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Protein

Membrane-spanning 4-domains subfamily A member 7

Gene

MS4A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in signal transduction as a component of a multimeric receptor complex.

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-spanning 4-domains subfamily A member 7
Alternative name(s):
CD20 antigen-like 4
CD20/FC-epsilon-RI-beta family member 4
Four-span transmembrane protein 2
Gene namesi
Name:MS4A7
Synonyms:4SPAN2, CD20L4, CFFM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:13378. MS4A7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence AnalysisAdd
BLAST
Topological domaini69 – 8315ExtracellularSequence AnalysisAdd
BLAST
Transmembranei84 – 10421HelicalSequence AnalysisAdd
BLAST
Topological domaini105 – 12117CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence AnalysisAdd
BLAST
Topological domaini143 – 17836ExtracellularSequence AnalysisAdd
BLAST
Transmembranei179 – 19921HelicalSequence AnalysisAdd
BLAST
Topological domaini200 – 24041CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31124.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Membrane-spanning 4-domains subfamily A member 7PRO_0000158643Add
BLAST

Proteomic databases

PaxDbiQ9GZW8.
PRIDEiQ9GZW8.

PTM databases

PhosphoSiteiQ9GZW8.

Expressioni

Tissue specificityi

Ubiquitous expression in normal tissues. Expression is more elevated in adult liver, lung, spleen, and heart than in their fetal counterparts, and is higher in normal tissues than in the cancerous tissue or cell lines. Low levels of expression were detected in the promonocytic stage, whereas high levels of expression were detected in mature monocytes.

Gene expression databases

BgeeiQ9GZW8.
CleanExiHS_MS4A7.
ExpressionAtlasiQ9GZW8. baseline and differential.
GenevestigatoriQ9GZW8.

Organism-specific databases

HPAiCAB026387.
HPA017418.

Interactioni

Protein-protein interaction databases

BioGridi121808. 2 interactions.
IntActiQ9GZW8. 3 interactions.
MINTiMINT-1387242.
STRINGi9606.ENSP00000300184.

Family & Domainsi

Sequence similaritiesi

Belongs to the MS4A family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41459.
GeneTreeiENSGT00510000047037.
HOGENOMiHOG000293396.
HOVERGENiHBG052387.
InParanoidiQ9GZW8.
OMAiSVFWWKQ.
OrthoDBiEOG7XPZ7D.
PhylomeDBiQ9GZW8.
TreeFamiTF335157.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR030417. MS4A.
IPR030423. MS4A7.
[Graphical view]
PANTHERiPTHR23320. PTHR23320. 1 hit.
PTHR23320:SF8. PTHR23320:SF8. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9GZW8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLQSQTMGV SHSFTPKGIT IPQREKPGHM YQNEDYLQNG LPTETTVLGT
60 70 80 90 100
VQILCCLLIS SLGAILVFAP YPSHFNPAIS TTLMSGYPFL GALCFGITGS
110 120 130 140 150
LSIISGKQST KPFDLSSLTS NAVSSVTAGA GLFLLADSMV ALRTASQHCG
160 170 180 190 200
SEMDYLSSLP YSEYYYPIYE IKDCLLTSVS LTGVLVVMLI FTVLELLLAA
210 220 230 240
YSSVFWWKQL YSNNPGSSFS STQSQDHIQQ VKKSSSRSWI
Length:240
Mass (Da):26,131
Last modified:February 28, 2001 - v1
Checksum:i512BC9C126C76DC0
GO
Isoform 2 (identifier: Q9GZW8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     50-94: Missing.

Note: No experimental confirmation available.

Show »
Length:195
Mass (Da):21,404
Checksum:i4AF51AD87DF2A74B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341E → K.
Corresponds to variant rs2233241 [ dbSNP | Ensembl ].
VAR_053520
Natural varianti112 – 1121P → H.
Corresponds to variant rs2233249 [ dbSNP | Ensembl ].
VAR_053521
Natural varianti157 – 1571S → F.
Corresponds to variant rs2233251 [ dbSNP | Ensembl ].
VAR_053522

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei50 – 9445Missing in isoform 2. 1 PublicationVSP_042009Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026043 mRNA. Translation: BAB18755.1.
AF309653 mRNA. Translation: AAG30930.1.
AF237916 mRNA. Translation: AAK37599.1.
AF350501 mRNA. Translation: AAL56221.1.
AF201951 mRNA. Translation: AAF17243.1.
AK075106 mRNA. Translation: BAC11405.1.
AK297027 mRNA. Translation: BAG59556.1.
CR457187 mRNA. Translation: CAG33468.1.
AP003127 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73878.1.
CH471076 Genomic DNA. Translation: EAW73879.1.
BC020673 mRNA. Translation: AAH20673.1.
CCDSiCCDS7985.1. [Q9GZW8-1]
CCDS7986.1. [Q9GZW8-2]
RefSeqiNP_067024.1. NM_021201.4. [Q9GZW8-1]
NP_996821.1. NM_206938.1. [Q9GZW8-2]
NP_996822.1. NM_206939.1. [Q9GZW8-1]
NP_996823.1. NM_206940.1. [Q9GZW8-2]
UniGeneiHs.530735.

Genome annotation databases

EnsembliENST00000300184; ENSP00000300184; ENSG00000166927. [Q9GZW8-1]
ENST00000358246; ENSP00000350983; ENSG00000166927. [Q9GZW8-2]
ENST00000534016; ENSP00000434637; ENSG00000166927. [Q9GZW8-2]
GeneIDi58475.
KEGGihsa:58475.
UCSCiuc001npe.3. human. [Q9GZW8-1]
uc001npg.3. human. [Q9GZW8-2]

Polymorphism databases

DMDMi29611829.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026043 mRNA. Translation: BAB18755.1.
AF309653 mRNA. Translation: AAG30930.1.
AF237916 mRNA. Translation: AAK37599.1.
AF350501 mRNA. Translation: AAL56221.1.
AF201951 mRNA. Translation: AAF17243.1.
AK075106 mRNA. Translation: BAC11405.1.
AK297027 mRNA. Translation: BAG59556.1.
CR457187 mRNA. Translation: CAG33468.1.
AP003127 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73878.1.
CH471076 Genomic DNA. Translation: EAW73879.1.
BC020673 mRNA. Translation: AAH20673.1.
CCDSiCCDS7985.1. [Q9GZW8-1]
CCDS7986.1. [Q9GZW8-2]
RefSeqiNP_067024.1. NM_021201.4. [Q9GZW8-1]
NP_996821.1. NM_206938.1. [Q9GZW8-2]
NP_996822.1. NM_206939.1. [Q9GZW8-1]
NP_996823.1. NM_206940.1. [Q9GZW8-2]
UniGeneiHs.530735.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121808. 2 interactions.
IntActiQ9GZW8. 3 interactions.
MINTiMINT-1387242.
STRINGi9606.ENSP00000300184.

PTM databases

PhosphoSiteiQ9GZW8.

Polymorphism databases

DMDMi29611829.

Proteomic databases

PaxDbiQ9GZW8.
PRIDEiQ9GZW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300184; ENSP00000300184; ENSG00000166927. [Q9GZW8-1]
ENST00000358246; ENSP00000350983; ENSG00000166927. [Q9GZW8-2]
ENST00000534016; ENSP00000434637; ENSG00000166927. [Q9GZW8-2]
GeneIDi58475.
KEGGihsa:58475.
UCSCiuc001npe.3. human. [Q9GZW8-1]
uc001npg.3. human. [Q9GZW8-2]

Organism-specific databases

CTDi58475.
GeneCardsiGC11P060145.
HGNCiHGNC:13378. MS4A7.
HPAiCAB026387.
HPA017418.
MIMi606502. gene.
neXtProtiNX_Q9GZW8.
PharmGKBiPA31124.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41459.
GeneTreeiENSGT00510000047037.
HOGENOMiHOG000293396.
HOVERGENiHBG052387.
InParanoidiQ9GZW8.
OMAiSVFWWKQ.
OrthoDBiEOG7XPZ7D.
PhylomeDBiQ9GZW8.
TreeFamiTF335157.

Miscellaneous databases

ChiTaRSiMS4A7. human.
GeneWikiiMS4A7.
GenomeRNAii58475.
NextBioi64904.
PROiQ9GZW8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9GZW8.
CleanExiHS_MS4A7.
ExpressionAtlasiQ9GZW8. baseline and differential.
GenevestigatoriQ9GZW8.

Family and domain databases

InterProiIPR007237. CD20-like.
IPR030417. MS4A.
IPR030423. MS4A7.
[Graphical view]
PANTHERiPTHR23320. PTHR23320. 1 hit.
PTHR23320:SF8. PTHR23320:SF8. 1 hit.
PfamiPF04103. CD20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor."
    Ishibashi K., Suzuki M., Sasaki S., Imai M.
    Gene 264:87-93(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "CFFM4: a new member of the CD20/Fc-epsilon-RI-beta-family."
    Gingras M.-C., Lapillonne H., Margolin J.F.
    Immunogenetics 53:468-476(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Peripheral blood.
  3. "Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse."
    Liang Y., Tedder T.F.
    Genomics 72:119-127(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Parathyroid.
  4. "Isolation of a family of hematopoietic-expressed four-transmembrane genes related to CD20 and Fc-epsilon-RI-beta."
    Hulett M.D., Pagler E., Hogarth P.M., Eyre H.J., Baker E., Crawford J., Sutherland G.R., Parish C.R.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Novel genes expressed in human dendritic cells."
    Li Y., Gu J., Peng Y., Qian B., Xu S., Han Z., Fu G., Chen Z.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Dendritic cell.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta and Umbilical cord blood.
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.

Entry informationi

Entry nameiMS4A7_HUMAN
AccessioniPrimary (citable) accession number: Q9GZW8
Secondary accession number(s): A6NP53, Q6IAG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2003
Last sequence update: February 28, 2001
Last modified: March 31, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.