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Q9GZV4

- IF5A2_HUMAN

UniProt

Q9GZV4 - IF5A2_HUMAN

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Protein
Eukaryotic translation initiation factor 5A-2
Gene
EIF5A2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation By similarity.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. ribosome binding Source: InterPro
  3. translation elongation factor activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. mRNA transport Source: UniProtKB-KW
  3. peptidyl-lysine modification to peptidyl-hypusine Source: Reactome
  4. polyamine homeostasis Source: UniProtKB
  5. positive regulation of cell proliferation Source: UniProtKB
  6. positive regulation of translational elongation Source: InterPro
  7. positive regulation of translational termination Source: InterPro
  8. post-translational protein modification Source: Reactome
  9. protein transport Source: UniProtKB-KW
  10. spermatogenesis Source: UniProtKB
  11. translational frameshifting Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

mRNA transport, Protein biosynthesis, Protein transport, Translocation, Transport

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_12469. Hypusine synthesis from eIF5A-lysine.

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 5A-2
Short name:
eIF-5A-2
Short name:
eIF-5A2
Alternative name(s):
Eukaryotic initiation factor 5A isoform 2
Gene namesi
Name:EIF5A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:3301. EIF5A2.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Nucleusnuclear pore complex By similarity
Note: Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions By similarity.

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. nuclear pore Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 153152Eukaryotic translation initiation factor 5A-2
PRO_0000229764Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei50 – 501Hypusine

Post-translational modificationi

eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group (from spermidine).

Keywords - PTMi

Acetylation, Hypusine

Proteomic databases

MaxQBiQ9GZV4.
PaxDbiQ9GZV4.
PRIDEiQ9GZV4.

PTM databases

PhosphoSiteiQ9GZV4.

Expressioni

Tissue specificityi

Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis. Overexpressed in some cancer cells.2 Publications

Gene expression databases

ArrayExpressiQ9GZV4.
BgeeiQ9GZV4.
CleanExiHS_EIF5A2.
GenevestigatoriQ9GZV4.

Organism-specific databases

HPAiHPA029090.

Interactioni

Protein-protein interaction databases

BioGridi121162. 11 interactions.
IntActiQ9GZV4. 8 interactions.
MINTiMINT-1453868.
STRINGi9606.ENSP00000295822.

Structurei

3D structure databases

ProteinModelPortaliQ9GZV4.
SMRiQ9GZV4. Positions 15-150.

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-5A family.

Phylogenomic databases

eggNOGiCOG0231.
HOGENOMiHOG000106270.
HOVERGENiHBG001104.
InParanoidiQ9GZV4.
KOiK03263.
OMAiCAMSEEC.
OrthoDBiEOG7KSXB7.
PhylomeDBiQ9GZV4.
TreeFamiTF101534.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR020189. Transl_elong_IF5A_C.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11673. PTHR11673. 1 hit.
PfamiPF01287. eIF-5a. 1 hit.
[Graphical view]
PIRSFiPIRSF003025. eIF5A. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00037. eIF_5A. 1 hit.
PROSITEiPS00302. IF5A_HYPUSINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GZV4-1 [UniParc]FASTAAdd to Basket

« Hide

MADEIDFTTG DAGASSTYPM QCSALRKNGF VVLKGRPCKI VEMSTSKTGK    50
HGHAKVHLVG IDIFTGKKYE DICPSTHNMD VPNIKRNDYQ LICIQDGYLS 100
LLTETGEVRE DLKLPEGELG KEIEGKYNAG EDVQVSVMCA MSEEYAVAIK 150
PCK 153
Length:153
Mass (Da):16,793
Last modified:January 23, 2007 - v3
Checksum:i632BFE7F6DB073BD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421E → D.1 Publication
VAR_027943

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF262027 mRNA. Translation: AAF98810.1.
AF293387, AF293386 Genomic DNA. Translation: AAG23176.1.
AY205258 mRNA. Translation: AAO18676.1.
AY205259 mRNA. Translation: AAO18677.1.
AY205260 mRNA. Translation: AAO18678.1.
AY205261 mRNA. Translation: AAO18679.1.
AK311962 mRNA. Translation: BAG34902.1.
CH471052 Genomic DNA. Translation: EAW78501.1.
BC036072 mRNA. Translation: AAH36072.1.
CCDSiCCDS3214.1.
RefSeqiNP_065123.1. NM_020390.5.
UniGeneiHs.164144.

Genome annotation databases

EnsembliENST00000295822; ENSP00000295822; ENSG00000163577.
GeneIDi56648.
KEGGihsa:56648.
UCSCiuc003fhd.3. human.

