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Q9GZV7 (HPLN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hyaluronan and proteoglycan link protein 2
Alternative name(s):
Brain link protein 1
Gene names
Name:HAPLN2
Synonyms:BRAL1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Tissue specificity

Expressed only in adult brain. Ref.1

Sequence similarities

Belongs to the HAPLN family.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Contains 2 Link domains.

Ontologies

Keywords
   Cellular componentExtracellular matrix
Secreted
   DomainImmunoglobulin domain
Repeat
Signal
   LigandHyaluronic acid
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: InterPro

   Cellular_componentproteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhyaluronic acid binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 340314Hyaluronan and proteoglycan link protein 2
PRO_0000013187

Regions

Domain34 – 144111Ig-like V-type
Domain148 – 24295Link 1
Domain245 – 33894Link 2

Amino acid modifications

Disulfide bond57 ↔ 128 By similarity
Disulfide bond170 ↔ 240 By similarity
Disulfide bond194 ↔ 215 By similarity
Disulfide bond265 ↔ 336 By similarity
Disulfide bond290 ↔ 311 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9GZV7 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 62CCC1D86385F5C7

FASTA34037,775
        10         20         30         40         50         60 
MPGWLTLPTL CRFLLWAFTI FHKAQGDPAS HPGPHYLLPP IHEVIHSHRG ATATLPCVLG 

        70         80         90        100        110        120 
TTPPSYKVRW SKVEPGELRE TLILITNGLH ARGYGPLGGR ARMRRGHRLD ASLVIAGVRL 

       130        140        150        160        170        180 
EDEGRYRCEL INGIEDESVA LTLSLEGVVF PYQPSRGRYQ FNYYEAKQAC EEQDGRLATY 

       190        200        210        220        230        240 
SQLYQAWTEG LDWCNAGWLL EGSVRYPVLT ARAPCGGRGR PGIRSYGPRD RMRDRYDAFC 

       250        260        270        280        290        300 
FTSALAGQVF FVPGRLTLSE AHAACRRRGA VVAKVGHLYA AWKFSGLDQC DGGWLADGSV 

       310        320        330        340 
RFPITTPRPR CGGLPDPGVR SFGFPRPQQA AYGTYCYAEN 

« Hide

References

« Hide 'large scale' references
[1]"The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain."
Hirakawa S., Oohashi T., Su W.-D., Yoshioka H., Murakami T., Arata J., Ninomiya Y.
Biochem. Biophys. Res. Commun. 276:982-989(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.
[3]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB049061 Genomic DNA. Translation: BAB17669.1.
AB049054 mRNA. Translation: BAB17662.1.
AK090712 mRNA. Translation: BAG52217.1.
CH471121 Genomic DNA. Translation: EAW52933.1.
CH471121 Genomic DNA. Translation: EAW52934.1.
BC029864 mRNA. Translation: AAH29864.1.
CCDSCCDS1148.1.
PIRJC7505.
RefSeqNP_068589.1. NM_021817.2.
XP_005245472.1. XM_005245415.1.
UniGeneHs.410719.

3D structure databases

ProteinModelPortalQ9GZV7.
SMRQ9GZV7. Positions 45-241, 255-337.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM20177844.

Proteomic databases

MaxQBQ9GZV7.
PaxDbQ9GZV7.
PeptideAtlasQ9GZV7.
PRIDEQ9GZV7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000255039; ENSP00000255039; ENSG00000132702.
GeneID60484.
KEGGhsa:60484.
UCSCuc001fpn.1. human.

Organism-specific databases

CTD60484.
GeneCardsGC01P156589.
HGNCHGNC:17410. HAPLN2.
HPAHPA045765.
neXtProtNX_Q9GZV7.
PharmGKBPA134878581.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146628.
HOGENOMHOG000234353.
HOVERGENHBG051922.
InParanoidQ9GZV7.
KOK06851.
OMACFTSALA.
OrthoDBEOG7ZWD1D.
PhylomeDBQ9GZV7.
TreeFamTF332134.

Gene expression databases

ArrayExpressQ9GZV7.
BgeeQ9GZV7.
CleanExHS_HAPLN2.
GenevestigatorQ9GZV7.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.10.100.10. 2 hits.
InterProIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
IPR000538. Link.
[Graphical view]
PfamPF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSPR01265. LINKMODULE.
SMARTSM00409. IG. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMSSF56436. SSF56436. 2 hits.
PROSITEPS50835. IG_LIKE. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHAPLN2. human.
GeneWikiHAPLN2.
GenomeRNAi60484.
NextBio65359.
PROQ9GZV7.

Entry information

Entry nameHPLN2_HUMAN
AccessionPrimary (citable) accession number: Q9GZV7
Secondary accession number(s): Q5T3J0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM