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Q9GZX5 (ZN350_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 350
Alternative name(s):
KRAB zinc finger protein ZFQR
Zinc finger and BRCA1-interacting protein with a KRAB domain 1
Zinc finger protein ZBRK1
Gene names
Name:ZNF350
Synonyms:ZBRK1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length532 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3. Ref.1

Subunit structure

Interacts with BRCA1. Interacts with RNF11. Ref.1 Ref.9

Subcellular location

Nucleus. Nucleus matrix. Note: Associated with the nuclear matrix. Ref.2 Ref.7

Tissue specificity

Widely expressed. Ref.2

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 8 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

BRCA1P383983EBI-396421,EBI-349905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 532532Zinc finger protein 350
PRO_0000047546

Regions

Domain8 – 7972KRAB
Zinc finger206 – 22823C2H2-type 1
Zinc finger234 – 25623C2H2-type 2
Zinc finger262 – 28423C2H2-type 3
Zinc finger290 – 31223C2H2-type 4
Zinc finger318 – 34023C2H2-type 5
Zinc finger346 – 36823C2H2-type 6
Zinc finger374 – 39623C2H2-type 7
Zinc finger402 – 42423C2H2-type 8

Natural variations

Natural variant371M → I.
Corresponds to variant rs4987241 [ dbSNP | Ensembl ].
VAR_046718
Natural variant661L → P. Ref.1 Ref.3 Ref.8
Corresponds to variant rs2278420 [ dbSNP | Ensembl ].
VAR_019902
Natural variant691I → T.
Corresponds to variant rs4987042 [ dbSNP | Ensembl ].
VAR_046719
Natural variant1321R → C.
Corresponds to variant rs28997584 [ dbSNP | Ensembl ].
VAR_046720
Natural variant4061E → K.
Corresponds to variant rs3764539 [ dbSNP | Ensembl ].
VAR_046721
Natural variant4721S → P. Ref.8
Corresponds to variant rs4986771 [ dbSNP | Ensembl ].
VAR_019903
Natural variant5011R → S. Ref.1 Ref.3 Ref.8
Corresponds to variant rs2278415 [ dbSNP | Ensembl ].
VAR_019904
Natural variant5241V → I. Ref.2 Ref.8
Corresponds to variant rs4988337 [ dbSNP | Ensembl ].
VAR_019905

Sequences

Sequence LengthMass (Da)Tools
Q9GZX5 [UniParc].

Last modified November 30, 2010. Version 3.
Checksum: FEF12A92F95BAC8A

FASTA53260,011
        10         20         30         40         50         60 
MIQAQESITL EDVAVDFTWE EWQLLGAAQK DLYRDVMLEN YSNLVAVGYQ ASKPDALFKL 

        70         80         90        100        110        120 
EQGEQLWTIE DGIHSGACSD IWKVDHVLER LQSESLVNRR KPCHEHDAFE NIVHCSKSQF 

       130        140        150        160        170        180 
LLGQNHDIFD LRGKSLKSNL TLVNQSKGYE IKNSVEFTGN GDSFLHANHE RLHTAIKFPA 

       190        200        210        220        230        240 
SQKLISTKSQ FISPKHQKTR KLEKHHVCSE CGKAFIKKSW LTDHQVMHTG EKPHRCSLCE 

       250        260        270        280        290        300 
KAFSRKFMLT EHQRTHTGEK PYECPECGKA FLKKSRLNIH QKTHTGEKPY ICSECGKGFI 

       310        320        330        340        350        360 
QKGNLIVHQR IHTGEKPYIC NECGKGFIQK TCLIAHQRFH TGKTPFVCSE CGKSCSQKSG 

       370        380        390        400        410        420 
LIKHQRIHTG EKPFECSECG KAFSTKQKLI VHQRTHTGER PYGCNECGKA FAYMSCLVKH 

       430        440        450        460        470        480 
KRIHTREKQE AAKVENPPAE RHSSLHTSDV MQEKNSANGA TTQVPSVAPQ TSLNISGLLA 

       490        500        510        520        530 
NRNVVLVGQP VVRCAASGDN RGFAQDRNLV NAVNVVVPSV INYVLFYVTE NP 

« Hide

References

« Hide 'large scale' references
[1]"Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1."
Zheng L., Pan H., Li S., Flesken-Nikitin A., Chen L.P., Boyer G.T., Lee H.W.
Mol. Cell 6:757-768(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PRO-66 AND SER-501, FUNCTION, INTERACTION WITH BRCA1.
[2]"Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells."
Ran Q., Wadhwa R., Bischof O., Venable S., Smith J.R., Pereira-Smith O.M.
Exp. Cell Res. 263:156-162(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-524, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-66 AND SER-501.
Tissue: Placenta.
[4]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[7]"Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1."
Wang W., Cai J., Wu Y., Hu L., Chen Z., Hu J., Chen Z., Li W., Guo M., Huang Z.
Cell. Mol. Life Sci. 70:3947-3958(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[8]"Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals."
Rutter J.L., Smith A.M., Davila M.R., Sigurdson A.J., Giusti R.M., Pineda M.A., Doody M.M., Tucker M.A., Greene M.H., Zhang J., Struewing J.P.
Hum. Mutat. 22:121-128(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS PRO-66; PRO-472; SER-501 AND ILE-524.
[9]"An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein."
Li H., Seth A.K.
Oncogene 23:1801-1808(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RNF11.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF295096 mRNA. Translation: AAG17439.1.
AF309561 mRNA. Translation: AAG25714.1.
AK023467 mRNA. Translation: BAB14583.1.
AC011460 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72056.1.
BC009921 mRNA. Translation: AAH09921.1.
CCDSCCDS12845.1.
RefSeqNP_067645.3. NM_021632.3.
UniGeneHs.407694.

3D structure databases

ProteinModelPortalQ9GZX5.
SMRQ9GZX5. Positions 8-49, 154-457.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121889. 7 interactions.
IntActQ9GZX5. 5 interactions.
MINTMINT-1198135.
STRING9606.ENSP00000365906.

PTM databases

PhosphoSiteQ9GZX5.

Polymorphism databases

DMDM313104255.

Proteomic databases

MaxQBQ9GZX5.
PaxDbQ9GZX5.
PRIDEQ9GZX5.

Protocols and materials databases

DNASU59348.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000243644; ENSP00000243644; ENSG00000256683.
GeneID59348.
KEGGhsa:59348.
UCSCuc002pyd.3. human.

Organism-specific databases

CTD59348.
GeneCardsGC19M052470.
HGNCHGNC:16656. ZNF350.
HPAHPA001521.
MIM605422. gene.
neXtProtNX_Q9GZX5.
PharmGKBPA134972827.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ9GZX5.
KOK09228.
OMALTDHQII.
OrthoDBEOG7KSX7Q.
PhylomeDBQ9GZX5.
TreeFamTF340593.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9GZX5.
BgeeQ9GZX5.
CleanExHS_ZNF350.
GenevestigatorQ9GZX5.

Family and domain databases

Gene3D3.30.160.60. 8 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiZNF350.
GenomeRNAi59348.
NextBio65253.
PROQ9GZX5.
SOURCESearch...

Entry information

Entry nameZN350_HUMAN
AccessionPrimary (citable) accession number: Q9GZX5
Secondary accession number(s): Q96G73, Q9HAQ4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM