Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hyaluronan and proteoglycan link protein 2

Gene

HAPLN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Hyaluronic acid

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132702-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan and proteoglycan link protein 2
Alternative name(s):
Brain link protein 1
Gene namesi
Name:HAPLN2
Synonyms:BRAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:17410. HAPLN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi60484.
OpenTargetsiENSG00000132702.
PharmGKBiPA134878581.

Polymorphism and mutation databases

BioMutaiHAPLN2.
DMDMi20177844.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001318727 – 340Hyaluronan and proteoglycan link protein 2Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 128By similarity
Disulfide bondi170 ↔ 240By similarity
Disulfide bondi194 ↔ 215By similarity
Disulfide bondi265 ↔ 336By similarity
Disulfide bondi290 ↔ 311By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9GZV7.
PaxDbiQ9GZV7.
PeptideAtlasiQ9GZV7.
PRIDEiQ9GZV7.

Expressioni

Tissue specificityi

Expressed only in adult brain.1 Publication

Gene expression databases

BgeeiENSG00000132702.
CleanExiHS_HAPLN2.
ExpressionAtlasiQ9GZV7. baseline and differential.
GenevisibleiQ9GZV7. HS.

Organism-specific databases

HPAiHPA045765.

Interactioni

Protein-protein interaction databases

IntActiQ9GZV7. 20 interactors.
STRINGi9606.ENSP00000255039.

Structurei

3D structure databases

ProteinModelPortaliQ9GZV7.
SMRiQ9GZV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 144Ig-like V-typeAdd BLAST111
Domaini148 – 242Link 1PROSITE-ProRule annotationAdd BLAST95
Domaini245 – 338Link 2PROSITE-ProRule annotationAdd BLAST94

Sequence similaritiesi

Belongs to the HAPLN family.Curated
Contains 2 Link domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIS5. Eukaryota.
ENOG410XVBZ. LUCA.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000234353.
HOVERGENiHBG051922.
InParanoidiQ9GZV7.
KOiK06851.
OMAiCFTSALA.
OrthoDBiEOG091G09EL.
PhylomeDBiQ9GZV7.
TreeFamiTF332134.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProiIPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link_dom.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF56436. SSF56436. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GZV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGWLTLPTL CRFLLWAFTI FHKAQGDPAS HPGPHYLLPP IHEVIHSHRG
60 70 80 90 100
ATATLPCVLG TTPPSYKVRW SKVEPGELRE TLILITNGLH ARGYGPLGGR
110 120 130 140 150
ARMRRGHRLD ASLVIAGVRL EDEGRYRCEL INGIEDESVA LTLSLEGVVF
160 170 180 190 200
PYQPSRGRYQ FNYYEAKQAC EEQDGRLATY SQLYQAWTEG LDWCNAGWLL
210 220 230 240 250
EGSVRYPVLT ARAPCGGRGR PGIRSYGPRD RMRDRYDAFC FTSALAGQVF
260 270 280 290 300
FVPGRLTLSE AHAACRRRGA VVAKVGHLYA AWKFSGLDQC DGGWLADGSV
310 320 330 340
RFPITTPRPR CGGLPDPGVR SFGFPRPQQA AYGTYCYAEN
Length:340
Mass (Da):37,775
Last modified:March 1, 2001 - v1
Checksum:i62CCC1D86385F5C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049061 Genomic DNA. Translation: BAB17669.1.
AB049054 mRNA. Translation: BAB17662.1.
AK090712 mRNA. Translation: BAG52217.1.
CH471121 Genomic DNA. Translation: EAW52933.1.
CH471121 Genomic DNA. Translation: EAW52934.1.
BC029864 mRNA. Translation: AAH29864.1.
CCDSiCCDS1148.1.
PIRiJC7505.
RefSeqiNP_068589.1. NM_021817.2.
XP_005245472.1. XM_005245415.2.
XP_011508155.1. XM_011509853.2.
XP_016857509.1. XM_017002020.1.
UniGeneiHs.410719.

Genome annotation databases

EnsembliENST00000255039; ENSP00000255039; ENSG00000132702.
GeneIDi60484.
KEGGihsa:60484.
UCSCiuc001fpn.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049061 Genomic DNA. Translation: BAB17669.1.
AB049054 mRNA. Translation: BAB17662.1.
AK090712 mRNA. Translation: BAG52217.1.
CH471121 Genomic DNA. Translation: EAW52933.1.
CH471121 Genomic DNA. Translation: EAW52934.1.
BC029864 mRNA. Translation: AAH29864.1.
CCDSiCCDS1148.1.
PIRiJC7505.
RefSeqiNP_068589.1. NM_021817.2.
XP_005245472.1. XM_005245415.2.
XP_011508155.1. XM_011509853.2.
XP_016857509.1. XM_017002020.1.
UniGeneiHs.410719.

3D structure databases

ProteinModelPortaliQ9GZV7.
SMRiQ9GZV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9GZV7. 20 interactors.
STRINGi9606.ENSP00000255039.

Polymorphism and mutation databases

BioMutaiHAPLN2.
DMDMi20177844.

Proteomic databases

MaxQBiQ9GZV7.
PaxDbiQ9GZV7.
PeptideAtlasiQ9GZV7.
PRIDEiQ9GZV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255039; ENSP00000255039; ENSG00000132702.
GeneIDi60484.
KEGGihsa:60484.
UCSCiuc001fpn.1. human.

Organism-specific databases

CTDi60484.
DisGeNETi60484.
GeneCardsiHAPLN2.
HGNCiHGNC:17410. HAPLN2.
HPAiHPA045765.
neXtProtiNX_Q9GZV7.
OpenTargetsiENSG00000132702.
PharmGKBiPA134878581.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIS5. Eukaryota.
ENOG410XVBZ. LUCA.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000234353.
HOVERGENiHBG051922.
InParanoidiQ9GZV7.
KOiK06851.
OMAiCFTSALA.
OrthoDBiEOG091G09EL.
PhylomeDBiQ9GZV7.
TreeFamiTF332134.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000132702-MONOMER.

Miscellaneous databases

ChiTaRSiHAPLN2. human.
GeneWikiiHAPLN2.
GenomeRNAii60484.
PROiQ9GZV7.

Gene expression databases

BgeeiENSG00000132702.
CleanExiHS_HAPLN2.
ExpressionAtlasiQ9GZV7. baseline and differential.
GenevisibleiQ9GZV7. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProiIPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link_dom.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF56436. SSF56436. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHPLN2_HUMAN
AccessioniPrimary (citable) accession number: Q9GZV7
Secondary accession number(s): Q5T3J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.