Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Carbohydrate sulfotransferase 6

Gene

CHST6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non-reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N-acetyllactosamine structures.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 55PAPSBy similarity7
Nucleotide bindingi202 – 210PAPSBy similarity9

GO - Molecular functioni

  • N-acetylglucosamine 6-O-sulfotransferase activity Source: UniProtKB

GO - Biological processi

  • carbohydrate metabolic process Source: UniProtKB-KW
  • keratan sulfate biosynthetic process Source: UniProtKB
  • N-acetylglucosamine metabolic process Source: UniProtKB
  • sulfur compound metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

ReactomeiR-HSA-2022854. Keratan sulfate biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbohydrate sulfotransferase 6 (EC:2.8.2.-)
Alternative name(s):
Corneal N-acetylglucosamine-6-O-sulfotransferase
Short name:
C-GlcNAc6ST
Short name:
hCGn6ST
Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta
Short name:
GST4-beta
N-acetylglucosamine 6-O-sulfotransferase 5
Short name:
GlcNAc6ST-5
Short name:
Gn6st-5
Gene namesi
Name:CHST6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:6938. CHST6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5CytoplasmicSequence analysis5
Transmembranei6 – 26Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini27 – 395LumenalSequence analysisAdd BLAST369

GO - Cellular componenti

  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: Reactome
  • integral component of membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

Macular dystrophy, corneal (MCD)17 Publications
The disease is caused by mutations affecting the gene represented in this entry. CHST6 homozygous missense mutations have been observed in patients with macular corneal dystrophy type I, while type II patients show a large deletion and replacement in the upstream region of CHST6. The only missense mutation for type II is Cys-50, which is heterozygous with a replacement in the upstream region on the other allele of CHST6.
Disease descriptionAn ocular disease characterized by bilateral, progressive corneal opacification, and reduced corneal sensitivity. Onset occurs in the first decade, usually between ages 5 and 9. Painful attacks with photophobia, foreign body sensations, and recurrent erosions occur in most patients. The disease is due to deposition of an unsulfated keratan sulfate both within the intracellular space (within the keratocytes and endothelial cells) and in the extracellular corneal stroma. Macular corneal dystrophy is divided into the clinically indistinguishable types I, IA, and II based on analysis of the normally sulfated, or antigenic, keratan sulfate levels in serum and immunohistochemical evaluation of the cornea. Patients with types I and IA macular corneal dystrophy have undetectable serum levels of antigenic keratan sulfate, whereas those with type II macular corneal dystrophy have normal or low levels, depending on the population examined.
See also OMIM:217800
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02141715L → P in MCD. 1 Publication1
Natural variantiVAR_02141822L → R in MCD. 1 PublicationCorresponds to variant rs68043642dbSNPEnsembl.1
Natural variantiVAR_02141931P → S in MCD. 1 PublicationCorresponds to variant rs72547549dbSNPEnsembl.1
Natural variantiVAR_02142042H → Y in MCD. 1 Publication1
Natural variantiVAR_02142150R → C in MCD; abolishes ability to sulfate keratan. 2 PublicationsCorresponds to variant rs28937877dbSNPEnsembl.1
Natural variantiVAR_02142251S → L in MCD. 2 PublicationsCorresponds to variant rs370335460dbSNPEnsembl.1
Natural variantiVAR_02142352G → D in MCD. 1 Publication1
Natural variantiVAR_02142453S → L in MCD. 2 Publications1
Natural variantiVAR_02142559L → P in MCD. 1 Publication1
Natural variantiVAR_02142661N → T in MCD. 1 PublicationCorresponds to variant rs72547548dbSNPEnsembl.1
Natural variantiVAR_02142766V → L in MCD. 1 PublicationCorresponds to variant rs72547547dbSNPEnsembl.1
Natural variantiVAR_02142868Y → H in MCD. 1 PublicationCorresponds to variant rs775742450dbSNPEnsembl.1
Natural variantiVAR_02142970M → L in MCD. 1 Publication1
Natural variantiVAR_02143072P → S in MCD. 2 PublicationsCorresponds to variant rs377617168dbSNPEnsembl.1
Natural variantiVAR_02143176V → M in MCD. 1 Publication1
Natural variantiVAR_02143293R → H in MCD. 1 Publication1
Natural variantiVAR_02143397R → P in MCD. 1 PublicationCorresponds to variant rs72547546dbSNPEnsembl.1
Natural variantiVAR_02143498S → W in MCD. 1 Publication1
Natural variantiVAR_021435102C → G in MCD. 3 PublicationsCorresponds to variant rs121917822dbSNPEnsembl.1
Natural variantiVAR_021436102C → Y in MCD. 1 Publication1
Natural variantiVAR_021437104M → V in MCD. 1 Publication1
Natural variantiVAR_021438107F → S in MCD. 2 PublicationsCorresponds to variant rs72547545dbSNPEnsembl.1
Natural variantiVAR_021439110Y → C in MCD. 1 PublicationCorresponds to variant rs72547544dbSNPEnsembl.1
Natural variantiVAR_075522118S → F in MCD; unknown pathological significance. 1 Publication1
Natural variantiVAR_021440121F → L in MCD. 1 Publication1
Natural variantiVAR_021441122Q → P in MCD. 1 PublicationCorresponds to variant rs758105699dbSNPEnsembl.1
Natural variantiVAR_021442127R → C in MCD. 1 Publication1
Natural variantiVAR_021443128A → V in MCD. 1 PublicationCorresponds to variant rs72547543dbSNPEnsembl.1
Natural variantiVAR_021444131S → P in MCD. 1 Publication1
Natural variantiVAR_021445152L → P in MCD. 1 PublicationCorresponds to variant rs142954809dbSNPEnsembl.1
Natural variantiVAR_021446162R → G in MCD. 1 PublicationCorresponds to variant rs117435647dbSNPEnsembl.1
Natural variantiVAR_021447166R → P in MCD. 2 PublicationsCorresponds to variant rs72547542dbSNPEnsembl.1
Natural variantiVAR_021448174K → R in MCD; abolishes ability to sulfate keratan. 3 PublicationsCorresponds to variant rs28937878dbSNPEnsembl.1
Natural variantiVAR_075523177R → G in MCD; found in a compound heterozygote with Q-211. 1 Publication1
Natural variantiVAR_021449177R → H in MCD. 1 Publication1
Natural variantiVAR_075524186P → R in MCD. 2 PublicationsCorresponds to variant rs376162109dbSNPEnsembl.1
Natural variantiVAR_021450198V → E in MCD. 1 Publication1
Natural variantiVAR_021451200L → R in MCD. 5 PublicationsCorresponds to variant rs28937879dbSNPEnsembl.1
Natural variantiVAR_021452202R → S in MCD. 1 Publication1
Natural variantiVAR_021453203D → E in MCD; abolishes ability to sulfate keratan. 2 PublicationsCorresponds to variant rs28937878dbSNPEnsembl.1
Natural variantiVAR_021454204P → Q in MCD. 3 PublicationsCorresponds to variant rs759870075dbSNPEnsembl.1
Natural variantiVAR_021455205R → L in MCD. 1 Publication1
Natural variantiVAR_021456205R → Q in MCD. 1 PublicationCorresponds to variant rs377706989dbSNPEnsembl.1
Natural variantiVAR_075525205R → W in MCD. 2 PublicationsCorresponds to variant rs750219546dbSNPEnsembl.1
Natural variantiVAR_021457206A → T in MCD. 1 PublicationCorresponds to variant rs374493344dbSNPEnsembl.1
Natural variantiVAR_021458206A → V in MCD. 1 Publication1
Natural variantiVAR_021459210S → F in MCD. 1 PublicationCorresponds to variant rs745571211dbSNPEnsembl.1
Natural variantiVAR_021460211R → Q in MCD; found in a compound heterozygote with G-177. 3 PublicationsCorresponds to variant rs771397083dbSNPEnsembl.1
Natural variantiVAR_021461211R → W in MCD; abolishes ability to sulfate keratan. 3 PublicationsCorresponds to variant rs202175444dbSNPEnsembl.1
Natural variantiVAR_021462217A → T in MCD; abolishes ability to sulfate keratan. 2 PublicationsCorresponds to variant rs752785520dbSNPEnsembl.1
Natural variantiVAR_021463221D → E in MCD. 1 Publication1
Natural variantiVAR_021464221D → Y in MCD. 1 Publication1
Natural variantiVAR_021465249H → P in MCD. 1 PublicationCorresponds to variant rs72547540dbSNPEnsembl.1
Natural variantiVAR_021466268Y → C in MCD. 1 PublicationCorresponds to variant rs72547539dbSNPEnsembl.1
Natural variantiVAR_021467274E → K in MCD; abolishes ability to sulfate keratan. 4 PublicationsCorresponds to variant rs72547538dbSNPEnsembl.1
Natural variantiVAR_021468276L → P in MCD. 2 PublicationsCorresponds to variant rs121917824dbSNPEnsembl.1
Natural variantiVAR_075526308H → Y in MCD; unknown pathological significance. 1 Publication1
Natural variantiVAR_021469358Y → D in MCD. 1 Publication1
Natural variantiVAR_075527358Y → H in MCD; found in a compound heterozygote also carrying an early stop codon. 2 Publications1

Keywords - Diseasei

Corneal dystrophy, Disease mutation

Organism-specific databases

DisGeNETi4166.
MalaCardsiCHST6.
MIMi217800. phenotype.
OpenTargetsiENSG00000183196.
Orphaneti98969. Macular corneal dystrophy.
PharmGKBiPA26506.

Polymorphism and mutation databases

BioMutaiCHST6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000851971 – 395Carbohydrate sulfotransferase 6Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi116N-linked (GlcNAc...)Sequence analysis1
Glycosylationi229N-linked (GlcNAc...)Sequence analysis1
Glycosylationi305N-linked (GlcNAc...)Sequence analysis1
Glycosylationi328N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9GZX3.
PaxDbiQ9GZX3.
PeptideAtlasiQ9GZX3.
PRIDEiQ9GZX3.

PTM databases

iPTMnetiQ9GZX3.
PhosphoSitePlusiQ9GZX3.

Expressioni

Tissue specificityi

Expressed in cornea. Mainly expressed in brain. Also expressed in spinal cord and trachea.3 Publications

Gene expression databases

BgeeiENSG00000183196.
CleanExiHS_CHST6.
GenevisibleiQ9GZX3. HS.

Interactioni

Protein-protein interaction databases

BioGridi110334. 13 interactors.
STRINGi9606.ENSP00000328983.

Structurei

3D structure databases

ProteinModelPortaliQ9GZX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJXD. Eukaryota.
ENOG4110V0B. LUCA.
GeneTreeiENSGT00530000062902.
HOGENOMiHOG000261614.
HOVERGENiHBG050949.
InParanoidiQ9GZX3.
KOiK09671.
OMAiNGFTWAS.
OrthoDBiEOG091G0V3Y.
PhylomeDBiQ9GZX3.
TreeFamiTF342871.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR016469. Carbohydrate_sulfotransferase.
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9GZX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLPRVSSTA VTALLLAQTF LLLFLVSRPG PSSPAGGEAR VHVLVLSSWR
60 70 80 90 100
SGSSFVGQLF NQHPDVFYLM EPAWHVWTTL SQGSAATLHM AVRDLVRSVF
110 120 130 140 150
LCDMDVFDAY LPWRRNLSDL FQWAVSRALC SPPACSAFPR GAISSEAVCK
160 170 180 190 200
PLCARQSFTL AREACRSYSH VVLKEVRFFN LQVLYPLLSD PALNLRIVHL
210 220 230 240 250
VRDPRAVLRS REQTAKALAR DNGIVLGTNG TWVEADPGLR VVREVCRSHV
260 270 280 290 300
RIAEAATLKP PPFLRGRYRL VRFEDLAREP LAEIRALYAF TGLSLTPQLE
310 320 330 340 350
AWIHNITHGS GPGARREAFK TSSRNALNVS QAWRHALPFA KIRRVQELCA
360 370 380 390
GALQLLGYRP VYSEDEQRNL ALDLVLPRGL NGFTWASSTA SHPRN
Length:395
Mass (Da):44,099
Last modified:March 1, 2001 - v1
Checksum:i433CA60248A48F67
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02141715L → P in MCD. 1 Publication1
Natural variantiVAR_02141822L → R in MCD. 1 PublicationCorresponds to variant rs68043642dbSNPEnsembl.1
Natural variantiVAR_02141931P → S in MCD. 1 PublicationCorresponds to variant rs72547549dbSNPEnsembl.1
Natural variantiVAR_02142042H → Y in MCD. 1 Publication1
Natural variantiVAR_02142150R → C in MCD; abolishes ability to sulfate keratan. 2 PublicationsCorresponds to variant rs28937877dbSNPEnsembl.1
Natural variantiVAR_02142251S → L in MCD. 2 PublicationsCorresponds to variant rs370335460dbSNPEnsembl.1
Natural variantiVAR_02142352G → D in MCD. 1 Publication1
Natural variantiVAR_02142453S → L in MCD. 2 Publications1
Natural variantiVAR_02142559L → P in MCD. 1 Publication1
Natural variantiVAR_02142661N → T in MCD. 1 PublicationCorresponds to variant rs72547548dbSNPEnsembl.1
Natural variantiVAR_02142766V → L in MCD. 1 PublicationCorresponds to variant rs72547547dbSNPEnsembl.1
Natural variantiVAR_02142868Y → H in MCD. 1 PublicationCorresponds to variant rs775742450dbSNPEnsembl.1
Natural variantiVAR_02142970M → L in MCD. 1 Publication1
Natural variantiVAR_02143072P → S in MCD. 2 PublicationsCorresponds to variant rs377617168dbSNPEnsembl.1
Natural variantiVAR_02143176V → M in MCD. 1 Publication1
Natural variantiVAR_02143293R → H in MCD. 1 Publication1
Natural variantiVAR_02143397R → P in MCD. 1 PublicationCorresponds to variant rs72547546dbSNPEnsembl.1
Natural variantiVAR_02143498S → W in MCD. 1 Publication1
Natural variantiVAR_021435102C → G in MCD. 3 PublicationsCorresponds to variant rs121917822dbSNPEnsembl.1
Natural variantiVAR_021436102C → Y in MCD. 1 Publication1
Natural variantiVAR_021437104M → V in MCD. 1 Publication1
Natural variantiVAR_021438107F → S in MCD. 2 PublicationsCorresponds to variant rs72547545dbSNPEnsembl.1
Natural variantiVAR_021439110Y → C in MCD. 1 PublicationCorresponds to variant rs72547544dbSNPEnsembl.1
Natural variantiVAR_075522118S → F in MCD; unknown pathological significance. 1 Publication1
Natural variantiVAR_021440121F → L in MCD. 1 Publication1
Natural variantiVAR_021441122Q → P in MCD. 1 PublicationCorresponds to variant rs758105699dbSNPEnsembl.1
Natural variantiVAR_021442127R → C in MCD. 1 Publication1
Natural variantiVAR_021443128A → V in MCD. 1 PublicationCorresponds to variant rs72547543dbSNPEnsembl.1
Natural variantiVAR_021444131S → P in MCD. 1 Publication1
Natural variantiVAR_021445152L → P in MCD. 1 PublicationCorresponds to variant rs142954809dbSNPEnsembl.1
Natural variantiVAR_021446162R → G in MCD. 1 PublicationCorresponds to variant rs117435647dbSNPEnsembl.1
Natural variantiVAR_021447166R → P in MCD. 2 PublicationsCorresponds to variant rs72547542dbSNPEnsembl.1
Natural variantiVAR_021448174K → R in MCD; abolishes ability to sulfate keratan. 3 PublicationsCorresponds to variant rs28937878dbSNPEnsembl.1
Natural variantiVAR_075523177R → G in MCD; found in a compound heterozygote with Q-211. 1 Publication1
Natural variantiVAR_021449177R → H in MCD. 1 Publication1
Natural variantiVAR_075524186P → R in MCD. 2 PublicationsCorresponds to variant rs376162109dbSNPEnsembl.1
Natural variantiVAR_021450198V → E in MCD. 1 Publication1
Natural variantiVAR_021451200L → R in MCD. 5 PublicationsCorresponds to variant rs28937879dbSNPEnsembl.1
Natural variantiVAR_021452202R → S in MCD. 1 Publication1
Natural variantiVAR_021453203D → E in MCD; abolishes ability to sulfate keratan. 2 PublicationsCorresponds to variant rs28937878dbSNPEnsembl.1
Natural variantiVAR_021454204P → Q in MCD. 3 PublicationsCorresponds to variant rs759870075dbSNPEnsembl.1
Natural variantiVAR_021455205R → L in MCD. 1 Publication1
Natural variantiVAR_021456205R → Q in MCD. 1 PublicationCorresponds to variant rs377706989dbSNPEnsembl.1
Natural variantiVAR_075525205R → W in MCD. 2 PublicationsCorresponds to variant rs750219546dbSNPEnsembl.1
Natural variantiVAR_021457206A → T in MCD. 1 PublicationCorresponds to variant rs374493344dbSNPEnsembl.1
Natural variantiVAR_021458206A → V in MCD. 1 Publication1
Natural variantiVAR_021459210S → F in MCD. 1 PublicationCorresponds to variant rs745571211dbSNPEnsembl.1
Natural variantiVAR_021460211R → Q in MCD; found in a compound heterozygote with G-177. 3 PublicationsCorresponds to variant rs771397083dbSNPEnsembl.1
Natural variantiVAR_021461211R → W in MCD; abolishes ability to sulfate keratan. 3 PublicationsCorresponds to variant rs202175444dbSNPEnsembl.1
Natural variantiVAR_021462217A → T in MCD; abolishes ability to sulfate keratan. 2 PublicationsCorresponds to variant rs752785520dbSNPEnsembl.1
Natural variantiVAR_021463221D → E in MCD. 1 Publication1
Natural variantiVAR_021464221D → Y in MCD. 1 Publication1
Natural variantiVAR_021465249H → P in MCD. 1 PublicationCorresponds to variant rs72547540dbSNPEnsembl.1
Natural variantiVAR_021466268Y → C in MCD. 1 PublicationCorresponds to variant rs72547539dbSNPEnsembl.1
Natural variantiVAR_021467274E → K in MCD; abolishes ability to sulfate keratan. 4 PublicationsCorresponds to variant rs72547538dbSNPEnsembl.1
Natural variantiVAR_021468276L → P in MCD. 2 PublicationsCorresponds to variant rs121917824dbSNPEnsembl.1
Natural variantiVAR_075526308H → Y in MCD; unknown pathological significance. 1 Publication1
Natural variantiVAR_021469358Y → D in MCD. 1 Publication1
Natural variantiVAR_075527358Y → H in MCD; found in a compound heterozygote also carrying an early stop codon. 2 Publications1
Natural variantiVAR_033735369N → D.Corresponds to variant rs35036798dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF219990 mRNA. Translation: AAG26325.1.
AF219991 Genomic DNA. Translation: AAG26327.1.
AF280086 mRNA. Translation: AAG48244.1.
CH471114 Genomic DNA. Translation: EAW95640.1.
CH471114 Genomic DNA. Translation: EAW95641.1.
BC074883 mRNA. Translation: AAH74883.1.
BC074834 mRNA. Translation: AAH74834.1.
CCDSiCCDS10918.1.
RefSeqiNP_067628.1. NM_021615.4.
XP_005256012.1. XM_005255955.4.
XP_011521387.1. XM_011523085.2.
UniGeneiHs.655622.

Genome annotation databases

EnsembliENST00000332272; ENSP00000328983; ENSG00000183196.
ENST00000390664; ENSP00000375079; ENSG00000183196.
GeneIDi4166.
KEGGihsa:4166.
UCSCiuc002fef.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF219990 mRNA. Translation: AAG26325.1.
AF219991 Genomic DNA. Translation: AAG26327.1.
AF280086 mRNA. Translation: AAG48244.1.
CH471114 Genomic DNA. Translation: EAW95640.1.
CH471114 Genomic DNA. Translation: EAW95641.1.
BC074883 mRNA. Translation: AAH74883.1.
BC074834 mRNA. Translation: AAH74834.1.
CCDSiCCDS10918.1.
RefSeqiNP_067628.1. NM_021615.4.
XP_005256012.1. XM_005255955.4.
XP_011521387.1. XM_011523085.2.
UniGeneiHs.655622.

3D structure databases

ProteinModelPortaliQ9GZX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110334. 13 interactors.
STRINGi9606.ENSP00000328983.

PTM databases

iPTMnetiQ9GZX3.
PhosphoSitePlusiQ9GZX3.

Polymorphism and mutation databases

BioMutaiCHST6.

Proteomic databases

EPDiQ9GZX3.
PaxDbiQ9GZX3.
PeptideAtlasiQ9GZX3.
PRIDEiQ9GZX3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332272; ENSP00000328983; ENSG00000183196.
ENST00000390664; ENSP00000375079; ENSG00000183196.
GeneIDi4166.
KEGGihsa:4166.
UCSCiuc002fef.4. human.

Organism-specific databases

CTDi4166.
DisGeNETi4166.
GeneCardsiCHST6.
HGNCiHGNC:6938. CHST6.
MalaCardsiCHST6.
MIMi217800. phenotype.
605294. gene.
neXtProtiNX_Q9GZX3.
OpenTargetsiENSG00000183196.
Orphaneti98969. Macular corneal dystrophy.
PharmGKBiPA26506.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJXD. Eukaryota.
ENOG4110V0B. LUCA.
GeneTreeiENSGT00530000062902.
HOGENOMiHOG000261614.
HOVERGENiHBG050949.
InParanoidiQ9GZX3.
KOiK09671.
OMAiNGFTWAS.
OrthoDBiEOG091G0V3Y.
PhylomeDBiQ9GZX3.
TreeFamiTF342871.

Enzyme and pathway databases

ReactomeiR-HSA-2022854. Keratan sulfate biosynthesis.

Miscellaneous databases

ChiTaRSiCHST6. human.
GeneWikiiCHST6.
GenomeRNAii4166.
PROiQ9GZX3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183196.
CleanExiHS_CHST6.
GenevisibleiQ9GZX3. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR016469. Carbohydrate_sulfotransferase.
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCHST6_HUMAN
AccessioniPrimary (citable) accession number: Q9GZX3
Secondary accession number(s): D3DUK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

PubMed:12824236 reported a Gly-204 variant, however according to their results reported in figure 1, it is a Gln-204 variant.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.