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Q9GZX7

- AICDA_HUMAN

UniProt

Q9GZX7 - AICDA_HUMAN

Protein

Single-stranded DNA cytosine deaminase

Gene

AICDA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.4 Publications

    Catalytic activityi

    Cytosine in single-stranded DNA + H2O = uracil in single-stranded DNA + NH3.

    Cofactori

    Zinc.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi56 – 561Zinc; catalyticBy similarity
    Active sitei58 – 581Proton donorBy similarity
    Metal bindingi87 – 871Zinc; catalyticBy similarity
    Metal bindingi90 – 901Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. cytidine deaminase activity Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. B cell differentiation Source: UniProtKB
    2. cellular response to lipopolysaccharide Source: Ensembl
    3. DNA demethylation Source: UniProtKB
    4. isotype switching Source: Ensembl
    5. mRNA processing Source: UniProtKB-KW
    6. negative regulation of methylation-dependent chromatin silencing Source: UniProtKB
    7. somatic diversification of immunoglobulins Source: UniProtKB
    8. somatic hypermutation of immunoglobulin genes Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    mRNA processing

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Single-stranded DNA cytosine deaminase (EC:3.5.4.38)
    Alternative name(s):
    Activation-induced cytidine deaminase
    Cytidine aminohydrolase
    Gene namesi
    Name:AICDA
    Synonyms:AID
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:13203. AICDA.

    Subcellular locationi

    Nucleus. Cytoplasm
    Note: Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Immunodeficiency with hyper-IgM 2 (HIGM2) [MIM:605258]: A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti24 – 241R → W in HIGM2; Completely abolishes nuclear import and interaction with CTNNBL1, diminishes interaction with KPNA1 and abolishes immunoglobulin class switching. 1 Publication
    VAR_013774
    Natural varianti80 – 801W → R in HIGM2. 1 Publication
    VAR_013775
    Natural varianti106 – 1061L → P in HIGM2. 1 Publication
    VAR_013776
    Natural varianti139 – 1391M → V in HIGM2. 1 Publication
    VAR_013777
    Natural varianti151 – 1511F → S in HIGM2. 1 Publication
    VAR_013778

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi10 – 101K → A: Little effect on nuclear import; when associated with A-193. No effect on CTNNBL1 binding. 1 Publication
    Mutagenesisi18 – 181V → S: Greatly impaired nuclear import; when associated with V-19 and A-193. Reduced interaction with both CTNNBL1 and KPNA1, and abolishes immunoglobulin class switching; when associated with V-19. 1 Publication
    Mutagenesisi19 – 191R → V: Greatly impaired nuclear import; when associated with S-18 and A-193. Reduced interaction with both CTNNBL1 and KPNA1, and abolishes immunoglobulin class switching; when associated with S-18. 1 Publication
    Mutagenesisi20 – 201W → K: Impaired nuclear import; when associated with A-193. No effect on CTNNBL1 binding. 1 Publication
    Mutagenesisi27 – 271T → A: Loss of phosphorylation. No effect on cytidine deaminase activity. Impaired class-switch recombination activity. 2 Publications
    Mutagenesisi27 – 271T → E: Phosphomimetic mutant which shows loss of cytidine deaminase activity and impaired class-switch recombination activity. 2 Publications
    Mutagenesisi38 – 381S → A: Loss of phosphorylation. Impaired class-switch recombination activity. No effect on interaction with CTNNBL1. 2 Publications
    Mutagenesisi38 – 381S → D: No effect on interaction with CTNNBL1. 2 Publications
    Mutagenesisi39 – 424ATSF → GGQV: Greatly reduced interaction with CTNNBL1 but no effect on subcellular location, enzyme activity, ability to oligomerize nor on phosphorylation at Ser-38. Diminished antibody diversification.
    Mutagenesisi50 – 501R → G: Some reduced nuclear import; when associated with A-193. 1 Publication
    Mutagenesisi112 – 1121R → D: Greatly reduced nuclear import; when associated with A-193. 1 Publication
    Mutagenesisi193 – 1931F → A: Completely abolishes nuclear import; when associated with W-24 or D-112. Little affect on nuclear import; when associated with A-10. Greatly impaired nuclear import; when associated with K-20 or G-50. Almost completely abolishes nuclear import; when associated with S-18 and V-19. 1 Publication

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi605258. phenotype.
    Orphaneti101089. Hyper-IgM syndrome type 2.
    PharmGKBiPA24644.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198Single-stranded DNA cytosine deaminasePRO_0000171687Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei27 – 271Phosphothreonine; by PKA1 Publication
    Modified residuei38 – 381Phosphoserine; by PKA2 Publications

    Post-translational modificationi

    Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity.2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9GZX7.
    PaxDbiQ9GZX7.
    PRIDEiQ9GZX7.

    PTM databases

    PhosphoSiteiQ9GZX7.

    Expressioni

    Tissue specificityi

    Strongly expressed in lymph nodes and tonsils.1 Publication

    Inductioni

    Negatively regulated by microRNA-155 (miR-155).1 Publication

    Gene expression databases

    ArrayExpressiQ9GZX7.
    BgeeiQ9GZX7.
    CleanExiHS_AICDA.
    GenevestigatoriQ9GZX7.

    Interactioni

    Subunit structurei

    Interacts with CTNNBL1; the interaction is important for the immunoglobulin switch activity of AICDA. Interacts (via its NLS) with KPNA1. Interacts with PKA/PRKACA and PRKAR1A/PKR1. Interacts with TRIM28 and NCL By similarity. Interacts with SUPT6H.By similarity4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DNAJA1P316896EBI-3834328,EBI-347834
    DNAJA2O608843EBI-3834328,EBI-352957
    GADD45AP245225EBI-3834328,EBI-448167
    HSPA8P111422EBI-3834328,EBI-351896
    TDGQ135695EBI-3834328,EBI-348333

    Protein-protein interaction databases

    BioGridi121497. 55 interactions.
    DIPiDIP-48519N.
    IntActiQ9GZX7. 23 interactions.
    MINTiMINT-4717382.
    STRINGi9606.ENSP00000229335.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GZX7.
    SMRiQ9GZX7. Positions 6-180.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 3030Nuclear localization signalAdd
    BLAST
    Regioni2 – 2625Interaction with SUPT6HAdd
    BLAST
    Regioni39 – 424Important for interaction with CTNNBL1
    Regioni183 – 19816Nuclear export signalAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG39659.
    HOGENOMiHOG000033754.
    HOVERGENiHBG050434.
    InParanoidiQ9GZX7.
    KOiK10989.
    OMAiIMTFKDY.
    OrthoDBiEOG708W0R.
    PhylomeDBiQ9GZX7.
    TreeFamiTF331356.

    Family and domain databases

    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR013158. APOBEC_N.
    IPR016193. Cytidine_deaminase-like.
    [Graphical view]
    PfamiPF08210. APOBEC_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF53927. SSF53927. 1 hit.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9GZX7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDSLLMNRRK FLYQFKNVRW AKGRRETYLC YVVKRRDSAT SFSLDFGYLR    50
    NKNGCHVELL FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVADFLRG 100
    NPNLSLRIFT ARLYFCEDRK AEPEGLRRLH RAGVQIAIMT FKDYFYCWNT 150
    FVENHERTFK AWEGLHENSV RLSRQLRRIL LPLYEVDDLR DAFRTLGL 198
    Length:198
    Mass (Da):23,954
    Last modified:March 1, 2001 - v1
    Checksum:i3C27BB143DB184A9
    GO
    Isoform 2 (identifier: Q9GZX7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         143-152: Missing.

    Show »
    Length:188
    Mass (Da):22,614
    Checksum:i02C20DFDA47793E3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti119 – 1191R → H in AAM95406. (PubMed:12202747)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti24 – 241R → W in HIGM2; Completely abolishes nuclear import and interaction with CTNNBL1, diminishes interaction with KPNA1 and abolishes immunoglobulin class switching. 1 Publication
    VAR_013774
    Natural varianti25 – 251R → C.1 Publication
    VAR_014091
    Natural varianti80 – 801W → R in HIGM2. 1 Publication
    VAR_013775
    Natural varianti106 – 1061L → P in HIGM2. 1 Publication
    VAR_013776
    Natural varianti139 – 1391M → V in HIGM2. 1 Publication
    VAR_013777
    Natural varianti151 – 1511F → S in HIGM2. 1 Publication
    VAR_013778

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei143 – 15210Missing in isoform 2. 1 PublicationVSP_047803

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB040431 mRNA. Translation: BAB12721.1.
    AB040430 Genomic DNA. Translation: BAB12720.1.
    AF529819 mRNA. Translation: AAM95406.1.
    AY536516 mRNA. Translation: AAS92920.1.
    BT007402 mRNA. Translation: AAP36066.1.
    AC092184 Genomic DNA. No translation available.
    BC006296 mRNA. Translation: AAH06296.1.
    CCDSiCCDS41747.1. [Q9GZX7-1]
    RefSeqiNP_065712.1. NM_020661.2. [Q9GZX7-1]
    UniGeneiHs.149342.

    Genome annotation databases

    EnsembliENST00000229335; ENSP00000229335; ENSG00000111732. [Q9GZX7-1]
    ENST00000537228; ENSP00000445691; ENSG00000111732. [Q9GZX7-2]
    GeneIDi57379.
    KEGGihsa:57379.
    UCSCiuc001qur.2. human. [Q9GZX7-1]

    Polymorphism databases

    DMDMi23813666.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    AICDAbase

    AICDA mutation db

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB040431 mRNA. Translation: BAB12721.1 .
    AB040430 Genomic DNA. Translation: BAB12720.1 .
    AF529819 mRNA. Translation: AAM95406.1 .
    AY536516 mRNA. Translation: AAS92920.1 .
    BT007402 mRNA. Translation: AAP36066.1 .
    AC092184 Genomic DNA. No translation available.
    BC006296 mRNA. Translation: AAH06296.1 .
    CCDSi CCDS41747.1. [Q9GZX7-1 ]
    RefSeqi NP_065712.1. NM_020661.2. [Q9GZX7-1 ]
    UniGenei Hs.149342.

    3D structure databases

    ProteinModelPortali Q9GZX7.
    SMRi Q9GZX7. Positions 6-180.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121497. 55 interactions.
    DIPi DIP-48519N.
    IntActi Q9GZX7. 23 interactions.
    MINTi MINT-4717382.
    STRINGi 9606.ENSP00000229335.

    PTM databases

    PhosphoSitei Q9GZX7.

    Polymorphism databases

    DMDMi 23813666.

    Proteomic databases

    MaxQBi Q9GZX7.
    PaxDbi Q9GZX7.
    PRIDEi Q9GZX7.

    Protocols and materials databases

    DNASUi 57379.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000229335 ; ENSP00000229335 ; ENSG00000111732 . [Q9GZX7-1 ]
    ENST00000537228 ; ENSP00000445691 ; ENSG00000111732 . [Q9GZX7-2 ]
    GeneIDi 57379.
    KEGGi hsa:57379.
    UCSCi uc001qur.2. human. [Q9GZX7-1 ]

    Organism-specific databases

    CTDi 57379.
    GeneCardsi GC12M008754.
    HGNCi HGNC:13203. AICDA.
    MIMi 605257. gene.
    605258. phenotype.
    neXtProti NX_Q9GZX7.
    Orphaneti 101089. Hyper-IgM syndrome type 2.
    PharmGKBi PA24644.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39659.
    HOGENOMi HOG000033754.
    HOVERGENi HBG050434.
    InParanoidi Q9GZX7.
    KOi K10989.
    OMAi IMTFKDY.
    OrthoDBi EOG708W0R.
    PhylomeDBi Q9GZX7.
    TreeFami TF331356.

    Miscellaneous databases

    GeneWikii AICDA.
    GenomeRNAii 57379.
    NextBioi 63478.
    PROi Q9GZX7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9GZX7.
    Bgeei Q9GZX7.
    CleanExi HS_AICDA.
    Genevestigatori Q9GZX7.

    Family and domain databases

    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR013158. APOBEC_N.
    IPR016193. Cytidine_deaminase-like.
    [Graphical view ]
    Pfami PF08210. APOBEC_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53927. SSF53927. 1 hit.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (hAID) gene."
      Muto T., Muramatsu M., Taniwaki M., Kinoshita K., Honjo T.
      Genomics 68:85-88(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANTS HIGM2 TRP-24; ARG-80; PRO-106; VAL-139 AND SER-151.
    3. "Somatic hypermutation of the AID transgene in B and non-B cells."
      Martin A., Scharff M.D.
      Proc. Natl. Acad. Sci. U.S.A. 99:12304-12308(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Intracellular localization of AID isoforms."
      Roa S., Gonzalez-Sarmiento R.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: B-cell.
    8. "Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1."
      Ito S., Nagaoka H., Shinkura R., Begum N., Muramatsu M., Nakata M., Honjo T.
      Proc. Natl. Acad. Sci. U.S.A. 101:1975-1980(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    9. "PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells."
      Pasqualucci L., Kitaura Y., Gu H., Dalla-Favera R.
      Proc. Natl. Acad. Sci. U.S.A. 103:395-400(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-27 AND SER-38, INTERACTION WITH PRKACA AND PRKAR1A, MUTAGENESIS OF THR-27 AND SER-38.
    10. "Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1."
      Conticello S.G., Ganesh K., Xue K., Lu M., Rada C., Neuberger M.S.
      Mol. Cell 31:474-484(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CTNNBL1, FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-38, IDENTIFICATION BY MASS SPECTROMETRY, MUTAGENESIS OF 39-ALA--PHE-42 AND SER-38.
    11. "Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain."
      Guo J.U., Su Y., Zhong C., Ming G.L., Song H.
      Cell 145:423-434(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN DNA DEMETHYLATION.
    12. "CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31."
      Ganesh K., Adam S., Taylor B., Simpson P., Rada C., Neuberger M.
      J. Biol. Chem. 286:17091-17102(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CTNNBL1, FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-10; VAL-18; ARG-19; TRP-20; ARG-50; ARG-112 AND PHE-193, CHARACTERIZATION OF VARIANT TRP-24.
    13. "Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein."
      Demorest Z.L., Li M., Harris R.S.
      J. Biol. Chem. 286:26568-26575(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF THR-27.
    14. Cited for: FUNCTION, INTERACTION WITH SUPT6H.
    15. "BCL6 positively regulates AID and germinal center gene expression via repression of miR-155."
      Basso K., Schneider C., Shen Q., Holmes A.B., Setty M., Leslie C., Dalla-Favera R.
      J. Exp. Med. 209:2455-2465(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    16. "Association between a new polymorphism in the activation-induced cytidine deaminase gene and atopic asthma and the regulation of total serum IgE levels."
      Noguchi E., Shibasaki M., Inudou M., Kamioka M., Yokouchi Y., Yamakawa-Kobayashi K., Hamaguchi H., Matsui A., Arinami T.
      J. Allergy Clin. Immunol. 108:382-386(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CYS-25.

    Entry informationi

    Entry nameiAICDA_HUMAN
    AccessioniPrimary (citable) accession number: Q9GZX7
    Secondary accession number(s): Q6QJ81, Q8NFC1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3