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Protein

Putative SCAN domain-containing protein SCAND2P

Gene

SCAND2P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Putative SCAN domain-containing protein SCAND2P
Alternative name(s):
SCAN domain-containing protein 2 pseudogene
Gene namesi
Name:SCAND2P
Synonyms:SCAND2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:10567. SCAND2P.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi29839632.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976331 – 306Putative SCAN domain-containing protein SCAND2PAdd BLAST306

Proteomic databases

PeptideAtlasiQ9GZW5.
PRIDEiQ9GZW5.

PTM databases

iPTMnetiQ9GZW5.
PhosphoSitePlusiQ9GZW5.

Structurei

3D structure databases

ProteinModelPortaliQ9GZW5.
SMRiQ9GZW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 129SCAN boxPROSITE-ProRule annotationAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi155 – 217Ala-richAdd BLAST63
Compositional biasi191 – 276Arg-richAdd BLAST86

Phylogenomic databases

InParanoidiQ9GZW5.
PhylomeDBiQ9GZW5.

Family and domain databases

InterProiView protein in InterPro
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
PfamiView protein in Pfam
PF02023. SCAN. 1 hit.
SMARTiView protein in SMART
SM00431. SCAN. 1 hit.
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiView protein in PROSITE
PS50804. SCAN_BOX. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9GZW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVAVDQQIQ TPSVQDLQIV KLEEDSHWEQ EISLQGNYPG PETSCQSFWH
60 70 80 90 100
FRYQEASRPR EALLQLQKLC CQWLRPEKCT KEQILELLVL EQFPTVLLQE
110 120 130 140 150
IQIWVRQQHP ESGEEAVALV EDLQKEPGRQ RLEPRARPSG RTPPAQLRSP
160 170 180 190 200
WPMTAAGPAS RARASETGST ASCAGRWRTC CAAAAAPSAA RSASARTGRS
210 220 230 240 250
TSSCARAARA PSATEGALTR TPAPRRPLQR RRPGTGPWRP GRQRGAGTAP
260 270 280 290 300
PGTQPRQRPS PRPTPRRPRP RLARPRAGQK PWLLVIRSME RVMYVMLIIQ

METEDV
Note: No experimental confirmation available.
Length:306
Mass (Da):34,217
Last modified:April 11, 2003 - v2
Checksum:iD5E11136D30983EB
GO
Isoform 2 (identifier: Q9GZW5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-152: RARPSGRTPPAQLRSPWP → CLMWLWEFLQRRAGVARR
     153-306: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:152
Mass (Da):17,993
Checksum:iD4E8965ACEF1A98B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6D → V in BAF83178 (PubMed:14702039).Curated1
Sequence conflicti94P → R in AAG34567 (PubMed:11056053).Curated1
Sequence conflicti94P → R in AAG33966 (PubMed:11056053).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034421110P → T. Corresponds to variant dbSNP:rs16974462Ensembl.1
Natural variantiVAR_021961185A → T. Corresponds to variant dbSNP:rs698620Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007110135 – 152RARPS…RSPWP → CLMWLWEFLQRRAGVARR in isoform 2. 2 PublicationsAdd BLAST18
Alternative sequenceiVSP_007111153 – 306Missing in isoform 2. 2 PublicationsAdd BLAST154

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229246 mRNA. Translation: AAG33966.1.
AF244812 Genomic DNA. Translation: AAG34567.1.
AK022844 mRNA. Translation: BAB14268.1.
AK290489 mRNA. Translation: BAF83178.1.
BC011547 mRNA. No translation available.
BC012929 mRNA. No translation available.
BC063836 mRNA. No translation available.
UniGeneiHs.658114.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSCND2_HUMAN
AccessioniPrimary (citable) accession number: Q9GZW5
Secondary accession number(s): A8K374, Q9H9G1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: March 15, 2017
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot