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Q9GZU2 (PEG3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Paternally-expressed gene 3 protein
Alternative name(s):
Zinc finger and SCAN domain-containing protein 24
Gene names
Name:PEG3
Synonyms:KIAA0287, ZSCAN24
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1588 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B By similarity. Possesses a tumor suppressing activity in glioma cells. Ref.7

Subunit structure

Homodimer. Interacts with SIAH1A and SIAH2. Interacts with TRAF2 By similarity. Ref.11

Subcellular location

Nucleus By similarity. Cytoplasm By similarity.

Tissue specificity

Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines. Ref.5 Ref.7 Ref.8

Domain

The SCAN domain enables PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion. Ref.11

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 12 C2H2-type zinc fingers.

Contains 1 SCAN box domain.

Sequence caution

The sequence BAB85588.1 differs from that shown. Reason: Frameshift at several positions.

The sequence CAI45975.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9GZU2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9GZU2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.
Isoform 3 (identifier: Q9GZU2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     258-287: Missing.
     547-550: SPTF → NPCL
     551-1588: Missing.
Isoform 4 (identifier: Q9GZU2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.
     161-161: S → SG
     257-257: L → LG

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15881588Paternally-expressed gene 3 protein
PRO_0000249228

Regions

Domain46 – 12883SCAN box
Repeat1397 – 140372-1
Repeat1404 – 141072-2
Repeat1411 – 141772-3
Repeat1418 – 142251-1
Repeat1425 – 142951-2
Repeat1432 – 143651-3
Repeat1439 – 144351-4
Zinc finger452 – 47423C2H2-type 1
Zinc finger505 – 52723C2H2-type 2
Zinc finger563 – 58523C2H2-type 3
Zinc finger627 – 64923C2H2-type 4
Zinc finger969 – 99123C2H2-type 5
Zinc finger1107 – 112923C2H2-type 6
Zinc finger1163 – 118523C2H2-type 7
Zinc finger1225 – 124723C2H2-type 8
Zinc finger1282 – 130423C2H2-type 9
Zinc finger1332 – 135423C2H2-type 10
Zinc finger1505 – 152723C2H2-type 11
Zinc finger1564 – 158623C2H2-type 12
Region1397 – 1417213 X 7 AA repeat of P-E-V-E-A-A-E
Region1418 – 1443264 X 5 AA repeat of P-X-G-E-A
Compositional bias1352 – 1512161Glu-rich

Natural variations

Alternative sequence1 – 126126Missing in isoform 2 and isoform 4.
VSP_020371
Alternative sequence1611S → SG in isoform 4.
VSP_045527
Alternative sequence2571L → LG in isoform 4.
VSP_045528
Alternative sequence258 – 28730Missing in isoform 3.
VSP_020372
Alternative sequence547 – 5504SPTF → NPCL in isoform 3.
VSP_020373
Alternative sequence551 – 15881038Missing in isoform 3.
VSP_020374
Natural variant2351A → T.
Corresponds to variant rs2191432 [ dbSNP | Ensembl ].
VAR_027397
Natural variant5941R → H in a colorectal cancer sample; somatic mutation. Ref.12
VAR_035562
Natural variant6241E → G.
Corresponds to variant rs36016896 [ dbSNP | Ensembl ].
VAR_052725
Natural variant8391V → L.
Corresponds to variant rs7251798 [ dbSNP | Ensembl ].
VAR_027398
Natural variant9471N → S. Ref.4
Corresponds to variant rs35851866 [ dbSNP | Ensembl ].
VAR_052726
Natural variant9831D → G.
Corresponds to variant rs10412932 [ dbSNP | Ensembl ].
VAR_027399
Natural variant14561A → V.
Corresponds to variant rs34831553 [ dbSNP | Ensembl ].
VAR_052727
Natural variant15761R → H.
Corresponds to variant rs34051133 [ dbSNP | Ensembl ].
VAR_052728
Natural variant15761R → L. Ref.1
VAR_027400

Experimental info

Sequence conflict310 – 3112SH → PP in BAB85588. Ref.7
Sequence conflict4391F → L in BAG58536. Ref.2
Sequence conflict6771K → I in BAB85588. Ref.7
Sequence conflict6901G → A in BAB85588. Ref.7
Sequence conflict7501F → V in BAB85588. Ref.7
Sequence conflict7551N → Y in BAB85588. Ref.7
Sequence conflict11171V → M in BAB85588. Ref.7
Sequence conflict11451I → V in BAB85588. Ref.7
Sequence conflict15871T → M in BAB85588. Ref.7

Secondary structure

................. 1588
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 7E4F34A01F189F3E

FASTA1,588180,827
        10         20         30         40         50         60 
MLPPKHLSAT KPKKSWAPNL YELDSDLTKE PDVIIGEGPT DSEFFHQRFR NLIYVEFVGP 

        70         80         90        100        110        120 
RKTLIKLRNL CLDWLQPETR TKEEIIELLV LEQYLTIIPE KLKPWVRAKK PENCEKLVTL 

       130        140        150        160        170        180 
LENYKEMYQP EDDNNSDVTS DDDMTRNRRE SSPPHSVHSF SDRDWDRRGR SRDMEPRDRW 

       190        200        210        220        230        240 
SHTRNPRSRM PPRDLSLPVV AKTSFEMDRE DDRDSRAYES RSQDAESYQN VVDLAEDRKP 

       250        260        270        280        290        300 
HNTIQDNMEN YRKLLSLVQL AEDDGHSHMT QGHSSRSKRS AYPSTSRGLK TMPEAKKSTH 

       310        320        330        340        350        360 
RRGICEDESS HGVIMEKFIK DVSRSSKSGR ARESSDRSQR FPRMSDDNWK DISLNKRESV 

       370        380        390        400        410        420 
IQQRVYEGNA FRGGFRFNST LVSRKRVLER KRRYHFDTDG KGSIHDQKGC PRKKPFECGS 

       430        440        450        460        470        480 
EMRKAMSVSS LSSLSSPSFT ESQPIDFGAM PYVCDECGRS FSVISEFVEH QIMHTRENLY 

       490        500        510        520        530        540 
EYGESFIHSV AVSEVQKSQV GGKRFECKDC GETFNKSAAL AEHRKIHARG YLVECKNQEC 

       550        560        570        580        590        600 
EEAFMPSPTF SELQKIYGKD KFYECRVCKE TFLHSSALIE HQKIHFGDDK DNEREHERER 

       610        620        630        640        650        660 
ERERGETFRP SPALNEFQKM YGKEKMYECK VCGETFLHSS SLKEHQKIHT RGNPFENKGK 

       670        680        690        700        710        720 
VCEETFIPGQ SLKRRQKTYN KEKLCDFTDG RDAFMQSSEL SEHQKIHSRK NLFEGRGYEK 

       730        740        750        760        770        780 
SVIHSGPFTE SQKSHTITRP LESDEDEKAF TISSNPYENQ KIPTKENVYE AKSYERSVIH 

       790        800        810        820        830        840 
SLASVEAQKS HSVAGPSKPK VMAESTIQSF DAINHQRVRA GGNTSEGREY SRSVIHSLVA 

       850        860        870        880        890        900 
SKPPRSHNGN ELVESNEKGE SSIYISDLND KRQKIPAREN PCEGGSKNRN YEDSVIQSVF 

       910        920        930        940        950        960 
RAKPQKSVPG EGSGEFKKDG EFSVPSSNVR EYQKARAKKK YIEHRSNETS VIHSLPFGEQ 

       970        980        990       1000       1010       1020 
TFRPRGMLYE CQECGECFAH SSDLTEHQKI HDREKPSGSR NYEWSVIRSL APTDPQTSYA 

      1030       1040       1050       1060       1070       1080 
QEQYAKEQAR NKCKDFRQFF ATSEDLNTNQ KIYDQEKSHG EESQGENTDG EETHSEETHG 

      1090       1100       1110       1120       1130       1140 
QETIEDPVIQ GSDMEDPQKD DPDDKIYECE DCGLGFVDLT DLTDHQKVHS RKCLVDSREY 

