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Protein

Hyaluronan and proteoglycan link protein 2

Gene

HAPLN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity).By similarity

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: GO_Central
  2. hyaluronic acid binding Source: GO_Central

GO - Biological processi

  1. cell adhesion Source: GO_Central
  2. central nervous system development Source: GO_Central
  3. establishment of blood-nerve barrier Source: Ensembl
  4. extracellular matrix assembly Source: Ensembl
  5. skeletal system development Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

Hyaluronic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan and proteoglycan link protein 2
Alternative name(s):
Brain link protein 1
Gene namesi
Name:HAPLN2
Synonyms:BRAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:17410. HAPLN2.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134878581.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 340314Hyaluronan and proteoglycan link protein 2PRO_0000013187Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 128By similarity
Disulfide bondi170 ↔ 240By similarity
Disulfide bondi194 ↔ 215By similarity
Disulfide bondi265 ↔ 336By similarity
Disulfide bondi290 ↔ 311By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9GZV7.
PaxDbiQ9GZV7.
PeptideAtlasiQ9GZV7.
PRIDEiQ9GZV7.

Expressioni

Tissue specificityi

Expressed only in adult brain.1 Publication

Gene expression databases

BgeeiQ9GZV7.
CleanExiHS_HAPLN2.
ExpressionAtlasiQ9GZV7. baseline and differential.
GenevestigatoriQ9GZV7.

Organism-specific databases

HPAiHPA045765.

Structurei

3D structure databases

ProteinModelPortaliQ9GZV7.
SMRiQ9GZV7. Positions 44-134, 149-241, 255-337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 144111Ig-like V-typeAdd
BLAST
Domaini148 – 24295Link 1PROSITE-ProRule annotationAdd
BLAST
Domaini245 – 33894Link 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the HAPLN family.Curated
Contains 2 Link domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG146628.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000234353.
HOVERGENiHBG051922.
InParanoidiQ9GZV7.
KOiK06851.
OMAiCFTSALA.
OrthoDBiEOG7ZWD1D.
PhylomeDBiQ9GZV7.
TreeFamiTF332134.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00409. IG. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GZV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGWLTLPTL CRFLLWAFTI FHKAQGDPAS HPGPHYLLPP IHEVIHSHRG
60 70 80 90 100
ATATLPCVLG TTPPSYKVRW SKVEPGELRE TLILITNGLH ARGYGPLGGR
110 120 130 140 150
ARMRRGHRLD ASLVIAGVRL EDEGRYRCEL INGIEDESVA LTLSLEGVVF
160 170 180 190 200
PYQPSRGRYQ FNYYEAKQAC EEQDGRLATY SQLYQAWTEG LDWCNAGWLL
210 220 230 240 250
EGSVRYPVLT ARAPCGGRGR PGIRSYGPRD RMRDRYDAFC FTSALAGQVF
260 270 280 290 300
FVPGRLTLSE AHAACRRRGA VVAKVGHLYA AWKFSGLDQC DGGWLADGSV
310 320 330 340
RFPITTPRPR CGGLPDPGVR SFGFPRPQQA AYGTYCYAEN
Length:340
Mass (Da):37,775
Last modified:February 28, 2001 - v1
Checksum:i62CCC1D86385F5C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049061 Genomic DNA. Translation: BAB17669.1.
AB049054 mRNA. Translation: BAB17662.1.
AK090712 mRNA. Translation: BAG52217.1.
CH471121 Genomic DNA. Translation: EAW52933.1.
CH471121 Genomic DNA. Translation: EAW52934.1.
BC029864 mRNA. Translation: AAH29864.1.
CCDSiCCDS1148.1.
PIRiJC7505.
RefSeqiNP_068589.1. NM_021817.2.
XP_005245472.1. XM_005245415.1.
UniGeneiHs.410719.

Genome annotation databases

EnsembliENST00000255039; ENSP00000255039; ENSG00000132702.
GeneIDi60484.
KEGGihsa:60484.
UCSCiuc001fpn.1. human.

Polymorphism databases

DMDMi20177844.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049061 Genomic DNA. Translation: BAB17669.1.
AB049054 mRNA. Translation: BAB17662.1.
AK090712 mRNA. Translation: BAG52217.1.
CH471121 Genomic DNA. Translation: EAW52933.1.
CH471121 Genomic DNA. Translation: EAW52934.1.
BC029864 mRNA. Translation: AAH29864.1.
CCDSiCCDS1148.1.
PIRiJC7505.
RefSeqiNP_068589.1. NM_021817.2.
XP_005245472.1. XM_005245415.1.
UniGeneiHs.410719.

3D structure databases

ProteinModelPortaliQ9GZV7.
SMRiQ9GZV7. Positions 44-134, 149-241, 255-337.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism databases

DMDMi20177844.

Proteomic databases

MaxQBiQ9GZV7.
PaxDbiQ9GZV7.
PeptideAtlasiQ9GZV7.
PRIDEiQ9GZV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255039; ENSP00000255039; ENSG00000132702.
GeneIDi60484.
KEGGihsa:60484.
UCSCiuc001fpn.1. human.

Organism-specific databases

CTDi60484.
GeneCardsiGC01P156589.
HGNCiHGNC:17410. HAPLN2.
HPAiHPA045765.
neXtProtiNX_Q9GZV7.
PharmGKBiPA134878581.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG146628.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000234353.
HOVERGENiHBG051922.
InParanoidiQ9GZV7.
KOiK06851.
OMAiCFTSALA.
OrthoDBiEOG7ZWD1D.
PhylomeDBiQ9GZV7.
TreeFamiTF332134.

Miscellaneous databases

ChiTaRSiHAPLN2. human.
GeneWikiiHAPLN2.
GenomeRNAii60484.
NextBioi65359.
PROiQ9GZV7.

Gene expression databases

BgeeiQ9GZV7.
CleanExiHS_HAPLN2.
ExpressionAtlasiQ9GZV7. baseline and differential.
GenevestigatoriQ9GZV7.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00409. IG. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain."
    Hirakawa S., Oohashi T., Su W.-D., Yoshioka H., Murakami T., Arata J., Ninomiya Y.
    Biochem. Biophys. Res. Commun. 276:982-989(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiHPLN2_HUMAN
AccessioniPrimary (citable) accession number: Q9GZV7
Secondary accession number(s): Q5T3J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 15, 2002
Last sequence update: February 28, 2001
Last modified: February 3, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.