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Protein

Nuclear RNA export factor 2

Gene

NXF2

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the export of mRNA from the nucleus to the cytoplasm.

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. RNA binding Source: UniProtKB

GO - Biological processi

  1. mRNA export from nucleus Source: UniProtKB
  2. multicellular organismal development Source: UniProtKB
  3. RNA transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

mRNA transport, Transport

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear RNA export factor 2
Alternative name(s):
Cancer/testis antigen 39
Short name:
CT39
TAP-like protein 2
Short name:
TAPL-2
Gene namesi
Name:NXF2
Synonyms:TAPL2
AND
Name:NXF2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:8072. NXF2.
HGNC:23984. NXF2B.

Subcellular locationi

Nucleusnucleoplasm. Cytoplasm
Note: Localized in the nucleoplasm and at the nuclear envelope. Shuttles between the nucleus and the cytoplasm.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nuclear RNA export factor complex Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi598 – 5981E → A: Has no effect on FG-nucleoporin binding. 1 Publication
Mutagenesisi599 – 5991W → A: Suppresses FG-nucleoporin binding. 1 Publication
Mutagenesisi600 – 6001N → A: Has no effect on FG-nucleoporin binding. 1 Publication

Organism-specific databases

PharmGKBiPA162398310.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 626626Nuclear RNA export factor 2PRO_0000220533Add
BLAST

Proteomic databases

PaxDbiQ9GZY0.
PRIDEiQ9GZY0.

PTM databases

PhosphoSiteiQ9GZY0.

Expressioni

Tissue specificityi

Expressed almost exclusively in testis. Also expressed in several cancers.1 Publication

Gene expression databases

BgeeiQ9GZY0.
CleanExiHS_NXF2.
HS_NXF2B.
ExpressionAtlasiQ9GZY0. baseline.
GenevestigatoriQ9GZY0.

Interactioni

Subunit structurei

Interacts with NXT1, NXT2, E1B-AP5, the REF proteins and with nucleoporins, Nup62, Nup153 and Nup214.1 Publication

Protein-protein interaction databases

BioGridi121026. 5 interactions.
IntActiQ9GZY0. 1 interaction.
STRINGi9606.ENSP00000361835.

Structurei

3D structure databases

ProteinModelPortaliQ9GZY0.
SMRiQ9GZY0. Positions 123-365, 377-559, 566-622.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini124 – 20380RRMAdd
BLAST
Repeati271 – 29626LRR 1Add
BLAST
Repeati297 – 32024LRR 2Add
BLAST
Repeati321 – 34828LRR 3Add
BLAST
Repeati349 – 37628LRR 4Add
BLAST
Domaini391 – 541151NTF2PROSITE-ProRule annotationAdd
BLAST
Domaini570 – 62556TAP-CPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi528 – 5314Poly-Ser
Compositional biasi561 – 5644Poly-Ser

Domaini

The NTF2 domain heterodimerizes with NXT1 and NXT2. The formation of NXF1/NXT1 heterodimers is required for NXF2-mediated nuclear mRNA export.
The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus.
The C-terminal fragment, containing the TAP domain (also called UBA-like domain) and part of the NTF2-like domain, named the NPC-binding domain, mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF2 to the nuclear rim.
The RNA-binding domain is a non-canonical RNP-type domain.

