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Protein

Interleukin-22

Gene

IL22

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that contributes to the inflammatory response in vivo.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • interleukin-22 receptor binding Source: UniProtKB

GO - Biological processi

  • acute-phase response Source: UniProtKB
  • cell-cell signaling Source: UniProtKB
  • immune response Source: GO_Central
  • inflammatory response Source: UniProtKB
  • positive regulation of JAK-STAT cascade Source: GO_Central
  • response to glucocorticoid Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127318-MONOMER.
ReactomeiR-HSA-8854691. Interleukin-19, 20, 22, 24.
SignaLinkiQ9GZX6.
SIGNORiQ9GZX6.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-22
Short name:
IL-22
Alternative name(s):
Cytokine Zcyto18
IL-10-related T-cell-derived-inducible factor
Short name:
IL-TIF
Gene namesi
Name:IL22
Synonyms:ILTIF, ZCYTO18
ORF Names:UNQ3099/PRO10096
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:14900. IL22.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi50616.
OpenTargetsiENSG00000127318.
PharmGKBiPA29822.

Polymorphism and mutation databases

BioMutaiIL22.
DMDMi17366814.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 331 PublicationAdd BLAST33
ChainiPRO_000001538334 – 179Interleukin-22Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 1321 Publication
Glycosylationi54N-linked (GlcNAc...)1 Publication1
Glycosylationi68N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi89 ↔ 1781 Publication
Glycosylationi97N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZX6.
PeptideAtlasiQ9GZX6.
PRIDEiQ9GZX6.

PTM databases

iPTMnetiQ9GZX6.
PhosphoSitePlusiQ9GZX6.

Expressioni

Gene expression databases

BgeeiENSG00000127318.
CleanExiHS_IL22.
GenevisibleiQ9GZX6. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IL22RA1Q8N6P76EBI-8040250,EBI-3940749

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • interleukin-22 receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119096. 3 interactors.
DIPiDIP-46035N.
IntActiQ9GZX6. 3 interactors.
MINTiMINT-6693924.
STRINGi9606.ENSP00000329384.

Structurei

Secondary structure

1179
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi44 – 47Combined sources4
Helixi50 – 65Combined sources16
Beta strandi74 – 76Combined sources3
Helixi77 – 80Combined sources4
Helixi85 – 87Combined sources3
Helixi88 – 102Combined sources15
Turni103 – 109Combined sources7
Helixi114 – 129Combined sources16
Helixi141 – 155Combined sources15
Helixi157 – 165Combined sources9
Helixi167 – 178Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M4RX-ray2.00A/B29-179[»]
1YKBX-ray2.60A/B/C/D/E/F38-179[»]
3DGCX-ray2.50L/M39-179[»]
3DLQX-ray1.90I29-179[»]
3G9VX-ray2.76B/D29-179[»]
3Q1SX-ray2.15I29-179[»]
ProteinModelPortaliQ9GZX6.
SMRiQ9GZX6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9GZX6.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IV9D. Eukaryota.
ENOG4112217. LUCA.
GeneTreeiENSGT00510000048550.
HOGENOMiHOG000280686.
HOVERGENiHBG018572.
InParanoidiQ9GZX6.
KOiK05445.
OMAiHIQKNVQ.
OrthoDBiEOG091G0MJW.
PhylomeDBiQ9GZX6.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
IPR020453. IL-22.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF14565. IL22. 1 hit.
[Graphical view]
PIRSFiPIRSF037726. Interleukin-22. 1 hit.
PRINTSiPR01936. INTRLEUKIN22.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GZX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALQKSVSS FLMGTLATSC LLLLALLVQG GAAAPISSHC RLDKSNFQQP
60 70 80 90 100
YITNRTFMLA KEASLADNNT DVRLIGEKLF HGVSMSERCY LMKQVLNFTL
110 120 130 140 150
EEVLFPQSDR FQPYMQEVVP FLARLSNRLS TCHIEGDDLH IQRNVQKLKD
160 170
TVKKLGESGE IKAIGELDLL FMSLRNACI
Length:179
Mass (Da):20,011
Last modified:March 1, 2001 - v1
Checksum:i3C35E64D60CF8767
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013078158S → G.1 PublicationCorresponds to variant rs2227507dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277247 mRNA. Translation: CAC06085.1.
AJ277248 Genomic DNA. Translation: CAC19409.1.
AF279437 mRNA. Translation: AAG22064.1.
AY358890 mRNA. Translation: AAQ89249.1.
AF387519 Genomic DNA. Translation: AAK62468.1.
BC066263 mRNA. Translation: AAH66263.1.
BC067510 mRNA. Translation: AAH67510.1.
BC069112 mRNA. Translation: AAH69112.1.
BC069308 mRNA. Translation: AAH69308.1.
BC070261 mRNA. Translation: AAH70261.1.
CCDSiCCDS8982.1.
RefSeqiNP_065386.1. NM_020525.4.
UniGeneiHs.287369.

Genome annotation databases

EnsembliENST00000328087; ENSP00000329384; ENSG00000127318.
ENST00000538666; ENSP00000442424; ENSG00000127318.
GeneIDi50616.
KEGGihsa:50616.
UCSCiuc001sty.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs
Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277247 mRNA. Translation: CAC06085.1.
AJ277248 Genomic DNA. Translation: CAC19409.1.
AF279437 mRNA. Translation: AAG22064.1.
AY358890 mRNA. Translation: AAQ89249.1.
AF387519 Genomic DNA. Translation: AAK62468.1.
BC066263 mRNA. Translation: AAH66263.1.
BC067510 mRNA. Translation: AAH67510.1.
BC069112 mRNA. Translation: AAH69112.1.
BC069308 mRNA. Translation: AAH69308.1.
BC070261 mRNA. Translation: AAH70261.1.
CCDSiCCDS8982.1.
RefSeqiNP_065386.1. NM_020525.4.
UniGeneiHs.287369.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M4RX-ray2.00A/B29-179[»]
1YKBX-ray2.60A/B/C/D/E/F38-179[»]
3DGCX-ray2.50L/M39-179[»]
3DLQX-ray1.90I29-179[»]
3G9VX-ray2.76B/D29-179[»]
3Q1SX-ray2.15I29-179[»]
ProteinModelPortaliQ9GZX6.
SMRiQ9GZX6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119096. 3 interactors.
DIPiDIP-46035N.
IntActiQ9GZX6. 3 interactors.
MINTiMINT-6693924.
STRINGi9606.ENSP00000329384.

PTM databases

iPTMnetiQ9GZX6.
PhosphoSitePlusiQ9GZX6.

Polymorphism and mutation databases

BioMutaiIL22.
DMDMi17366814.

Proteomic databases

PaxDbiQ9GZX6.
PeptideAtlasiQ9GZX6.
PRIDEiQ9GZX6.

Protocols and materials databases

DNASUi50616.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328087; ENSP00000329384; ENSG00000127318.
ENST00000538666; ENSP00000442424; ENSG00000127318.
GeneIDi50616.
KEGGihsa:50616.
UCSCiuc001sty.2. human.

Organism-specific databases

CTDi50616.
DisGeNETi50616.
GeneCardsiIL22.
HGNCiHGNC:14900. IL22.
MIMi605330. gene.
neXtProtiNX_Q9GZX6.
OpenTargetsiENSG00000127318.
PharmGKBiPA29822.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IV9D. Eukaryota.
ENOG4112217. LUCA.
GeneTreeiENSGT00510000048550.
HOGENOMiHOG000280686.
HOVERGENiHBG018572.
InParanoidiQ9GZX6.
KOiK05445.
OMAiHIQKNVQ.
OrthoDBiEOG091G0MJW.
PhylomeDBiQ9GZX6.
TreeFamiTF333253.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000127318-MONOMER.
ReactomeiR-HSA-8854691. Interleukin-19, 20, 22, 24.
SignaLinkiQ9GZX6.
SIGNORiQ9GZX6.

Miscellaneous databases

EvolutionaryTraceiQ9GZX6.
GeneWikiiInterleukin_22.
GenomeRNAii50616.
PROiQ9GZX6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127318.
CleanExiHS_IL22.
GenevisibleiQ9GZX6. HS.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
IPR020453. IL-22.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PfamiPF14565. IL22. 1 hit.
[Graphical view]
PIRSFiPIRSF037726. Interleukin-22. 1 hit.
PRINTSiPR01936. INTRLEUKIN22.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL22_HUMAN
AccessioniPrimary (citable) accession number: Q9GZX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.