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Q9GZX6

- IL22_HUMAN

UniProt

Q9GZX6 - IL22_HUMAN

Protein

Interleukin-22

Gene

IL22

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cytokine that contributes to the inflammatory response in vivo.

    GO - Molecular functioni

    1. interleukin-22 receptor binding Source: UniProtKB

    GO - Biological processi

    1. acute-phase response Source: UniProtKB
    2. cell-cell signaling Source: UniProtKB
    3. inflammatory response Source: UniProtKB
    4. response to glucocorticoid Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Enzyme and pathway databases

    SignaLinkiQ9GZX6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-22
    Short name:
    IL-22
    Alternative name(s):
    Cytokine Zcyto18
    IL-10-related T-cell-derived-inducible factor
    Short name:
    IL-TIF
    Gene namesi
    Name:IL22
    Synonyms:ILTIF, ZCYTO18
    ORF Names:UNQ3099/PRO10096
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:14900. IL22.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29822.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 33331 PublicationAdd
    BLAST
    Chaini34 – 179146Interleukin-22PRO_0000015383Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi40 ↔ 1321 Publication
    Glycosylationi54 – 541N-linked (GlcNAc...)1 Publication
    Glycosylationi68 – 681N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi89 ↔ 1781 Publication
    Glycosylationi97 – 971N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9GZX6.
    PRIDEiQ9GZX6.

    Expressioni

    Gene expression databases

    BgeeiQ9GZX6.
    CleanExiHS_IL22.
    GenevestigatoriQ9GZX6.

    Interactioni

    Protein-protein interaction databases

    BioGridi119096. 3 interactions.
    DIPiDIP-46035N.
    IntActiQ9GZX6. 2 interactions.
    MINTiMINT-6693924.
    STRINGi9606.ENSP00000329384.

    Structurei

    Secondary structure

    1
    179
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi44 – 474
    Helixi50 – 6516
    Beta strandi74 – 763
    Helixi77 – 804
    Helixi85 – 873
    Helixi88 – 10215
    Turni103 – 1097
    Helixi114 – 12916
    Helixi141 – 15515
    Helixi157 – 1659
    Helixi167 – 17812

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1M4RX-ray2.00A/B29-179[»]
    1YKBX-ray2.60A/B/C/D/E/F38-179[»]
    3DGCX-ray2.50L/M39-179[»]
    3DLQX-ray1.90I29-179[»]
    3G9VX-ray2.76B/D29-179[»]
    3Q1SX-ray2.15I29-179[»]
    ProteinModelPortaliQ9GZX6.
    SMRiQ9GZX6. Positions 38-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9GZX6.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42949.
    HOGENOMiHOG000280686.
    HOVERGENiHBG018572.
    InParanoidiQ9GZX6.
    KOiK05445.
    OMAiYIRNRTY.
    OrthoDBiEOG7J9VR1.
    PhylomeDBiQ9GZX6.
    TreeFamiTF333253.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR020423. IL-10_CS.
    IPR020453. IL-22.
    [Graphical view]
    PfamiPF14565. IL22. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037726. Interleukin-22. 1 hit.
    PRINTSiPR01936. INTRLEUKIN22.
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9GZX6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAALQKSVSS FLMGTLATSC LLLLALLVQG GAAAPISSHC RLDKSNFQQP    50
    YITNRTFMLA KEASLADNNT DVRLIGEKLF HGVSMSERCY LMKQVLNFTL 100
    EEVLFPQSDR FQPYMQEVVP FLARLSNRLS TCHIEGDDLH IQRNVQKLKD 150
    TVKKLGESGE IKAIGELDLL FMSLRNACI 179
    Length:179
    Mass (Da):20,011
    Last modified:March 1, 2001 - v1
    Checksum:i3C35E64D60CF8767
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti158 – 1581S → G.1 Publication
    Corresponds to variant rs2227507 [ dbSNP | Ensembl ].
    VAR_013078

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ277247 mRNA. Translation: CAC06085.1.
    AJ277248 Genomic DNA. Translation: CAC19409.1.
    AF279437 mRNA. Translation: AAG22064.1.
    AY358890 mRNA. Translation: AAQ89249.1.
    AF387519 Genomic DNA. Translation: AAK62468.1.
    BC066263 mRNA. Translation: AAH66263.1.
    BC067510 mRNA. Translation: AAH67510.1.
    BC069112 mRNA. Translation: AAH69112.1.
    BC069308 mRNA. Translation: AAH69308.1.
    BC070261 mRNA. Translation: AAH70261.1.
    CCDSiCCDS8982.1.
    RefSeqiNP_065386.1. NM_020525.4.
    XP_005268986.1. XM_005268929.1.
    UniGeneiHs.287369.

