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Protein

Uncharacterized protein C6orf62

Gene

C6orf62

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C6orf62
Alternative name(s):
HBV X-transactivated gene 12 protein
HBV XAg-transactivated protein 12
Gene namesi
Name:C6orf62
Synonyms:XTP12
ORF Names:Nbla00237
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20998. C6orf62.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134946342.

Polymorphism and mutation databases

BioMutaiC6orf62.
DMDMi30912736.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Uncharacterized protein C6orf62PRO_0000089514Add
BLAST

Proteomic databases

MaxQBiQ9GZU0.
PaxDbiQ9GZU0.
PRIDEiQ9GZU0.

PTM databases

iPTMnetiQ9GZU0.
PhosphoSiteiQ9GZU0.

Expressioni

Gene expression databases

BgeeiQ9GZU0.
CleanExiHS_C6orf62.
ExpressionAtlasiQ9GZU0. baseline and differential.
GenevisibleiQ9GZU0. HS.

Organism-specific databases

HPAiHPA030564.
HPA030566.

Interactioni

Protein-protein interaction databases

BioGridi123568. 2 interactions.
IntActiQ9GZU0. 1 interaction.
MINTiMINT-4711756.

Structurei

3D structure databases

ProteinModelPortaliQ9GZU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHYG. Eukaryota.
ENOG410YSA6. LUCA.
GeneTreeiENSGT00390000008115.
HOGENOMiHOG000007668.
HOVERGENiHBG050910.
InParanoidiQ9GZU0.
OMAiTVFKLCS.
OrthoDBiEOG7Z3F5C.
PhylomeDBiQ9GZU0.
TreeFamiTF329480.

Family and domain databases

InterProiIPR027903. DUF4566.
[Graphical view]
PfamiPF15130. DUF4566. 1 hit.
[Graphical view]
ProDomiPD313493. Uncharacterised_C6orf62. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9GZU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDPNSRKKQ ALNRLRAQLR KKKESLADQF DFKMYIAFVF KEKKKKSALF
60 70 80 90 100
EVSEVIPVMT NNYEENILKG VRDSSYSLES SLELLQKDVV QLHAPRYQSM
110 120 130 140 150
RRDVIGCTQE MDFILWPRND IEKIVCLLFS RWKESDEPFR PVQAKFEFHH
160 170 180 190 200
GDYEKQFLHV LSRKDKTGIV VNNPNQSVFL FIDRQHLQTP KNKATIFKLC
210 220
SICLYLPQEQ LTHWAVGTIE DHLRPYMPE
Length:229
Mass (Da):27,083
Last modified:March 1, 2001 - v1
Checksum:i816716AD3837FAB9
GO
Isoform 2 (identifier: Q9GZU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: Missing.
     30-43: FDFKMYIAFVFKEK → MSENLSDPVSPVVR

Note: No experimental confirmation available.
Show »
Length:200
Mass (Da):23,437
Checksum:i76760950996E8108
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti229 – 2291E → D in CAG33573 (Ref. 5) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti116 – 1161W → C.
Corresponds to variant rs34238213 [ dbSNP | Ensembl ].
VAR_050803
Natural varianti140 – 1401R → S.
Corresponds to variant rs35050510 [ dbSNP | Ensembl ].
VAR_050804

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2929Missing in isoform 2. CuratedVSP_015616Add
BLAST
Alternative sequencei30 – 4314FDFKM…VFKEK → MSENLSDPVSPVVR in isoform 2. CuratedVSP_015617Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598792 mRNA. Translation: AAT09203.1.
AL136632 mRNA. Translation: CAB66567.1.
AB075502 mRNA. Translation: BAE45752.1.
AK022681 mRNA. Translation: BAB14175.1.
CR533486 mRNA. Translation: CAG38517.1.
CR457292 mRNA. Translation: CAG33573.1.
AL031775, AL133264 Genomic DNA. Translation: CAI20135.1.
AL031775, AL133264 Genomic DNA. Translation: CAI20136.1.
AL133264, AL031775 Genomic DNA. Translation: CAI20341.1.
AL133264, AL031775 Genomic DNA. Translation: CAI20342.1.
CH471087 Genomic DNA. Translation: EAW55461.1.
BC047866 mRNA. Translation: AAH47866.1.
CCDSiCCDS4559.1. [Q9GZU0-1]
RefSeqiNP_112201.1. NM_030939.4. [Q9GZU0-1]
XP_011513230.1. XM_011514928.1. [Q9GZU0-2]
UniGeneiHs.744857.

Genome annotation databases

EnsembliENST00000378102; ENSP00000367342; ENSG00000112308. [Q9GZU0-2]
ENST00000378119; ENSP00000367359; ENSG00000112308. [Q9GZU0-1]
GeneIDi81688.
KEGGihsa:81688.
UCSCiuc003nel.5. human. [Q9GZU0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY598792 mRNA. Translation: AAT09203.1.
AL136632 mRNA. Translation: CAB66567.1.
AB075502 mRNA. Translation: BAE45752.1.
AK022681 mRNA. Translation: BAB14175.1.
CR533486 mRNA. Translation: CAG38517.1.
CR457292 mRNA. Translation: CAG33573.1.
AL031775, AL133264 Genomic DNA. Translation: CAI20135.1.
AL031775, AL133264 Genomic DNA. Translation: CAI20136.1.
AL133264, AL031775 Genomic DNA. Translation: CAI20341.1.
AL133264, AL031775 Genomic DNA. Translation: CAI20342.1.
CH471087 Genomic DNA. Translation: EAW55461.1.
BC047866 mRNA. Translation: AAH47866.1.
CCDSiCCDS4559.1. [Q9GZU0-1]
RefSeqiNP_112201.1. NM_030939.4. [Q9GZU0-1]
XP_011513230.1. XM_011514928.1. [Q9GZU0-2]
UniGeneiHs.744857.

3D structure databases

ProteinModelPortaliQ9GZU0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123568. 2 interactions.
IntActiQ9GZU0. 1 interaction.
MINTiMINT-4711756.

PTM databases

iPTMnetiQ9GZU0.
PhosphoSiteiQ9GZU0.

Polymorphism and mutation databases

BioMutaiC6orf62.
DMDMi30912736.

Proteomic databases

MaxQBiQ9GZU0.
PaxDbiQ9GZU0.
PRIDEiQ9GZU0.

Protocols and materials databases

DNASUi81688.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378102; ENSP00000367342; ENSG00000112308. [Q9GZU0-2]
ENST00000378119; ENSP00000367359; ENSG00000112308. [Q9GZU0-1]
GeneIDi81688.
KEGGihsa:81688.
UCSCiuc003nel.5. human. [Q9GZU0-1]

Organism-specific databases

CTDi81688.
GeneCardsiC6orf62.
H-InvDBHIX0200842.
HGNCiHGNC:20998. C6orf62.
HPAiHPA030564.
HPA030566.
neXtProtiNX_Q9GZU0.
PharmGKBiPA134946342.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHYG. Eukaryota.
ENOG410YSA6. LUCA.
GeneTreeiENSGT00390000008115.
HOGENOMiHOG000007668.
HOVERGENiHBG050910.
InParanoidiQ9GZU0.
OMAiTVFKLCS.
OrthoDBiEOG7Z3F5C.
PhylomeDBiQ9GZU0.
TreeFamiTF329480.

Miscellaneous databases

ChiTaRSiC6orf62. human.
GenomeRNAii81688.
PROiQ9GZU0.

Gene expression databases

BgeeiQ9GZU0.
CleanExiHS_C6orf62.
ExpressionAtlasiQ9GZU0. baseline and differential.
GenevisibleiQ9GZU0. HS.

Family and domain databases

InterProiIPR027903. DUF4566.
[Graphical view]
PfamiPF15130. DUF4566. 1 hit.
[Graphical view]
ProDomiPD313493. Uncharacterised_C6orf62. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Screening and cloning of the target genes transactivated by hepatitis B virus X protein by microarray assay."
    Gong M., Cheng J., Ji D., Liu Y., Guo J.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
    Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
    Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Neuroblastoma.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.

Entry informationi

Entry nameiCF062_HUMAN
AccessioniPrimary (citable) accession number: Q9GZU0
Secondary accession number(s): Q3LIB6
, Q5JVZ2, Q5JVZ3, Q6IA63, Q9H1Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.