      1150       1160       1170       1180       1190       1200 
THSVIHTHSI SEYQRDYTGE QLYECPKCGE SFIHSSFLFE HQRIHEQDQL YSMKGCDDGF 

      1210       1220       1230       1240       1250       1260 
IALLPMKPRR NRAAERNPAL AGSAIRCLLC GQGFIHSSAL NEHMRLHRED DLLEQSQMAE 

      1270       1280       1290       1300       1310       1320 
EAIIPGLALT EFQRSQTEER LFECAVCGES FVNPAELADH VTVHKNEPYE YGSSYTHTSF 

      1330       1340       1350       1360       1370       1380 
LTEPLKGAIP FYECKDCGKS FIHSTVLTKH KELHLEEEEE DEAAAAAAAA AQEVEANVHV 

      1390       1400       1410       1420       1430       1440 
PQVVLRIQGL NVEAAEPEVE AAEPEVEAAE PEVEAAEPNG EAEGPDGEAA EPIGEAGQPN 

      1450       1460       1470       1480       1490       1500 
GEAEQPNGDA DEPDGAGIED PEERAEEPEG KAEEPEGDAD EPDGVGIEDP EEGEDQEIQV 

      1510       1520       1530       1540       1550       1560 
EEPYYDCHEC TETFTSSTAF SEHLKTHASM IIFEPANAFG ECSGYIERAS TSTGGANQAD 

      1570       1580 
EKYFKCDVCG QLFNDRLSLA RHQNTHTG 

« Hide

Isoform 2 [UniParc].

Checksum: 29F1A63C6CC02BFF
Show »

FASTA1,462165,957
Isoform 3 [UniParc].

Checksum: AA43A03C9CE8D178
Show »

FASTA52060,547
Isoform 4 [UniParc].

Checksum: B57A789363951AE6
Show »

FASTA1,464166,071

References

« Hide 'large scale' references
[1]"The human homologue (PEG3) of the mouse paternally expressed gene 3 (Peg3) is maternally imprinted but not mutated in women with familial recurrent hydatidiform molar pregnancies."
Van den Veyver I.B., Norman B., Tran C.Q., Bourjac J., Slim R.
J. Soc. Gynecol. Invest. 8:305-313(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT LEU-1576.
Tissue: Fetal kidney.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Hippocampus.
[3]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-1588 (ISOFORM 3), VARIANT SER-947.
Tissue: Liver.
[5]"Paternal monoallelic expression of PEG3 in the human placenta."
Hiby S.E., Lough M., Keverne E.B., Surani M.A., Loke Y.W., King A.
Hum. Mol. Genet. 10:1093-1100(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 127-456, TISSUE SPECIFICITY.
[6]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 781-1588.
Tissue: Amygdala.
[7]"Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line."
Kohda T., Asai A., Kuroiwa Y., Kobayashi S., Aisaka K., Nagashima G., Yoshida M.C., Kondo Y., Kagiyama N., Kirino T., Kaneko-Ishino T., Ishino F.
Genes Cells 6:237-247(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 302-1588 (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[8]"The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4."
Kim J., Ashworth L., Branscomb E., Stubbs L.
Genome Res. 7:532-540(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 974-1588, TISSUE SPECIFICITY.
[9]"Sequence analysis of a 2 Mb region containing a zinc finger (ZNF) gene cluster in 19q13.4."
Lamerdin J.E., McCready P.M., Kim J., Skowronski E., Viswanathan V., Burkhart-Schultz K., Gordon L., Dias J., Ramirez M., Stilwagen S., Phan H., Velasco N., Do L., Regala W., Terry A., Garnes J., Danganan L., Erler A. expand/collapse author list , Christensen M., Georgescu A., Avila J., Liu S., Attix C., Andreise T., Trankheim M., Amico-Keller G., Coefield J., Duarte S., Lucas S., Bruce R., Thomas P., Quan G., Kronmiller B., Arellano A., Saunders C., Ow D., Nolan M., Trong S., Kobayashi A., Olsen A.S., Carrano A.V.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 974-1588.
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"Structure of the SCAN domain of human paternally expressed gene 3 protein."
Rimsa V., Eadsforth T.C., Hunter W.N.
PLoS ONE 8:E69538-E69538(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 40-130, SCAN DOMAIN, SUBUNIT.
[12]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-594.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF208980 expand/collapse EMBL AC list , AF208974, AF208975, AF208976, AF208977, AF208978, AF208979 Genomic DNA. Translation: AAG42324.1.
AF208980 expand/collapse EMBL AC list , AF208974, AF208975, AF208976, AF208977, AF208978, AF208979 Genomic DNA. Translation: AAG42325.1.
AF208967 mRNA. Translation: AAG35739.1.
AF208968 mRNA. Translation: AAG35740.1.
AF208969 mRNA. Translation: AAG35741.1.
AF208970 mRNA. Translation: AAG35742.1.
AK295679 mRNA. Translation: BAG58536.1.
CH471135 Genomic DNA. Translation: EAW72474.1.
BC052616 mRNA. Translation: AAH52616.1.
BC150272 mRNA. Translation: AAI50273.1.
AB003039 mRNA. Translation: BAB85588.1. Frameshift.
CR933682 mRNA. Translation: CAI45975.1. Different initiation.
U90336 mRNA. Translation: AAB50011.1.
AC006115 Genomic DNA. Translation: AAC83176.1.
RefSeqNP_001139656.1. NM_001146184.1.
NP_001139657.1. NM_001146185.1.
NP_001139658.1. NM_001146186.1.
NP_001139659.1. NM_001146187.1.
NP_006201.1. NM_006210.2.
UniGeneHs.731875.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4BHXX-ray1.95A/B40-130[»]
ProteinModelPortalQ9GZU2.
SMRQ9GZU2. Positions 40-129, 363-767, 969-1360, 1477-1586.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111204. 8 interactions.
DIPDIP-38426N.
IntActQ9GZU2. 3 interactions.
MINTMINT-2861650.

PTM databases

PhosphoSiteQ9GZU2.

Polymorphism databases

DMDM74762724.

Proteomic databases

PaxDbQ9GZU2.
PRIDEQ9GZU2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000326441; ENSP00000326581; ENSG00000198300. [Q9GZU2-1]
ENST00000423103; ENSP00000403051; ENSG00000198300. [Q9GZU2-1]
ENST00000593695; ENSP00000472402; ENSG00000198300. [Q9GZU2-2]
ENST00000598410; ENSP00000473190; ENSG00000198300. [Q9GZU2-4]
ENST00000599534; ENSP00000472395; ENSG00000198300. [Q9GZU2-1]
ENST00000599577; ENSP00000469486; ENSG00000198300. [Q9GZU2-1]
GeneID5178.
KEGGhsa:5178.
UCSCuc002qnt.2. human. [Q9GZU2-1]
uc002qnw.2. human.

Organism-specific databases

CTD5178.
GeneCardsGC19M057321.
HGNCHGNC:8826. PEG3.
HPAHPA026070.
MIM601483. gene.
neXtProtNX_Q9GZU2.
PharmGKBPA33171.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000001564.
HOVERGENHBG079943.
InParanoidQ9GZU2.
KOK09230.
OMAKAMSMSS.
OrthoDBEOG7P02H3.
PhylomeDBQ9GZU2.
TreeFamTF337075.

Gene expression databases

ArrayExpressQ9GZU2.
BgeeQ9GZU2.
CleanExHS_PEG3.
GenevestigatorQ9GZU2.

Family and domain databases

Gene3D3.30.160.60. 10 hits.
InterProIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERPTHR10032. PTHR10032. 1 hit.
PfamPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 10 hits.
[Graphical view]
SMARTSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMSSF47353. SSF47353. 1 hit.
PROSITEPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPEG3.
GenomeRNAi5178.
NextBio20042.
PROQ9GZU2.
SOURCESearch...

Entry information

Entry namePEG3_HUMAN
AccessionPrimary (citable) accession number: Q9GZU2
Secondary accession number(s): A7E2B8 expand/collapse secondary AC list , B4DIM4, C9JP50, P78418, Q5H9P9, Q7Z7H7, Q8TF75, Q9GZY2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM