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Protein

Protein FAM192A

Gene

FAM192A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM192A
Alternative name(s):
NEFA-interacting nuclear protein NIP30
Gene namesi
Name:FAM192A
Synonyms:C16orf94, NIP30
ORF Names:CDA018, CDA10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29856. FAM192A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165450001.

Polymorphism and mutation databases

BioMutaiFAM192A.
DMDMi46577123.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Protein FAM192APRO_0000096847Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei17 – 171PhosphoserineCombined sources
Modified residuei139 – 1391N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9GZU8.
MaxQBiQ9GZU8.
PaxDbiQ9GZU8.
PeptideAtlasiQ9GZU8.
PRIDEiQ9GZU8.

PTM databases

iPTMnetiQ9GZU8.
PhosphoSiteiQ9GZU8.

Expressioni

Gene expression databases

BgeeiQ9GZU8.
ExpressionAtlasiQ9GZU8. baseline and differential.
GenevisibleiQ9GZU8. HS.

Organism-specific databases

HPAiHPA054382.
HPA059652.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF2Q129333EBI-2371956,EBI-355744

Protein-protein interaction databases

BioGridi123067. 42 interactions.
IntActiQ9GZU8. 20 interactions.
MINTiMINT-3065324.
STRINGi9606.ENSP00000335808.

Structurei

3D structure databases

ProteinModelPortaliQ9GZU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4036. Eukaryota.
ENOG4111INN. LUCA.
GeneTreeiENSGT00500000044916.
HOGENOMiHOG000045055.
HOVERGENiHBG052624.
InParanoidiQ9GZU8.
OMAiWERVRQP.
OrthoDBiEOG7HF1MF.
PhylomeDBiQ9GZU8.
TreeFamiTF314540.

Family and domain databases

InterProiIPR019331. FAM192A/Fyv6_N.
[Graphical view]
PfamiPF10187. Nefa_Nip30_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GZU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGGDDGNLI IKKRFVSEAE LDERRKRRQE EWEKVRKPED PEECPEEVYD
60 70 80 90 100
PRSLYERLQE QKDRKQQEYE EQFKFKNMVR GLDEDETNFL DEVSRQQELI
110 120 130 140 150
EKQRREEELK ELKEYRNNLK KVGISQENKK EVEKKLTVKP IETKNKFSQA
160 170 180 190 200
KLLAGAVKHK SSESGNSVKR LKPDPEPDDK NQEPSSCKSL GNTSLSGPSI
210 220 230 240 250
HCPSAAVCIG ILPGLGAYSG SSDSESSSDS EGTINATGKI VSSIFRTNTF

LEAP
Length:254
Mass (Da):28,912
Last modified:March 1, 2001 - v1
Checksum:i725D2AD4AB3AD5DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356585 mRNA. Translation: AAK43697.1.
AF212249 mRNA. Translation: AAK14932.1.
AF271785 mRNA. Translation: AAG44796.1.
AK023291 mRNA. Translation: BAB14512.1.
AK025452 mRNA. Translation: BAB15136.1.
AL834421 mRNA. Translation: CAD39082.1.
BC020536 mRNA. Translation: AAH20536.1.
BC071952 mRNA. Translation: AAH71952.1.
CCDSiCCDS42168.1.
RefSeqiNP_079222.1. NM_024946.2.
XP_005256217.1. XM_005256160.2.
XP_005256220.1. XM_005256163.2.
XP_005256221.1. XM_005256164.2.
XP_005256222.1. XM_005256165.2.
XP_011521642.1. XM_011523340.1.
XP_011521643.1. XM_011523341.1.
XP_011521644.1. XM_011523342.1.
XP_011521645.1. XM_011523343.1.
UniGeneiHs.396740.

Genome annotation databases

EnsembliENST00000309137; ENSP00000335808; ENSG00000172775.
ENST00000389447; ENSP00000374098; ENSG00000172775.
ENST00000564108; ENSP00000456211; ENSG00000172775.
ENST00000567439; ENSP00000457850; ENSG00000172775.
ENST00000569266; ENSP00000457740; ENSG00000172775.
GeneIDi80011.
KEGGihsa:80011.
UCSCiuc021tiy.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356585 mRNA. Translation: AAK43697.1.
AF212249 mRNA. Translation: AAK14932.1.
AF271785 mRNA. Translation: AAG44796.1.
AK023291 mRNA. Translation: BAB14512.1.
AK025452 mRNA. Translation: BAB15136.1.
AL834421 mRNA. Translation: CAD39082.1.
BC020536 mRNA. Translation: AAH20536.1.
BC071952 mRNA. Translation: AAH71952.1.
CCDSiCCDS42168.1.
RefSeqiNP_079222.1. NM_024946.2.
XP_005256217.1. XM_005256160.2.
XP_005256220.1. XM_005256163.2.
XP_005256221.1. XM_005256164.2.
XP_005256222.1. XM_005256165.2.
XP_011521642.1. XM_011523340.1.
XP_011521643.1. XM_011523341.1.
XP_011521644.1. XM_011523342.1.
XP_011521645.1. XM_011523343.1.
UniGeneiHs.396740.

3D structure databases

ProteinModelPortaliQ9GZU8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123067. 42 interactions.
IntActiQ9GZU8. 20 interactions.
MINTiMINT-3065324.
STRINGi9606.ENSP00000335808.

PTM databases

iPTMnetiQ9GZU8.
PhosphoSiteiQ9GZU8.

Polymorphism and mutation databases

BioMutaiFAM192A.
DMDMi46577123.

Proteomic databases

EPDiQ9GZU8.
MaxQBiQ9GZU8.
PaxDbiQ9GZU8.
PeptideAtlasiQ9GZU8.
PRIDEiQ9GZU8.

Protocols and materials databases

DNASUi80011.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309137; ENSP00000335808; ENSG00000172775.
ENST00000389447; ENSP00000374098; ENSG00000172775.
ENST00000564108; ENSP00000456211; ENSG00000172775.
ENST00000567439; ENSP00000457850; ENSG00000172775.
ENST00000569266; ENSP00000457740; ENSG00000172775.
GeneIDi80011.
KEGGihsa:80011.
UCSCiuc021tiy.1. human.

Organism-specific databases

CTDi80011.
GeneCardsiFAM192A.
HGNCiHGNC:29856. FAM192A.
HPAiHPA054382.
HPA059652.
neXtProtiNX_Q9GZU8.
PharmGKBiPA165450001.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4036. Eukaryota.
ENOG4111INN. LUCA.
GeneTreeiENSGT00500000044916.
HOGENOMiHOG000045055.
HOVERGENiHBG052624.
InParanoidiQ9GZU8.
OMAiWERVRQP.
OrthoDBiEOG7HF1MF.
PhylomeDBiQ9GZU8.
TreeFamiTF314540.

Miscellaneous databases

GeneWikiiNIP30.
GenomeRNAii80011.
PROiQ9GZU8.

Gene expression databases

BgeeiQ9GZU8.
ExpressionAtlasiQ9GZU8. baseline and differential.
GenevisibleiQ9GZU8. HS.

Family and domain databases

InterProiIPR019331. FAM192A/Fyv6_N.
[Graphical view]
PfamiPF10187. Nefa_Nip30_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Barnikol-Watanabe S., Barnikol H.U., Kroll K., Hirschfeld G., Schwarzer C.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A novel gene expressed in human pheochromocytoma."
    Li Y., Huang Q., Peng Y., Song H., Yu Y., Xu S., Ren S., Chen Z., Han Z.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pheochromocytoma.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph node.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Eye.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-139, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiF192A_HUMAN
AccessioniPrimary (citable) accession number: Q9GZU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.