Sequence similaritiesi

Belongs to the NXF family.Curated
Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 NTF2 domain.PROSITE-ProRule annotation
Contains 1 TAP-C domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiNOG324438.
GeneTreeiENSGT00390000007539.
HOGENOMiHOG000236269.
HOVERGENiHBG013199.
InParanoidiQ9GZY0.
KOiK14284.
OMAiRNCHYEH.
OrthoDBiEOG7QZGB9.
PhylomeDBiQ9GZY0.
TreeFamiTF314566.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR001611. Leu-rich_rpt.
IPR002075. NTF2.
IPR018222. Nuclear_transport_factor_2_euk.
IPR012677. Nucleotide-bd_a/b_plait.
IPR030217. NXF_fam.
IPR005637. TAP_C_dom.
IPR015245. Tap_RNA-bd.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR10662. PTHR10662. 1 hit.
PfamiPF02136. NTF2. 1 hit.
PF09162. Tap-RNA_bind. 1 hit.
PF03943. TAP_C. 1 hit.
[Graphical view]
ProDomiPD043466. Tap_RNA_bd. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00804. TAP_C. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS51450. LRR. 3 hits.
PS50177. NTF2_DOMAIN. 1 hit.
PS51281. TAP_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GZY0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCSTLKKCGT YRTEVAECHD HGSTFQGRKK GGSSFRDNFD KRSCHYEHGG
60 70 80 90 100
YERPPSHCQE NDGSVEMRDV HKDQQLRHTP YSIRCERRMK WHSEDEIRIT
110 120 130 140 150
TWRNRKPPER KMSQNTQDGY TRNWFKVTIP YGIKYDKAWL MNSIQSHCSD
160 170 180 190 200
RFTPVDFHYV RNRACFFVQD ASAASALKDV SYKIYDDENQ KICIFVNHST
210 220 230 240 250
APYSVKNKLK PGQMEMLKLT MNKRYNVSQQ ALDLQNLRFD PDLMGRDIDI
260 270 280 290 300
ILNRRNCMAA TLKIIERNFP ELLSLNLCNN KLYQLDGLSD ITEKAPKVKT
310 320 330 340 350
LNLSKNKLES AWELGKVKGL KLEELWLEGN PLCSTFSDQS AYVSAIRDCF
360 370 380 390 400
PKLLRLDGRE LSAPVIVDID SSETMKPCKE NFTGSETLKH LVLQFLQQYY
410 420 430 440 450
SIYDSGDRQG LLGAYHDEAC FSLAIPFDPK DSAPSSLCKY FEDSRNMKTL
460 470 480 490 500
KDPYLKGELL RRTKRDIVDS LSALPKTQHD LSSILVDVWC QTERMLCFSV
510 520 530 540 550
NGVFKEVEGQ SQGSVLAFTR TFIATPGSSS SLCIVNDELF VRDASPQETQ
560 570 580 590 600
SAFSIPVSTL SSSSEPSLSQ EQQEMVQAFS AQSGMKLEWS QKCLQDNEWN
610 620
YTRAGQAFTM LQTEGKIPAE AFKQIS
Length:626
Mass (Da):71,627
Last modified:March 1, 2001 - v1
Checksum:i319CFEDF3E67A163
GO

Sequence cautioni

The sequence AAK31975.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA91154.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAB75659.1 differs from that shown.The sequence differs from that shown due to either intron retention or a splicing event.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277526 mRNA. Translation: CAC16588.1.
AJ277659 mRNA. Translation: CAC20433.1.
AL157436 mRNA. Translation: CAB75659.1. Sequence problems.
Z81367 Genomic DNA. Translation: CAI42026.1.
AL590069 Genomic DNA. Translation: CAD13494.1.
BC015020 mRNA. Translation: AAH15020.1.
AF285596 mRNA. Translation: AAK31975.1. Different initiation.
AK000423 mRNA. Translation: BAA91154.1. Different initiation.
CCDSiCCDS14497.1.
CCDS43979.1.
RefSeqiNP_001093156.1. NM_001099686.2.
NP_071336.1. NM_022053.3.
UniGeneiHs.530358.
Hs.648337.
Hs.737538.

Genome annotation databases

EnsembliENST00000602195; ENSP00000472530; ENSG00000269437.
ENST00000604395; ENSP00000474659; ENSG00000269437.
ENST00000604790; ENSP00000474598; ENSG00000269405.
ENST00000618302; ENSP00000484645; ENSG00000269437.
ENST00000625106; ENSP00000485586; ENSG00000269405.
GeneIDi56001.
728343.
KEGGihsa:56001.
hsa:728343.
UCSCiuc004eiv.4. human.

Polymorphism databases

DMDMi20978536.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277526 mRNA. Translation: CAC16588.1.
AJ277659 mRNA. Translation: CAC20433.1.
AL157436 mRNA. Translation: CAB75659.1. Sequence problems.
Z81367 Genomic DNA. Translation: CAI42026.1.
AL590069 Genomic DNA. Translation: CAD13494.1.
BC015020 mRNA. Translation: AAH15020.1.
AF285596 mRNA. Translation: AAK31975.1. Different initiation.
AK000423 mRNA. Translation: BAA91154.1. Different initiation.
CCDSiCCDS14497.1.
CCDS43979.1.
RefSeqiNP_001093156.1. NM_001099686.2.
NP_071336.1. NM_022053.3.
UniGeneiHs.530358.
Hs.648337.
Hs.737538.

3D structure databases

ProteinModelPortaliQ9GZY0.
SMRiQ9GZY0. Positions 123-365, 377-559, 566-622.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121026. 5 interactions.
IntActiQ9GZY0. 1 interaction.
STRINGi9606.ENSP00000361835.

PTM databases

PhosphoSiteiQ9GZY0.

Polymorphism databases

DMDMi20978536.

Proteomic databases

PaxDbiQ9GZY0.
PRIDEiQ9GZY0.

Protocols and materials databases

DNASUi56001.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000602195; ENSP00000472530; ENSG00000269437.
ENST00000604395; ENSP00000474659; ENSG00000269437.
ENST00000604790; ENSP00000474598; ENSG00000269405.
ENST00000618302; ENSP00000484645; ENSG00000269437.
ENST00000625106; ENSP00000485586; ENSG00000269405.
GeneIDi56001.
728343.
KEGGihsa:56001.
hsa:728343.
UCSCiuc004eiv.4. human.

Organism-specific databases

CTDi56001.
728343.
GeneCardsiGC0XM101615.
GC0XP101471.
HGNCiHGNC:8072. NXF2.
HGNC:23984. NXF2B.
MIMi300315. gene.
neXtProtiNX_Q9GZY0.
PharmGKBiPA162398310.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG324438.
GeneTreeiENSGT00390000007539.
HOGENOMiHOG000236269.
HOVERGENiHBG013199.
InParanoidiQ9GZY0.
KOiK14284.
OMAiRNCHYEH.
OrthoDBiEOG7QZGB9.
PhylomeDBiQ9GZY0.
TreeFamiTF314566.

Miscellaneous databases

GeneWikiiNXF2.
NextBioi61450.
PROiQ9GZY0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9GZY0.
CleanExiHS_NXF2.
HS_NXF2B.
ExpressionAtlasiQ9GZY0. baseline.
GenevestigatoriQ9GZY0.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR001611. Leu-rich_rpt.
IPR002075. NTF2.
IPR018222. Nuclear_transport_factor_2_euk.
IPR012677. Nucleotide-bd_a/b_plait.
IPR030217. NXF_fam.
IPR005637. TAP_C_dom.
IPR015245. Tap_RNA-bd.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR10662. PTHR10662. 1 hit.
PfamiPF02136. NTF2. 1 hit.
PF09162. Tap-RNA_bind. 1 hit.
PF03943. TAP_C. 1 hit.
[Graphical view]
ProDomiPD043466. Tap_RNA_bd. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00804. TAP_C. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
PROSITEiPS51450. LRR. 3 hits.
PS50177. NTF2_DOMAIN. 1 hit.
PS51281. TAP_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture."
    Herold A., Suyama M., Rodrigues J.P., Braun I.C., Kutay U., Carmo-Fonseca M., Bork P., Izaurralde E.
    Mol. Cell. Biol. 20:8996-9008(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS.
    Tissue: Testis.
  2. "NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation."
    Jun L., Frints S., Duhamel H., Herold A., Abad-Rodrigues J., Dotti C., Izaurralde E., Marynen P., Froyen G.
    Curr. Biol. 11:1381-1391(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  6. "An abundance of X-linked genes expressed in spermatogonia."
    Wang P.J., McCarrey J.R., Yang F., Page D.C.
    Nat. Genet. 27:422-426(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-626.
    Tissue: Testis.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 98-626.
  8. "Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export."
    Black B.E., Levesque L., Holaska J.M., Wood T.C., Paschal B.M.
    Mol. Cell. Biol. 19:8616-8624(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NXT1.
  9. "Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia."
    Loriot A., Boon T., De Smet C.
    Int. J. Cancer 105:371-376(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.

Entry informationi

Entry nameiNXF2_HUMAN
AccessioniPrimary (citable) accession number: Q9GZY0
Secondary accession number(s): Q9BXU4, Q9NSS1, Q9NX66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.