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Protein

Hyaluronan and proteoglycan link protein 2

Gene

HAPLN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandHyaluronic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan and proteoglycan link protein 2
Alternative name(s):
Brain link protein 1
Gene namesi
Name:HAPLN2
Synonyms:BRAL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000132702.12
HGNCiHGNC:17410 HAPLN2
neXtProtiNX_Q9GZV7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi60484
OpenTargetsiENSG00000132702
PharmGKBiPA134878581

Polymorphism and mutation databases

BioMutaiHAPLN2
DMDMi20177844

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001318727 – 340Hyaluronan and proteoglycan link protein 2Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 128By similarity
Disulfide bondi170 ↔ 240By similarity
Disulfide bondi194 ↔ 215By similarity
Disulfide bondi265 ↔ 336By similarity
Disulfide bondi290 ↔ 311By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ9GZV7
PaxDbiQ9GZV7
PeptideAtlasiQ9GZV7
PRIDEiQ9GZV7
ProteomicsDBi80158

Expressioni

Tissue specificityi

Expressed only in adult brain.1 Publication

Gene expression databases

BgeeiENSG00000132702
CleanExiHS_HAPLN2
ExpressionAtlasiQ9GZV7 baseline and differential
GenevisibleiQ9GZV7 HS

Organism-specific databases

HPAiHPA045765

Interactioni

Protein-protein interaction databases

IntActiQ9GZV7, 35 interactors
STRINGi9606.ENSP00000255039

Structurei

3D structure databases

ProteinModelPortaliQ9GZV7
SMRiQ9GZV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 144Ig-like V-typeAdd BLAST111
Domaini148 – 242Link 1PROSITE-ProRule annotationAdd BLAST95
Domaini245 – 338Link 2PROSITE-ProRule annotationAdd BLAST94

Sequence similaritiesi

Belongs to the HAPLN family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIS5 Eukaryota
ENOG410XVBZ LUCA
GeneTreeiENSGT00760000119025
HOGENOMiHOG000234353
HOVERGENiHBG051922
InParanoidiQ9GZV7
KOiK06851
OMAiRDRYDAF
OrthoDBiEOG091G09EL
PhylomeDBiQ9GZV7
TreeFamiTF332134

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.100.10, 2 hits
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR000538 Link_dom
PfamiView protein in Pfam
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GZV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGWLTLPTL CRFLLWAFTI FHKAQGDPAS HPGPHYLLPP IHEVIHSHRG
60 70 80 90 100
ATATLPCVLG TTPPSYKVRW SKVEPGELRE TLILITNGLH ARGYGPLGGR
110 120 130 140 150
ARMRRGHRLD ASLVIAGVRL EDEGRYRCEL INGIEDESVA LTLSLEGVVF
160 170 180 190 200
PYQPSRGRYQ FNYYEAKQAC EEQDGRLATY SQLYQAWTEG LDWCNAGWLL
210 220 230 240 250
EGSVRYPVLT ARAPCGGRGR PGIRSYGPRD RMRDRYDAFC FTSALAGQVF
260 270 280 290 300
FVPGRLTLSE AHAACRRRGA VVAKVGHLYA AWKFSGLDQC DGGWLADGSV
310 320 330 340
RFPITTPRPR CGGLPDPGVR SFGFPRPQQA AYGTYCYAEN
Length:340
Mass (Da):37,775
Last modified:March 1, 2001 - v1
Checksum:i62CCC1D86385F5C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049061 Genomic DNA Translation: BAB17669.1
AB049054 mRNA Translation: BAB17662.1
AK090712 mRNA Translation: BAG52217.1
CH471121 Genomic DNA Translation: EAW52933.1
CH471121 Genomic DNA Translation: EAW52934.1
BC029864 mRNA Translation: AAH29864.1
CCDSiCCDS1148.1
PIRiJC7505
RefSeqiNP_068589.1, NM_021817.2
XP_005245472.1, XM_005245415.2
XP_011508155.1, XM_011509853.2
XP_016857509.1, XM_017002020.1
UniGeneiHs.410719

Genome annotation databases

EnsembliENST00000255039; ENSP00000255039; ENSG00000132702
GeneIDi60484
KEGGihsa:60484
UCSCiuc001fpn.1 human

Similar proteinsi

Entry informationi

Entry nameiHPLN2_HUMAN
AccessioniPrimary (citable) accession number: Q9GZV7
Secondary accession number(s): Q5T3J0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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