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Q9GZW8

- MS4A7_HUMAN

UniProt

Q9GZW8 - MS4A7_HUMAN

Protein

Membrane-spanning 4-domains subfamily A member 7

Gene

MS4A7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    May be involved in signal transduction as a component of a multimeric receptor complex.

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 7
    Alternative name(s):
    CD20 antigen-like 4
    CD20/FC-epsilon-RI-beta family member 4
    Four-span transmembrane protein 2
    Gene namesi
    Name:MS4A7
    Synonyms:4SPAN2, CD20L4, CFFM4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:13378. MS4A7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31124.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 240240Membrane-spanning 4-domains subfamily A member 7PRO_0000158643Add
    BLAST

    Proteomic databases

    PaxDbiQ9GZW8.
    PRIDEiQ9GZW8.

    PTM databases

    PhosphoSiteiQ9GZW8.

    Expressioni

    Tissue specificityi

    Ubiquitous expression in normal tissues. Expression is more elevated in adult liver, lung, spleen, and heart than in their fetal counterparts, and is higher in normal tissues than in the cancerous tissue or cell lines. Low levels of expression were detected in the promonocytic stage, whereas high levels of expression were detected in mature monocytes.

    Gene expression databases

    ArrayExpressiQ9GZW8.
    BgeeiQ9GZW8.
    CleanExiHS_MS4A7.
    GenevestigatoriQ9GZW8.

    Organism-specific databases

    HPAiCAB026387.
    HPA017418.

    Interactioni

    Protein-protein interaction databases

    BioGridi121808. 2 interactions.
    IntActiQ9GZW8. 3 interactions.
    MINTiMINT-1387242.
    STRINGi9606.ENSP00000300184.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GZW8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4747CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini69 – 8315ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini105 – 12117CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini143 – 17836ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini200 – 24041CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei48 – 6821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei84 – 10421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei122 – 14221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MS4A family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41459.
    HOGENOMiHOG000293396.
    HOVERGENiHBG052387.
    InParanoidiQ9GZW8.
    OMAiQILCCLM.
    OrthoDBiEOG7XPZ7D.
    PhylomeDBiQ9GZW8.
    TreeFamiTF335157.

    Family and domain databases

    InterProiIPR007237. CD20-like.
    [Graphical view]
    PfamiPF04103. CD20. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9GZW8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLLQSQTMGV SHSFTPKGIT IPQREKPGHM YQNEDYLQNG LPTETTVLGT    50
    VQILCCLLIS SLGAILVFAP YPSHFNPAIS TTLMSGYPFL GALCFGITGS 100
    LSIISGKQST KPFDLSSLTS NAVSSVTAGA GLFLLADSMV ALRTASQHCG 150
    SEMDYLSSLP YSEYYYPIYE IKDCLLTSVS LTGVLVVMLI FTVLELLLAA 200
    YSSVFWWKQL YSNNPGSSFS STQSQDHIQQ VKKSSSRSWI 240
    Length:240
    Mass (Da):26,131
    Last modified:March 1, 2001 - v1
    Checksum:i512BC9C126C76DC0
    GO
    Isoform 2 (identifier: Q9GZW8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         50-94: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:195
    Mass (Da):21,404
    Checksum:i4AF51AD87DF2A74B
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti34 – 341E → K.
    Corresponds to variant rs2233241 [ dbSNP | Ensembl ].
    VAR_053520
    Natural varianti112 – 1121P → H.
    Corresponds to variant rs2233249 [ dbSNP | Ensembl ].
    VAR_053521
    Natural varianti157 – 1571S → F.
    Corresponds to variant rs2233251 [ dbSNP | Ensembl ].
    VAR_053522

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei50 – 9445Missing in isoform 2. 1 PublicationVSP_042009Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026043 mRNA. Translation: BAB18755.1.
    AF309653 mRNA. Translation: AAG30930.1.
    AF237916 mRNA. Translation: AAK37599.1.
    AF350501 mRNA. Translation: AAL56221.1.
    AF201951 mRNA. Translation: AAF17243.1.
    AK075106 mRNA. Translation: BAC11405.1.
    AK297027 mRNA. Translation: BAG59556.1.
    CR457187 mRNA. Translation: CAG33468.1.
    AP003127 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW73878.1.
    CH471076 Genomic DNA. Translation: EAW73879.1.
    BC020673 mRNA. Translation: AAH20673.1.
    CCDSiCCDS7985.1. [Q9GZW8-1]
    CCDS7986.1. [Q9GZW8-2]
    RefSeqiNP_067024.1. NM_021201.4. [Q9GZW8-1]
    NP_996821.1. NM_206938.1. [Q9GZW8-2]
    NP_996822.1. NM_206939.1. [Q9GZW8-1]
    NP_996823.1. NM_206940.1. [Q9GZW8-2]
    UniGeneiHs.530735.

    Genome annotation databases

    EnsembliENST00000300184; ENSP00000300184; ENSG00000166927. [Q9GZW8-1]
    ENST00000358246; ENSP00000350983; ENSG00000166927. [Q9GZW8-2]
    ENST00000534016; ENSP00000434637; ENSG00000166927. [Q9GZW8-2]
    GeneIDi58475.
    KEGGihsa:58475.
    UCSCiuc001npe.3. human. [Q9GZW8-1]
    uc001npg.3. human. [Q9GZW8-2]

    Polymorphism databases

    DMDMi29611829.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026043 mRNA. Translation: BAB18755.1 .
    AF309653 mRNA. Translation: AAG30930.1 .
    AF237916 mRNA. Translation: AAK37599.1 .
    AF350501 mRNA. Translation: AAL56221.1 .
    AF201951 mRNA. Translation: AAF17243.1 .
    AK075106 mRNA. Translation: BAC11405.1 .
    AK297027 mRNA. Translation: BAG59556.1 .
    CR457187 mRNA. Translation: CAG33468.1 .
    AP003127 Genomic DNA. No translation available.
    CH471076 Genomic DNA. Translation: EAW73878.1 .
    CH471076 Genomic DNA. Translation: EAW73879.1 .
    BC020673 mRNA. Translation: AAH20673.1 .
    CCDSi CCDS7985.1. [Q9GZW8-1 ]
    CCDS7986.1. [Q9GZW8-2 ]
    RefSeqi NP_067024.1. NM_021201.4. [Q9GZW8-1 ]
    NP_996821.1. NM_206938.1. [Q9GZW8-2 ]
    NP_996822.1. NM_206939.1. [Q9GZW8-1 ]
    NP_996823.1. NM_206940.1. [Q9GZW8-2 ]
    UniGenei Hs.530735.

    3D structure databases

    ProteinModelPortali Q9GZW8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121808. 2 interactions.
    IntActi Q9GZW8. 3 interactions.
    MINTi MINT-1387242.
    STRINGi 9606.ENSP00000300184.

    PTM databases

    PhosphoSitei Q9GZW8.

    Polymorphism databases

    DMDMi 29611829.

    Proteomic databases

    PaxDbi Q9GZW8.
    PRIDEi Q9GZW8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300184 ; ENSP00000300184 ; ENSG00000166927 . [Q9GZW8-1 ]
    ENST00000358246 ; ENSP00000350983 ; ENSG00000166927 . [Q9GZW8-2 ]
    ENST00000534016 ; ENSP00000434637 ; ENSG00000166927 . [Q9GZW8-2 ]
    GeneIDi 58475.
    KEGGi hsa:58475.
    UCSCi uc001npe.3. human. [Q9GZW8-1 ]
    uc001npg.3. human. [Q9GZW8-2 ]

    Organism-specific databases

    CTDi 58475.
    GeneCardsi GC11P060145.
    HGNCi HGNC:13378. MS4A7.
    HPAi CAB026387.
    HPA017418.
    MIMi 606502. gene.
    neXtProti NX_Q9GZW8.
    PharmGKBi PA31124.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41459.
    HOGENOMi HOG000293396.
    HOVERGENi HBG052387.
    InParanoidi Q9GZW8.
    OMAi QILCCLM.
    OrthoDBi EOG7XPZ7D.
    PhylomeDBi Q9GZW8.
    TreeFami TF335157.

    Miscellaneous databases

    ChiTaRSi MS4A7. human.
    GeneWikii MS4A7.
    GenomeRNAii 58475.
    NextBioi 64904.
    PROi Q9GZW8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9GZW8.
    Bgeei Q9GZW8.
    CleanExi HS_MS4A7.
    Genevestigatori Q9GZW8.

    Family and domain databases

    InterProi IPR007237. CD20-like.
    [Graphical view ]
    Pfami PF04103. CD20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor."
      Ishibashi K., Suzuki M., Sasaki S., Imai M.
      Gene 264:87-93(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "CFFM4: a new member of the CD20/Fc-epsilon-RI-beta-family."
      Gingras M.-C., Lapillonne H., Margolin J.F.
      Immunogenetics 53:468-476(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Peripheral blood.
    3. "Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse."
      Liang Y., Tedder T.F.
      Genomics 72:119-127(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Parathyroid.
    4. "Isolation of a family of hematopoietic-expressed four-transmembrane genes related to CD20 and Fc-epsilon-RI-beta."
      Hulett M.D., Pagler E., Hogarth P.M., Eyre H.J., Baker E., Crawford J., Sutherland G.R., Parish C.R.
      Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Novel genes expressed in human dendritic cells."
      Li Y., Gu J., Peng Y., Qian B., Xu S., Han Z., Fu G., Chen Z.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Dendritic cell.
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta and Umbilical cord blood.
    7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.

    Entry informationi

    Entry nameiMS4A7_HUMAN
    AccessioniPrimary (citable) accession number: Q9GZW8
    Secondary accession number(s): A6NP53, Q6IAG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2003
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3