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Protein

Single-stranded DNA cytosine deaminase

Gene

AICDA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.4 Publications

Catalytic activityi

Cytosine in single-stranded DNA + H2O = uracil in single-stranded DNA + NH3.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi56 – 561Zinc; catalyticBy similarity
Active sitei58 – 581Proton donorBy similarity
Metal bindingi87 – 871Zinc; catalyticBy similarity
Metal bindingi90 – 901Zinc; catalyticBy similarity

GO - Molecular functioni

  1. cytidine deaminase activity Source: UniProtKB
  2. ubiquitin protein ligase binding Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. B cell differentiation Source: UniProtKB
  2. cellular response to lipopolysaccharide Source: Ensembl
  3. DNA demethylation Source: UniProtKB
  4. isotype switching Source: Ensembl
  5. mRNA processing Source: UniProtKB-KW
  6. negative regulation of methylation-dependent chromatin silencing Source: UniProtKB
  7. somatic diversification of immunoglobulins Source: UniProtKB
  8. somatic hypermutation of immunoglobulin genes Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Single-stranded DNA cytosine deaminase (EC:3.5.4.38)
Alternative name(s):
Activation-induced cytidine deaminase
Cytidine aminohydrolase
Gene namesi
Name:AICDA
Synonyms:AID
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:13203. AICDA.

Subcellular locationi

Nucleus. Cytoplasm
Note: Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency with hyper-IgM 21 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.

See also OMIM:605258
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241R → W in HIGM2; Completely abolishes nuclear import and interaction with CTNNBL1, diminishes interaction with KPNA1 and abolishes immunoglobulin class switching. 2 Publications
VAR_013774
Natural varianti80 – 801W → R in HIGM2. 1 Publication
VAR_013775
Natural varianti106 – 1061L → P in HIGM2. 1 Publication
VAR_013776
Natural varianti139 – 1391M → V in HIGM2. 1 Publication
VAR_013777
Natural varianti151 – 1511F → S in HIGM2. 1 Publication
VAR_013778

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi10 – 101K → A: Little effect on nuclear import; when associated with A-193. No effect on CTNNBL1 binding. 1 Publication
Mutagenesisi18 – 181V → S: Greatly impaired nuclear import; when associated with V-19 and A-193. Reduced interaction with both CTNNBL1 and KPNA1, and abolishes immunoglobulin class switching; when associated with V-19. 1 Publication
Mutagenesisi19 – 191R → V: Greatly impaired nuclear import; when associated with S-18 and A-193. Reduced interaction with both CTNNBL1 and KPNA1, and abolishes immunoglobulin class switching; when associated with S-18. 1 Publication
Mutagenesisi20 – 201W → K: Impaired nuclear import; when associated with A-193. No effect on CTNNBL1 binding. 1 Publication
Mutagenesisi27 – 271T → A: Loss of phosphorylation. No effect on cytidine deaminase activity. Impaired class-switch recombination activity. 2 Publications
Mutagenesisi27 – 271T → E: Phosphomimetic mutant which shows loss of cytidine deaminase activity and impaired class-switch recombination activity. 2 Publications
Mutagenesisi38 – 381S → A: Loss of phosphorylation. Impaired class-switch recombination activity. No effect on interaction with CTNNBL1. 2 Publications
Mutagenesisi38 – 381S → D: No effect on interaction with CTNNBL1. 2 Publications
Mutagenesisi39 – 424ATSF → GGQV: Greatly reduced interaction with CTNNBL1 but no effect on subcellular location, enzyme activity, ability to oligomerize nor on phosphorylation at Ser-38. Diminished antibody diversification. 1 Publication
Mutagenesisi50 – 501R → G: Some reduced nuclear import; when associated with A-193. 1 Publication
Mutagenesisi112 – 1121R → D: Greatly reduced nuclear import; when associated with A-193. 1 Publication
Mutagenesisi193 – 1931F → A: Completely abolishes nuclear import; when associated with W-24 or D-112. Little affect on nuclear import; when associated with A-10. Greatly impaired nuclear import; when associated with K-20 or G-50. Almost completely abolishes nuclear import; when associated with S-18 and V-19. 1 Publication

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi605258. phenotype.
Orphaneti101089. Hyper-IgM syndrome type 2.
PharmGKBiPA24644.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198Single-stranded DNA cytosine deaminasePRO_0000171687Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271Phosphothreonine; by PKA1 Publication
Modified residuei38 – 381Phosphoserine; by PKA2 Publications

Post-translational modificationi

Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity.2 Publications
Probably monoubiquitinated on several residues by RNF126.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9GZX7.
PaxDbiQ9GZX7.
PRIDEiQ9GZX7.

PTM databases

PhosphoSiteiQ9GZX7.

Expressioni

Tissue specificityi

Strongly expressed in lymph nodes and tonsils.1 Publication

Inductioni

Negatively regulated by microRNA-155 (miR-155).1 Publication

Gene expression databases

BgeeiQ9GZX7.
CleanExiHS_AICDA.
ExpressionAtlasiQ9GZX7. baseline and differential.
GenevestigatoriQ9GZX7.

Interactioni

Subunit structurei

Interacts with CTNNBL1; the interaction is important for the immunoglobulin switch activity of AICDA. Interacts (via its NLS) with KPNA1. Interacts with PKA/PRKACA and PRKAR1A/PKR1. Interacts with TRIM28 and NCL (By similarity). Interacts with SUPT6H. Interacts with RNF126.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DNAJA1P316896EBI-3834328,EBI-347834
DNAJA2O608843EBI-3834328,EBI-352957
GADD45AP245225EBI-3834328,EBI-448167
HSPA8P111422EBI-3834328,EBI-351896
TDGQ135695EBI-3834328,EBI-348333

Protein-protein interaction databases

BioGridi121497. 55 interactions.
DIPiDIP-48519N.
IntActiQ9GZX7. 23 interactions.
MINTiMINT-4717382.
STRINGi9606.ENSP00000229335.

Structurei

3D structure databases

ProteinModelPortaliQ9GZX7.
SMRiQ9GZX7. Positions 6-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 2625Interaction with SUPT6HAdd
BLAST
Regioni39 – 424Important for interaction with CTNNBL1
Regioni88 – 11629Required for interaction with RNF1261 PublicationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1 – 3030Nuclear localization signalAdd
BLAST
Motifi183 – 19816Nuclear export signalAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG39659.
GeneTreeiENSGT00530000062933.
HOGENOMiHOG000033754.
HOVERGENiHBG050434.
InParanoidiQ9GZX7.
KOiK10989.
OMAiIMTFKDY.
OrthoDBiEOG708W0R.
PhylomeDBiQ9GZX7.
TreeFamiTF331356.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR013158. APOBEC_N.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF08210. APOBEC_N. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9GZX7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSLLMNRRK FLYQFKNVRW AKGRRETYLC YVVKRRDSAT SFSLDFGYLR
60 70 80 90 100
NKNGCHVELL FLRYISDWDL DPGRCYRVTW FTSWSPCYDC ARHVADFLRG
110 120 130 140 150
NPNLSLRIFT ARLYFCEDRK AEPEGLRRLH RAGVQIAIMT FKDYFYCWNT
160 170 180 190
FVENHERTFK AWEGLHENSV RLSRQLRRIL LPLYEVDDLR DAFRTLGL
Length:198
Mass (Da):23,954
Last modified:March 1, 2001 - v1
Checksum:i3C27BB143DB184A9
GO
Isoform 2 (identifier: Q9GZX7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-152: Missing.

Show »
Length:188
Mass (Da):22,614
Checksum:i02C20DFDA47793E3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti119 – 1191R → H in AAM95406 (PubMed:12202747).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241R → W in HIGM2; Completely abolishes nuclear import and interaction with CTNNBL1, diminishes interaction with KPNA1 and abolishes immunoglobulin class switching. 2 Publications
VAR_013774
Natural varianti25 – 251R → C.1 Publication
VAR_014091
Natural varianti80 – 801W → R in HIGM2. 1 Publication
VAR_013775
Natural varianti106 – 1061L → P in HIGM2. 1 Publication
VAR_013776
Natural varianti139 – 1391M → V in HIGM2. 1 Publication
VAR_013777
Natural varianti151 – 1511F → S in HIGM2. 1 Publication
VAR_013778

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei143 – 15210Missing in isoform 2. 1 PublicationVSP_047803

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040431 mRNA. Translation: BAB12721.1.
AB040430 Genomic DNA. Translation: BAB12720.1.
AF529819 mRNA. Translation: AAM95406.1.
AY536516 mRNA. Translation: AAS92920.1.
BT007402 mRNA. Translation: AAP36066.1.
AC092184 Genomic DNA. No translation available.
BC006296 mRNA. Translation: AAH06296.1.
CCDSiCCDS41747.1. [Q9GZX7-1]
RefSeqiNP_065712.1. NM_020661.2. [Q9GZX7-1]
UniGeneiHs.149342.

Genome annotation databases

EnsembliENST00000229335; ENSP00000229335; ENSG00000111732. [Q9GZX7-1]
ENST00000537228; ENSP00000445691; ENSG00000111732. [Q9GZX7-2]
GeneIDi57379.
KEGGihsa:57379.
UCSCiuc001qup.1. human.
uc001qur.2. human. [Q9GZX7-1]

Polymorphism databases

DMDMi23813666.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

AICDAbase

AICDA mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040431 mRNA. Translation: BAB12721.1.
AB040430 Genomic DNA. Translation: BAB12720.1.
AF529819 mRNA. Translation: AAM95406.1.
AY536516 mRNA. Translation: AAS92920.1.
BT007402 mRNA. Translation: AAP36066.1.
AC092184 Genomic DNA. No translation available.
BC006296 mRNA. Translation: AAH06296.1.
CCDSiCCDS41747.1. [Q9GZX7-1]
RefSeqiNP_065712.1. NM_020661.2. [Q9GZX7-1]
UniGeneiHs.149342.

3D structure databases

ProteinModelPortaliQ9GZX7.
SMRiQ9GZX7. Positions 6-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121497. 55 interactions.
DIPiDIP-48519N.
IntActiQ9GZX7. 23 interactions.
MINTiMINT-4717382.
STRINGi9606.ENSP00000229335.

PTM databases

PhosphoSiteiQ9GZX7.

Polymorphism databases

DMDMi23813666.

Proteomic databases

MaxQBiQ9GZX7.
PaxDbiQ9GZX7.
PRIDEiQ9GZX7.

Protocols and materials databases

DNASUi57379.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229335; ENSP00000229335; ENSG00000111732. [Q9GZX7-1]
ENST00000537228; ENSP00000445691; ENSG00000111732. [Q9GZX7-2]
GeneIDi57379.
KEGGihsa:57379.
UCSCiuc001qup.1. human.
uc001qur.2. human. [Q9GZX7-1]

Organism-specific databases

CTDi57379.
GeneCardsiGC12M008754.
HGNCiHGNC:13203. AICDA.
MIMi605257. gene.
605258. phenotype.
neXtProtiNX_Q9GZX7.
Orphaneti101089. Hyper-IgM syndrome type 2.
PharmGKBiPA24644.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39659.
GeneTreeiENSGT00530000062933.
HOGENOMiHOG000033754.
HOVERGENiHBG050434.
InParanoidiQ9GZX7.
KOiK10989.
OMAiIMTFKDY.
OrthoDBiEOG708W0R.
PhylomeDBiQ9GZX7.
TreeFamiTF331356.

Miscellaneous databases

GeneWikiiAICDA.
GenomeRNAii57379.
NextBioi63478.
PROiQ9GZX7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9GZX7.
CleanExiHS_AICDA.
ExpressionAtlasiQ9GZX7. baseline and differential.
GenevestigatoriQ9GZX7.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR013158. APOBEC_N.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF08210. APOBEC_N. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (hAID) gene."
    Muto T., Muramatsu M., Taniwaki M., Kinoshita K., Honjo T.
    Genomics 68:85-88(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANTS HIGM2 TRP-24; ARG-80; PRO-106; VAL-139 AND SER-151.
  3. "Somatic hypermutation of the AID transgene in B and non-B cells."
    Martin A., Scharff M.D.
    Proc. Natl. Acad. Sci. U.S.A. 99:12304-12308(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Intracellular localization of AID isoforms."
    Roa S., Gonzalez-Sarmiento R.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: B-cell.
  8. "Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1."
    Ito S., Nagaoka H., Shinkura R., Begum N., Muramatsu M., Nakata M., Honjo T.
    Proc. Natl. Acad. Sci. U.S.A. 101:1975-1980(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. "PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells."
    Pasqualucci L., Kitaura Y., Gu H., Dalla-Favera R.
    Proc. Natl. Acad. Sci. U.S.A. 103:395-400(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-27 AND SER-38, INTERACTION WITH PRKACA AND PRKAR1A, MUTAGENESIS OF THR-27 AND SER-38.
  10. "Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1."
    Conticello S.G., Ganesh K., Xue K., Lu M., Rada C., Neuberger M.S.
    Mol. Cell 31:474-484(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CTNNBL1, FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-38, IDENTIFICATION BY MASS SPECTROMETRY, MUTAGENESIS OF 39-ALA--PHE-42 AND SER-38.
  11. "Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain."
    Guo J.U., Su Y., Zhong C., Ming G.L., Song H.
    Cell 145:423-434(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN DNA DEMETHYLATION.
  12. "CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31."
    Ganesh K., Adam S., Taylor B., Simpson P., Rada C., Neuberger M.
    J. Biol. Chem. 286:17091-17102(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CTNNBL1, FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-10; VAL-18; ARG-19; TRP-20; ARG-50; ARG-112 AND PHE-193, CHARACTERIZATION OF VARIANT TRP-24.
  13. "Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein."
    Demorest Z.L., Li M., Harris R.S.
    J. Biol. Chem. 286:26568-26575(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF THR-27.
  14. Cited for: FUNCTION, INTERACTION WITH SUPT6H.
  15. "BCL6 positively regulates AID and germinal center gene expression via repression of miR-155."
    Basso K., Schneider C., Shen Q., Holmes A.B., Setty M., Leslie C., Dalla-Favera R.
    J. Exp. Med. 209:2455-2465(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  16. "Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase."
    Delker R.K., Zhou Y., Strikoudis A., Stebbins C.E., Papavasiliou F.N.
    Proc. Natl. Acad. Sci. U.S.A. 110:1029-1034(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RNF126, UBIQUITINATION BY RNF126.
  17. "Association between a new polymorphism in the activation-induced cytidine deaminase gene and atopic asthma and the regulation of total serum IgE levels."
    Noguchi E., Shibasaki M., Inudou M., Kamioka M., Yokouchi Y., Yamakawa-Kobayashi K., Hamaguchi H., Matsui A., Arinami T.
    J. Allergy Clin. Immunol. 108:382-386(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT CYS-25.

Entry informationi

Entry nameiAICDA_HUMAN
AccessioniPrimary (citable) accession number: Q9GZX7
Secondary accession number(s): Q6QJ81, Q8NFC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2001
Last modified: February 4, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.