Polymorphism databases

DMDMi74762725.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF262027 mRNA. Translation: AAF98810.1 .
AF293387 , AF293386 Genomic DNA. Translation: AAG23176.1 .
AY205258 mRNA. Translation: AAO18676.1 .
AY205259 mRNA. Translation: AAO18677.1 .
AY205260 mRNA. Translation: AAO18678.1 .
AY205261 mRNA. Translation: AAO18679.1 .
AK311962 mRNA. Translation: BAG34902.1 .
CH471052 Genomic DNA. Translation: EAW78501.1 .
BC036072 mRNA. Translation: AAH36072.1 .
CCDSi CCDS3214.1.
RefSeqi NP_065123.1. NM_020390.5.
UniGenei Hs.164144.

3D structure databases

ProteinModelPortali Q9GZV4.
SMRi Q9GZV4. Positions 15-150.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121162. 11 interactions.
IntActi Q9GZV4. 8 interactions.
MINTi MINT-1453868.
STRINGi 9606.ENSP00000295822.

PTM databases

PhosphoSitei Q9GZV4.

Polymorphism databases

DMDMi 74762725.

Proteomic databases

MaxQBi Q9GZV4.
PaxDbi Q9GZV4.
PRIDEi Q9GZV4.

Protocols and materials databases

DNASUi 56648.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295822 ; ENSP00000295822 ; ENSG00000163577 .
GeneIDi 56648.
KEGGi hsa:56648.
UCSCi uc003fhd.3. human.

Organism-specific databases

CTDi 56648.
GeneCardsi GC03M170607.
HGNCi HGNC:3301. EIF5A2.
HPAi HPA029090.
MIMi 605782. gene.
neXtProti NX_Q9GZV4.
PharmGKBi PA27727.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0231.
HOGENOMi HOG000106270.
HOVERGENi HBG001104.
InParanoidi Q9GZV4.
KOi K03263.
OMAi CAMSEEC.
OrthoDBi EOG7KSXB7.
PhylomeDBi Q9GZV4.
TreeFami TF101534.

Enzyme and pathway databases

Reactomei REACT_12469. Hypusine synthesis from eIF5A-lysine.

Miscellaneous databases

ChiTaRSi EIF5A2. human.
GeneWikii EIF5A2.
GenomeRNAii 56648.
NextBioi 62085.
PROi Q9GZV4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9GZV4.
Bgeei Q9GZV4.
CleanExi HS_EIF5A2.
Genevestigatori Q9GZV4.

Family and domain databases

Gene3Di 2.30.30.30. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR012340. NA-bd_OB-fold.
IPR014722. Rib_L2_dom2.
IPR019769. Trans_elong_IF5A_hypusine_site.
IPR001884. Transl_elong_IF5A.
IPR020189. Transl_elong_IF5A_C.
IPR008991. Translation_prot_SH3-like.
[Graphical view ]
PANTHERi PTHR11673. PTHR11673. 1 hit.
Pfami PF01287. eIF-5a. 1 hit.
[Graphical view ]
PIRSFi PIRSF003025. eIF5A. 1 hit.
SUPFAMi SSF50104. SSF50104. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00037. eIF_5A. 1 hit.
PROSITEi PS00302. IF5A_HYPUSINE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a novel candidate oncogene within a frequently amplified region at 3q26 in ovarian cancer."
    Guan X.-Y.Y., Sham J.S.T., Tang T.C.-M., Fang Y., Huo K.-K., Yang J.-M.
    Cancer Res. 61:3806-3809(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovarian carcinoma.
  2. "Human eIF5A2 on chromosome 3q25-q27 is a phylogenetically conserved vertebrate variant of eukaryotic translation initiation factor 5A with tissue-specific expression."
    Jenkins Z.A., Haag P.G., Johansson H.E.
    Genomics 71:101-109(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
  3. "Expression of eIF5A genes in human cancer cells."
    Clement P.M.J., Jenkins Z.A., Park M.H., Johansson H.E.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. Cited for: FUNCTION, HYPUSINE AT LYS-50.
  8. "Differential expression of eIF5A-1 and eIF5A-2 in human cancer cells."
    Clement P.M.J., Johansson H.E., Wolff E.C., Park M.H.
    FEBS J. 273:1102-1114(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  10. "Screening the SPO11 and EIF5A2 genes in a population of infertile men."
    Christensen G.L., Ivanov I.P., Atkins J.F., Mielnik A., Schlegel P.N., Carrell D.T.
    Fertil. Steril. 84:758-760(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ASP-42.

Entry informationi

Entry nameiIF5A2_HUMAN
AccessioniPrimary (citable) accession number: Q9GZV4
Secondary accession number(s): B2R4V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Translation initiation factors
    List of translation initiation factor entries
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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