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Q9GZX5

- ZN350_HUMAN

UniProt

Q9GZX5 - ZN350_HUMAN

Protein

Zinc finger protein 350

Gene

ZNF350

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri206 – 22823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri234 – 25623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri262 – 28423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri290 – 31223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri318 – 34023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri346 – 36823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri374 – 39623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri402 – 42423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: UniProtKB
    2. regulation of transcription, DNA-templated Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 350
    Alternative name(s):
    KRAB zinc finger protein ZFQR
    Zinc finger and BRCA1-interacting protein with a KRAB domain 1
    Zinc finger protein ZBRK1
    Gene namesi
    Name:ZNF350
    Synonyms:ZBRK1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:16656. ZNF350.

    Subcellular locationi

    Nucleus. Nucleus matrix
    Note: Associated with the nuclear matrix.

    GO - Cellular componenti

    1. nuclear matrix Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB
    3. transcriptional repressor complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134972827.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 532532Zinc finger protein 350PRO_0000047546Add
    BLAST

    Proteomic databases

    MaxQBiQ9GZX5.
    PaxDbiQ9GZX5.
    PRIDEiQ9GZX5.

    PTM databases

    PhosphoSiteiQ9GZX5.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ9GZX5.
    BgeeiQ9GZX5.
    CleanExiHS_ZNF350.
    GenevestigatoriQ9GZX5.

    Organism-specific databases

    HPAiHPA001521.

    Interactioni

    Subunit structurei

    Interacts with BRCA1. Interacts with RNF11.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BRCA1P383983EBI-396421,EBI-349905

    Protein-protein interaction databases

    BioGridi121889. 7 interactions.
    IntActiQ9GZX5. 5 interactions.
    MINTiMINT-1198135.
    STRINGi9606.ENSP00000365906.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GZX5.
    SMRiQ9GZX5. Positions 8-49, 154-457.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri206 – 22823C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri234 – 25623C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri262 – 28423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri290 – 31223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri318 – 34023C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri346 – 36823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri374 – 39623C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri402 – 42423C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ9GZX5.
    KOiK09228.
    OMAiLTDHQII.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ9GZX5.
    TreeFamiTF340593.

    Family and domain databases

    Gene3Di3.30.160.60. 8 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9GZX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIQAQESITL EDVAVDFTWE EWQLLGAAQK DLYRDVMLEN YSNLVAVGYQ    50
    ASKPDALFKL EQGEQLWTIE DGIHSGACSD IWKVDHVLER LQSESLVNRR 100
    KPCHEHDAFE NIVHCSKSQF LLGQNHDIFD LRGKSLKSNL TLVNQSKGYE 150
    IKNSVEFTGN GDSFLHANHE RLHTAIKFPA SQKLISTKSQ FISPKHQKTR 200
    KLEKHHVCSE CGKAFIKKSW LTDHQVMHTG EKPHRCSLCE KAFSRKFMLT 250
    EHQRTHTGEK PYECPECGKA FLKKSRLNIH QKTHTGEKPY ICSECGKGFI 300
    QKGNLIVHQR IHTGEKPYIC NECGKGFIQK TCLIAHQRFH TGKTPFVCSE 350
    CGKSCSQKSG LIKHQRIHTG EKPFECSECG KAFSTKQKLI VHQRTHTGER 400
    PYGCNECGKA FAYMSCLVKH KRIHTREKQE AAKVENPPAE RHSSLHTSDV 450
    MQEKNSANGA TTQVPSVAPQ TSLNISGLLA NRNVVLVGQP VVRCAASGDN 500
    RGFAQDRNLV NAVNVVVPSV INYVLFYVTE NP 532
    Length:532
    Mass (Da):60,011
    Last modified:November 30, 2010 - v3
    Checksum:iFEF12A92F95BAC8A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti37 – 371M → I.
    Corresponds to variant rs4987241 [ dbSNP | Ensembl ].
    VAR_046718
    Natural varianti66 – 661L → P.3 Publications
    Corresponds to variant rs2278420 [ dbSNP | Ensembl ].
    VAR_019902
    Natural varianti69 – 691I → T.
    Corresponds to variant rs4987042 [ dbSNP | Ensembl ].
    VAR_046719
    Natural varianti132 – 1321R → C.
    Corresponds to variant rs28997584 [ dbSNP | Ensembl ].
    VAR_046720
    Natural varianti406 – 4061E → K.
    Corresponds to variant rs3764539 [ dbSNP | Ensembl ].
    VAR_046721
    Natural varianti472 – 4721S → P.1 Publication
    Corresponds to variant rs4986771 [ dbSNP | Ensembl ].
    VAR_019903
    Natural varianti501 – 5011R → S.3 Publications
    Corresponds to variant rs2278415 [ dbSNP | Ensembl ].
    VAR_019904
    Natural varianti524 – 5241V → I.2 Publications
    Corresponds to variant rs4988337 [ dbSNP | Ensembl ].
    VAR_019905

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF295096 mRNA. Translation: AAG17439.1.
    AF309561 mRNA. Translation: AAG25714.1.
    AK023467 mRNA. Translation: BAB14583.1.
    AC011460 Genomic DNA. No translation available.
    CH471135 Genomic DNA. Translation: EAW72056.1.
    BC009921 mRNA. Translation: AAH09921.1.
    CCDSiCCDS12845.1.
    RefSeqiNP_067645.3. NM_021632.3.
    UniGeneiHs.407694.

    Genome annotation databases

    EnsembliENST00000243644; ENSP00000243644; ENSG00000256683.
    GeneIDi59348.
    KEGGihsa:59348.
    UCSCiuc002pyd.3. human.

    Polymorphism databases

    DMDMi313104255.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF295096 mRNA. Translation: AAG17439.1 .
    AF309561 mRNA. Translation: AAG25714.1 .
    AK023467 mRNA. Translation: BAB14583.1 .
    AC011460 Genomic DNA. No translation available.
    CH471135 Genomic DNA. Translation: EAW72056.1 .
    BC009921 mRNA. Translation: AAH09921.1 .
    CCDSi CCDS12845.1.
    RefSeqi NP_067645.3. NM_021632.3.
    UniGenei Hs.407694.

    3D structure databases

    ProteinModelPortali Q9GZX5.
    SMRi Q9GZX5. Positions 8-49, 154-457.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121889. 7 interactions.
    IntActi Q9GZX5. 5 interactions.
    MINTi MINT-1198135.
    STRINGi 9606.ENSP00000365906.

    PTM databases

    PhosphoSitei Q9GZX5.

    Polymorphism databases

    DMDMi 313104255.

    Proteomic databases

    MaxQBi Q9GZX5.
    PaxDbi Q9GZX5.
    PRIDEi Q9GZX5.

    Protocols and materials databases

    DNASUi 59348.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000243644 ; ENSP00000243644 ; ENSG00000256683 .
    GeneIDi 59348.
    KEGGi hsa:59348.
    UCSCi uc002pyd.3. human.

    Organism-specific databases

    CTDi 59348.
    GeneCardsi GC19M052470.
    HGNCi HGNC:16656. ZNF350.
    HPAi HPA001521.
    MIMi 605422. gene.
    neXtProti NX_Q9GZX5.
    PharmGKBi PA134972827.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q9GZX5.
    KOi K09228.
    OMAi LTDHQII.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q9GZX5.
    TreeFami TF340593.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    GeneWikii ZNF350.
    GenomeRNAii 59348.
    NextBioi 65253.
    PROi Q9GZX5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9GZX5.
    Bgeei Q9GZX5.
    CleanExi HS_ZNF350.
    Genevestigatori Q9GZX5.

    Family and domain databases

    Gene3Di 3.30.160.60. 8 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 8 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 8 hits.
    PS50157. ZINC_FINGER_C2H2_2. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1."
      Zheng L., Pan H., Li S., Flesken-Nikitin A., Chen L.P., Boyer G.T., Lee H.W.
      Mol. Cell 6:757-768(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS PRO-66 AND SER-501, FUNCTION, INTERACTION WITH BRCA1.
    2. "Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells."
      Ran Q., Wadhwa R., Bischof O., Venable S., Smith J.R., Pereira-Smith O.M.
      Exp. Cell Res. 263:156-162(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-524, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-66 AND SER-501.
      Tissue: Placenta.
    4. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    7. "Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1."
      Wang W., Cai J., Wu Y., Hu L., Chen Z., Hu J., Chen Z., Li W., Guo M., Huang Z.
      Cell. Mol. Life Sci. 70:3947-3958(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    8. "Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals."
      Rutter J.L., Smith A.M., Davila M.R., Sigurdson A.J., Giusti R.M., Pineda M.A., Doody M.M., Tucker M.A., Greene M.H., Zhang J., Struewing J.P.
      Hum. Mutat. 22:121-128(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS PRO-66; PRO-472; SER-501 AND ILE-524.
    9. "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein."
      Li H., Seth A.K.
      Oncogene 23:1801-1808(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RNF11.

    Entry informationi

    Entry nameiZN350_HUMAN
    AccessioniPrimary (citable) accession number: Q9GZX5
    Secondary accession number(s): Q96G73, Q9HAQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 113 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3