SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9GZX5

- ZN350_HUMAN

UniProt

Q9GZX5 - ZN350_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Zinc finger protein 350

Gene
ZNF350, ZBRK1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri206 – 22823C2H2-type 1Add
BLAST
Zinc fingeri234 – 25623C2H2-type 2Add
BLAST
Zinc fingeri262 – 28423C2H2-type 3Add
BLAST
Zinc fingeri290 – 31223C2H2-type 4Add
BLAST
Zinc fingeri318 – 34023C2H2-type 5Add
BLAST
Zinc fingeri346 – 36823C2H2-type 6Add
BLAST
Zinc fingeri374 – 39623C2H2-type 7Add
BLAST
Zinc fingeri402 – 42423C2H2-type 8Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: IntAct

GO - Biological processi

  1. negative regulation of transcription, DNA-templated Source: UniProtKB
  2. regulation of transcription, DNA-templated Source: UniProtKB
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 350
Alternative name(s):
KRAB zinc finger protein ZFQR
Zinc finger and BRCA1-interacting protein with a KRAB domain 1
Zinc finger protein ZBRK1
Gene namesi
Name:ZNF350
Synonyms:ZBRK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:16656. ZNF350.

Subcellular locationi

Nucleus. Nucleus matrix
Note: Associated with the nuclear matrix.2 Publications

GO - Cellular componenti

  1. nuclear matrix Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB
  3. transcriptional repressor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134972827.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Zinc finger protein 350PRO_0000047546Add
BLAST

Proteomic databases

MaxQBiQ9GZX5.
PaxDbiQ9GZX5.
PRIDEiQ9GZX5.

PTM databases

PhosphoSiteiQ9GZX5.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

ArrayExpressiQ9GZX5.
BgeeiQ9GZX5.
CleanExiHS_ZNF350.
GenevestigatoriQ9GZX5.

Organism-specific databases

HPAiHPA001521.

Interactioni

Subunit structurei

Interacts with BRCA1. Interacts with RNF11.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BRCA1P383983EBI-396421,EBI-349905

Protein-protein interaction databases

BioGridi121889. 7 interactions.
IntActiQ9GZX5. 5 interactions.
MINTiMINT-1198135.
STRINGi9606.ENSP00000365906.

Structurei

3D structure databases

ProteinModelPortaliQ9GZX5.
SMRiQ9GZX5. Positions 8-49, 154-457.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABAdd
BLAST

Sequence similaritiesi

Contains 1 KRAB domain.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri206 – 22823C2H2-type 1Add
BLAST
Zinc fingeri234 – 25623C2H2-type 2Add
BLAST
Zinc fingeri262 – 28423C2H2-type 3Add
BLAST
Zinc fingeri290 – 31223C2H2-type 4Add
BLAST
Zinc fingeri318 – 34023C2H2-type 5Add
BLAST
Zinc fingeri346 – 36823C2H2-type 6Add
BLAST
Zinc fingeri374 – 39623C2H2-type 7Add
BLAST
Zinc fingeri402 – 42423C2H2-type 8Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9GZX5.
KOiK09228.
OMAiLTDHQII.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9GZX5.
TreeFamiTF340593.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GZX5-1 [UniParc]FASTAAdd to Basket

« Hide

MIQAQESITL EDVAVDFTWE EWQLLGAAQK DLYRDVMLEN YSNLVAVGYQ    50
ASKPDALFKL EQGEQLWTIE DGIHSGACSD IWKVDHVLER LQSESLVNRR 100
KPCHEHDAFE NIVHCSKSQF LLGQNHDIFD LRGKSLKSNL TLVNQSKGYE 150
IKNSVEFTGN GDSFLHANHE RLHTAIKFPA SQKLISTKSQ FISPKHQKTR 200
KLEKHHVCSE CGKAFIKKSW LTDHQVMHTG EKPHRCSLCE KAFSRKFMLT 250
EHQRTHTGEK PYECPECGKA FLKKSRLNIH QKTHTGEKPY ICSECGKGFI 300
QKGNLIVHQR IHTGEKPYIC NECGKGFIQK TCLIAHQRFH TGKTPFVCSE 350
CGKSCSQKSG LIKHQRIHTG EKPFECSECG KAFSTKQKLI VHQRTHTGER 400
PYGCNECGKA FAYMSCLVKH KRIHTREKQE AAKVENPPAE RHSSLHTSDV 450
MQEKNSANGA TTQVPSVAPQ TSLNISGLLA NRNVVLVGQP VVRCAASGDN 500
RGFAQDRNLV NAVNVVVPSV INYVLFYVTE NP 532
Length:532
Mass (Da):60,011
Last modified:November 30, 2010 - v3
Checksum:iFEF12A92F95BAC8A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371M → I.
Corresponds to variant rs4987241 [ dbSNP | Ensembl ].
VAR_046718
Natural varianti66 – 661L → P.3 Publications
Corresponds to variant rs2278420 [ dbSNP | Ensembl ].
VAR_019902
Natural varianti69 – 691I → T.
Corresponds to variant rs4987042 [ dbSNP | Ensembl ].
VAR_046719
Natural varianti132 – 1321R → C.
Corresponds to variant rs28997584 [ dbSNP | Ensembl ].
VAR_046720
Natural varianti406 – 4061E → K.
Corresponds to variant rs3764539 [ dbSNP | Ensembl ].
VAR_046721
Natural varianti472 – 4721S → P.1 Publication
Corresponds to variant rs4986771 [ dbSNP | Ensembl ].
VAR_019903
Natural varianti501 – 5011R → S.3 Publications
Corresponds to variant rs2278415 [ dbSNP | Ensembl ].
VAR_019904
Natural varianti524 – 5241V → I.2 Publications
Corresponds to variant rs4988337 [ dbSNP | Ensembl ].
VAR_019905

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF295096 mRNA. Translation: AAG17439.1.
AF309561 mRNA. Translation: AAG25714.1.
AK023467 mRNA. Translation: BAB14583.1.
AC011460 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72056.1.
BC009921 mRNA. Translation: AAH09921.1.
CCDSiCCDS12845.1.
RefSeqiNP_067645.3. NM_021632.3.
UniGeneiHs.407694.

Genome annotation databases

EnsembliENST00000243644; ENSP00000243644; ENSG00000256683.
GeneIDi59348.
KEGGihsa:59348.
UCSCiuc002pyd.3. human.

Polymorphism databases

DMDMi313104255.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF295096 mRNA. Translation: AAG17439.1 .
AF309561 mRNA. Translation: AAG25714.1 .
AK023467 mRNA. Translation: BAB14583.1 .
AC011460 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72056.1 .
BC009921 mRNA. Translation: AAH09921.1 .
CCDSi CCDS12845.1.
RefSeqi NP_067645.3. NM_021632.3.
UniGenei Hs.407694.

3D structure databases

ProteinModelPortali Q9GZX5.
SMRi Q9GZX5. Positions 8-49, 154-457.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121889. 7 interactions.
IntActi Q9GZX5. 5 interactions.
MINTi MINT-1198135.
STRINGi 9606.ENSP00000365906.

PTM databases

PhosphoSitei Q9GZX5.

Polymorphism databases

DMDMi 313104255.

Proteomic databases

MaxQBi Q9GZX5.
PaxDbi Q9GZX5.
PRIDEi Q9GZX5.

Protocols and materials databases

DNASUi 59348.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000243644 ; ENSP00000243644 ; ENSG00000256683 .
GeneIDi 59348.
KEGGi hsa:59348.
UCSCi uc002pyd.3. human.

Organism-specific databases

CTDi 59348.
GeneCardsi GC19M052470.
HGNCi HGNC:16656. ZNF350.
HPAi HPA001521.
MIMi 605422. gene.
neXtProti NX_Q9GZX5.
PharmGKBi PA134972827.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q9GZX5.
KOi K09228.
OMAi LTDHQII.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q9GZX5.
TreeFami TF340593.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GeneWikii ZNF350.
GenomeRNAii 59348.
NextBioi 65253.
PROi Q9GZX5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9GZX5.
Bgeei Q9GZX5.
CleanExi HS_ZNF350.
Genevestigatori Q9GZX5.

Family and domain databases

Gene3Di 3.30.160.60. 8 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1."
    Zheng L., Pan H., Li S., Flesken-Nikitin A., Chen L.P., Boyer G.T., Lee H.W.
    Mol. Cell 6:757-768(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PRO-66 AND SER-501, FUNCTION, INTERACTION WITH BRCA1.
  2. "Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells."
    Ran Q., Wadhwa R., Bischof O., Venable S., Smith J.R., Pereira-Smith O.M.
    Exp. Cell Res. 263:156-162(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-524, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-66 AND SER-501.
    Tissue: Placenta.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  7. "Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1."
    Wang W., Cai J., Wu Y., Hu L., Chen Z., Hu J., Chen Z., Li W., Guo M., Huang Z.
    Cell. Mol. Life Sci. 70:3947-3958(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. "Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals."
    Rutter J.L., Smith A.M., Davila M.R., Sigurdson A.J., Giusti R.M., Pineda M.A., Doody M.M., Tucker M.A., Greene M.H., Zhang J., Struewing J.P.
    Hum. Mutat. 22:121-128(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS PRO-66; PRO-472; SER-501 AND ILE-524.
  9. "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein."
    Li H., Seth A.K.
    Oncogene 23:1801-1808(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RNF11.

Entry informationi

Entry nameiZN350_HUMAN
AccessioniPrimary (citable) accession number: Q9GZX5
Secondary accession number(s): Q96G73, Q9HAQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 30, 2010
Last modified: September 3, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi