ID WN10A_HUMAN Reviewed; 417 AA. AC Q9GZT5; Q53S44; Q96TA7; Q9H7S8; DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2001, sequence version 1. DT 24-JAN-2024, entry version 181. DE RecName: Full=Protein Wnt-10a; DE Flags: Precursor; GN Name=WNT10A; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y., Kelsell D.P., RA Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A., Culbert A.A., RA Reith A.D., Barnes M.R.; RT "Molecular cloning and characterization of six novel human WNT genes."; RL Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Rump A., Hayes C., Brown S.D.M., Rosenthal A.; RT "Genomic sequence of the Wnt6 gene and the Wnt10a gene from human 2q35."; RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=11350055; DOI=10.1006/bbrc.2001.4855; RA Kirikoshi H., Sekihara H., Katoh M.; RT "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to- RT tail manner, are strongly co-expressed in SW480 cells."; RL Biochem. Biophys. Res. Commun. 283:798-805(2001). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Placenta, and Thymus; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP INVOLVEMENT IN OODD, AND FUNCTION. RX PubMed=17847007; DOI=10.1086/520064; RA Adaimy L., Chouery E., Megarbane H., Mroueh S., Delague V., Nicolas E., RA Belguith H., de Mazancourt P., Megarbane A.; RT "Mutation in WNT10A is associated with an autosomal recessive ectodermal RT dysplasia: the odonto-onycho-dermal dysplasia."; RL Am. J. Hum. Genet. 81:821-828(2007). RN [9] RP INTERACTION WITH AFM, AND SUBCELLULAR LOCATION. RX PubMed=26902720; DOI=10.7554/elife.11621; RA Mihara E., Hirai H., Yamamoto H., Tamura-Kawakami K., Matano M., RA Kikuchi A., Sato T., Takagi J.; RT "Active and water-soluble form of lipidated Wnt protein is maintained by a RT serum glycoprotein afamin/alpha-albumin."; RL Elife 5:0-0(2016). RN [10] RP INVOLVEMENT IN STHAG4, AND VARIANT STHAG4 SER-213. RX PubMed=27657131; DOI=10.3390/genes7090065; RA Zeng B., Xiao X., Li S., Lu H., Lu J., Zhu L., Yu D., Zhao W.; RT "Eight mutations of three genes (EDA, EDAR, and WNT10A) identified in seven RT hypohidrotic ectodermal dysplasia patients."; RL Genes (Basel) 7:0-0(2016). RN [11] RP VARIANTS OODD GLN-128 AND ILE-228, AND INVOLVEMENT IN SSPS. RX PubMed=19559398; DOI=10.1016/j.ajhg.2009.06.001; RA Bohring A., Stamm T., Spaich C., Haase C., Spree K., Hehr U., Hoffmann M., RA Ledig S., Sel S., Wieacker P., Ropke A.; RT "WNT10A mutations are a frequent cause of a broad spectrum of ectodermal RT dysplasias with sex-biased manifestation pattern in heterozygotes."; RL Am. J. Hum. Genet. 85:97-105(2009). RN [12] RP INVOLVEMENT IN STHAG4, VARIANTS STHAG4 TYR-143; MET-145 AND ILE-228, AND RP VARIANT CYS-360. RX PubMed=20979233; DOI=10.1002/humu.21384; RA Cluzeau C., Hadj-Rabia S., Jambou M., Mansour S., Guigue P., Masmoudi S., RA Bal E., Chassaing N., Vincent M.C., Viot G., Clauss F., Maniere M.C., RA Toupenay S., Le Merrer M., Lyonnet S., Cormier-Daire V., Amiel J., RA Faivre L., de Prost Y., Munnich A., Bonnefont J.P., Bodemer C., Smahi A.; RT "Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of RT hypohidrotic/anhidrotic ectodermal dysplasia cases."; RL Hum. Mutat. 32:70-72(2011). RN [13] RP VARIANT OODD VAL-131. RX PubMed=19471313; DOI=10.1038/ejhg.2009.81; RA Nawaz S., Klar J., Wajid M., Aslam M., Tariq M., Schuster J., Baig S.M., RA Dahl N.; RT "WNT10A missense mutation associated with a complete odonto-onycho-dermal RT dysplasia syndrome."; RL Eur. J. Hum. Genet. 17:1600-1605(2009). RN [14] RP VARIANTS STHAG4 ASN-217 AND ILE-228. RX PubMed=21484994; DOI=10.1002/ajmg.a.33840; RA Kantaputra P., Sripathomsawat W.; RT "WNT10A and isolated hypodontia."; RL Am. J. Med. Genet. A 155:1119-1122(2011). RN [15] RP VARIANTS SSPS THR-131 AND CYS-266. RX PubMed=21143469; DOI=10.1111/j.1399-0004.2010.01513.x; RA Castori M., Castiglia D., Brancati F., Foglio M., Heath S., Floriddia G., RA Madonna S., Fischer J., Zambruno G.; RT "Two families confirm Schoepf-Schulz-Passarge syndrome as a discrete entity RT within the WNT10A phenotypic spectrum."; RL Clin. Genet. 79:92-95(2011). RN [16] RP VARIANTS STHAG4 LYS-95; GLN-128; MET-145; TRP-163; CYS-277 AND LYS-306. RX PubMed=22581971; DOI=10.1136/jmedgenet-2012-100750; RA van den Boogaard M.J., Creton M., Bronkhorst Y., van der Hout A., RA Hennekam E., Lindhout D., Cune M., Ploos van Amstel H.K.; RT "Mutations in WNT10A are present in more than half of isolated hypodontia RT cases."; RL J. Med. Genet. 49:327-331(2012). RN [17] RP VARIANTS STHAG4 SER-126; SER-213; SER-266; ILE-357 AND CYS-379, AND RP FUNCTION. RX PubMed=23401279; DOI=10.1002/ajmg.a.35747; RA Plaisancie J., Bailleul-Forestier I., Gaston V., Vaysse F., Lacombe D., RA Holder-Espinasse M., Abramowicz M., Coubes C., Plessis G., Faivre L., RA Demeer B., Vincent-Delorme C., Dollfus H., Sigaudy S., Guillen-Navarro E., RA Verloes A., Jonveaux P., Martin-Coignard D., Colin E., Bieth E., Calvas P., RA Chassaing N.; RT "Mutations in WNT10A are frequently involved in oligodontia associated with RT minor signs of ectodermal dysplasia."; RL Am. J. Med. Genet. A 161A:671-678(2013). RN [18] RP VARIANTS STHAG4 TRP-70; 107-CYS--LYS-417 DEL; CYS-113; SER-213; CYS-223 AND RP ILE-228. RX PubMed=24449199; DOI=10.1002/ajmg.a.36243; RA Arzoo P.S., Klar J., Bergendal B., Norderyd J., Dahl N.; RT "WNT10A mutations account for 1/4 of population-based isolated oligodontia RT and show phenotypic correlations."; RL Am. J. Med. Genet. A 164A:353-359(2014). RN [19] RP VARIANTS STHAG4 CYS-171 AND SER-213. RX PubMed=24311251; DOI=10.1002/ajmg.a.36280; RA Kantaputra P., Kaewgahya M., Kantaputra W.; RT "WNT10A mutations also associated with agenesis of the maxillary permanent RT canines, a separate entity."; RL Am. J. Med. Genet. A 164A:360-363(2014). RN [20] RP VARIANTS OODD SER-213 AND CYS-356. RX PubMed=24458874; DOI=10.1002/ajmg.a.36388; RA Kantaputra P., Kaewgahya M., Jotikasthira D., Kantaputra W.; RT "Tricho-odonto-onycho-dermal dysplasia and WNT10A mutations."; RL Am. J. Med. Genet. A 164A:1041-1048(2014). RN [21] RP VARIANTS STHAG4 SER-213 AND ILE-357, AND FUNCTION. RX PubMed=29178643; DOI=10.1002/mgg3.332; RA Yuan Q., Zhao M., Tandon B., Maili L., Liu X., Zhang A., Baugh E.H., RA Tran T., Silva R.M., Hecht J.T., Swindell E.C., Wagner D.S., Letra A.; RT "Role of WNT10A in failure of tooth development in humans and zebrafish."; RL Mol. Genet. Genomic Med. 5:730-741(2017). RN [22] RP INVOLVEMENT IN OODD, AND FUNCTION. RX PubMed=28589954; DOI=10.1038/ncomms15397; RA Xu M., Horrell J., Snitow M., Cui J., Gochnauer H., Syrett C.M., RA Kallish S., Seykora J.T., Liu F., Gaillard D., Katz J.P., Kaestner K.H., RA Levin B., Mansfield C., Douglas J.E., Cowart B.J., Tordoff M., Liu F., RA Zhu X., Barlow L.A., Rubin A.I., McGrath J.A., Morrisey E.E., Chu E.Y., RA Millar S.E.; RT "WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell RT proliferation and KLF4-mediated differentiation."; RL Nat. Commun. 