    Genome annotation databases

    EnsembliENST00000328087; ENSP00000329384; ENSG00000127318.
    ENST00000538666; ENSP00000442424; ENSG00000127318.
    GeneIDi50616.
    KEGGihsa:50616.
    UCSCiuc001sty.1. human.

    Polymorphism databases

    DMDMi17366814.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs
    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ277247 mRNA. Translation: CAC06085.1 .
    AJ277248 Genomic DNA. Translation: CAC19409.1 .
    AF279437 mRNA. Translation: AAG22064.1 .
    AY358890 mRNA. Translation: AAQ89249.1 .
    AF387519 Genomic DNA. Translation: AAK62468.1 .
    BC066263 mRNA. Translation: AAH66263.1 .
    BC067510 mRNA. Translation: AAH67510.1 .
    BC069112 mRNA. Translation: AAH69112.1 .
    BC069308 mRNA. Translation: AAH69308.1 .
    BC070261 mRNA. Translation: AAH70261.1 .
    CCDSi CCDS8982.1.
    RefSeqi NP_065386.1. NM_020525.4.
    XP_005268986.1. XM_005268929.1.
    UniGenei Hs.287369.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1M4R X-ray 2.00 A/B 29-179 [» ]
    1YKB X-ray 2.60 A/B/C/D/E/F 38-179 [» ]
    3DGC X-ray 2.50 L/M 39-179 [» ]
    3DLQ X-ray 1.90 I 29-179 [» ]
    3G9V X-ray 2.76 B/D 29-179 [» ]
    3Q1S X-ray 2.15 I 29-179 [» ]
    ProteinModelPortali Q9GZX6.
    SMRi Q9GZX6. Positions 38-179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119096. 3 interactions.
    DIPi DIP-46035N.
    IntActi Q9GZX6. 2 interactions.
    MINTi MINT-6693924.
    STRINGi 9606.ENSP00000329384.

    Polymorphism databases

    DMDMi 17366814.

    Proteomic databases

    PaxDbi Q9GZX6.
    PRIDEi Q9GZX6.

    Protocols and materials databases

    DNASUi 50616.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328087 ; ENSP00000329384 ; ENSG00000127318 .
    ENST00000538666 ; ENSP00000442424 ; ENSG00000127318 .
    GeneIDi 50616.
    KEGGi hsa:50616.
    UCSCi uc001sty.1. human.

    Organism-specific databases

    CTDi 50616.
    GeneCardsi GC12M068642.
    HGNCi HGNC:14900. IL22.
    MIMi 605330. gene.
    neXtProti NX_Q9GZX6.
    PharmGKBi PA29822.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42949.
    HOGENOMi HOG000280686.
    HOVERGENi HBG018572.
    InParanoidi Q9GZX6.
    KOi K05445.
    OMAi YIRNRTY.
    OrthoDBi EOG7J9VR1.
    PhylomeDBi Q9GZX6.
    TreeFami TF333253.

    Enzyme and pathway databases

    SignaLinki Q9GZX6.

    Miscellaneous databases

    EvolutionaryTracei Q9GZX6.
    GeneWikii Interleukin_22.
    GenomeRNAii 50616.
    NextBioi 53128.
    PROi Q9GZX6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9GZX6.
    CleanExi HS_IL22.
    Genevestigatori Q9GZX6.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR020423. IL-10_CS.
    IPR020453. IL-22.
    [Graphical view ]
    Pfami PF14565. IL22. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037726. Interleukin-22. 1 hit.
    PRINTSi PR01936. INTRLEUKIN22.
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00520. INTERLEUKIN_10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor."
      Dumoutier L., Van Roost E., Colau D., Renauld J.-C.
      Proc. Natl. Acad. Sci. U.S.A. 97:10144-10149(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes."
      Dumoutier L., Van Roost E., Colau D., Ameye G., Michaux L., Renauld J.-C.
      Genes Immun. 1:488-494(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R."
      Xie M.-H., Aggarwal S., Ho W.-H., Foster J., Zhang Z., Stinson J., Wood W.I., Goddard A.D., Gurney A.L.
      J. Biol. Chem. 275:31335-31339(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. SeattleSNPs variation discovery resource
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-158.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood.
    7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 34-48.
    8. "Crystallization and synchrotron X-ray diffraction studies of human interleukin-22."
      Nagem R.A., Lucchesi K.W., Colau D., Dumoutier L., Renauld J.-C., Polikarpov I.
      Acta Crystallogr. D 58:529-530(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 29-179.
    9. Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 38-179, GLYCOSYLATION AT ASN-54 AND ASN-97.
    10. "Structure of IL-22 bound to its high-affinity IL-22R1 chain."
      Jones B.C., Logsdon N.J., Walter M.R.
      Structure 16:1333-1344(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 39-179 IN COMPLEX WITH IL22RA1, DISULFIDE BONDS.

    Entry informationi

    Entry nameiIL22_HUMAN
    AccessioniPrimary (citable) accession number: Q9GZX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3