ID   MS4A7_HUMAN             Reviewed;         240 AA.
AC   Q9GZW8; A6NP53; Q6IAG8;
DT   04-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   24-JAN-2024, entry version 164.
DE   RecName: Full=Membrane-spanning 4-domains subfamily A member 7;
DE   AltName: Full=CD20 antigen-like 4;
DE   AltName: Full=CD20/FC-epsilon-RI-beta family member 4;
DE   AltName: Full=Four-span transmembrane protein 2;
GN   Name=MS4A7; Synonyms=4SPAN2, CD20L4, CFFM4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=11245982; DOI=10.1016/s0378-1119(00)00598-9;
RA   Ishibashi K., Suzuki M., Sasaki S., Imai M.;
RT   "Identification of a new multigene four-transmembrane family (MS4A) related
RT   to CD20, HTm4 and beta subunit of the high-affinity IgE receptor.";
RL   Gene 264:87-93(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Peripheral blood;
RX   PubMed=11685457; DOI=10.1007/s002510100345;
RA   Gingras M.-C., Lapillonne H., Margolin J.F.;
RT   "CFFM4: a new member of the CD20/Fc-epsilon-RI-beta-family.";
RL   Immunogenetics 53:468-476(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Parathyroid;
RX   PubMed=11401424; DOI=10.1006/geno.2000.6472;
RA   Liang Y., Tedder T.F.;
RT   "Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene
RT   family: sixteen new MS4A family members expressed in human and mouse.";
RL   Genomics 72:119-127(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Hulett M.D., Pagler E., Hogarth P.M., Eyre H.J., Baker E., Crawford J.,
RA   Sutherland G.R., Parish C.R.;
RT   "Isolation of a family of hematopoietic-expressed four-transmembrane genes
RT   related to CD20 and Fc-epsilon-RI-beta.";
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Dendritic cell;
RA   Li Y., Gu J., Peng Y., Qian B., Xu S., Han Z., Fu G., Chen Z.;
RT   "Novel genes expressed in human dendritic cells.";
RL   Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Placenta, and Umbilical cord blood;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [10]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in signal transduction as a component of a
CC       multimeric receptor complex.
CC   -!- INTERACTION:
CC       Q9GZW8; P21854: CD72; NbExp=3; IntAct=EBI-721391, EBI-307924;
CC       Q9GZW8; Q8N682: DRAM1; NbExp=3; IntAct=EBI-721391, EBI-10305400;
CC       Q9GZW8; P54849: EMP1; NbExp=3; IntAct=EBI-721391, EBI-4319440;
CC       Q9GZW8; P24593: IGFBP5; NbExp=3; IntAct=EBI-721391, EBI-720480;
CC       Q9GZW8; P05107: ITGB2; NbExp=3; IntAct=EBI-721391, EBI-300173;
CC       Q9GZW8; O43561-2: LAT; NbExp=3; IntAct=EBI-721391, EBI-8070286;
CC       Q9GZW8; P26678: PLN; NbExp=3; IntAct=EBI-721391, EBI-692836;
CC       Q9GZW8; Q01453: PMP22; NbExp=3; IntAct=EBI-721391, EBI-2845982;
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9GZW8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9GZW8-2; Sequence=VSP_042009;
CC   -!- TISSUE SPECIFICITY: Ubiquitous expression in normal tissues. Expression
CC       is more elevated in adult liver, lung, spleen, and heart than in their
CC       fetal counterparts, and is higher in normal tissues than in the
CC       cancerous tissue or cell lines. Low levels of expression were detected
CC       in the promonocytic stage, whereas high levels of expression were
CC       detected in mature monocytes.
CC   -!- SIMILARITY: Belongs to the MS4A family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB026043; BAB18755.1; -; mRNA.
DR   EMBL; AF309653; AAG30930.1; -; mRNA.
DR   EMBL; AF237916; AAK37599.1; -; mRNA.
DR   EMBL; AF350501; AAL56221.1; -; mRNA.
DR   EMBL; AF201951; AAF17243.1; -; mRNA.
DR   EMBL; AK075106; BAC11405.1; -; mRNA.
DR   EMBL; AK297027; BAG59556.1; -; mRNA.
DR   EMBL; CR457187; CAG33468.1; -; mRNA.
DR   EMBL; AP003127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471076; EAW73878.1; -; Genomic_DNA.
DR   EMBL; CH471076; EAW73879.1; -; Genomic_DNA.
DR   EMBL; BC020673; AAH20673.1; -; mRNA.
DR   CCDS; CCDS7985.1; -. [Q9GZW8-1]
DR   CCDS; CCDS7986.1; -. [Q9GZW8-2]
DR   RefSeq; NP_067024.1; NM_021201.4. [Q9GZW8-1]
DR   RefSeq; NP_996821.1; NM_206938.1. [Q9GZW8-2]
DR   RefSeq; NP_996822.1; NM_206939.1. [Q9GZW8-1]
DR   RefSeq; NP_996823.1; NM_206940.1. [Q9GZW8-2]
DR   AlphaFoldDB; Q9GZW8; -.
DR   SMR; Q9GZW8; -.
DR   BioGRID; 121808; 15.
DR   IntAct; Q9GZW8; 12.
DR   STRING; 9606.ENSP00000300184; -.
DR   iPTMnet; Q9GZW8; -.
DR   PhosphoSitePlus; Q9GZW8; -.
DR   BioMuta; MS4A7; -.
DR   DMDM; 29611829; -.
DR   jPOST; Q9GZW8; -.
DR   MassIVE; Q9GZW8; -.
DR   PaxDb; 9606-ENSP00000300184; -.
DR   PeptideAtlas; Q9GZW8; -.
DR   Antibodypedia; 2586; 163 antibodies from 22 providers.
DR   DNASU; 58475; -.
DR   Ensembl; ENST00000300184.8; ENSP00000300184.3; ENSG00000166927.13. [Q9GZW8-1]
DR   Ensembl; ENST00000358246.5; ENSP00000350983.1; ENSG00000166927.13. [Q9GZW8-2]
DR   Ensembl; ENST00000534016.5; ENSP00000434637.1; ENSG00000166927.13. [Q9GZW8-2]
DR   GeneID; 58475; -.
DR   KEGG; hsa:58475; -.
DR   MANE-Select; ENST00000300184.8; ENSP00000300184.3; NM_021201.5; NP_067024.1.
DR   UCSC; uc001npf.4; human. [Q9GZW8-1]
DR   AGR; HGNC:13378; -.
DR   CTD; 58475; -.
DR   DisGeNET; 58475; -.
DR   GeneCards; MS4A7; -.
DR   HGNC; HGNC:13378; MS4A7.
DR   HPA; ENSG00000166927; Tissue enhanced (lymphoid).
DR   MIM; 606502; gene.
DR   neXtProt; NX_Q9GZW8; -.
DR   NIAGADS; ENSG00000166927; -.
DR   OpenTargets; ENSG00000166927; -.
DR   PharmGKB; PA31124; -.
DR   VEuPathDB; HostDB:ENSG00000166927; -.
DR   eggNOG; ENOG502RP28; Eukaryota.
DR   GeneTree; ENSGT00940000162779; -.
DR   HOGENOM; CLU_089673_0_0_1; -.
DR   InParanoid; Q9GZW8; -.
DR   OMA; PYSSHFN; -.
DR   OrthoDB; 5265300at2759; -.
DR   PhylomeDB; Q9GZW8; -.
DR   TreeFam; TF335157; -.
DR   PathwayCommons; Q9GZW8; -.
DR   SignaLink; Q9GZW8; -.
DR   BioGRID-ORCS; 58475; 23 hits in 1125 CRISPR screens.
DR   ChiTaRS; MS4A7; human.
DR   GeneWiki; MS4A7; -.
DR   GenomeRNAi; 58475; -.
DR   Pharos; Q9GZW8; Tdark.
DR   PRO; PR:Q9GZW8; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q9GZW8; Protein.
DR   Bgee; ENSG00000166927; Expressed in monocyte and 139 other cell types or tissues.
DR   ExpressionAtlas; Q9GZW8; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005802; C:trans-Golgi network; IDA:ARUK-UCL.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR007237; CD20-like.
DR   InterPro; IPR030417; MS4A.
DR   PANTHER; PTHR23320:SF8; MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 7; 1.
DR   PANTHER; PTHR23320; MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED; 1.
DR   Pfam; PF04103; CD20; 1.
DR   Genevisible; Q9GZW8; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Membrane; Receptor; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..240
FT                   /note="Membrane-spanning 4-domains subfamily A member 7"
FT                   /id="PRO_0000158643"
FT   TOPO_DOM        1..47
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        69..83
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..121
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        143..178
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        200..240
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          218..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         50..94
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_042009"
FT   VARIANT         34
FT                   /note="E -> K (in dbSNP:rs2233241)"
FT                   /id="VAR_053520"
FT   VARIANT         112
FT                   /note="P -> H (in dbSNP:rs2233249)"
FT                   /id="VAR_053521"
FT   VARIANT         157
FT                   /note="S -> F (in dbSNP:rs2233251)"
FT                   /id="VAR_053522"
SQ   SEQUENCE   240 AA;  26131 MW;  512BC9C126C76DC0 CRC64;
     MLLQSQTMGV SHSFTPKGIT IPQREKPGHM YQNEDYLQNG LPTETTVLGT VQILCCLLIS
     SLGAILVFAP YPSHFNPAIS TTLMSGYPFL GALCFGITGS LSIISGKQST KPFDLSSLTS
     NAVSSVTAGA GLFLLADSMV ALRTASQHCG SEMDYLSSLP YSEYYYPIYE IKDCLLTSVS
     LTGVLVVMLI FTVLELLLAA YSSVFWWKQL YSNNPGSSFS STQSQDHIQQ VKKSSSRSWI
//