8:15397-15397(2017). RN [23] RP VARIANT STHAG4 ILE-228. RX PubMed=30046887; DOI=10.1007/s00439-018-1907-y; RA Du R., Dinckan N., Song X., Coban-Akdemir Z., Jhangiani S.N., Guven Y., RA Aktoren O., Kayserili H., Petty L.E., Muzny D.M., Below J.E., RA Boerwinkle E., Wu N., Gibbs R.A., Posey J.E., Lupski J.R., Letra A., RA Uyguner Z.O.; RT "Identification of likely pathogenic and known variants in TSPEAR, LAMB3, RT BCOR, and WNT10A in four Turkish families with tooth agenesis."; RL Hum. Genet. 137:689-703(2018). RN [24] RP VARIANT STHAG4 CYS-293, AND VARIANTS GLY-292; 347-GLU--LYS-417 DEL AND RP CYS-348. RX PubMed=35537890; DOI=10.1016/j.identj.2022.04.006; RA Kantaputra P., Jatooratthawichot P., Tantachamroon O., Nanekrungsan K., RA Intachai W., Olsen B., Tongsima S., Ngamphiw C., Cairns J.R.K.; RT "Novel dental anomaly-associated mutations in WNT10A protein binding RT sites."; RL Int. Dent. J. 0:0-0(2022). CC -!- FUNCTION: Ligand for members of the frizzled family of seven CC transmembrane receptors (Probable). Functions in the canonical CC Wnt/beta-catenin signaling pathway (By similarity). Plays a role in CC normal ectoderm development (PubMed:17847007, PubMed:28589954). CC Required for normal tooth development (PubMed:17847007, CC PubMed:29178643, PubMed:28589954). Required for normal postnatal CC development and maintenance of tongue papillae and sweat ducts CC (PubMed:28589954). Required for normal proliferation of basal cells in CC tongue filiform papillae, plantar epithelium and sweat ducts. Required CC for normal expression of keratins in tongue papillae (By similarity). CC Required for normal expression of KRT9 in foot plant epithelium CC (PubMed:28589954). Required for normal hair follicle function CC (PubMed:28589954). {ECO:0000250|UniProtKB:P70701, CC ECO:0000269|PubMed:17847007, ECO:0000269|PubMed:28589954, CC ECO:0000269|PubMed:29178643, ECO:0000305}. CC -!- SUBUNIT: Forms a soluble 1:1 complex with AFM; this prevents CC oligomerization and is required for prolonged biological activity CC (PubMed:26902720). The complex with AFM may represent the physiological CC form in body fluids (PubMed:26902720). CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular CC matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}. CC -!- PTM: Palmitoleoylation is required for efficient binding to frizzled CC receptors. Depalmitoleoylation leads to Wnt signaling pathway CC inhibition. {ECO:0000250|UniProtKB:P27467, CC ECO:0000250|UniProtKB:P56704}. CC -!- DISEASE: Odonto-onycho-dermal dysplasia (OODD) [MIM:257980]: A rare CC autosomal recessive ectodermal dysplasia characterized by dry hair, CC severe hypodontia, smooth tongue with marked reduction of fungiform and CC filiform papillae, onychodysplasia, keratoderma and hyperhidrosis of CC palms and soles, and hyperkeratosis of the skin. CC {ECO:0000269|PubMed:17847007, ECO:0000269|PubMed:19471313, CC ECO:0000269|PubMed:19559398, ECO:0000269|PubMed:24458874, CC ECO:0000269|PubMed:28589954}. Note=The disease is caused by variants CC affecting the gene represented in this entry. CC -!- DISEASE: Schopf-Schulz-Passarge syndrome (SSPS) [MIM:224750]: A rare CC ectodermal dysplasia, characterized chiefly by cysts of the eyelid CC margins, palmoplantar keratoderma, hypodontia, hypotrichosis and nail CC dystrophy. Multiple eyelid apocrine hidrocystomas are the hallmark of CC this condition, although they usually appear in adulthood. The CC concomitant presence of eccrine syringofibroadenoma in most patients CC and of other adnexal skin tumors in some affected subjects indicates CC that Schopf-Schulz-Passarge syndrome is a genodermatosis with skin CC appendage neoplasms. {ECO:0000269|PubMed:19559398, CC ECO:0000269|PubMed:21143469}. Note=The disease is caused by variants CC affecting the gene represented in this entry. CC -!- DISEASE: Tooth agenesis, selective, 4 (STHAG4) [MIM:150400]: A form of CC selective tooth agenesis, a common anomaly characterized by the CC congenital absence of one or more teeth. Selective tooth agenesis CC without associated systemic disorders has sometimes been divided into 2 CC types: oligodontia, defined as agenesis of 6 or more permanent teeth, CC and hypodontia, defined as agenesis of less than 6 teeth. The number in CC both cases does not include absence of third molars (wisdom teeth). In CC STHAG4, the upper lateral incisors are absent or peg-shaped. Some CC STHAG4 patients manifest mild features of ectodermal dysplasia, CC including sparse hair, sparse eyebrows, short eyelashes, abnormalities CC of the nails, sweating anomalies and dry skin. STHAG4 inheritance is CC autosomal dominant or autosomal recessive. CC {ECO:0000269|PubMed:20979233, ECO:0000269|PubMed:21484994, CC ECO:0000269|PubMed:22581971, ECO:0000269|PubMed:23401279, CC ECO:0000269|PubMed:24311251, ECO:0000269|PubMed:24449199, CC ECO:0000269|PubMed:27657131, ECO:0000269|PubMed:29178643, CC ECO:0000269|PubMed:30046887, ECO:0000269|PubMed:35537890}. Note=The CC disease is caused by variants affecting the gene represented in this CC entry. CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY009400; AAG38660.1; -; mRNA. DR EMBL; AF315943; AAG45153.1; -; Genomic_DNA. DR EMBL; AB059569; BAB55602.1; -; mRNA. DR EMBL; AK024363; BAB14898.1; -; mRNA. DR EMBL; AK315081; BAG37548.1; -; mRNA. DR EMBL; AC073128; AAY24175.1; -; Genomic_DNA. DR EMBL; CH471063; EAW70659.1; -; Genomic_DNA. DR EMBL; BC052234; AAH52234.1; -; mRNA. DR CCDS; CCDS2426.1; -. DR PIR; JC7693; JC7693. DR RefSeq; NP_079492.2; NM_025216.2. DR AlphaFoldDB; Q9GZT5; -. DR SMR; Q9GZT5; -. DR BioGRID; 123238; 42. DR IntAct; Q9GZT5; 2. DR STRING; 9606.ENSP00000258411; -. DR GlyCosmos; Q9GZT5; 3 sites, 1 glycan. DR GlyGen; Q9GZT5; 3 sites, 1 O-linked glycan (1 site). DR iPTMnet; Q9GZT5; -. DR PhosphoSitePlus; Q9GZT5; -. DR BioMuta; WNT10A; -. DR DMDM; 14424011; -. DR MassIVE; Q9GZT5; -. DR PaxDb; 9606-ENSP00000258411; -. DR PeptideAtlas; Q9GZT5; -. DR ProteomicsDB; 80132; -. DR Antibodypedia; 2463; 231 antibodies from 35 providers. DR DNASU; 80326; -. DR Ensembl; ENST00000258411.8; ENSP00000258411.3; ENSG00000135925.9. DR GeneID; 80326; -. DR KEGG; hsa:80326; -. DR MANE-Select; ENST00000258411.8; ENSP00000258411.3; NM_025216.3; NP_079492.2. DR UCSC; uc002vjd.2; human. DR AGR; HGNC:13829; -. DR CTD; 80326; -. DR DisGeNET; 80326; -. DR GeneCards; WNT10A; -. DR GeneReviews; WNT10A; -. DR HGNC; HGNC:13829; WNT10A. DR HPA; ENSG00000135925; Tissue enhanced (esophagus, skin). DR MalaCards; WNT10A; -. DR MIM; 150400; phenotype. DR MIM; 224750; phenotype. DR MIM; 257980; phenotype. DR MIM; 606268; gene. DR neXtProt; NX_Q9GZT5; -. DR OpenTargets; ENSG00000135925; -. DR Orphanet; 248; Autosomal recessive hypohidrotic ectodermal dysplasia. DR Orphanet; 2227; NON RARE IN EUROPE: Hypodontia. DR Orphanet; 2721; Odonto-onycho-dermal dysplasia. DR Orphanet; 99798; Oligodontia. DR Orphanet; 50944; Schoepf-Schulz-Passarge syndrome. DR PharmGKB; PA37817; -. DR VEuPathDB; HostDB:ENSG00000135925; -. DR eggNOG; KOG3913; Eukaryota. DR GeneTree; ENSGT00940000160299; -. DR HOGENOM; CLU_033039_1_3_1; -. DR InParanoid; Q9GZT5; -. DR OMA; DAWEWGG; -. DR OrthoDB; 2874082at2759; -. DR PhylomeDB; Q9GZT5; -. DR TreeFam; TF105310; -. DR PathwayCommons; Q9GZT5; -. DR Reactome; R-HSA-3238698; WNT ligand biogenesis and trafficking. DR Reactome; R-HSA-373080; Class B/2 (Secretin family receptors). DR SignaLink; Q9GZT5; -. DR SIGNOR; Q9GZT5; -. DR BioGRID-ORCS; 80326; 9 hits in 1151 CRISPR screens. DR ChiTaRS; WNT10A; human. DR GeneWiki; WNT10A; -. DR GenomeRNAi; 80326; -. DR Pharos; Q9GZT5; Tbio. DR PRO; PR:Q9GZT5; -. DR Proteomes; UP000005640; Chromosome 2. DR RNAct; Q9GZT5; Protein. DR Bgee; ENSG00000135925; Expressed in primordial germ cell in gonad and 97 other cell types or tissues. DR ExpressionAtlas; Q9GZT5; baseline and differential. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central. DR GO; GO:0005109; F:frizzled binding; IBA:GO_Central. DR GO; GO:0048018; F:receptor ligand activity; IDA:WormBase. DR GO; GO:0060070; P:canonical Wnt signaling pathway; IDA:WormBase. DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central. DR GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:UniProtKB. DR GO; GO:0048730; P:epidermis morphogenesis; IMP:BHF-UCL. DR GO; GO:0001942; P:hair follicle development; IMP:BHF-UCL. DR GO; GO:0031069; P:hair follicle morphogenesis; IMP:BHF-UCL. DR GO; GO:0014033; P:neural crest cell differentiation; IEA:Ensembl. DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central. DR GO; GO:0042476; P:odontogenesis; IMP:BHF-UCL. DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl. DR GO; GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IEA:Ensembl. DR GO; GO:0048733; P:sebaceous gland development; IMP:BHF-UCL. DR GO; GO:0043588; P:skin development; IMP:BHF-UCL. DR GO; GO:0043586; P:tongue development; IMP:BHF-UCL. DR Gene3D; 3.30.2460.20; -; 1. DR InterPro; IPR005817; Wnt. DR InterPro; IPR013302; Wnt10. DR InterPro; IPR043158; Wnt_C. DR InterPro; IPR018161; Wnt_CS. DR PANTHER; PTHR12027:SF89; PROTEIN WNT-10A; 1. DR PANTHER; PTHR12027; WNT RELATED; 1. DR Pfam; PF00110; wnt; 1. DR PRINTS; PR01893; WNT10PROTEIN. DR PRINTS; PR01349; WNTPROTEIN. DR SMART; SM00097; WNT1; 1. DR PROSITE; PS00246; WNT1; 1. DR Genevisible; Q9GZT5; HS. PE 1: Evidence at protein level; KW Developmental protein; Disease variant; Disulfide bond; KW Ectodermal dysplasia; Extracellular matrix; Glycoprotein; Hypotrichosis; KW Lipoprotein; Palmoplantar keratoderma; Phosphoprotein; Reference proteome; KW Secreted; Signal; Wnt signaling pathway. FT SIGNAL 1..35 FT /evidence="ECO:0000255" FT CHAIN 36..417 FT /note="Protein Wnt-10a" FT /id="PRO_0000041460" FT REGION 300..331 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 59 FT /note="Phosphothreonine" FT /evidence="ECO:0000250|UniProtKB:O00744" FT LIPID 268 FT /note="O-palmitoleoyl serine; by PORCN" FT /evidence="ECO:0000250|UniProtKB:P56704" FT CARBOHYD 106 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 363 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 96..107 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 149..157 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 159..214 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 262..276 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 264..271 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 346..377 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 362..372 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 376..416 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 392..407 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 394..404 FT /evidence="ECO:0000250|UniProtKB:P28026" FT DISULFID 399..400 FT /evidence="ECO:0000250|UniProtKB:P28026" FT VARIANT 70 FT /note="R -> W (in STHAG4; uncertain significance; FT dbSNP:rs146460077)" FT /evidence="ECO:0000269|PubMed:24449199" FT /id="VAR_079418" FT VARIANT 95 FT /note="E -> K (in STHAG4; dbSNP:rs318240759)" FT /evidence="ECO:0000269|PubMed:22581971" FT /id="VAR_069171" FT VARIANT 107..417 FT /note="Missing (in STHAG4)" FT /evidence="ECO:0000269|PubMed:24449199" FT /id="VAR_079419" FT VARIANT 113 FT /note="R -> C (in STHAG4; uncertain significance; FT dbSNP:rs141074983)" FT /evidence="ECO:0000269|PubMed:24449199" FT /id="VAR_079420" FT VARIANT 126 FT /note="G -> S (in STHAG4; uncertain significance; FT dbSNP:rs1245189224)" FT /evidence="ECO:0000269|PubMed:23401279" FT /id="VAR_077446" FT VARIANT 128 FT /note="R -> Q (in OODD and STHAG4; dbSNP:rs121908121)" FT /evidence="ECO:0000269|PubMed:19559398, FT ECO:0000269|PubMed:22581971" FT /id="VAR_062510" FT VARIANT 131 FT /note="A -> T (in SSPS; dbSNP:rs372993798)" FT /evidence="ECO:0000269|PubMed:21143469" FT /id="VAR_077447" FT VARIANT 131 FT /note="A -> V (in OODD)" FT /evidence="ECO:0000269|PubMed:19471313" FT /id="VAR_077448" FT VARIANT 143 FT /note="H -> Y (in STHAG4; uncertain significance; FT dbSNP:rs202024965)" FT /evidence="ECO:0000269|PubMed:20979233" FT /id="VAR_064837" FT VARIANT 145 FT /note="V -> M (in STHAG4; uncertain significance; FT dbSNP:rs543063101)" FT /evidence="ECO:0000269|PubMed:20979233, FT ECO:0000269|PubMed:22581971" FT /id="VAR_064838" FT VARIANT 163 FT /note="R -> W (in STHAG4; uncertain significance; FT dbSNP:rs368280129)" FT /evidence="ECO:0000269|PubMed:22581971" FT /id="VAR_069172" FT VARIANT 171 FT /note="R -> C (in STHAG4; uncertain significance; FT dbSNP:rs116998555)" FT /evidence="ECO:0000269|PubMed:24311251" FT /id="VAR_077449" FT VARIANT 213 FT /note="G -> S (in STHAG4 and OODD; uncertain significance; FT dbSNP:rs147680216)" FT /evidence="ECO:0000269|PubMed:23401279, FT ECO:0000269|PubMed:24311251, ECO:0000269|PubMed:24449199, FT ECO:0000269|PubMed:24458874, ECO:0000269|PubMed:27657131, FT