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Protein

NIF3-like protein 1

Gene

NIF3L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: UniProtKB-EC
  3. identical protein binding Source: UniProtKB
  4. metal ion binding Source: UniProtKB-KW
  5. transcription factor binding Source: BHF-UCL

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. negative regulation of nucleic acid-templated transcription Source: UniProtKB
  3. neuron differentiation Source: UniProtKB
  4. positive regulation of transcription, DNA-templated Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
NIF3-like protein 11 Publication
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 1 protein1 Publication
Gene namesi
Name:NIF3L1Imported
Synonyms:ALS2CR11 Publication
ORF Names:MDS015, My018
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:13390. NIF3L1.

Subcellular locationi

  1. Cytoplasm 2 Publications
  2. Nucleus By similarity

  3. Note: Interaction with COPS2 may regulate localization to the nucleus.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. mitochondrion Source: GO_Central
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31629.

Polymorphism and mutation databases

BioMutaiNIF3L1.
DMDMi160112850.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377NIF3-like protein 1PRO_0000147353Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei109 – 1091N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9GZT8.
PaxDbiQ9GZT8.
PRIDEiQ9GZT8.

PTM databases

PhosphoSiteiQ9GZT8.

Expressioni

Gene expression databases

BgeeiQ9GZT8.
CleanExiHS_NIF3L1.
ExpressionAtlasiQ9GZT8. baseline and differential.
GenevestigatoriQ9GZT8.

Organism-specific databases

HPAiHPA036335.
HPA036336.
HPA061466.

Interactioni

Subunit structurei

Homodimer (PubMed:12951069). Interacts with COPS2 (By similarity). Interacts with THOC7 (PubMed:12951069).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Q856013EBI-740897,EBI-9676175From a different organism.
AP5B1Q2VPB73EBI-740897,EBI-5917279
ARPINQ7Z6K53EBI-740897,EBI-10258086
BEND7Q8N7W23EBI-740897,EBI-743382
CCDC102BA1A4H13EBI-740897,EBI-10171570
CDKN2BP427723EBI-740897,EBI-711280
CDKN2CP427733EBI-740897,EBI-711290
DCDC2Q9UHG03EBI-740897,EBI-10303987
DHPSP493663EBI-740897,EBI-741925
DMC1Q145653EBI-740897,EBI-930865
DUSP23Q9BVJ73EBI-740897,EBI-724940
DYNLT3P518083EBI-740897,EBI-743027
EIF5A2Q9GZV43EBI-740897,EBI-748028
EPHB6O15197-23EBI-740897,EBI-10182490
FAM49BQ9NUQ93EBI-740897,EBI-1055930
FXR2P511163EBI-740897,EBI-740459
GRB2P629933EBI-740897,EBI-401755
LAMTOR3Q9UHA43EBI-740897,EBI-1038192
LMO2P257913EBI-740897,EBI-739696
NATD1Q8N6N63EBI-740897,EBI-8656665
NUDT14O958483EBI-740897,EBI-536866
ORC5LA4D0P73EBI-740897,EBI-10173275
RABAC1Q9UI143EBI-740897,EBI-712367
STK16O757163EBI-740897,EBI-749295
SULT1A2P502263EBI-740897,EBI-6137631
SULT1A3P0DMM93EBI-740897,EBI-10196922
SYT17Q9BSW73EBI-740897,EBI-745392
taxP140793EBI-740897,EBI-9675698From a different organism.
TRIP13Q156453EBI-740897,EBI-358993
YES1P079473EBI-740897,EBI-515331

Protein-protein interaction databases

BioGridi121922. 107 interactions.
IntActiQ9GZT8. 67 interactions.
MINTiMINT-1438019.
STRINGi9606.ENSP00000386394.

Structurei

3D structure databases

ProteinModelPortaliQ9GZT8.
SMRiQ9GZT8. Positions 52-377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni244 – 377134Mediates interaction with COPS2By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I type 2 family.Curated

Phylogenomic databases

eggNOGiCOG0327.
GeneTreeiENSGT00390000003590.
HOGENOMiHOG000014260.
HOVERGENiHBG029337.
InParanoidiQ9GZT8.
OMAiCPHTAVD.
PhylomeDBiQ9GZT8.
TreeFamiTF324125.

Family and domain databases

InterProiIPR002678. GTP_cyclohydrolase_I/Nif3.
IPR017222. GTP_cyclohydrolase_I/NIF3_euk.
[Graphical view]
PANTHERiPTHR13799. PTHR13799. 1 hit.
PfamiPF01784. NIF3. 1 hit.
[Graphical view]
PIRSFiPIRSF037490. UCP037490_NIF3_euk. 1 hit.
SUPFAMiSSF102705. SSF102705. 1 hit.
TIGRFAMsiTIGR00486. YbgI_SA1388. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9GZT8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSSCVRPVP TTVRFVDSLI CNSSRSFMDL KALLSSLNDF ASLSFAESWD
60 70 80 90 100
NVGLLVEPSP PHTVNTLFLT NDLTEEVMEE VLQKKADLIL SYHPPIFRPM
110 120 130 140 150
KRITWNTWKE RLVIRALENR VGIYSPHTAY DAAPQGVNNW LAKGLGACTS
160 170 180 190 200
RPIHPSKAPN YPTEGNHRVE FNVNYTQDLD KVMSAVKGID GVSVTSFSAR
210 220 230 240 250
TGNEEQTRIN LNCTQKALMQ VVDFLSRNKQ LYQKTEILSL EKPLLLHTGM
260 270 280 290 300
GRLCTLDESV SLATMIDRIK RHLKLSHIRL ALGVGRTLES QVKVVALCAG
310 320 330 340 350
SGSSVLQGVE ADLYLTGEMS HHDTLDAASQ GINVILCEHS NTERGFLSDL
360 370
RDMLDSHLEN KINIILSETD RDPLQVV
Length:377
Mass (Da):41,968
Last modified:November 13, 2007 - v2
Checksum:i41BDCADDD81CA0D8
GO
Isoform 2 (identifier: Q9GZT8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Show »
Length:350
Mass (Da):38,984
Checksum:i81F1A5AD35B25ED7
GO
Isoform 3 (identifier: Q9GZT8-3) [UniParc]FASTAAdd to basket

Also known as: beta

The sequence of this isoform differs from the canonical sequence as follows:
     243-377: PLLLHTGMGR...ETDRDPLQVV → SLKSKSWPCV...MILWMLLPKE

Show »
Length:285
Mass (Da):32,164
Checksum:i5084AD8C6E9700EC
GO

Sequence cautioni

The sequence AAG14952.1 differs from that shown. Reason: Frameshift at positions 104 and 109. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti109 – 1091K → E in AAG14952 (Ref. 5) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti324 – 3241T → I.
Corresponds to variant rs7917 [ dbSNP | Ensembl ].
VAR_037084

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2727Missing in isoform 2. 4 PublicationsVSP_029328Add
BLAST
Alternative sequencei243 – 377135PLLLH…PLQVV → SLKSKSWPCVLVLGAAFCRV LRLTFTSQVRCPIMILWMLL PKE in isoform 3. 1 PublicationVSP_043248Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF283538 mRNA. Translation: AAG44846.1.
AB038949 mRNA. Translation: BAB32499.1.
AY251943 mRNA. Translation: AAP84063.1.
AF060513 mRNA. Translation: AAG43131.1.
AF182416 mRNA. Translation: AAG14952.1. Frameshift.
AK023378 mRNA. Translation: BAB14551.1.
AC005037 Genomic DNA. Translation: AAY14724.1.
CH471063 Genomic DNA. Translation: EAW70224.1.
BC007654 mRNA. Translation: AAH07654.1.
CCDSiCCDS42797.1. [Q9GZT8-2]
CCDS46485.1. [Q9GZT8-1]
CCDS46486.1. [Q9GZT8-3]
RefSeqiNP_001129511.1. NM_001136039.2. [Q9GZT8-1]
NP_001135827.1. NM_001142355.1. [Q9GZT8-2]
NP_001135828.1. NM_001142356.1. [Q9GZT8-3]
NP_068596.2. NM_021824.3. [Q9GZT8-2]
XP_005246799.1. XM_005246742.2. [Q9GZT8-1]
UniGeneiHs.145284.

Genome annotation databases

EnsembliENST00000359683; ENSP00000352711; ENSG00000196290. [Q9GZT8-2]
ENST00000409020; ENSP00000386394; ENSG00000196290. [Q9GZT8-1]
ENST00000409357; ENSP00000387315; ENSG00000196290. [Q9GZT8-1]
ENST00000409588; ENSP00000387021; ENSG00000196290. [Q9GZT8-3]
GeneIDi60491.
KEGGihsa:60491.
UCSCiuc002uwl.2. human. [Q9GZT8-1]
uc002uwq.2. human. [Q9GZT8-3]

Polymorphism and mutation databases

BioMutaiNIF3L1.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF283538 mRNA. Translation: AAG44846.1.
AB038949 mRNA. Translation: BAB32499.1.
AY251943 mRNA. Translation: AAP84063.1.
AF060513 mRNA. Translation: AAG43131.1.
AF182416 mRNA. Translation: AAG14952.1. Frameshift.
AK023378 mRNA. Translation: BAB14551.1.
AC005037 Genomic DNA. Translation: AAY14724.1.
CH471063 Genomic DNA. Translation: EAW70224.1.
BC007654 mRNA. Translation: AAH07654.1.
CCDSiCCDS42797.1. [Q9GZT8-2]
CCDS46485.1. [Q9GZT8-1]
CCDS46486.1. [Q9GZT8-3]
RefSeqiNP_001129511.1. NM_001136039.2. [Q9GZT8-1]
NP_001135827.1. NM_001142355.1. [Q9GZT8-2]
NP_001135828.1. NM_001142356.1. [Q9GZT8-3]
NP_068596.2. NM_021824.3. [Q9GZT8-2]
XP_005246799.1. XM_005246742.2. [Q9GZT8-1]
UniGeneiHs.145284.

3D structure databases

ProteinModelPortaliQ9GZT8.
SMRiQ9GZT8. Positions 52-377.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121922. 107 interactions.
IntActiQ9GZT8. 67 interactions.
MINTiMINT-1438019.
STRINGi9606.ENSP00000386394.

PTM databases

PhosphoSiteiQ9GZT8.

Polymorphism and mutation databases

BioMutaiNIF3L1.
DMDMi160112850.

Proteomic databases

MaxQBiQ9GZT8.
PaxDbiQ9GZT8.
PRIDEiQ9GZT8.

Protocols and materials databases

DNASUi60491.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359683; ENSP00000352711; ENSG00000196290. [Q9GZT8-2]
ENST00000409020; ENSP00000386394; ENSG00000196290. [Q9GZT8-1]
ENST00000409357; ENSP00000387315; ENSG00000196290. [Q9GZT8-1]
ENST00000409588; ENSP00000387021; ENSG00000196290. [Q9GZT8-3]
GeneIDi60491.
KEGGihsa:60491.
UCSCiuc002uwl.2. human. [Q9GZT8-1]
uc002uwq.2. human. [Q9GZT8-3]

Organism-specific databases

CTDi60491.
GeneCardsiGC02P201718.
HGNCiHGNC:13390. NIF3L1.
HPAiHPA036335.
HPA036336.
HPA061466.
MIMi605778. gene.
neXtProtiNX_Q9GZT8.
PharmGKBiPA31629.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0327.
GeneTreeiENSGT00390000003590.
HOGENOMiHOG000014260.
HOVERGENiHBG029337.
InParanoidiQ9GZT8.
OMAiCPHTAVD.
PhylomeDBiQ9GZT8.
TreeFamiTF324125.

Miscellaneous databases

GeneWikiiNIF3L1.
GenomeRNAii60491.
NextBioi65383.
PROiQ9GZT8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9GZT8.
CleanExiHS_NIF3L1.
ExpressionAtlasiQ9GZT8. baseline and differential.
GenevestigatoriQ9GZT8.

Family and domain databases

InterProiIPR002678. GTP_cyclohydrolase_I/Nif3.
IPR017222. GTP_cyclohydrolase_I/NIF3_euk.
[Graphical view]
PANTHERiPTHR13799. PTHR13799. 1 hit.
PfamiPF01784. NIF3. 1 hit.
[Graphical view]
PIRSFiPIRSF037490. UCP037490_NIF3_euk. 1 hit.
SUPFAMiSSF102705. SSF102705. 1 hit.
TIGRFAMsiTIGR00486. YbgI_SA1388. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a novel human gene, NIF3L1, and its mouse ortholog, Nif3l1, highly conserved from bacteria to mammals."
    Tascou S., Uedelhoven J., Dixkens C., Nayernia K., Engel W., Burfeind P.
    Cytogenet. Cell Genet. 90:330-336(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION.
  2. "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2."
    Hadano S., Yanagisawa Y., Skaug J., Fichter K., Nasir J., Martindale D., Koop B.F., Scherer S.W., Nicholson D.W., Rouleau G.A., Ikeda J.-E., Hayden M.R.
    Genomics 71:200-213(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "NIF3L1 interacts with WBSCR14."
    Merla G., Reymond A.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  4. Mao Y.M., Xie Y., Huang X.Y., Ying K., Dai J.L.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Fetal brain.
  5. "Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
    Huang C., Qian B., Tu Y., Gu W., Wang Y., Han Z., Chen Z.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Hematopoietic stem cell.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Ovarian carcinoma.
  7. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  10. "Identification and characterization of NIF3L1 BP1, a novel cytoplasmic interaction partner of the NIF3L1 protein."
    Tascou S., Kang T.W., Trappe R., Engel W., Burfeind P.
    Biochem. Biophys. Res. Commun. 309:440-448(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), HOMODIMERIZATION, INTERACTION WITH THOC7, SUBCELLULAR LOCATION.
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-109, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiGTPC1_HUMAN
AccessioniPrimary (citable) accession number: Q9GZT8
Secondary accession number(s): Q53TX4
, Q6X735, Q9H2D2, Q9HC18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: November 13, 2007
Last modified: April 29, 2015
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.