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Q9GZX6 (IL22_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-22

Short name=IL-22
Alternative name(s):
Cytokine Zcyto18
IL-10-related T-cell-derived-inducible factor
Short name=IL-TIF
Gene names
Name:IL22
Synonyms:ILTIF, ZCYTO18
ORF Names:UNQ3099/PRO10096
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length179 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytokine that contributes to the inflammatory response in vivo.

Subcellular location

Secreted.

Sequence similarities

Belongs to the IL-10 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333 Ref.7
Chain34 – 179146Interleukin-22
PRO_0000015383

Amino acid modifications

Glycosylation541N-linked (GlcNAc...) Ref.9
Glycosylation681N-linked (GlcNAc...) Potential
Glycosylation971N-linked (GlcNAc...) Ref.9
Disulfide bond40 ↔ 132 Ref.10
Disulfide bond89 ↔ 178 Ref.10

Natural variations

Natural variant1581S → G. Ref.5
Corresponds to variant rs2227507 [ dbSNP | Ensembl ].
VAR_013078

Secondary structure

.................... 179
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9GZX6 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 3C35E64D60CF8767

FASTA17920,011
        10         20         30         40         50         60 
MAALQKSVSS FLMGTLATSC LLLLALLVQG GAAAPISSHC RLDKSNFQQP YITNRTFMLA 

        70         80         90        100        110        120 
KEASLADNNT DVRLIGEKLF HGVSMSERCY LMKQVLNFTL EEVLFPQSDR FQPYMQEVVP 

       130        140        150        160        170 
FLARLSNRLS TCHIEGDDLH IQRNVQKLKD TVKKLGESGE IKAIGELDLL FMSLRNACI 

« Hide

References

« Hide 'large scale' references
[1]"Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor."
Dumoutier L., Van Roost E., Colau D., Renauld J.-C.
Proc. Natl. Acad. Sci. U.S.A. 97:10144-10149(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes."
Dumoutier L., Van Roost E., Colau D., Ameye G., Michaux L., Renauld J.-C.
Genes Immun. 1:488-494(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R."
Xie M.-H., Aggarwal S., Ho W.-H., Foster J., Zhang Z., Stinson J., Wood W.I., Goddard A.D., Gurney A.L.
J. Biol. Chem. 275:31335-31339(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]SeattleSNPs variation discovery resource
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-158.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Blood.
[7]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 34-48.
[8]"Crystallization and synchrotron X-ray diffraction studies of human interleukin-22."
Nagem R.A., Lucchesi K.W., Colau D., Dumoutier L., Renauld J.-C., Polikarpov I.
Acta Crystallogr. D 58:529-530(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 29-179.
[9]"Structure of insect-cell-derived IL-22."
Xu T., Logsdon N.J., Walter M.R.
Acta Crystallogr. D 61:942-950(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 38-179, GLYCOSYLATION AT ASN-54 AND ASN-97.
[10]"Structure of IL-22 bound to its high-affinity IL-22R1 chain."
Jones B.C., Logsdon N.J., Walter M.R.
Structure 16:1333-1344(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 39-179 IN COMPLEX WITH IL22RA1, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ277247 mRNA. Translation: CAC06085.1.
AJ277248 Genomic DNA. Translation: CAC19409.1.
AF279437 mRNA. Translation: AAG22064.1.
AY358890 mRNA. Translation: AAQ89249.1.
AF387519 Genomic DNA. Translation: AAK62468.1.
BC066263 mRNA. Translation: AAH66263.1.
BC067510 mRNA. Translation: AAH67510.1.
BC069112 mRNA. Translation: AAH69112.1.
BC069308 mRNA. Translation: AAH69308.1.
BC070261 mRNA. Translation: AAH70261.1.
RefSeqNP_065386.1. NM_020525.4.
XP_005268986.1. XM_005268929.1.
UniGeneHs.287369.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1M4RX-ray2.00A/B29-179[»]
1YKBX-ray2.60A/B/C/D/E/F38-179[»]
3DGCX-ray2.50L/M39-179[»]
3DLQX-ray1.90I29-179[»]
3G9VX-ray2.76B/D29-179[»]
3Q1SX-ray2.15I29-179[»]
ProteinModelPortalQ9GZX6.
SMRQ9GZX6. Positions 38-179.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119096. 3 interactions.
DIPDIP-46035N.
IntActQ9GZX6. 2 interactions.
MINTMINT-6693924.
STRING9606.ENSP00000329384.

Polymorphism databases

DMDM17366814.

Proteomic databases

PaxDbQ9GZX6.
PRIDEQ9GZX6.

Protocols and materials databases

DNASU50616.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328087; ENSP00000329384; ENSG00000127318.
ENST00000538666; ENSP00000442424; ENSG00000127318.
GeneID50616.
KEGGhsa:50616.
UCSCuc001sty.1. human.

Organism-specific databases

CTD50616.
GeneCardsGC12M068642.
HGNCHGNC:14900. IL22.
MIM605330. gene.
neXtProtNX_Q9GZX6.
PharmGKBPA29822.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42949.
HOGENOMHOG000280686.
HOVERGENHBG018572.
InParanoidQ9GZX6.
KOK05445.
OMAIEGDDQH.
OrthoDBEOG7J9VR1.
PhylomeDBQ9GZX6.
TreeFamTF333253.

Enzyme and pathway databases

SignaLinkQ9GZX6.

Gene expression databases

BgeeQ9GZX6.
CleanExHS_IL22.
GenevestigatorQ9GZX6.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020423. IL-10_CS.
IPR020453. IL-22.
[Graphical view]
PIRSFPIRSF037726. Interleukin-22. 1 hit.
PRINTSPR01936. INTRLEUKIN22.
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9GZX6.
GeneWikiInterleukin_22.
GenomeRNAi50616.
NextBio53128.
PROQ9GZX6.
SOURCESearch...

Entry information

Entry nameIL22_HUMAN
AccessionPrimary (citable) accession number: Q9GZX6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM