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Protein

Uncharacterized protein C6orf62

Gene

C6orf62

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C6orf62
Alternative name(s):
HBV X-transactivated gene 12 protein
HBV XAg-transactivated protein 12
Gene namesi
Name:C6orf62
Synonyms:XTP12
ORF Names:Nbla00237
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112308.12.
HGNCiHGNC:20998. C6orf62.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000112308.
PharmGKBiPA134946342.

Polymorphism and mutation databases

BioMutaiC6orf62.
DMDMi30912736.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000895141 – 229Uncharacterized protein C6orf62Add BLAST229

Proteomic databases

MaxQBiQ9GZU0.
PaxDbiQ9GZU0.
PeptideAtlasiQ9GZU0.
PRIDEiQ9GZU0.

PTM databases

iPTMnetiQ9GZU0.
PhosphoSitePlusiQ9GZU0.

Expressioni

Gene expression databases

BgeeiENSG00000112308.
CleanExiHS_C6orf62.
ExpressionAtlasiQ9GZU0. baseline and differential.
GenevisibleiQ9GZU0. HS.

Organism-specific databases

HPAiHPA030564.
HPA030566.

Interactioni

Protein-protein interaction databases

BioGridi123568. 2 interactors.
IntActiQ9GZU0. 1 interactor.
MINTiMINT-4711756.

Structurei

3D structure databases

ProteinModelPortaliQ9GZU0.
SMRiQ9GZU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHYG. Eukaryota.
ENOG410YSA6. LUCA.
GeneTreeiENSGT00390000008115.
HOGENOMiHOG000007668.
HOVERGENiHBG050910.
InParanoidiQ9GZU0.
OMAiTVFKLCS.
OrthoDBiEOG091G0HWA.
PhylomeDBiQ9GZU0.
TreeFamiTF329480.

Family and domain databases

InterProiView protein in InterPro
IPR027903. DUF4566.
PfamiView protein in Pfam
PF15130. DUF4566. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD313493. Uncharacterised_C6orf62. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9GZU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDPNSRKKQ ALNRLRAQLR KKKESLADQF DFKMYIAFVF KEKKKKSALF
60 70 80 90 100
EVSEVIPVMT NNYEENILKG VRDSSYSLES SLELLQKDVV QLHAPRYQSM
110 120 130 140 150
RRDVIGCTQE MDFILWPRND IEKIVCLLFS RWKESDEPFR PVQAKFEFHH
160 170 180 190 200
GDYEKQFLHV LSRKDKTGIV VNNPNQSVFL FIDRQHLQTP KNKATIFKLC
210 220
SICLYLPQEQ LTHWAVGTIE DHLRPYMPE
Length:229
Mass (Da):27,083
Last modified:March 1, 2001 - v1
Checksum:i816716AD3837FAB9
GO
Isoform 2 (identifier: Q9GZU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     30-43: FDFKMYIAFVFKEK → MSENLSDPVSPVVR

Note: No experimental confirmation available.
Show »
Length:200
Mass (Da):23,437
Checksum:i76760950996E8108
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229E → D in CAG33573 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050803116W → C. Corresponds to variant dbSNP:rs34238213Ensembl.1
Natural variantiVAR_050804140R → S. Corresponds to variant dbSNP:rs35050510Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0156161 – 29Missing in isoform 2. CuratedAdd BLAST29
Alternative sequenceiVSP_01561730 – 43FDFKM…VFKEK → MSENLSDPVSPVVR in isoform 2. CuratedAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598792 mRNA. Translation: AAT09203.1.
AL136632 mRNA. Translation: CAB66567.1.
AB075502 mRNA. Translation: BAE45752.1.
AK022681 mRNA. Translation: BAB14175.1.
CR533486 mRNA. Translation: CAG38517.1.
CR457292 mRNA. Translation: CAG33573.1.
AL031775, AL133264 Genomic DNA. Translation: CAI20135.1.
AL031775, AL133264 Genomic DNA. Translation: CAI20136.1.
AL133264, AL031775 Genomic DNA. Translation: CAI20341.1.
AL133264, AL031775 Genomic DNA. Translation: CAI20342.1.
CH471087 Genomic DNA. Translation: EAW55461.1.
BC047866 mRNA. Translation: AAH47866.1.
CCDSiCCDS4559.1. [Q9GZU0-1]
RefSeqiNP_112201.1. NM_030939.4. [Q9GZU0-1]
XP_011513230.1. XM_011514928.2. [Q9GZU0-2]
UniGeneiHs.744857.

Genome annotation databases

EnsembliENST00000378102; ENSP00000367342; ENSG00000112308. [Q9GZU0-2]
ENST00000378119; ENSP00000367359; ENSG00000112308. [Q9GZU0-1]
GeneIDi81688.
KEGGihsa:81688.
UCSCiuc003nel.5. human. [Q9GZU0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCF062_HUMAN
AccessioniPrimary (citable) accession number: Q9GZU0
Secondary accession number(s): Q3LIB6
, Q5JVZ2, Q5JVZ3, Q6IA63, Q9H1Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: March 1, 2001
Last modified: September 27, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations