP00000474659; ENSG00000269437
ENST00000604790; ENSP00000474598; ENSG00000269405
ENST00000625106; ENSP00000485586; ENSG00000269405
GeneIDi56001
728343
KEGGihsa:56001
hsa:728343
UCSCiuc004eix.5 human

Similar proteinsi

Entry informationi

Entry nameiNXF2_HUMAN
AccessioniPrimary (citable) accession number: Q9GZY0
Secondary accession number(s): Q9BXU4, Q9NSS1, Q9NX66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 178 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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