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Protein

Interleukin-22

Gene

IL22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that contributes to the inflammatory response in vivo.

GO - Molecular functioni

  • interleukin-22 receptor binding Source: UniProtKB

GO - Biological processi

  • acute-phase response Source: UniProtKB
  • cell-cell signaling Source: UniProtKB
  • inflammatory response Source: UniProtKB
  • response to glucocorticoid Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

SignaLinkiQ9GZX6.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-22
Short name:
IL-22
Alternative name(s):
Cytokine Zcyto18
IL-10-related T-cell-derived-inducible factor
Short name:
IL-TIF
Gene namesi
Name:IL22
Synonyms:ILTIF, ZCYTO18
ORF Names:UNQ3099/PRO10096
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:14900. IL22.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29822.

Polymorphism and mutation databases

BioMutaiIL22.
DMDMi17366814.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 33331 PublicationAdd
BLAST
Chaini34 – 179146Interleukin-22PRO_0000015383Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 1321 Publication
Glycosylationi54 – 541N-linked (GlcNAc...)1 Publication
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi89 ↔ 1781 Publication
Glycosylationi97 – 971N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZX6.
PRIDEiQ9GZX6.

Expressioni

Gene expression databases

BgeeiQ9GZX6.
CleanExiHS_IL22.
GenevisibleiQ9GZX6. HS.

Interactioni

Protein-protein interaction databases

BioGridi119096. 3 interactions.
DIPiDIP-46035N.
IntActiQ9GZX6. 2 interactions.
MINTiMINT-6693924.
STRINGi9606.ENSP00000329384.

Structurei

Secondary structure

1
179
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi44 – 474Combined sources
Helixi50 – 6516Combined sources
Beta strandi74 – 763Combined sources
Helixi77 – 804Combined sources
Helixi85 – 873Combined sources
Helixi88 – 10215Combined sources
Turni103 – 1097Combined sources
Helixi114 – 12916Combined sources
Helixi141 – 15515Combined sources
Helixi157 – 1659Combined sources
Helixi167 – 17812Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M4RX-ray2.00A/B29-179[»]
1YKBX-ray2.60A/B/C/D/E/F38-179[»]
3DGCX-ray2.50L/M39-179[»]
3DLQX-ray1.90I29-179[»]
3G9VX-ray2.76B/D29-179[»]
3Q1SX-ray2.15I29-179[»]
ProteinModelPortaliQ9GZX6.
SMRiQ9GZX6. Positions 38-179.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9GZX6.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42949.
GeneTreeiENSGT00510000048550.
HOGENOMiHOG000280686.
HOVERGENiHBG018572.
InParanoidiQ9GZX6.
KOiK05445.
OMAiHIQKNVQ.
OrthoDBiEOG7J9VR1.
PhylomeDBiQ9GZX6.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020423. IL-10_CS.
IPR020453. IL-22.
[Graphical view]
PfamiPF14565. IL22. 1 hit.
[Graphical view]
PIRSFiPIRSF037726. Interleukin-22. 1 hit.
PRINTSiPR01936. INTRLEUKIN22.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GZX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALQKSVSS FLMGTLATSC LLLLALLVQG GAAAPISSHC RLDKSNFQQP
60 70 80 90 100
YITNRTFMLA KEASLADNNT DVRLIGEKLF HGVSMSERCY LMKQVLNFTL
110 120 130 140 150
EEVLFPQSDR FQPYMQEVVP FLARLSNRLS TCHIEGDDLH IQRNVQKLKD
160 170
TVKKLGESGE IKAIGELDLL FMSLRNACI
Length:179
Mass (Da):20,011
Last modified:March 1, 2001 - v1
Checksum:i3C35E64D60CF8767
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti158 – 1581S → G.1 Publication
Corresponds to variant rs2227507 [ dbSNP | Ensembl ].
VAR_013078

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277247 mRNA. Translation: CAC06085.1.
AJ277248 Genomic DNA. Translation: CAC19409.1.
AF279437 mRNA. Translation: AAG22064.1.
AY358890 mRNA. Translation: AAQ89249.1.
AF387519 Genomic DNA. Translation: AAK62468.1.
BC066263 mRNA. Translation: AAH66263.1.
BC067510 mRNA. Translation: AAH67510.1.
BC069112 mRNA. Translation: AAH69112.1.
BC069308 mRNA. Translation: AAH69308.1.
BC070261 mRNA. Translation: AAH70261.1.
CCDSiCCDS8982.1.
RefSeqiNP_065386.1. NM_020525.4.
UniGeneiHs.287369.

Genome annotation databases

EnsembliENST00000328087; ENSP00000329384; ENSG00000127318.
ENST00000538666; ENSP00000442424; ENSG00000127318.
GeneIDi50616.
KEGGihsa:50616.
UCSCiuc001sty.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277247 mRNA. Translation: CAC06085.1.
AJ277248 Genomic DNA. Translation: CAC19409.1.
AF279437 mRNA. Translation: AAG22064.1.
AY358890 mRNA. Translation: AAQ89249.1.
AF387519 Genomic DNA. Translation: AAK62468.1.
BC066263 mRNA. Translation: AAH66263.1.
BC067510 mRNA. Translation: AAH67510.1.
BC069112 mRNA. Translation: AAH69112.1.
BC069308 mRNA. Translation: AAH69308.1.
BC070261 mRNA. Translation: AAH70261.1.
CCDSiCCDS8982.1.
RefSeqiNP_065386.1. NM_020525.4.
UniGeneiHs.287369.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M4RX-ray2.00A/B29-179[»]
1YKBX-ray2.60A/B/C/D/E/F38-179[»]
3DGCX-ray2.50L/M39-179[»]
3DLQX-ray1.90I29-179[»]
3G9VX-ray2.76B/D29-179[»]
3Q1SX-ray2.15I29-179[»]
ProteinModelPortaliQ9GZX6.
SMRiQ9GZX6. Positions 38-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119096. 3 interactions.
DIPiDIP-46035N.
IntActiQ9GZX6. 2 interactions.
MINTiMINT-6693924.
STRINGi9606.ENSP00000329384.

Polymorphism and mutation databases

BioMutaiIL22.
DMDMi17366814.

Proteomic databases

PaxDbiQ9GZX6.
PRIDEiQ9GZX6.

Protocols and materials databases

DNASUi50616.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328087; ENSP00000329384; ENSG00000127318.
ENST00000538666; ENSP00000442424; ENSG00000127318.
GeneIDi50616.
KEGGihsa:50616.
UCSCiuc001sty.1. human.

Organism-specific databases

CTDi50616.
GeneCardsiGC12M068642.
HGNCiHGNC:14900. IL22.
MIMi605330. gene.
neXtProtiNX_Q9GZX6.
PharmGKBiPA29822.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG42949.
GeneTreeiENSGT00510000048550.
HOGENOMiHOG000280686.
HOVERGENiHBG018572.
InParanoidiQ9GZX6.
KOiK05445.
OMAiHIQKNVQ.
OrthoDBiEOG7J9VR1.
PhylomeDBiQ9GZX6.
TreeFamiTF333253.

Enzyme and pathway databases

SignaLinkiQ9GZX6.

Miscellaneous databases

EvolutionaryTraceiQ9GZX6.
GeneWikiiInterleukin_22.
GenomeRNAii50616.
NextBioi53128.
PROiQ9GZX6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9GZX6.
CleanExiHS_IL22.
GenevisibleiQ9GZX6. HS.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020423. IL-10_CS.
IPR020453. IL-22.
[Graphical view]
PfamiPF14565. IL22. 1 hit.
[Graphical view]
PIRSFiPIRSF037726. Interleukin-22. 1 hit.
PRINTSiPR01936. INTRLEUKIN22.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor."
    Dumoutier L., Van Roost E., Colau D., Renauld J.-C.
    Proc. Natl. Acad. Sci. U.S.A. 97:10144-10149(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes."
    Dumoutier L., Van Roost E., Colau D., Ameye G., Michaux L., Renauld J.-C.
    Genes Immun. 1:488-494(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R."
    Xie M.-H., Aggarwal S., Ho W.-H., Foster J., Zhang Z., Stinson J., Wood W.I., Goddard A.D., Gurney A.L.
    J. Biol. Chem. 275:31335-31339(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. SeattleSNPs variation discovery resource
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-158.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 34-48.
  8. "Crystallization and synchrotron X-ray diffraction studies of human interleukin-22."
    Nagem R.A., Lucchesi K.W., Colau D., Dumoutier L., Renauld J.-C., Polikarpov I.
    Acta Crystallogr. D 58:529-530(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 29-179.
  9. Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 38-179, GLYCOSYLATION AT ASN-54 AND ASN-97.
  10. "Structure of IL-22 bound to its high-affinity IL-22R1 chain."
    Jones B.C., Logsdon N.J., Walter M.R.
    Structure 16:1333-1344(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 39-179 IN COMPLEX WITH IL22RA1, DISULFIDE BONDS.

Entry informationi

Entry nameiIL22_HUMAN
AccessioniPrimary (citable) accession number: Q9GZX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: June 24, 2015
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.