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Q9GZX6

- IL22_HUMAN

UniProt

Q9GZX6 - IL22_HUMAN

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Protein

Interleukin-22

Gene

IL22

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cytokine that contributes to the inflammatory response in vivo.

GO - Molecular functioni

  1. interleukin-22 receptor binding Source: UniProtKB

GO - Biological processi

  1. acute-phase response Source: UniProtKB
  2. cell-cell signaling Source: UniProtKB
  3. inflammatory response Source: UniProtKB
  4. response to glucocorticoid Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

SignaLinkiQ9GZX6.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-22
Short name:
IL-22
Alternative name(s):
Cytokine Zcyto18
IL-10-related T-cell-derived-inducible factor
Short name:
IL-TIF
Gene namesi
Name:IL22
Synonyms:ILTIF, ZCYTO18
ORF Names:UNQ3099/PRO10096
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:14900. IL22.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29822.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 33331 PublicationAdd
BLAST
Chaini34 – 179146Interleukin-22PRO_0000015383Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 1321 Publication
Glycosylationi54 – 541N-linked (GlcNAc...)1 Publication
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi89 ↔ 1781 Publication
Glycosylationi97 – 971N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZX6.
PRIDEiQ9GZX6.

Expressioni

Gene expression databases

BgeeiQ9GZX6.
CleanExiHS_IL22.
GenevestigatoriQ9GZX6.

Interactioni

Protein-protein interaction databases

BioGridi119096. 3 interactions.
DIPiDIP-46035N.
IntActiQ9GZX6. 2 interactions.
MINTiMINT-6693924.
STRINGi9606.ENSP00000329384.

Structurei

Secondary structure

1
179
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi44 – 474
Helixi50 – 6516
Beta strandi74 – 763
Helixi77 – 804
Helixi85 – 873
Helixi88 – 10215
Turni103 – 1097
Helixi114 – 12916
Helixi141 – 15515
Helixi157 – 1659
Helixi167 – 17812

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M4RX-ray2.00A/B29-179[»]
1YKBX-ray2.60A/B/C/D/E/F38-179[»]
3DGCX-ray2.50L/M39-179[»]
3DLQX-ray1.90I29-179[»]
3G9VX-ray2.76B/D29-179[»]
3Q1SX-ray2.15I29-179[»]
ProteinModelPortaliQ9GZX6.
SMRiQ9GZX6. Positions 38-179.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9GZX6.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42949.
GeneTreeiENSGT00510000048550.
HOGENOMiHOG000280686.
HOVERGENiHBG018572.
InParanoidiQ9GZX6.
KOiK05445.
OMAiYIRNRTY.
OrthoDBiEOG7J9VR1.
PhylomeDBiQ9GZX6.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020423. IL-10_CS.
IPR020453. IL-22.
[Graphical view]
PfamiPF14565. IL22. 1 hit.
[Graphical view]
PIRSFiPIRSF037726. Interleukin-22. 1 hit.
PRINTSiPR01936. INTRLEUKIN22.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GZX6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAALQKSVSS FLMGTLATSC LLLLALLVQG GAAAPISSHC RLDKSNFQQP
60 70 80 90 100
YITNRTFMLA KEASLADNNT DVRLIGEKLF HGVSMSERCY LMKQVLNFTL
110 120 130 140 150
EEVLFPQSDR FQPYMQEVVP FLARLSNRLS TCHIEGDDLH IQRNVQKLKD
160 170
TVKKLGESGE IKAIGELDLL FMSLRNACI
Length:179
Mass (Da):20,011
Last modified:March 1, 2001 - v1
Checksum:i3C35E64D60CF8767
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti158 – 1581S → G.1 Publication
Corresponds to variant rs2227507 [ dbSNP | Ensembl ].
VAR_013078

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ277247 mRNA. Translation: CAC06085.1.
AJ277248 Genomic DNA. Translation: CAC19409.1.
AF279437 mRNA. Translation: AAG22064.1.
AY358890 mRNA. Translation: AAQ89249.1.
AF387519 Genomic DNA. Translation: AAK62468.1.
BC066263 mRNA. Translation: AAH66263.1.
BC067510 mRNA. Translation: AAH67510.1.
BC069112 mRNA. Translation: AAH69112.1.
BC069308 mRNA. Translation: AAH69308.1.
BC070261 mRNA. Translation: AAH70261.1.
CCDSiCCDS8982.1.
RefSeqiNP_065386.1. NM_020525.4.
XP_005268986.1. XM_005268929.1.
UniGeneiHs.287369.

Genome annotation databases

EnsembliENST00000328087; ENSP00000329384; ENSG00000127318.
ENST00000538666; ENSP00000442424; ENSG00000127318.
GeneIDi50616.
KEGGihsa:50616.
UCSCiuc001sty.1. human.

