Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9GZV8

- PRD14_HUMAN

UniProt

Q9GZV8 - PRD14_HUMAN

Protein

PR domain zinc finger protein 14

Gene

PRDM14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression By similarity. Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.By similarity2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri400 – 42425C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri432 – 45524C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri461 – 48323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri489 – 51123C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri517 – 54024C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri546 – 56823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. methyltransferase activity Source: UniProtKB-KW
    4. protein binding Source: IntAct

    GO - Biological processi

    1. cell fate specification Source: Ensembl
    2. cell morphogenesis Source: Ensembl
    3. fertilization Source: Ensembl
    4. germ cell development Source: Ensembl
    5. homeostasis of number of cells within a tissue Source: Ensembl
    6. regulation of transcription, DNA-templated Source: UniProtKB-KW
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_200812. Transcriptional regulation of pluripotent stem cells.
    SignaLinkiQ9GZV8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PR domain zinc finger protein 14 (EC:2.1.1.-)
    Alternative name(s):
    PR domain-containing protein 14
    Gene namesi
    Name:PRDM14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:14001. PRDM14.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33712.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 571571PR domain zinc finger protein 14PRO_0000047771Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei79 – 791Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9GZV8.
    PRIDEiQ9GZV8.

    PTM databases

    PhosphoSiteiQ9GZV8.

    Expressioni

    Tissue specificityi

    Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level).2 Publications

    Gene expression databases

    ArrayExpressiQ9GZV8.
    BgeeiQ9GZV8.
    CleanExiHS_PRDM14.
    GenevestigatoriQ9GZV8.

    Organism-specific databases

    HPAiHPA019094.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Hoxa1P090223EBI-3957793,EBI-3957603From a different organism.

    Protein-protein interaction databases

    BioGridi122025. 4 interactions.
    IntActiQ9GZV8. 4 interactions.
    MINTiMINT-7971034.
    STRINGi9606.ENSP00000276594.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GZV8.
    SMRiQ9GZV8. Positions 200-568.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini251 – 367117SETPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The first 5 zinc fingers, but not the last one, are required for DNA-binding and transcriptional activity.

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
    Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri400 – 42425C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri432 – 45524C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri461 – 48323C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri489 – 51123C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri517 – 54024C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri546 – 56823C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG297028.
    HOGENOMiHOG000115684.
    HOVERGENiHBG053668.
    InParanoidiQ9GZV8.
    OMAiPREVPHF.
    OrthoDBiEOG7B5WW5.
    PhylomeDBiQ9GZV8.
    TreeFamiTF106412.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR001214. SET_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00856. SET. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00317. SET. 1 hit.
    SM00355. ZnF_C2H2. 6 hits.
    [Graphical view]
    PROSITEiPS50280. SET. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9GZV8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALPRPSEAV PQDKVCYPPE SSPQNLAAYY TPFPSYGHYR NSLATVEEDF    50
    QPFRQLEAAA SAAPAMPPFP FRMAPPLLSP GLGLQREPLY DLPWYSKLPP 100
    WYPIPHVPRE VPPFLSSSHE YAGASSEDLG HQIIGGDNES GPCCGPDTLI 150
    PPPPADASLL PEGLRTSQLL PCSPSKQSED GPKPSNQEGK SPARFQFTEE 200
    DLHFVLYGVT PSLEHPASLH HAISGLLVPP DSSGSDSLPQ TLDKDSLQLP 250
    EGLCLMQTVF GEVPHFGVFC SSFIAKGVRF GPFQGKVVNA SEVKTYGDNS 300
    VMWEIFEDGH LSHFIDGKGG TGNWMSYVNC ARFPKEQNLV AVQCQGHIFY 350
    ESCKEIHQNQ ELLVWYGDCY EKFLDIPVSL QVTEPGKQPS GPSEESAEGY 400
    RCERCGKVFT YKYYRDKHLK YTPCVDKGDR KFPCSLCKRS FEKRDRLRIH 450
    ILHVHEKHRP HKCSTCGKCF SQSSSLNKHM RVHSGDRPYQ CVYCTKRFTA 500
    SSILRTHIRQ HSGEKPFKCK YCGKSFASHA AHDSHVRRSH KEDDGCSCSI 550
    CGKIFSDQET FYSHMKFHED Y 571
    Length:571
    Mass (Da):64,062
    Last modified:March 1, 2001 - v1
    Checksum:i60D5ACC96DADE500
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti244 – 2441K → E.1 Publication
    Corresponds to variant rs3750228 [ dbSNP | Ensembl ].
    VAR_021895

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF319458 mRNA. Translation: AAG39635.1.
    AK022595 mRNA. Translation: BAB14120.1.
    BC052311 mRNA. Translation: AAH52311.1.
    CCDSiCCDS6206.1.
    RefSeqiNP_078780.1. NM_024504.3.
    UniGeneiHs.736037.

    Genome annotation databases

    EnsembliENST00000276594; ENSP00000276594; ENSG00000147596.
    GeneIDi63978.
    KEGGihsa:63978.
    UCSCiuc003xym.3. human.

    Polymorphism databases

    DMDMi17368925.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF319458 mRNA. Translation: AAG39635.1 .
    AK022595 mRNA. Translation: BAB14120.1 .
    BC052311 mRNA. Translation: AAH52311.1 .
    CCDSi CCDS6206.1.
    RefSeqi NP_078780.1. NM_024504.3.
    UniGenei Hs.736037.

    3D structure databases

    ProteinModelPortali Q9GZV8.
    SMRi Q9GZV8. Positions 200-568.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122025. 4 interactions.
    IntActi Q9GZV8. 4 interactions.
    MINTi MINT-7971034.
    STRINGi 9606.ENSP00000276594.

    PTM databases

    PhosphoSitei Q9GZV8.

    Polymorphism databases

    DMDMi 17368925.

    Proteomic databases

    PaxDbi Q9GZV8.
    PRIDEi Q9GZV8.

    Protocols and materials databases

    DNASUi 63978.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000276594 ; ENSP00000276594 ; ENSG00000147596 .
    GeneIDi 63978.
    KEGGi hsa:63978.
    UCSCi uc003xym.3. human.

    Organism-specific databases

    CTDi 63978.
    GeneCardsi GC08M070963.
    HGNCi HGNC:14001. PRDM14.
    HPAi HPA019094.
    MIMi 611781. gene.
    neXtProti NX_Q9GZV8.
    PharmGKBi PA33712.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG297028.
    HOGENOMi HOG000115684.
    HOVERGENi HBG053668.
    InParanoidi Q9GZV8.
    OMAi PREVPHF.
    OrthoDBi EOG7B5WW5.
    PhylomeDBi Q9GZV8.
    TreeFami TF106412.

    Enzyme and pathway databases

    Reactomei REACT_200812. Transcriptional regulation of pluripotent stem cells.
    SignaLinki Q9GZV8.

    Miscellaneous databases

    GenomeRNAii 63978.
    NextBioi 65790.
    PROi Q9GZV8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9GZV8.
    Bgeei Q9GZV8.
    CleanExi HS_PRDM14.
    Genevestigatori Q9GZV8.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR001214. SET_dom.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00856. SET. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00317. SET. 1 hit.
    SM00355. ZnF_C2H2. 6 hits.
    [Graphical view ]
    PROSITEi PS50280. SET. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 5 hits.
    PS50157. ZINC_FINGER_C2H2_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A family of novel PR-domain (PRDM) genes as candidate tumor suppressors."
      Yang X.-H., Huang S.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-244.
      Tissue: Ovary.
    4. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    5. "A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity."
      Chia N.Y., Chan Y.S., Feng B., Lu X., Orlov Y.L., Moreau D., Kumar P., Yang L., Jiang J., Lau M.S., Huss M., Soh B.S., Kraus P., Li P., Lufkin T., Lim B., Clarke N.D., Bard F., Ng H.H.
      Nature 468:316-320(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPRD14_HUMAN
    AccessioniPrimary (citable) accession number: Q9GZV8
    Secondary accession number(s): Q86UX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3