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Q9GZV7

- HPLN2_HUMAN

UniProt

Q9GZV7 - HPLN2_HUMAN

Protein

Hyaluronan and proteoglycan link protein 2

Gene

HAPLN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid By similarity.By similarity

    GO - Molecular functioni

    1. hyaluronic acid binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell adhesion Source: InterPro

    Keywords - Ligandi

    Hyaluronic acid

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronan and proteoglycan link protein 2
    Alternative name(s):
    Brain link protein 1
    Gene namesi
    Name:HAPLN2
    Synonyms:BRAL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:17410. HAPLN2.

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134878581.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 340314Hyaluronan and proteoglycan link protein 2PRO_0000013187Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi57 ↔ 128By similarity
    Disulfide bondi170 ↔ 240By similarity
    Disulfide bondi194 ↔ 215By similarity
    Disulfide bondi265 ↔ 336By similarity
    Disulfide bondi290 ↔ 311By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ9GZV7.
    PaxDbiQ9GZV7.
    PeptideAtlasiQ9GZV7.
    PRIDEiQ9GZV7.

    Expressioni

    Tissue specificityi

    Expressed only in adult brain.1 Publication

    Gene expression databases

    ArrayExpressiQ9GZV7.
    BgeeiQ9GZV7.
    CleanExiHS_HAPLN2.
    GenevestigatoriQ9GZV7.

    Organism-specific databases

    HPAiHPA045765.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GZV7.
    SMRiQ9GZV7. Positions 45-241, 255-337.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 144111Ig-like V-typeAdd
    BLAST
    Domaini148 – 24295Link 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini245 – 33894Link 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the HAPLN family.Curated
    Contains 2 Link domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG146628.
    HOGENOMiHOG000234353.
    HOVERGENiHBG051922.
    InParanoidiQ9GZV7.
    KOiK06851.
    OMAiCFTSALA.
    OrthoDBiEOG7ZWD1D.
    PhylomeDBiQ9GZV7.
    TreeFamiTF332134.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.100.10. 2 hits.
    InterProiIPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR000538. Link.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    PF00193. Xlink. 2 hits.
    [Graphical view]
    PRINTSiPR01265. LINKMODULE.
    SMARTiSM00409. IG. 1 hit.
    SM00445. LINK. 2 hits.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 2 hits.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS01241. LINK_1. 2 hits.
    PS50963. LINK_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9GZV7-1 [UniParc]FASTAAdd to Basket

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    MPGWLTLPTL CRFLLWAFTI FHKAQGDPAS HPGPHYLLPP IHEVIHSHRG    50
    ATATLPCVLG TTPPSYKVRW SKVEPGELRE TLILITNGLH ARGYGPLGGR 100
    ARMRRGHRLD ASLVIAGVRL EDEGRYRCEL INGIEDESVA LTLSLEGVVF 150
    PYQPSRGRYQ FNYYEAKQAC EEQDGRLATY SQLYQAWTEG LDWCNAGWLL 200
    EGSVRYPVLT ARAPCGGRGR PGIRSYGPRD RMRDRYDAFC FTSALAGQVF 250
    FVPGRLTLSE AHAACRRRGA VVAKVGHLYA AWKFSGLDQC DGGWLADGSV 300
    RFPITTPRPR CGGLPDPGVR SFGFPRPQQA AYGTYCYAEN 340
    Length:340
    Mass (Da):37,775
    Last modified:March 1, 2001 - v1
    Checksum:i62CCC1D86385F5C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049061 Genomic DNA. Translation: BAB17669.1.
    AB049054 mRNA. Translation: BAB17662.1.
    AK090712 mRNA. Translation: BAG52217.1.
    CH471121 Genomic DNA. Translation: EAW52933.1.
    CH471121 Genomic DNA. Translation: EAW52934.1.
    BC029864 mRNA. Translation: AAH29864.1.
    CCDSiCCDS1148.1.
    PIRiJC7505.
    RefSeqiNP_068589.1. NM_021817.2.
    XP_005245472.1. XM_005245415.1.
    UniGeneiHs.410719.

    Genome annotation databases

    EnsembliENST00000255039; ENSP00000255039; ENSG00000132702.
    GeneIDi60484.
    KEGGihsa:60484.
    UCSCiuc001fpn.1. human.

    Polymorphism databases

    DMDMi20177844.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049061 Genomic DNA. Translation: BAB17669.1 .
    AB049054 mRNA. Translation: BAB17662.1 .
    AK090712 mRNA. Translation: BAG52217.1 .
    CH471121 Genomic DNA. Translation: EAW52933.1 .
    CH471121 Genomic DNA. Translation: EAW52934.1 .
    BC029864 mRNA. Translation: AAH29864.1 .
    CCDSi CCDS1148.1.
    PIRi JC7505.
    RefSeqi NP_068589.1. NM_021817.2.
    XP_005245472.1. XM_005245415.1.
    UniGenei Hs.410719.

    3D structure databases

    ProteinModelPortali Q9GZV7.
    SMRi Q9GZV7. Positions 45-241, 255-337.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 20177844.

    Proteomic databases

    MaxQBi Q9GZV7.
    PaxDbi Q9GZV7.
    PeptideAtlasi Q9GZV7.
    PRIDEi Q9GZV7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000255039 ; ENSP00000255039 ; ENSG00000132702 .
    GeneIDi 60484.
    KEGGi hsa:60484.
    UCSCi uc001fpn.1. human.

    Organism-specific databases

    CTDi 60484.
    GeneCardsi GC01P156589.
    HGNCi HGNC:17410. HAPLN2.
    HPAi HPA045765.
    neXtProti NX_Q9GZV7.
    PharmGKBi PA134878581.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146628.
    HOGENOMi HOG000234353.
    HOVERGENi HBG051922.
    InParanoidi Q9GZV7.
    KOi K06851.
    OMAi CFTSALA.
    OrthoDBi EOG7ZWD1D.
    PhylomeDBi Q9GZV7.
    TreeFami TF332134.

    Miscellaneous databases

    ChiTaRSi HAPLN2. human.
    GeneWikii HAPLN2.
    GenomeRNAii 60484.
    NextBioi 65359.
    PROi Q9GZV7.

    Gene expression databases

    ArrayExpressi Q9GZV7.
    Bgeei Q9GZV7.
    CleanExi HS_HAPLN2.
    Genevestigatori Q9GZV7.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.100.10. 2 hits.
    InterProi IPR016186. C-type_lectin-like.
    IPR016187. C-type_lectin_fold.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    IPR000538. Link.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    PF00193. Xlink. 2 hits.
    [Graphical view ]
    PRINTSi PR01265. LINKMODULE.
    SMARTi SM00409. IG. 1 hit.
    SM00445. LINK. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 2 hits.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS01241. LINK_1. 2 hits.
    PS50963. LINK_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain."
      Hirakawa S., Oohashi T., Su W.-D., Yoshioka H., Murakami T., Arata J., Ninomiya Y.
      Biochem. Biophys. Res. Commun. 276:982-989(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiHPLN2_HUMAN
    AccessioniPrimary (citable) accession number: Q9GZV7
    Secondary accession number(s): Q5T3J0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3