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Q9GZW8

- MS4A7_HUMAN

UniProt

Q9GZW8 - MS4A7_HUMAN

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Protein
Membrane-spanning 4-domains subfamily A member 7
Gene
MS4A7, 4SPAN2, CD20L4, CFFM4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in signal transduction as a component of a multimeric receptor complex.

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-spanning 4-domains subfamily A member 7
Alternative name(s):
CD20 antigen-like 4
CD20/FC-epsilon-RI-beta family member 4
Four-span transmembrane protein 2
Gene namesi
Name:MS4A7
Synonyms:4SPAN2, CD20L4, CFFM4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:13378. MS4A7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei48 – 6821Helical; Reviewed prediction
Add
BLAST
Topological domaini69 – 8315Extracellular Reviewed prediction
Add
BLAST
Transmembranei84 – 10421Helical; Reviewed prediction
Add
BLAST
Topological domaini105 – 12117Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei122 – 14221Helical; Reviewed prediction
Add
BLAST
Topological domaini143 – 17836Extracellular Reviewed prediction
Add
BLAST
Transmembranei179 – 19921Helical; Reviewed prediction
Add
BLAST
Topological domaini200 – 24041Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31124.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Membrane-spanning 4-domains subfamily A member 7
PRO_0000158643Add
BLAST

Proteomic databases

PaxDbiQ9GZW8.
PRIDEiQ9GZW8.

PTM databases

PhosphoSiteiQ9GZW8.

Expressioni

Tissue specificityi

Ubiquitous expression in normal tissues. Expression is more elevated in adult liver, lung, spleen, and heart than in their fetal counterparts, and is higher in normal tissues than in the cancerous tissue or cell lines. Low levels of expression were detected in the promonocytic stage, whereas high levels of expression were detected in mature monocytes.

Gene expression databases

ArrayExpressiQ9GZW8.
BgeeiQ9GZW8.
CleanExiHS_MS4A7.
GenevestigatoriQ9GZW8.

Organism-specific databases

HPAiCAB026387.
HPA017418.

Interactioni

Protein-protein interaction databases

BioGridi121808. 2 interactions.
IntActiQ9GZW8. 3 interactions.
MINTiMINT-1387242.
STRINGi9606.ENSP00000300184.

Structurei

3D structure databases

ProteinModelPortaliQ9GZW8.

Family & Domainsi

Sequence similaritiesi

Belongs to the MS4A family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41459.
HOGENOMiHOG000293396.
HOVERGENiHBG052387.
InParanoidiQ9GZW8.
OMAiQILCCLM.
OrthoDBiEOG7XPZ7D.
PhylomeDBiQ9GZW8.
TreeFamiTF335157.

Family and domain databases

InterProiIPR007237. CD20-like.
[Graphical view]
PfamiPF04103. CD20. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9GZW8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLLQSQTMGV SHSFTPKGIT IPQREKPGHM YQNEDYLQNG LPTETTVLGT    50
VQILCCLLIS SLGAILVFAP YPSHFNPAIS TTLMSGYPFL GALCFGITGS 100
LSIISGKQST KPFDLSSLTS NAVSSVTAGA GLFLLADSMV ALRTASQHCG 150
SEMDYLSSLP YSEYYYPIYE IKDCLLTSVS LTGVLVVMLI FTVLELLLAA 200
YSSVFWWKQL YSNNPGSSFS STQSQDHIQQ VKKSSSRSWI 240
Length:240
Mass (Da):26,131
Last modified:March 1, 2001 - v1
Checksum:i512BC9C126C76DC0
GO
Isoform 2 (identifier: Q9GZW8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     50-94: Missing.

Note: No experimental confirmation available.

Show »
Length:195
Mass (Da):21,404
Checksum:i4AF51AD87DF2A74B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341E → K.
Corresponds to variant rs2233241 [ dbSNP | Ensembl ].
VAR_053520
Natural varianti112 – 1121P → H.
Corresponds to variant rs2233249 [ dbSNP | Ensembl ].
VAR_053521
Natural varianti157 – 1571S → F.
Corresponds to variant rs2233251 [ dbSNP | Ensembl ].
VAR_053522

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei50 – 9445Missing in isoform 2.
VSP_042009Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026043 mRNA. Translation: BAB18755.1.
AF309653 mRNA. Translation: AAG30930.1.
AF237916 mRNA. Translation: AAK37599.1.
AF350501 mRNA. Translation: AAL56221.1.
AF201951 mRNA. Translation: AAF17243.1.
AK075106 mRNA. Translation: BAC11405.1.
AK297027 mRNA. Translation: BAG59556.1.
CR457187 mRNA. Translation: CAG33468.1.
AP003127 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73878.1.
CH471076 Genomic DNA. Translation: EAW73879.1.
BC020673 mRNA. Translation: AAH20673.1.
CCDSiCCDS7985.1. [Q9GZW8-1]
CCDS7986.1. [Q9GZW8-2]
RefSeqiNP_067024.1. NM_021201.4. [Q9GZW8-1]
NP_996821.1. NM_206938.1. [Q9GZW8-2]
NP_996822.1. NM_206939.1. [Q9GZW8-1]
NP_996823.1. NM_206940.1. [Q9GZW8-2]
UniGeneiHs.530735.

Genome annotation databases

EnsembliENST00000300184; ENSP00000300184; ENSG00000166927. [Q9GZW8-1]
ENST00000358246; ENSP00000350983; ENSG00000166927. [Q9GZW8-2]
ENST00000534016; ENSP00000434637; ENSG00000166927. [Q9GZW8-2]
GeneIDi58475.
KEGGihsa:58475.
UCSCiuc001npe.3. human. [Q9GZW8-1]
uc001npg.3. human. [Q9GZW8-2]

Polymorphism databases

DMDMi29611829.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026043 mRNA. Translation: BAB18755.1 .
AF309653 mRNA. Translation: AAG30930.1 .
AF237916 mRNA. Translation: AAK37599.1 .
AF350501 mRNA. Translation: AAL56221.1 .
AF201951 mRNA. Translation: AAF17243.1 .
AK075106 mRNA. Translation: BAC11405.1 .
AK297027 mRNA. Translation: BAG59556.1 .
CR457187 mRNA. Translation: CAG33468.1 .
AP003127 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73878.1 .
CH471076 Genomic DNA. Translation: EAW73879.1 .
BC020673 mRNA. Translation: AAH20673.1 .
CCDSi CCDS7985.1. [Q9GZW8-1 ]
CCDS7986.1. [Q9GZW8-2 ]
RefSeqi NP_067024.1. NM_021201.4. [Q9GZW8-1 ]
NP_996821.1. NM_206938.1. [Q9GZW8-2 ]
NP_996822.1. NM_206939.1. [Q9GZW8-1 ]
NP_996823.1. NM_206940.1. [Q9GZW8-2 ]
UniGenei Hs.530735.

3D structure databases

ProteinModelPortali Q9GZW8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121808. 2 interactions.
IntActi Q9GZW8. 3 interactions.
MINTi MINT-1387242.
STRINGi 9606.ENSP00000300184.

PTM databases

PhosphoSitei Q9GZW8.

Polymorphism databases

DMDMi 29611829.

Proteomic databases

PaxDbi Q9GZW8.
PRIDEi Q9GZW8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000300184 ; ENSP00000300184 ; ENSG00000166927 . [Q9GZW8-1 ]
ENST00000358246 ; ENSP00000350983 ; ENSG00000166927 . [Q9GZW8-2 ]
ENST00000534016 ; ENSP00000434637 ; ENSG00000166927 . [Q9GZW8-2 ]
GeneIDi 58475.
KEGGi hsa:58475.
UCSCi uc001npe.3. human. [Q9GZW8-1 ]
uc001npg.3. human. [Q9GZW8-2 ]

Organism-specific databases

CTDi 58475.
GeneCardsi GC11P060145.
HGNCi HGNC:13378. MS4A7.
HPAi CAB026387.
HPA017418.
MIMi 606502. gene.
neXtProti NX_Q9GZW8.
PharmGKBi PA31124.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41459.
HOGENOMi HOG000293396.
HOVERGENi HBG052387.
InParanoidi Q9GZW8.
OMAi QILCCLM.
OrthoDBi EOG7XPZ7D.
PhylomeDBi Q9GZW8.
TreeFami TF335157.

Miscellaneous databases

ChiTaRSi MS4A7. human.
GeneWikii MS4A7.
GenomeRNAii 58475.
NextBioi 64904.
PROi Q9GZW8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9GZW8.
Bgeei Q9GZW8.
CleanExi HS_MS4A7.
Genevestigatori Q9GZW8.

Family and domain databases

InterProi IPR007237. CD20-like.
[Graphical view ]
Pfami PF04103. CD20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor."
    Ishibashi K., Suzuki M., Sasaki S., Imai M.
    Gene 264:87-93(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "CFFM4: a new member of the CD20/Fc-epsilon-RI-beta-family."
    Gingras M.-C., Lapillonne H., Margolin J.F.
    Immunogenetics 53:468-476(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Peripheral blood.
  3. "Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse."
    Liang Y., Tedder T.F.
    Genomics 72:119-127(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Parathyroid.
  4. "Isolation of a family of hematopoietic-expressed four-transmembrane genes related to CD20 and Fc-epsilon-RI-beta."
    Hulett M.D., Pagler E., Hogarth P.M., Eyre H.J., Baker E., Crawford J., Sutherland G.R., Parish C.R.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Novel genes expressed in human dendritic cells."
    Li Y., Gu J., Peng Y., Qian B., Xu S., Han Z., Fu G., Chen Z.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Dendritic cell.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta and Umbilical cord blood.
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.

Entry informationi

Entry nameiMS4A7_HUMAN
AccessioniPrimary (citable) accession number: Q9GZW8
Secondary accession number(s): A6NP53, Q6IAG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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