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Q9GZU2

- PEG3_HUMAN

UniProt

Q9GZU2 - PEG3_HUMAN

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Protein

Paternally-expressed gene 3 protein

Gene

PEG3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri452 – 47423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri505 – 52723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri563 – 58523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri627 – 64923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri969 – 99123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1107 – 112923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1163 – 118523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1225 – 124723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1282 – 130423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1332 – 135423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1505 – 152723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1564 – 158623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. genetic imprinting Source: Ensembl
  3. in utero embryonic development Source: Ensembl
  4. multicellular organism growth Source: Ensembl
  5. regulation of transcription from RNA polymerase II promoter Source: GOC
  6. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Paternally-expressed gene 3 protein
Alternative name(s):
Zinc finger and SCAN domain-containing protein 24
Gene namesi
Name:PEG3
Synonyms:KIAA0287, ZSCAN24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:8826. PEG3.

Subcellular locationi

Nucleus PROSITE-ProRule annotation. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33171.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15881588Paternally-expressed gene 3 proteinPRO_0000249228Add
BLAST

Proteomic databases

MaxQBiQ9GZU2.
PaxDbiQ9GZU2.
PRIDEiQ9GZU2.

PTM databases

PhosphoSiteiQ9GZU2.

Expressioni

Tissue specificityi

Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines.3 Publications

Gene expression databases

BgeeiQ9GZU2.
CleanExiHS_PEG3.
ExpressionAtlasiQ9GZU2. baseline and differential.
GenevestigatoriQ9GZU2.

Organism-specific databases

HPAiHPA026070.

Interactioni

Subunit structurei

Homodimer. Interacts with SIAH1A and SIAH2. Interacts with TRAF2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi111204. 8 interactions.
DIPiDIP-38426N.
IntActiQ9GZU2. 4 interactions.
MINTiMINT-2861650.

Structurei

Secondary structure

1
1588
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi42 – 5110Combined sources
Turni56 – 583Combined sources
Helixi60 – 7516Combined sources
Helixi77 – 793Combined sources
Helixi82 – 9716Combined sources
Helixi100 – 1023Combined sources
Helixi103 – 1097Combined sources
Helixi114 – 1218Combined sources
Turni122 – 1243Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BHXX-ray1.95A/B40-130[»]
ProteinModelPortaliQ9GZU2.
SMRiQ9GZU2. Positions 40-129, 358-395, 398-767, 969-1358, 1497-1531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 12883SCAN boxPROSITE-ProRule annotationAdd
BLAST
Repeati1397 – 140372-1
Repeati1404 – 141072-2
Repeati1411 – 141772-3
Repeati1418 – 142251-1
Repeati1425 – 142951-2
Repeati1432 – 143651-3
Repeati1439 – 144351-4

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1397 – 1417213 X 7 AA repeat of P-E-V-E-A-A-EAdd
BLAST
Regioni1418 – 1443264 X 5 AA repeat of P-X-G-E-AAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1352 – 1512161Glu-richAdd
BLAST

Domaini

The SCAN domain enables PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion.

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri452 – 47423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri505 – 52723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri563 – 58523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri627 – 64923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri969 – 99123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1107 – 112923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1163 – 118523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1225 – 124723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1282 – 130423C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1332 – 135423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1505 – 152723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1564 – 158623C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00770000120631.
HOGENOMiHOG000001564.
HOVERGENiHBG079943.
InParanoidiQ9GZU2.
KOiK09230.
OMAiKAMSMSS.
OrthoDBiEOG7P02H3.
PhylomeDBiQ9GZU2.
TreeFamiTF337075.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 10 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9GZU2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPPKHLSAT KPKKSWAPNL YELDSDLTKE PDVIIGEGPT DSEFFHQRFR
60 70 80 90 100
NLIYVEFVGP RKTLIKLRNL CLDWLQPETR TKEEIIELLV LEQYLTIIPE
110 120 130 140 150
KLKPWVRAKK PENCEKLVTL LENYKEMYQP EDDNNSDVTS DDDMTRNRRE
160 170 180 190 200
SSPPHSVHSF SDRDWDRRGR SRDMEPRDRW SHTRNPRSRM PPRDLSLPVV
210 220 230 240 250
AKTSFEMDRE DDRDSRAYES RSQDAESYQN VVDLAEDRKP HNTIQDNMEN
260 270 280 290 300
YRKLLSLVQL AEDDGHSHMT QGHSSRSKRS AYPSTSRGLK TMPEAKKSTH
310 320 330 340 350
RRGICEDESS HGVIMEKFIK DVSRSSKSGR ARESSDRSQR FPRMSDDNWK
360 370 380 390 400
DISLNKRESV IQQRVYEGNA FRGGFRFNST LVSRKRVLER KRRYHFDTDG
410 420 430 440 450
KGSIHDQKGC PRKKPFECGS EMRKAMSVSS LSSLSSPSFT ESQPIDFGAM
460 470 480 490 500
PYVCDECGRS FSVISEFVEH QIMHTRENLY EYGESFIHSV AVSEVQKSQV
510 520 530 540 550
GGKRFECKDC GETFNKSAAL AEHRKIHARG YLVECKNQEC EEAFMPSPTF
560 570 580 590 600
SELQKIYGKD KFYECRVCKE TFLHSSALIE HQKIHFGDDK DNEREHERER
610 620 630 640 650
ERERGETFRP SPALNEFQKM YGKEKMYECK VCGETFLHSS SLKEHQKIHT
660 670 680 690 700
RGNPFENKGK VCEETFIPGQ SLKRRQKTYN KEKLCDFTDG RDAFMQSSEL
710 720 730 740 750
SEHQKIHSRK NLFEGRGYEK SVIHSGPFTE SQKSHTITRP LESDEDEKAF
760 770 780 790 800
TISSNPYENQ KIPTKENVYE AKSYERSVIH SLASVEAQKS HSVAGPSKPK
810 820 830 840 850
VMAESTIQSF DAINHQRVRA GGNTSEGREY SRSVIHSLVA SKPPRSHNGN
860 870 880 890 900
ELVESNEKGE SSIYISDLND KRQKIPAREN PCEGGSKNRN YEDSVIQSVF
910 920 930 940 950
RAKPQKSVPG EGSGEFKKDG EFSVPSSNVR EYQKARAKKK YIEHRSNETS
960 970 980 990 1000
VIHSLPFGEQ TFRPRGMLYE CQECGECFAH SSDLTEHQKI HDREKPSGSR
1010 1020 1030 1040 1050
NYEWSVIRSL APTDPQTSYA QEQYAKEQAR NKCKDFRQFF ATSEDLNTNQ
1060 1070 1080 1090 1100
KIYDQEKSHG EESQGENTDG EETHSEETHG QETIEDPVIQ GSDMEDPQKD
1110 1120 1130 1140 1150
DPDDKIYECE DCGLGFVDLT DLTDHQKVHS RKCLVDSREY THSVIHTHSI
1160 1170 1180 1190 1200
SEYQRDYTGE QLYECPKCGE SFIHSSFLFE HQRIHEQDQL YSMKGCDDGF
1210 1220 1230 1240 1250
IALLPMKPRR NRAAERNPAL AGSAIRCLLC GQGFIHSSAL NEHMRLHRED
1260 1270 1280 1290 1300
DLLEQSQMAE EAIIPGLALT EFQRSQTEER LFECAVCGES FVNPAELADH
1310 1320 1330 1340 1350
VTVHKNEPYE YGSSYTHTSF LTEPLKGAIP FYECKDCGKS FIHSTVLTKH
1360 1370 1380 1390 1400
KELHLEEEEE DEAAAAAAAA AQEVEANVHV PQVVLRIQGL NVEAAEPEVE
1410 1420 1430 1440 1450
AAEPEVEAAE PEVEAAEPNG EAEGPDGEAA EPIGEAGQPN GEAEQPNGDA
1460 1470 1480 1490 1500
DEPDGAGIED PEERAEEPEG KAEEPEGDAD EPDGVGIEDP EEGEDQEIQV
1510 1520 1530 1540 1550
EEPYYDCHEC TETFTSSTAF SEHLKTHASM IIFEPANAFG ECSGYIERAS
1560 1570 1580
TSTGGANQAD EKYFKCDVCG QLFNDRLSLA RHQNTHTG
Length:1,588
Mass (Da):180,827
Last modified:March 1, 2001 - v1
Checksum:i7E4F34A01F189F3E
GO
Isoform 2 (identifier: Q9GZU2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.

Show »
Length:1,462
Mass (Da):165,957
Checksum:i29F1A63C6CC02BFF
GO
Isoform 3 (identifier: Q9GZU2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-287: Missing.
     547-550: SPTF → NPCL
     551-1588: Missing.

Show »
Length:520
Mass (Da):60,547
Checksum:iAA43A03C9CE8D178
GO
Isoform 4 (identifier: Q9GZU2-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-126: Missing.
     161-161: S → SG
     257-257: L → LG

Show »
Length:1,464
Mass (Da):166,071
Checksum:iB57A789363951AE6
GO

Sequence cautioni

The sequence BAB85588.1 differs from that shown. Reason: Frameshift at several positions. Curated
The sequence CAI45975.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti310 – 3112SH → PP in BAB85588. (PubMed:11260267)Curated
Sequence conflicti439 – 4391F → L in BAG58536. (PubMed:14702039)Curated
Sequence conflicti677 – 6771K → I in BAB85588. (PubMed:11260267)Curated
Sequence conflicti690 – 6901G → A in BAB85588. (PubMed:11260267)Curated
Sequence conflicti750 – 7501F → V in BAB85588. (PubMed:11260267)Curated
Sequence conflicti755 – 7551N → Y in BAB85588. (PubMed:11260267)Curated
Sequence conflicti1117 – 11171V → M in BAB85588. (PubMed:11260267)Curated
Sequence conflicti1145 – 11451I → V in BAB85588. (PubMed:11260267)Curated
Sequence conflicti1587 – 15871T → M in BAB85588. (PubMed:11260267)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti235 – 2351A → T.
Corresponds to variant rs2191432 [ dbSNP | Ensembl ].
VAR_027397
Natural varianti594 – 5941R → H in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035562
Natural varianti624 – 6241E → G.
Corresponds to variant rs36016896 [ dbSNP | Ensembl ].
VAR_052725
Natural varianti839 – 8391V → L.
Corresponds to variant rs7251798 [ dbSNP | Ensembl ].
VAR_027398
Natural varianti947 – 9471N → S.1 Publication
Corresponds to variant rs35851866 [ dbSNP | Ensembl ].
VAR_052726
Natural varianti983 – 9831D → G.
Corresponds to variant rs10412932 [ dbSNP | Ensembl ].
VAR_027399
Natural varianti1456 – 14561A → V.
Corresponds to variant rs34831553 [ dbSNP | Ensembl ].
VAR_052727
Natural varianti1576 – 15761R → H.
Corresponds to variant rs34051133 [ dbSNP | Ensembl ].
VAR_052728
Natural varianti1576 – 15761R → L.1 Publication
VAR_027400

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 126126Missing in isoform 2 and isoform 4. 3 PublicationsVSP_020371Add
BLAST
Alternative sequencei161 – 1611S → SG in isoform 4. 2 PublicationsVSP_045527
Alternative sequencei257 – 2571L → LG in isoform 4. 2 PublicationsVSP_045528
Alternative sequencei258 – 28730Missing in isoform 3. 1 PublicationVSP_020372Add
BLAST
Alternative sequencei547 – 5504SPTF → NPCL in isoform 3. 1 PublicationVSP_020373
Alternative sequencei551 – 15881038Missing in isoform 3. 1 PublicationVSP_020374Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208980
, AF208974, AF208975, AF208976, AF208977, AF208978, AF208979 Genomic DNA. Translation: AAG42324.1.
AF208980
, AF208974, AF208975, AF208976, AF208977, AF208978, AF208979 Genomic DNA. Translation: AAG42325.1.
AF208967 mRNA. Translation: AAG35739.1.
AF208968 mRNA. Translation: AAG35740.1.
AF208969 mRNA. Translation: AAG35741.1.
AF208970 mRNA. Translation: AAG35742.1.
AK295679 mRNA. Translation: BAG58536.1.
CH471135 Genomic DNA. Translation: EAW72474.1.
BC052616 mRNA. Translation: AAH52616.1.
BC150272 mRNA. Translation: AAI50273.1.
AB003039 mRNA. Translation: BAB85588.1. Frameshift.
CR933682 mRNA. Translation: CAI45975.1. Different initiation.
U90336 mRNA. Translation: AAB50011.1.
AC006115 Genomic DNA. Translation: AAC83176.1.
CCDSiCCDS12948.1. [Q9GZU2-1]
CCDS58684.1. [Q9GZU2-4]
CCDS58685.1. [Q9GZU2-2]
RefSeqiNP_001139656.1. NM_001146184.1. [Q9GZU2-1]
NP_001139657.1. NM_001146185.1. [Q9GZU2-2]
NP_001139658.1. NM_001146186.1. [Q9GZU2-1]
NP_001139659.1. NM_001146187.1. [Q9GZU2-4]
NP_006201.1. NM_006210.2. [Q9GZU2-1]
UniGeneiHs.731875.

Genome annotation databases

EnsembliENST00000326441; ENSP00000326581; ENSG00000198300. [Q9GZU2-1]
ENST00000593695; ENSP00000472402; ENSG00000198300. [Q9GZU2-2]
ENST00000598410; ENSP00000473190; ENSG00000198300. [Q9GZU2-4]
ENST00000599534; ENSP00000472395; ENSG00000198300. [Q9GZU2-1]
ENST00000599577; ENSP00000469486; ENSG00000198300. [Q9GZU2-1]
GeneIDi5178.
KEGGihsa:5178.
UCSCiuc002qnt.2. human. [Q9GZU2-1]
uc002qnw.2. human.

Polymorphism databases

DMDMi74762724.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208980
, AF208974 , AF208975 , AF208976 , AF208977 , AF208978 , AF208979 Genomic DNA. Translation: AAG42324.1 .
AF208980
, AF208974 , AF208975 , AF208976 , AF208977 , AF208978 , AF208979 Genomic DNA. Translation: AAG42325.1 .
AF208967 mRNA. Translation: AAG35739.1 .
AF208968 mRNA. Translation: AAG35740.1 .
AF208969 mRNA. Translation: AAG35741.1 .
AF208970 mRNA. Translation: AAG35742.1 .
AK295679 mRNA. Translation: BAG58536.1 .
CH471135 Genomic DNA. Translation: EAW72474.1 .
BC052616 mRNA. Translation: AAH52616.1 .
BC150272 mRNA. Translation: AAI50273.1 .
AB003039 mRNA. Translation: BAB85588.1 . Frameshift.
CR933682 mRNA. Translation: CAI45975.1 . Different initiation.
U90336 mRNA. Translation: AAB50011.1 .
AC006115 Genomic DNA. Translation: AAC83176.1 .
CCDSi CCDS12948.1. [Q9GZU2-1 ]
CCDS58684.1. [Q9GZU2-4 ]
CCDS58685.1. [Q9GZU2-2 ]
RefSeqi NP_001139656.1. NM_001146184.1. [Q9GZU2-1 ]
NP_001139657.1. NM_001146185.1. [Q9GZU2-2 ]
NP_001139658.1. NM_001146186.1. [Q9GZU2-1 ]
NP_001139659.1. NM_001146187.1. [Q9GZU2-4 ]
NP_006201.1. NM_006210.2. [Q9GZU2-1 ]
UniGenei Hs.731875.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BHX X-ray 1.95 A/B 40-130 [» ]
ProteinModelPortali Q9GZU2.
SMRi Q9GZU2. Positions 40-129, 358-395, 398-767, 969-1358, 1497-1531.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111204. 8 interactions.
DIPi DIP-38426N.
IntActi Q9GZU2. 4 interactions.
MINTi MINT-2861650.

PTM databases

PhosphoSitei Q9GZU2.

Polymorphism databases

DMDMi 74762724.

Proteomic databases

MaxQBi Q9GZU2.
PaxDbi Q9GZU2.
PRIDEi Q9GZU2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000326441 ; ENSP00000326581 ; ENSG00000198300 . [Q9GZU2-1 ]
ENST00000593695 ; ENSP00000472402 ; ENSG00000198300 . [Q9GZU2-2 ]
ENST00000598410 ; ENSP00000473190 ; ENSG00000198300 . [Q9GZU2-4 ]
ENST00000599534 ; ENSP00000472395 ; ENSG00000198300 . [Q9GZU2-1 ]
ENST00000599577 ; ENSP00000469486 ; ENSG00000198300 . [Q9GZU2-1 ]
GeneIDi 5178.
KEGGi hsa:5178.
UCSCi uc002qnt.2. human. [Q9GZU2-1 ]
uc002qnw.2. human.

Organism-specific databases

CTDi 5178.
GeneCardsi GC19M057321.
HGNCi HGNC:8826. PEG3.
HPAi HPA026070.
MIMi 601483. gene.
neXtProti NX_Q9GZU2.
PharmGKBi PA33171.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00770000120631.
HOGENOMi HOG000001564.
HOVERGENi HBG079943.
InParanoidi Q9GZU2.
KOi K09230.
OMAi KAMSMSS.
OrthoDBi EOG7P02H3.
PhylomeDBi Q9GZU2.
TreeFami TF337075.

Miscellaneous databases

GeneWikii PEG3.
GenomeRNAii 5178.
NextBioi 20042.
PROi Q9GZU2.
SOURCEi Search...

Gene expression databases

Bgeei Q9GZU2.
CleanExi HS_PEG3.
ExpressionAtlasi Q9GZU2. baseline and differential.
Genevestigatori Q9GZU2.

Family and domain databases

Gene3Di 3.30.160.60. 10 hits.
InterProi IPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
PANTHERi PTHR10032. PTHR10032. 1 hit.
Pfami PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 10 hits.
[Graphical view ]
SMARTi SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view ]
SUPFAMi SSF47353. SSF47353. 1 hit.
PROSITEi PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human homologue (PEG3) of the mouse paternally expressed gene 3 (Peg3) is maternally imprinted but not mutated in women with familial recurrent hydatidiform molar pregnancies."
    Van den Veyver I.B., Norman B., Tran C.Q., Bourjac J., Slim R.
    J. Soc. Gynecol. Invest. 8:305-313(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT LEU-1576.
    Tissue: Fetal kidney.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Hippocampus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-1588 (ISOFORM 3), VARIANT SER-947.
    Tissue: Liver.
  5. "Paternal monoallelic expression of PEG3 in the human placenta."
    Hiby S.E., Lough M., Keverne E.B., Surani M.A., Loke Y.W., King A.
    Hum. Mol. Genet. 10:1093-1100(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 127-456, TISSUE SPECIFICITY.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 781-1588.
    Tissue: Amygdala.
  7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 302-1588 (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
  8. "The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4."
    Kim J., Ashworth L., Branscomb E., Stubbs L.
    Genome Res. 7:532-540(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 974-1588, TISSUE SPECIFICITY.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 974-1588.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Structure of the SCAN domain of human paternally expressed gene 3 protein."
    Rimsa V., Eadsforth T.C., Hunter W.N.
    PLoS ONE 8:E69538-E69538(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 40-130, SCAN DOMAIN, SUBUNIT.
  12. Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-594.

Entry informationi

Entry nameiPEG3_HUMAN
AccessioniPrimary (citable) accession number: Q9GZU2
Secondary accession number(s): A7E2B8
, B4DIM4, C9JP50, P78418, Q5H9P9, Q7Z7H7, Q8TF75, Q9GZY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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