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Q9GZU2

- PEG3_HUMAN

UniProt

Q9GZU2 - PEG3_HUMAN

Protein

Paternally-expressed gene 3 protein

Gene

PEG3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B By similarity. Possesses a tumor suppressing activity in glioma cells.By similarity1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri452 – 47423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri505 – 52723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri563 – 58523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri627 – 64923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri969 – 99123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1107 – 112923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1163 – 118523C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1225 – 124723C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1282 – 130423C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1332 – 135423C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1505 – 152723C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1564 – 158623C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleic acid binding Source: InterPro
    3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. genetic imprinting Source: Ensembl
    3. in utero embryonic development Source: Ensembl
    4. multicellular organism growth Source: Ensembl
    5. regulation of transcription from RNA polymerase II promoter Source: GOC
    6. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Paternally-expressed gene 3 protein
    Alternative name(s):
    Zinc finger and SCAN domain-containing protein 24
    Gene namesi
    Name:PEG3
    Synonyms:KIAA0287, ZSCAN24
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:8826. PEG3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33171.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15881588Paternally-expressed gene 3 proteinPRO_0000249228Add
    BLAST

    Proteomic databases

    MaxQBiQ9GZU2.
    PaxDbiQ9GZU2.
    PRIDEiQ9GZU2.

    PTM databases

    PhosphoSiteiQ9GZU2.

    Expressioni

    Tissue specificityi

    Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines.3 Publications

    Gene expression databases

    ArrayExpressiQ9GZU2.
    BgeeiQ9GZU2.
    CleanExiHS_PEG3.
    GenevestigatoriQ9GZU2.

    Organism-specific databases

    HPAiHPA026070.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with SIAH1A and SIAH2. Interacts with TRAF2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi111204. 8 interactions.
    DIPiDIP-38426N.
    IntActiQ9GZU2. 4 interactions.
    MINTiMINT-2861650.

    Structurei

    Secondary structure

    1
    1588
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi42 – 5110
    Turni56 – 583
    Helixi60 – 7516
    Helixi77 – 793
    Helixi82 – 9716
    Helixi100 – 1023
    Helixi103 – 1097
    Helixi114 – 1218
    Turni122 – 1243

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4BHXX-ray1.95A/B40-130[»]
    ProteinModelPortaliQ9GZU2.
    SMRiQ9GZU2. Positions 40-129, 358-395, 398-767, 969-1358, 1497-1531.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 12883SCAN boxPROSITE-ProRule annotationAdd
    BLAST
    Repeati1397 – 140372-1
    Repeati1404 – 141072-2
    Repeati1411 – 141772-3
    Repeati1418 – 142251-1
    Repeati1425 – 142951-2
    Repeati1432 – 143651-3
    Repeati1439 – 144351-4

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1397 – 1417213 X 7 AA repeat of P-E-V-E-A-A-EAdd
    BLAST
    Regioni1418 – 1443264 X 5 AA repeat of P-X-G-E-AAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1352 – 1512161Glu-richAdd
    BLAST

    Domaini

    The SCAN domain enables PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion.

    Sequence similaritiesi

    Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SCAN box domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri452 – 47423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri505 – 52723C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri563 – 58523C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri627 – 64923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri969 – 99123C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1107 – 112923C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1163 – 118523C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1225 – 124723C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1282 – 130423C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1332 – 135423C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1505 – 152723C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1564 – 158623C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000001564.
    HOVERGENiHBG079943.
    InParanoidiQ9GZU2.
    KOiK09230.
    OMAiKAMSMSS.
    OrthoDBiEOG7P02H3.
    PhylomeDBiQ9GZU2.
    TreeFamiTF337075.

    Family and domain databases

    Gene3Di3.30.160.60. 10 hits.
    InterProiIPR027775. C2H2_Znf_fam.
    IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PANTHERiPTHR10032. PTHR10032. 1 hit.
    PfamiPF02023. SCAN. 1 hit.
    PF00096. zf-C2H2. 10 hits.
    [Graphical view]
    SMARTiSM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view]
    SUPFAMiSSF47353. SSF47353. 1 hit.
    PROSITEiPS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9GZU2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLPPKHLSAT KPKKSWAPNL YELDSDLTKE PDVIIGEGPT DSEFFHQRFR     50
    NLIYVEFVGP RKTLIKLRNL CLDWLQPETR TKEEIIELLV LEQYLTIIPE 100
    KLKPWVRAKK PENCEKLVTL LENYKEMYQP EDDNNSDVTS DDDMTRNRRE 150
    SSPPHSVHSF SDRDWDRRGR SRDMEPRDRW SHTRNPRSRM PPRDLSLPVV 200
    AKTSFEMDRE DDRDSRAYES RSQDAESYQN VVDLAEDRKP HNTIQDNMEN 250
    YRKLLSLVQL AEDDGHSHMT QGHSSRSKRS AYPSTSRGLK TMPEAKKSTH 300
    RRGICEDESS HGVIMEKFIK DVSRSSKSGR ARESSDRSQR FPRMSDDNWK 350
    DISLNKRESV IQQRVYEGNA FRGGFRFNST LVSRKRVLER KRRYHFDTDG 400
    KGSIHDQKGC PRKKPFECGS EMRKAMSVSS LSSLSSPSFT ESQPIDFGAM 450
    PYVCDECGRS FSVISEFVEH QIMHTRENLY EYGESFIHSV AVSEVQKSQV 500
    GGKRFECKDC GETFNKSAAL AEHRKIHARG YLVECKNQEC EEAFMPSPTF 550
    SELQKIYGKD KFYECRVCKE TFLHSSALIE HQKIHFGDDK DNEREHERER 600
    ERERGETFRP SPALNEFQKM YGKEKMYECK VCGETFLHSS SLKEHQKIHT 650
    RGNPFENKGK VCEETFIPGQ SLKRRQKTYN KEKLCDFTDG RDAFMQSSEL 700
    SEHQKIHSRK NLFEGRGYEK SVIHSGPFTE SQKSHTITRP LESDEDEKAF 750
    TISSNPYENQ KIPTKENVYE AKSYERSVIH SLASVEAQKS HSVAGPSKPK 800
    VMAESTIQSF DAINHQRVRA GGNTSEGREY SRSVIHSLVA SKPPRSHNGN 850
    ELVESNEKGE SSIYISDLND KRQKIPAREN PCEGGSKNRN YEDSVIQSVF 900
    RAKPQKSVPG EGSGEFKKDG EFSVPSSNVR EYQKARAKKK YIEHRSNETS 950
    VIHSLPFGEQ TFRPRGMLYE CQECGECFAH SSDLTEHQKI HDREKPSGSR 1000
    NYEWSVIRSL APTDPQTSYA QEQYAKEQAR NKCKDFRQFF ATSEDLNTNQ 1050
    KIYDQEKSHG EESQGENTDG EETHSEETHG QETIEDPVIQ GSDMEDPQKD 1100
    DPDDKIYECE DCGLGFVDLT DLTDHQKVHS RKCLVDSREY THSVIHTHSI 1150
    SEYQRDYTGE QLYECPKCGE SFIHSSFLFE HQRIHEQDQL YSMKGCDDGF 1200
    IALLPMKPRR NRAAERNPAL AGSAIRCLLC GQGFIHSSAL NEHMRLHRED 1250
    DLLEQSQMAE EAIIPGLALT EFQRSQTEER LFECAVCGES FVNPAELADH 1300
    VTVHKNEPYE YGSSYTHTSF LTEPLKGAIP FYECKDCGKS FIHSTVLTKH 1350
    KELHLEEEEE DEAAAAAAAA AQEVEANVHV PQVVLRIQGL NVEAAEPEVE 1400
    AAEPEVEAAE PEVEAAEPNG EAEGPDGEAA EPIGEAGQPN GEAEQPNGDA 1450
    DEPDGAGIED PEERAEEPEG KAEEPEGDAD EPDGVGIEDP EEGEDQEIQV 1500
    EEPYYDCHEC TETFTSSTAF SEHLKTHASM IIFEPANAFG ECSGYIERAS 1550
    TSTGGANQAD EKYFKCDVCG QLFNDRLSLA RHQNTHTG 1588
    Length:1,588
    Mass (Da):180,827
    Last modified:March 1, 2001 - v1
    Checksum:i7E4F34A01F189F3E
    GO
    Isoform 2 (identifier: Q9GZU2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-126: Missing.

    Show »
    Length:1,462
    Mass (Da):165,957
    Checksum:i29F1A63C6CC02BFF
    GO
    Isoform 3 (identifier: Q9GZU2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         258-287: Missing.
         547-550: SPTF → NPCL
         551-1588: Missing.

    Show »
    Length:520
    Mass (Da):60,547
    Checksum:iAA43A03C9CE8D178
    GO
    Isoform 4 (identifier: Q9GZU2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-126: Missing.
         161-161: S → SG
         257-257: L → LG

    Show »
    Length:1,464
    Mass (Da):166,071
    Checksum:iB57A789363951AE6
    GO

    Sequence cautioni

    The sequence BAB85588.1 differs from that shown. Reason: Frameshift at several positions.
    The sequence CAI45975.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti310 – 3112SH → PP in BAB85588. (PubMed:11260267)Curated
    Sequence conflicti439 – 4391F → L in BAG58536. (PubMed:14702039)Curated
    Sequence conflicti677 – 6771K → I in BAB85588. (PubMed:11260267)Curated
    Sequence conflicti690 – 6901G → A in BAB85588. (PubMed:11260267)Curated
    Sequence conflicti750 – 7501F → V in BAB85588. (PubMed:11260267)Curated
    Sequence conflicti755 – 7551N → Y in BAB85588. (PubMed:11260267)Curated
    Sequence conflicti1117 – 11171V → M in BAB85588. (PubMed:11260267)Curated
    Sequence conflicti1145 – 11451I → V in BAB85588. (PubMed:11260267)Curated
    Sequence conflicti1587 – 15871T → M in BAB85588. (PubMed:11260267)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti235 – 2351A → T.
    Corresponds to variant rs2191432 [ dbSNP | Ensembl ].
    VAR_027397
    Natural varianti594 – 5941R → H in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035562
    Natural varianti624 – 6241E → G.
    Corresponds to variant rs36016896 [ dbSNP | Ensembl ].
    VAR_052725
    Natural varianti839 – 8391V → L.
    Corresponds to variant rs7251798 [ dbSNP | Ensembl ].
    VAR_027398
    Natural varianti947 – 9471N → S.1 Publication
    Corresponds to variant rs35851866 [ dbSNP | Ensembl ].
    VAR_052726
    Natural varianti983 – 9831D → G.
    Corresponds to variant rs10412932 [ dbSNP | Ensembl ].
    VAR_027399
    Natural varianti1456 – 14561A → V.
    Corresponds to variant rs34831553 [ dbSNP | Ensembl ].
    VAR_052727
    Natural varianti1576 – 15761R → H.
    Corresponds to variant rs34051133 [ dbSNP | Ensembl ].
    VAR_052728
    Natural varianti1576 – 15761R → L.1 Publication
    VAR_027400

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 126126Missing in isoform 2 and isoform 4. 3 PublicationsVSP_020371Add
    BLAST
    Alternative sequencei161 – 1611S → SG in isoform 4. 2 PublicationsVSP_045527
    Alternative sequencei257 – 2571L → LG in isoform 4. 2 PublicationsVSP_045528
    Alternative sequencei258 – 28730Missing in isoform 3. 1 PublicationVSP_020372Add
    BLAST
    Alternative sequencei547 – 5504SPTF → NPCL in isoform 3. 1 PublicationVSP_020373
    Alternative sequencei551 – 15881038Missing in isoform 3. 1 PublicationVSP_020374Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF208980
    , AF208974, AF208975, AF208976, AF208977, AF208978, AF208979 Genomic DNA. Translation: AAG42324.1.
    AF208980
    , AF208974, AF208975, AF208976, AF208977, AF208978, AF208979 Genomic DNA. Translation: AAG42325.1.
    AF208967 mRNA. Translation: AAG35739.1.
    AF208968 mRNA. Translation: AAG35740.1.
    AF208969 mRNA. Translation: AAG35741.1.
    AF208970 mRNA. Translation: AAG35742.1.
    AK295679 mRNA. Translation: BAG58536.1.
    CH471135 Genomic DNA. Translation: EAW72474.1.
    BC052616 mRNA. Translation: AAH52616.1.
    BC150272 mRNA. Translation: AAI50273.1.
    AB003039 mRNA. Translation: BAB85588.1. Frameshift.
    CR933682 mRNA. Translation: CAI45975.1. Different initiation.
    U90336 mRNA. Translation: AAB50011.1.
    AC006115 Genomic DNA. Translation: AAC83176.1.
    CCDSiCCDS12948.1. [Q9GZU2-1]
    CCDS58684.1. [Q9GZU2-4]
    CCDS58685.1. [Q9GZU2-2]
    RefSeqiNP_001139656.1. NM_001146184.1. [Q9GZU2-1]
    NP_001139657.1. NM_001146185.1. [Q9GZU2-2]
    NP_001139658.1. NM_001146186.1. [Q9GZU2-1]
    NP_001139659.1. NM_001146187.1. [Q9GZU2-4]
    NP_006201.1. NM_006210.2. [Q9GZU2-1]
    UniGeneiHs.731875.

    Genome annotation databases

    EnsembliENST00000326441; ENSP00000326581; ENSG00000198300. [Q9GZU2-1]
    ENST00000593695; ENSP00000472402; ENSG00000198300. [Q9GZU2-2]
    ENST00000598410; ENSP00000473190; ENSG00000198300. [Q9GZU2-4]
    ENST00000599534; ENSP00000472395; ENSG00000198300. [Q9GZU2-1]
    ENST00000599577; ENSP00000469486; ENSG00000198300. [Q9GZU2-1]
    GeneIDi5178.
    KEGGihsa:5178.
    UCSCiuc002qnt.2. human. [Q9GZU2-1]
    uc002qnw.2. human.

    Polymorphism databases

    DMDMi74762724.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF208980
    , AF208974 , AF208975 , AF208976 , AF208977 , AF208978 , AF208979 Genomic DNA. Translation: AAG42324.1 .
    AF208980
    , AF208974 , AF208975 , AF208976 , AF208977 , AF208978 , AF208979 Genomic DNA. Translation: AAG42325.1 .
    AF208967 mRNA. Translation: AAG35739.1 .
    AF208968 mRNA. Translation: AAG35740.1 .
    AF208969 mRNA. Translation: AAG35741.1 .
    AF208970 mRNA. Translation: AAG35742.1 .
    AK295679 mRNA. Translation: BAG58536.1 .
    CH471135 Genomic DNA. Translation: EAW72474.1 .
    BC052616 mRNA. Translation: AAH52616.1 .
    BC150272 mRNA. Translation: AAI50273.1 .
    AB003039 mRNA. Translation: BAB85588.1 . Frameshift.
    CR933682 mRNA. Translation: CAI45975.1 . Different initiation.
    U90336 mRNA. Translation: AAB50011.1 .
    AC006115 Genomic DNA. Translation: AAC83176.1 .
    CCDSi CCDS12948.1. [Q9GZU2-1 ]
    CCDS58684.1. [Q9GZU2-4 ]
    CCDS58685.1. [Q9GZU2-2 ]
    RefSeqi NP_001139656.1. NM_001146184.1. [Q9GZU2-1 ]
    NP_001139657.1. NM_001146185.1. [Q9GZU2-2 ]
    NP_001139658.1. NM_001146186.1. [Q9GZU2-1 ]
    NP_001139659.1. NM_001146187.1. [Q9GZU2-4 ]
    NP_006201.1. NM_006210.2. [Q9GZU2-1 ]
    UniGenei Hs.731875.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4BHX X-ray 1.95 A/B 40-130 [» ]
    ProteinModelPortali Q9GZU2.
    SMRi Q9GZU2. Positions 40-129, 358-395, 398-767, 969-1358, 1497-1531.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111204. 8 interactions.
    DIPi DIP-38426N.
    IntActi Q9GZU2. 4 interactions.
    MINTi MINT-2861650.

    PTM databases

    PhosphoSitei Q9GZU2.

    Polymorphism databases

    DMDMi 74762724.

    Proteomic databases

    MaxQBi Q9GZU2.
    PaxDbi Q9GZU2.
    PRIDEi Q9GZU2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326441 ; ENSP00000326581 ; ENSG00000198300 . [Q9GZU2-1 ]
    ENST00000593695 ; ENSP00000472402 ; ENSG00000198300 . [Q9GZU2-2 ]
    ENST00000598410 ; ENSP00000473190 ; ENSG00000198300 . [Q9GZU2-4 ]
    ENST00000599534 ; ENSP00000472395 ; ENSG00000198300 . [Q9GZU2-1 ]
    ENST00000599577 ; ENSP00000469486 ; ENSG00000198300 . [Q9GZU2-1 ]
    GeneIDi 5178.
    KEGGi hsa:5178.
    UCSCi uc002qnt.2. human. [Q9GZU2-1 ]
    uc002qnw.2. human.

    Organism-specific databases

    CTDi 5178.
    GeneCardsi GC19M057321.
    HGNCi HGNC:8826. PEG3.
    HPAi HPA026070.
    MIMi 601483. gene.
    neXtProti NX_Q9GZU2.
    PharmGKBi PA33171.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000001564.
    HOVERGENi HBG079943.
    InParanoidi Q9GZU2.
    KOi K09230.
    OMAi KAMSMSS.
    OrthoDBi EOG7P02H3.
    PhylomeDBi Q9GZU2.
    TreeFami TF337075.

    Miscellaneous databases

    GeneWikii PEG3.
    GenomeRNAii 5178.
    NextBioi 20042.
    PROi Q9GZU2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9GZU2.
    Bgeei Q9GZU2.
    CleanExi HS_PEG3.
    Genevestigatori Q9GZU2.

    Family and domain databases

    Gene3Di 3.30.160.60. 10 hits.
    InterProi IPR027775. C2H2_Znf_fam.
    IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    PANTHERi PTHR10032. PTHR10032. 1 hit.
    Pfami PF02023. SCAN. 1 hit.
    PF00096. zf-C2H2. 10 hits.
    [Graphical view ]
    SMARTi SM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 12 hits.
    [Graphical view ]
    SUPFAMi SSF47353. SSF47353. 1 hit.
    PROSITEi PS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 12 hits.
    PS50157. ZINC_FINGER_C2H2_2. 12 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human homologue (PEG3) of the mouse paternally expressed gene 3 (Peg3) is maternally imprinted but not mutated in women with familial recurrent hydatidiform molar pregnancies."
      Van den Veyver I.B., Norman B., Tran C.Q., Bourjac J., Slim R.
      J. Soc. Gynecol. Invest. 8:305-313(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT LEU-1576.
      Tissue: Fetal kidney.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Hippocampus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-1588 (ISOFORM 3), VARIANT SER-947.
      Tissue: Liver.
    5. "Paternal monoallelic expression of PEG3 in the human placenta."
      Hiby S.E., Lough M., Keverne E.B., Surani M.A., Loke Y.W., King A.
      Hum. Mol. Genet. 10:1093-1100(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 127-456, TISSUE SPECIFICITY.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 781-1588.
      Tissue: Amygdala.
    7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 302-1588 (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    8. "The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4."
      Kim J., Ashworth L., Branscomb E., Stubbs L.
      Genome Res. 7:532-540(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 974-1588, TISSUE SPECIFICITY.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 974-1588.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Structure of the SCAN domain of human paternally expressed gene 3 protein."
      Rimsa V., Eadsforth T.C., Hunter W.N.
      PLoS ONE 8:E69538-E69538(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 40-130, SCAN DOMAIN, SUBUNIT.
    12. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-594.

    Entry informationi

    Entry nameiPEG3_HUMAN
    AccessioniPrimary (citable) accession number: Q9GZU2
    Secondary accession number(s): A7E2B8
    , B4DIM4, C9JP50, P78418, Q5H9P9, Q7Z7H7, Q8TF75, Q9GZY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3