Polymorphism databases

DMDMi17366814.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ277247 mRNA. Translation: CAC06085.1 .
AJ277248 Genomic DNA. Translation: CAC19409.1 .
AF279437 mRNA. Translation: AAG22064.1 .
AY358890 mRNA. Translation: AAQ89249.1 .
AF387519 Genomic DNA. Translation: AAK62468.1 .
BC066263 mRNA. Translation: AAH66263.1 .
BC067510 mRNA. Translation: AAH67510.1 .
BC069112 mRNA. Translation: AAH69112.1 .
BC069308 mRNA. Translation: AAH69308.1 .
BC070261 mRNA. Translation: AAH70261.1 .
CCDSi CCDS8982.1.
RefSeqi NP_065386.1. NM_020525.4.
XP_005268986.1. XM_005268929.1.
UniGenei Hs.287369.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1M4R X-ray 2.00 A/B 29-179 [» ]
1YKB X-ray 2.60 A/B/C/D/E/F 38-179 [» ]
3DGC X-ray 2.50 L/M 39-179 [» ]
3DLQ X-ray 1.90 I 29-179 [» ]
3G9V X-ray 2.76 B/D 29-179 [» ]
3Q1S X-ray 2.15 I 29-179 [» ]
ProteinModelPortali Q9GZX6.
SMRi Q9GZX6. Positions 38-179.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119096. 3 interactions.
DIPi DIP-46035N.
IntActi Q9GZX6. 2 interactions.
MINTi MINT-6693924.
STRINGi 9606.ENSP00000329384.

Polymorphism databases

DMDMi 17366814.

Proteomic databases

PaxDbi Q9GZX6.
PRIDEi Q9GZX6.

Protocols and materials databases

DNASUi 50616.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328087 ; ENSP00000329384 ; ENSG00000127318 .
ENST00000538666 ; ENSP00000442424 ; ENSG00000127318 .
GeneIDi 50616.
KEGGi hsa:50616.
UCSCi uc001sty.1. human.

Organism-specific databases

CTDi 50616.
GeneCardsi GC12M068642.
HGNCi HGNC:14900. IL22.
MIMi 605330. gene.
neXtProti NX_Q9GZX6.
PharmGKBi PA29822.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42949.
GeneTreei ENSGT00510000048550.
HOGENOMi HOG000280686.
HOVERGENi HBG018572.
InParanoidi Q9GZX6.
KOi K05445.
OMAi YIRNRTY.
OrthoDBi EOG7J9VR1.
PhylomeDBi Q9GZX6.
TreeFami TF333253.

Enzyme and pathway databases

SignaLinki Q9GZX6.

Miscellaneous databases

EvolutionaryTracei Q9GZX6.
GeneWikii Interleukin_22.
GenomeRNAii 50616.
NextBioi 53128.
PROi Q9GZX6.
SOURCEi Search...

Gene expression databases

Bgeei Q9GZX6.
CleanExi HS_IL22.
Genevestigatori Q9GZX6.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020423. IL-10_CS.
IPR020453. IL-22.
[Graphical view ]
Pfami PF14565. IL22. 1 hit.
[Graphical view ]
PIRSFi PIRSF037726. Interleukin-22. 1 hit.
PRINTSi PR01936. INTRLEUKIN22.
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00520. INTERLEUKIN_10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor."
    Dumoutier L., Van Roost E., Colau D., Renauld J.-C.
    Proc. Natl. Acad. Sci. U.S.A. 97:10144-10149(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes."
    Dumoutier L., Van Roost E., Colau D., Ameye G., Michaux L., Renauld J.-C.
    Genes Immun. 1:488-494(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R."
    Xie M.-H., Aggarwal S., Ho W.-H., Foster J., Zhang Z., Stinson J., Wood W.I., Goddard A.D., Gurney A.L.
    J. Biol. Chem. 275:31335-31339(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. SeattleSNPs variation discovery resource
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-158.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 34-48.
  8. "Crystallization and synchrotron X-ray diffraction studies of human interleukin-22."
    Nagem R.A., Lucchesi K.W., Colau D., Dumoutier L., Renauld J.-C., Polikarpov I.
    Acta Crystallogr. D 58:529-530(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 29-179.
  9. Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 38-179, GLYCOSYLATION AT ASN-54 AND ASN-97.
  10. "Structure of IL-22 bound to its high-affinity IL-22R1 chain."
    Jones B.C., Logsdon N.J., Walter M.R.
    Structure 16:1333-1344(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 39-179 IN COMPLEX WITH IL22RA1, DISULFIDE BONDS.

Entry informationi

Entry nameiIL22_HUMAN
AccessioniPrimary (citable) accession number: Q9GZX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3