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Q9GZW8 (MS4A7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Membrane-spanning 4-domains subfamily A member 7
Alternative name(s):
CD20 antigen-like 4
CD20/FC-epsilon-RI-beta family member 4
Four-span transmembrane protein 2
Gene names
Name:MS4A7
Synonyms:4SPAN2, CD20L4, CFFM4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length240 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in signal transduction as a component of a multimeric receptor complex.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Ubiquitous expression in normal tissues. Expression is more elevated in adult liver, lung, spleen, and heart than in their fetal counterparts, and is higher in normal tissues than in the cancerous tissue or cell lines. Low levels of expression were detected in the promonocytic stage, whereas high levels of expression were detected in mature monocytes.

Sequence similarities

Belongs to the MS4A family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionReceptor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9GZW8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9GZW8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     50-94: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 240240Membrane-spanning 4-domains subfamily A member 7
PRO_0000158643

Regions

Topological domain1 – 4747Cytoplasmic Potential
Transmembrane48 – 6821Helical; Potential
Topological domain69 – 8315Extracellular Potential
Transmembrane84 – 10421Helical; Potential
Topological domain105 – 12117Cytoplasmic Potential
Transmembrane122 – 14221Helical; Potential
Topological domain143 – 17836Extracellular Potential
Transmembrane179 – 19921Helical; Potential
Topological domain200 – 24041Cytoplasmic Potential

Natural variations

Alternative sequence50 – 9445Missing in isoform 2.
VSP_042009
Natural variant341E → K.
Corresponds to variant rs2233241 [ dbSNP | Ensembl ].
VAR_053520
Natural variant1121P → H.
Corresponds to variant rs2233249 [ dbSNP | Ensembl ].
VAR_053521
Natural variant1571S → F.
Corresponds to variant rs2233251 [ dbSNP | Ensembl ].
VAR_053522

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 512BC9C126C76DC0

FASTA24026,131
        10         20         30         40         50         60 
MLLQSQTMGV SHSFTPKGIT IPQREKPGHM YQNEDYLQNG LPTETTVLGT VQILCCLLIS 

        70         80         90        100        110        120 
SLGAILVFAP YPSHFNPAIS TTLMSGYPFL GALCFGITGS LSIISGKQST KPFDLSSLTS 

       130        140        150        160        170        180 
NAVSSVTAGA GLFLLADSMV ALRTASQHCG SEMDYLSSLP YSEYYYPIYE IKDCLLTSVS 

       190        200        210        220        230        240 
LTGVLVVMLI FTVLELLLAA YSSVFWWKQL YSNNPGSSFS STQSQDHIQQ VKKSSSRSWI 

« Hide

Isoform 2 [UniParc].

Checksum: 4AF51AD87DF2A74B
Show »

FASTA19521,404

References

« Hide 'large scale' references
[1]"Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor."
Ishibashi K., Suzuki M., Sasaki S., Imai M.
Gene 264:87-93(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"CFFM4: a new member of the CD20/Fc-epsilon-RI-beta-family."
Gingras M.-C., Lapillonne H., Margolin J.F.
Immunogenetics 53:468-476(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Peripheral blood.
[3]"Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse."
Liang Y., Tedder T.F.
Genomics 72:119-127(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Parathyroid.
[4]"Isolation of a family of hematopoietic-expressed four-transmembrane genes related to CD20 and Fc-epsilon-RI-beta."
Hulett M.D., Pagler E., Hogarth P.M., Eyre H.J., Baker E., Crawford J., Sutherland G.R., Parish C.R.
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"Novel genes expressed in human dendritic cells."
Li Y., Gu J., Peng Y., Qian B., Xu S., Han Z., Fu G., Chen Z.
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Dendritic cell.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Placenta and Umbilical cord blood.
[7]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB026043 mRNA. Translation: BAB18755.1.
AF309653 mRNA. Translation: AAG30930.1.
AF237916 mRNA. Translation: AAK37599.1.
AF350501 mRNA. Translation: AAL56221.1.
AF201951 mRNA. Translation: AAF17243.1.
AK075106 mRNA. Translation: BAC11405.1.
AK297027 mRNA. Translation: BAG59556.1.
CR457187 mRNA. Translation: CAG33468.1.
AP003127 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73878.1.
CH471076 Genomic DNA. Translation: EAW73879.1.
BC020673 mRNA. Translation: AAH20673.1.
RefSeqNP_067024.1. NM_021201.4.
NP_996821.1. NM_206938.1.
NP_996822.1. NM_206939.1.
NP_996823.1. NM_206940.1.
UniGeneHs.530735.

3D structure databases

ProteinModelPortalQ9GZW8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121808. 2 interactions.
IntActQ9GZW8. 3 interactions.
MINTMINT-1387242.
STRING9606.ENSP00000300184.

PTM databases

PhosphoSiteQ9GZW8.

Polymorphism databases

DMDM29611829.

Proteomic databases

PaxDbQ9GZW8.
PRIDEQ9GZW8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000300184; ENSP00000300184; ENSG00000166927. [Q9GZW8-1]
ENST00000358246; ENSP00000350983; ENSG00000166927. [Q9GZW8-2]
ENST00000534016; ENSP00000434637; ENSG00000166927. [Q9GZW8-2]
GeneID58475.
KEGGhsa:58475.
UCSCuc001npe.3. human. [Q9GZW8-1]
uc001npg.3. human. [Q9GZW8-2]

Organism-specific databases

CTD58475.
GeneCardsGC11P060145.
HGNCHGNC:13378. MS4A7.
HPACAB026387.
HPA017418.
MIM606502. gene.
neXtProtNX_Q9GZW8.
PharmGKBPA31124.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41459.
HOGENOMHOG000293396.
HOVERGENHBG052387.
InParanoidQ9GZW8.
OMASVFWWKQ.
OrthoDBEOG7XPZ7D.
PhylomeDBQ9GZW8.
TreeFamTF335157.

Gene expression databases

ArrayExpressQ9GZW8.
BgeeQ9GZW8.
CleanExHS_MS4A7.
GenevestigatorQ9GZW8.

Family and domain databases

InterProIPR007237. CD20-like.
[Graphical view]
PfamPF04103. CD20. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMS4A7. human.
GeneWikiMS4A7.
GenomeRNAi58475.
NextBio64904.
PROQ9GZW8.
SOURCESearch...

Entry information

Entry nameMS4A7_HUMAN
AccessionPrimary (citable) accession number: Q9GZW8
Secondary accession number(s): A6NP53, Q6IAG8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: March 1, 2001
Last modified: March 19, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM