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Protein

Zinc finger protein 350

Gene

ZNF350

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 228C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 368C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 350
Alternative name(s):
KRAB zinc finger protein ZFQR
Zinc finger and BRCA1-interacting protein with a KRAB domain 1
Zinc finger protein ZBRK1
Gene namesi
Name:ZNF350
Synonyms:ZBRK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000256683.6
HGNCiHGNC:16656 ZNF350
MIMi605422 gene
neXtProtiNX_Q9GZX5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi59348
OpenTargetsiENSG00000256683
PharmGKBiPA134972827

Polymorphism and mutation databases

BioMutaiZNF350
DMDMi313104255

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475461 – 532Zinc finger protein 350Add BLAST532

Proteomic databases

EPDiQ9GZX5
MaxQBiQ9GZX5
PaxDbiQ9GZX5
PeptideAtlasiQ9GZX5
PRIDEiQ9GZX5
ProteomicsDBi80166

PTM databases

iPTMnetiQ9GZX5
PhosphoSitePlusiQ9GZX5

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000256683
CleanExiHS_ZNF350
ExpressionAtlasiQ9GZX5 baseline and differential
GenevisibleiQ9GZX5 HS

Organism-specific databases

HPAiHPA001521

Interactioni

Subunit structurei

Interacts with BRCA1. Interacts with RNF11.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BRCA1P383983EBI-396421,EBI-349905

Protein-protein interaction databases

BioGridi121889, 10 interactors
CORUMiQ9GZX5
IntActiQ9GZX5, 6 interactors
MINTiQ9GZX5
STRINGi9606.ENSP00000243644

Structurei

3D structure databases

ProteinModelPortaliQ9GZX5
SMRiQ9GZX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 79KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 228C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri234 – 256C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri262 – 284C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri290 – 312C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri318 – 340C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri346 – 368C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri374 – 396C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri402 – 424C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00860000133760
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9GZX5
KOiK09228
OMAiLTDHQII
OrthoDBiEOG091G02KC
PhylomeDBiQ9GZX5
TreeFamiTF340593

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequencei

Sequence statusi: Complete.

Q9GZX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQAQESITL EDVAVDFTWE EWQLLGAAQK DLYRDVMLEN YSNLVAVGYQ
60 70 80 90 100
ASKPDALFKL EQGEQLWTIE DGIHSGACSD IWKVDHVLER LQSESLVNRR
110 120 130 140 150
KPCHEHDAFE NIVHCSKSQF LLGQNHDIFD LRGKSLKSNL TLVNQSKGYE
160 170 180 190 200
IKNSVEFTGN GDSFLHANHE RLHTAIKFPA SQKLISTKSQ FISPKHQKTR
210 220 230 240 250
KLEKHHVCSE CGKAFIKKSW LTDHQVMHTG EKPHRCSLCE KAFSRKFMLT
260 270 280 290 300
EHQRTHTGEK PYECPECGKA FLKKSRLNIH QKTHTGEKPY ICSECGKGFI
310 320 330 340 350
QKGNLIVHQR IHTGEKPYIC NECGKGFIQK TCLIAHQRFH TGKTPFVCSE
360 370 380 390 400
CGKSCSQKSG LIKHQRIHTG EKPFECSECG KAFSTKQKLI VHQRTHTGER
410 420 430 440 450
PYGCNECGKA FAYMSCLVKH KRIHTREKQE AAKVENPPAE RHSSLHTSDV
460 470 480 490 500
MQEKNSANGA TTQVPSVAPQ TSLNISGLLA NRNVVLVGQP VVRCAASGDN
510 520 530
RGFAQDRNLV NAVNVVVPSV INYVLFYVTE NP
Length:532
Mass (Da):60,011
Last modified:November 30, 2010 - v3
Checksum:iFEF12A92F95BAC8A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04671837M → I. Corresponds to variant dbSNP:rs4987241Ensembl.1
Natural variantiVAR_01990266L → P3 PublicationsCorresponds to variant dbSNP:rs2278420Ensembl.1
Natural variantiVAR_04671969I → T. Corresponds to variant dbSNP:rs4987042Ensembl.1
Natural variantiVAR_046720132R → C. Corresponds to variant dbSNP:rs28997584Ensembl.1
Natural variantiVAR_046721406E → K. Corresponds to variant dbSNP:rs3764539Ensembl.1
Natural variantiVAR_019903472S → P1 PublicationCorresponds to variant dbSNP:rs4986771Ensembl.1
Natural variantiVAR_019904501R → S3 PublicationsCorresponds to variant dbSNP:rs2278415Ensembl.1
Natural variantiVAR_019905524V → I2 PublicationsCorresponds to variant dbSNP:rs4988337Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295096 mRNA Translation: AAG17439.1
AF309561 mRNA Translation: AAG25714.1
AK023467 mRNA Translation: BAB14583.1
AC011460 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72056.1
BC009921 mRNA Translation: AAH09921.1
CCDSiCCDS12845.1
RefSeqiNP_067645.3, NM_021632.3
XP_016882587.1, XM_017027098.1
XP_016882588.1, XM_017027099.1
XP_016882589.1, XM_017027100.1
UniGeneiHs.407694

Genome annotation databases

EnsembliENST00000243644; ENSP00000243644; ENSG00000256683
GeneIDi59348
KEGGihsa:59348
UCSCiuc002pyd.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN350_HUMAN
AccessioniPrimary (citable) accession number: Q9GZX5
Secondary accession number(s): Q96G73, Q9HAQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 30, 2010
Last modified: June 20, 2018
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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