Q9GZV7 (HPLN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hyaluronan and proteoglycan link protein 2

Alternative name(s):
Brain link protein 1

Gene names

Name:	HAPLN2
Synonyms:	BRAL1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Tissue specificity	Expressed only in adult brain. Ref.1
Sequence similarities	Belongs to the HAPLN family. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Contains 2 Link domains.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Domain	Immunoglobulin domain Repeat Signal
Ligand	Hyaluronic acid
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	hyaluronic acid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 340	314	Hyaluronan and proteoglycan link protein 2		PRO_0000013187
Regions
	Domain	34 – 144	111	Ig-like V-type
	Domain	148 – 242	95	Link 1
	Domain	245 – 338	94	Link 2
Amino acid modifications
	Disulfide bond	57 ↔ 128		By similarity
	Disulfide bond	170 ↔ 240		By similarity
	Disulfide bond	194 ↔ 215		By similarity
	Disulfide bond	265 ↔ 336		By similarity
	Disulfide bond	290 ↔ 311		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9GZV7 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 62CCC1D86385F5C7	FASTA	340	37,775
	10 20 30 40 50 60 MPGWLTLPTL CRFLLWAFTI FHKAQGDPAS HPGPHYLLPP IHEVIHSHRG ATATLPCVLG 70 80 90 100 110 120 TTPPSYKVRW SKVEPGELRE TLILITNGLH ARGYGPLGGR ARMRRGHRLD ASLVIAGVRL 130 140 150 160 170 180 EDEGRYRCEL INGIEDESVA LTLSLEGVVF PYQPSRGRYQ FNYYEAKQAC EEQDGRLATY 190 200 210 220 230 240 SQLYQAWTEG LDWCNAGWLL EGSVRYPVLT ARAPCGGRGR PGIRSYGPRD RMRDRYDAFC 250 260 270 280 290 300 FTSALAGQVF FVPGRLTLSE AHAACRRRGA VVAKVGHLYA AWKFSGLDQC DGGWLADGSV 310 320 330 340 RFPITTPRPR CGGLPDPGVR SFGFPRPQQA AYGTYCYAEN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain." Hirakawa S., Oohashi T., Su W.-D., Yoshioka H., Murakami T., Arata J., Ninomiya Y. Biochem. Biophys. Res. Commun. 276:982-989(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB049061 Genomic DNA. Translation: BAB17669.1. AB049054 mRNA. Translation: BAB17662.1. BC029864 mRNA. Translation: AAH29864.1.
IPI	IPI00029184.
PIR	JC7505.
RefSeq	NP_068589.1. NM_021817.2.
UniGene	Hs.410719.
3D structure databases
ProteinModelPortal	Q9GZV7.
ModBase	Search...
Polymorphism databases
DMDM	20177844.
Proteomic databases
PaxDb	Q9GZV7.
PeptideAtlas	Q9GZV7.
PRIDE	Q9GZV7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000255039; ENSP00000255039; ENSG00000132702.
GeneID	60484.
KEGG	hsa:60484.
UCSC	uc001fpn.1. human.
Organism-specific databases
CTD	60484.
GeneCards	GC01P156589.
HGNC	HGNC:17410. HAPLN2.
HPA	HPA045765.
neXtProt	NX_Q9GZV7.
PharmGKB	PA134878581.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146628.
HOGENOM	HOG000234353.
HOVERGEN	HBG051922.
InParanoid	Q9GZV7.
KO	K06851.
OMA	CFTSALA.
OrthoDB	EOG4CVG76.
PhylomeDB	Q9GZV7.
Gene expression databases
ArrayExpress	Q9GZV7.
Bgee	Q9GZV7.
CleanEx	HS_HAPLN2.
Genevestigator	Q9GZV7.
GermOnline	ENSG00000132702. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 1 hit. 3.10.100.10. 2 hits.
InterPro	IPR016186. C-type_lectin-like. IPR016187. C-type_lectin_fold. IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR013106. Ig_V-set. IPR000538. Link. [Graphical view]
Pfam	PF07686. V-set. 1 hit. PF00193. Xlink. 2 hits. [Graphical view]
PRINTS	PR01265. LINKMODULE.
SMART	SM00409. IG. 1 hit. SM00445. LINK. 2 hits. [Graphical view]
SUPFAM	SSF56436. C-type_lectin_fold. 2 hits.
PROSITE	PS50835. IG_LIKE. 1 hit. PS01241. LINK_1. 2 hits. PS50963. LINK_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HAPLN2. human.
GenomeRNAi	60484.
NextBio	65359.

Entry information

Entry name

HPLN2_HUMAN

Accession

Primary (citable) accession number: Q9GZV7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.