ECO:0000269|PubMed:29178643" FT /id="VAR_077450" FT VARIANT 217 FT /note="D -> N (in STHAG4; uncertain significance; FT dbSNP:rs146902156)" FT /evidence="ECO:0000269|PubMed:21484994" FT /id="VAR_069173" FT VARIANT 223 FT /note="R -> C (in STHAG4; uncertain significance; FT dbSNP:rs149245953)" FT /evidence="ECO:0000269|PubMed:24449199" FT /id="VAR_079421" FT VARIANT 228 FT /note="F -> I (in OODD and STHAG4; also found in patients FT with an unclassified form of ectodermal dysplasia; FT dbSNP:rs121908120)" FT /evidence="ECO:0000269|PubMed:19559398, FT ECO:0000269|PubMed:20979233, ECO:0000269|PubMed:21484994, FT ECO:0000269|PubMed:24449199, ECO:0000269|PubMed:30046887" FT /id="VAR_062511" FT VARIANT 266 FT /note="G -> C (in SSPS)" FT /evidence="ECO:0000269|PubMed:21143469" FT /id="VAR_077451" FT VARIANT 266 FT /note="G -> S (in STHAG4; uncertain significance; FT dbSNP:rs778752861)" FT /evidence="ECO:0000269|PubMed:23401279" FT /id="VAR_077452" FT VARIANT 277 FT /note="W -> C (in STHAG4; dbSNP:rs1234227647)" FT /evidence="ECO:0000269|PubMed:22581971" FT /id="VAR_069174" FT VARIANT 292 FT /note="S -> G (found in a patient with dental anomalies; FT uncertain significance; dbSNP:rs767665930)" FT /evidence="ECO:0000269|PubMed:35537890" FT /id="VAR_086718" FT VARIANT 293 FT /note="R -> C (in STHAG4; uncertain significance; FT dbSNP:rs563548971)" FT /evidence="ECO:0000269|PubMed:35537890" FT /id="VAR_086719" FT VARIANT 302 FT /note="P -> T (in dbSNP:rs1057306)" FT /id="VAR_013239" FT VARIANT 306 FT /note="N -> K (in STHAG4; uncertain significance; FT dbSNP:rs745513263)" FT /evidence="ECO:0000269|PubMed:22581971" FT /id="VAR_069175" FT VARIANT 347..417 FT /note="Missing (found in patients with dental anomalies; FT uncertain significance)" FT /evidence="ECO:0000269|PubMed:35537890" FT /id="VAR_086720" FT VARIANT 348 FT /note="R -> C (found in a patient with dental anomalies; FT uncertain significance; dbSNP:rs978088338)" FT /evidence="ECO:0000269|PubMed:35537890" FT /id="VAR_086721" FT VARIANT 356 FT /note="G -> C (in OODD; uncertain significance)" FT /evidence="ECO:0000269|PubMed:24458874" FT /id="VAR_077453" FT VARIANT 357 FT /note="T -> I (in STHAG4; uncertain significance; FT dbSNP:rs750190755)" FT /evidence="ECO:0000269|PubMed:23401279, FT ECO:0000269|PubMed:29178643" FT /id="VAR_077454" FT VARIANT 360 FT /note="R -> C (found in patients with an unclassified form FT of ectodermal dysplasia; likely pathogenic)" FT /evidence="ECO:0000269|PubMed:20979233" FT /id="VAR_064839" FT VARIANT 379 FT /note="R -> C (in STHAG4; uncertain significance; FT dbSNP:rs1347556761)" FT /evidence="ECO:0000269|PubMed:23401279" FT /id="VAR_077455" FT CONFLICT 52 FT /note="E -> G (in Ref. 3; BAB55602 and 4; BAB14898)" FT /evidence="ECO:0000305" SQ SEQUENCE 417 AA; 46444 MW; 868DF5146A895319 CRC64; MGSAHPRPWL RLRPQPQPRP ALWVLLFFLL LLAAAMPRSA PNDILDLRLP PEPVLNANTV CLTLPGLSRR QMEVCVRHPD VAASAIQGIQ IAIHECQHQF RDQRWNCSSL ETRNKIPYES PIFSRGFRES AFAYAIAAAG VVHAVSNACA LGKLKACGCD ASRRGDEEAF RRKLHRLQLD ALQRGKGLSH GVPEHPALPT ASPGLQDSWE WGGCSPDMGF GERFSKDFLD SREPHRDIHA RMRLHNNRVG RQAVMENMRR KCKCHGTSGS CQLKTCWQVT PEFRTVGALL RSRFHRATLI RPHNRNGGQL EPGPAGAPSP APGAPGPRRR ASPADLVYFE KSPDFCEREP RLDSAGTVGR LCNKSSAGSD GCGSMCCGRG HNILRQTRSE RCHCRFHWCC FVVCEECRIT EWVSVCK //