Q9GZW8 (MS4A7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membrane-spanning 4-domains subfamily A member 7

Alternative name(s):
CD20 antigen-like 4
CD20/FC-epsilon-RI-beta family member 4
Four-span transmembrane protein 2

Gene names

Name:	MS4A7
Synonyms:	4SPAN2, CD20L4, CFFM4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	240 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in signal transduction as a component of a multimeric receptor complex.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Ubiquitous expression in normal tissues. Expression is more elevated in adult liver, lung, spleen, and heart than in their fetal counterparts, and is higher in normal tissues than in the cancerous tissue or cell lines. Low levels of expression were detected in the promonocytic stage, whereas high levels of expression were detected in mature monocytes.
Sequence similarities	Belongs to the MS4A family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9GZW8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9GZW8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     50-94: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 240	240	Membrane-spanning 4-domains subfamily A member 7		PRO_0000158643
Regions
	Topological domain	1 – 47	47	Cytoplasmic Potential
	Transmembrane	48 – 68	21	Helical; Potential
	Topological domain	69 – 83	15	Extracellular Potential
	Transmembrane	84 – 104	21	Helical; Potential
	Topological domain	105 – 121	17	Cytoplasmic Potential
	Transmembrane	122 – 142	21	Helical; Potential
	Topological domain	143 – 178	36	Extracellular Potential
	Transmembrane	179 – 199	21	Helical; Potential
	Topological domain	200 – 240	41	Cytoplasmic Potential
Natural variations
	Alternative sequence	50 – 94	45	Missing in isoform 2.		VSP_042009
	Natural variant	34	1	E → K. Corresponds to variant rs2233241 [ dbSNP | Ensembl ].		VAR_053520
	Natural variant	112	1	P → H. Corresponds to variant rs2233249 [ dbSNP | Ensembl ].		VAR_053521
	Natural variant	157	1	S → F. Corresponds to variant rs2233251 [ dbSNP | Ensembl ].		VAR_053522

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 512BC9C126C76DC0	FASTA	240	26,131
	10 20 30 40 50 60 MLLQSQTMGV SHSFTPKGIT IPQREKPGHM YQNEDYLQNG LPTETTVLGT VQILCCLLIS 70 80 90 100 110 120 SLGAILVFAP YPSHFNPAIS TTLMSGYPFL GALCFGITGS LSIISGKQST KPFDLSSLTS 130 140 150 160 170 180 NAVSSVTAGA GLFLLADSMV ALRTASQHCG SEMDYLSSLP YSEYYYPIYE IKDCLLTSVS 190 200 210 220 230 240 LTGVLVVMLI FTVLELLLAA YSSVFWWKQL YSNNPGSSFS STQSQDHIQQ VKKSSSRSWI
	Isoform 2 [UniParc]. Checksum: 4AF51AD87DF2A74B	FASTA	195	21,404
	10 20 30 40 50 60 MLLQSQTMGV SHSFTPKGIT IPQREKPGHM YQNEDYLQNG LPTETTVLGF GITGSLSIIS 70 80 90 100 110 120 GKQSTKPFDL SSLTSNAVSS VTAGAGLFLL ADSMVALRTA SQHCGSEMDY LSSLPYSEYY 130 140 150 160 170 180 YPIYEIKDCL LTSVSLTGVL VVMLIFTVLE LLLAAYSSVF WWKQLYSNNP GSSFSSTQSQ 190 DHIQQVKKSS SRSWI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor." Ishibashi K., Suzuki M., Sasaki S., Imai M. Gene 264:87-93(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"CFFM4: a new member of the CD20/Fc-epsilon-RI-beta-family." Gingras M.-C., Lapillonne H., Margolin J.F. Immunogenetics 53:468-476(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Peripheral blood.
[3]	"Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse." Liang Y., Tedder T.F. Genomics 72:119-127(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Parathyroid.
[4]	"Isolation of a family of hematopoietic-expressed four-transmembrane genes related to CD20 and Fc-epsilon-RI-beta." Hulett M.D., Pagler E., Hogarth P.M., Eyre H.J., Baker E., Crawford J., Sutherland G.R., Parish C.R. Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"Novel genes expressed in human dendritic cells." Li Y., Gu J., Peng Y., Qian B., Xu S., Han Z., Fu G., Chen Z. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Dendritic cell.
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Placenta and Umbilical cord blood.
[7]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[8]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB026043 mRNA. Translation: BAB18755.1. AF309653 mRNA. Translation: AAG30930.1. AF237916 mRNA. Translation: AAK37599.1. AF350501 mRNA. Translation: AAL56221.1. AF201951 mRNA. Translation: AAF17243.1. AK075106 mRNA. Translation: BAC11405.1. AK297027 mRNA. Translation: BAG59556.1. CR457187 mRNA. Translation: CAG33468.1. AP003127 Genomic DNA. No translation available. CH471076 Genomic DNA. Translation: EAW73878.1. CH471076 Genomic DNA. Translation: EAW73879.1. BC020673 mRNA. Translation: AAH20673.1.
IPI	IPI00009636.
RefSeq	NP_067024.1. NM_021201.4. NP_996821.1. NM_206938.1. NP_996822.1. NM_206939.1. NP_996823.1. NM_206940.1.
UniGene	Hs.530735.
3D structure databases
ProteinModelPortal	Q9GZW8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9GZW8. 3 interactions.
MINT	MINT-1387242.
STRING	9606.ENSP00000300184.
PTM databases
PhosphoSite	Q9GZW8.
Polymorphism databases
DMDM	29611829.
Proteomic databases
PaxDb	Q9GZW8.
PRIDE	Q9GZW8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000300184; ENSP00000300184; ENSG00000166927. ENST00000358246; ENSP00000350983; ENSG00000166927. ENST00000534016; ENSP00000434637; ENSG00000166927.
GeneID	58475.
KEGG	hsa:58475.
UCSC	uc001npe.3. human.
Organism-specific databases
CTD	58475.
GeneCards	GC11P060145.
HGNC	HGNC:13378. MS4A7.
HPA	CAB026387. HPA017418.
MIM	606502. gene.
neXtProt	NX_Q9GZW8.
PharmGKB	PA31124.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41459.
HOGENOM	HOG000293396.
HOVERGEN	HBG052387.
InParanoid	Q9GZW8.
OMA	PYSEYYY.
OrthoDB	EOG4J9N17.
PhylomeDB	Q9GZW8.
Gene expression databases
ArrayExpress	Q9GZW8.
Bgee	Q9GZW8.
CleanEx	HS_MS4A7.
Genevestigator	Q9GZW8.
GermOnline	ENSG00000166927. Homo sapiens.
Family and domain databases
InterPro	IPR007237. CD20-like. [Graphical view]
Pfam	PF04103. CD20. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MS4A7. human.
GenomeRNAi	58475.
NextBio	64904.
SOURCE	Search...

Entry information

Entry name

MS4A7_HUMAN

Accession

Primary (citable) accession number: Q9GZW8
Secondary accession number(s): A6NP53, Q6IAG8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2003
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.