Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9GZT5

- WN10A_HUMAN

UniProt

Q9GZT5 - WN10A_HUMAN

Protein

Protein Wnt-10a

Gene

WNT10A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome

    GO - Biological processi

    1. cell fate commitment Source: RefGenome
    2. cellular response to transforming growth factor beta stimulus Source: UniProtKB
    3. epidermis morphogenesis Source: BHF-UCL
    4. hair follicle development Source: BHF-UCL
    5. hair follicle morphogenesis Source: BHF-UCL
    6. neural crest cell differentiation Source: Ensembl
    7. neuron differentiation Source: RefGenome
    8. odontogenesis Source: BHF-UCL
    9. positive regulation of gene expression Source: Ensembl
    10. regulation of odontogenesis of dentin-containing tooth Source: Ensembl
    11. sebaceous gland development Source: BHF-UCL
    12. skin development Source: BHF-UCL
    13. tongue development Source: BHF-UCL
    14. Wnt signaling pathway Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-10a
    Gene namesi
    Name:WNT10A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:13829. WNT10A.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: RefGenome
    3. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Defects in WNT10A may be a cause of hypohidrotic/anhidrotic ectodermal dysplasia, a disorder characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. Most patients carrying WNT10A mutations present with sweating anomalies. However, comparison with cases harboring mutations in the ectodysplasin pathway identifies some phenotypic differences. Dermatological features (anomalies of hair and sweat glands) are less severe in patients carrying WNT10A mutations and facial dysmorphism can be absent. The dental phenotype consists in microdontia, whereas teeth agenesis is more frequent in patients carrying mutations in the ectodysplasin pathway.
    Odonto-onycho-dermal dysplasia (OODD) [MIM:257980]: A rare autosomal recessive ectodermal dysplasia characterized by dry hair, severe hypodontia, smooth tongue with marked reduction of fungiform and filiform papillae, onychodysplasia, keratoderma and hyperhidrosis of palms and soles, and hyperkeratosis of the skin.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti128 – 1281R → Q in OODD and STHAG4. 2 Publications
    Corresponds to variant rs121908121 [ dbSNP | Ensembl ].
    VAR_062510
    Natural varianti228 – 2281F → I in OODD and STHAG4; also found in a patient with hypohidrotic/anhidrotic ectodermal dysplasia. 3 Publications
    Corresponds to variant rs121908120 [ dbSNP | Ensembl ].
    VAR_062511
    Schopf-Schulz-Passarge syndrome (SSPS) [MIM:224750]: A rare ectodermal dysplasia, characterized chiefly by cysts of the eyelid margins, palmoplantar keratoderma, hypodontia, hypotrichosis and nail dystrophy. Multiple eyelid apocrine hidrocystomas are the hallmark of this condition, although they usually appear in adulthood. The concomitant presence of eccrine syringofibroadenoma in most patients and of other adnexal skin tumors in some affected subjects indicates that Schopf-Schulz-Passarge syndrome is a genodermatosis with skin appendage neoplasms.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Tooth agenesis selective 4 (STHAG4) [MIM:150400]: A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). In STHAG4, the upper lateral incisors are absent or peg-shaped.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti95 – 951E → K in STHAG4. 1 Publication
    Corresponds to variant rs318240759 [ dbSNP | Ensembl ].
    VAR_069171
    Natural varianti128 – 1281R → Q in OODD and STHAG4. 2 Publications
    Corresponds to variant rs121908121 [ dbSNP | Ensembl ].
    VAR_062510
    Natural varianti217 – 2171D → N in STHAG4. 1 Publication
    Corresponds to variant rs146902156 [ dbSNP | Ensembl ].
    VAR_069173
    Natural varianti228 – 2281F → I in OODD and STHAG4; also found in a patient with hypohidrotic/anhidrotic ectodermal dysplasia. 3 Publications
    Corresponds to variant rs121908120 [ dbSNP | Ensembl ].
    VAR_062511

    Keywords - Diseasei

    Disease mutation, Ectodermal dysplasia, Hypotrichosis, Palmoplantar keratoderma

    Organism-specific databases

    MIMi150400. phenotype.
    224750. phenotype.
    257980. phenotype.
    Orphaneti248. Autosomal recessive hypohidrotic ectodermal dysplasia.
    2227. Hypodontia.
    2721. Odonto-onycho-dermal dysplasia.
    99798. Oligodontia.
    50944. Schopf-Schulz-Passarge syndrome.
    PharmGKBiPA37817.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 417382Protein Wnt-10aPRO_0000041460Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi96 ↔ 107By similarity
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi149 ↔ 157By similarity
    Disulfide bondi159 ↔ 214By similarity
    Disulfide bondi262 ↔ 276By similarity
    Disulfide bondi264 ↔ 271By similarity
    Disulfide bondi362 ↔ 377By similarity
    Glycosylationi363 – 3631N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi392 ↔ 407By similarity
    Disulfide bondi394 ↔ 404By similarity
    Disulfide bondi399 ↔ 400By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9GZT5.
    PRIDEiQ9GZT5.

    PTM databases

    PhosphoSiteiQ9GZT5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9GZT5.
    BgeeiQ9GZT5.
    CleanExiHS_WNT10A.
    GenevestigatoriQ9GZT5.

    Organism-specific databases

    HPAiHPA013898.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9GZT5. 1 interaction.
    STRINGi9606.ENSP00000258411.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GZT5.
    SMRiQ9GZT5. Positions 82-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG240772.
    HOGENOMiHOG000039528.
    HOVERGENiHBG001595.
    InParanoidiQ9GZT5.
    KOiK01357.
    OMAiVPRSAPN.
    OrthoDBiEOG7C8GJ8.
    PhylomeDBiQ9GZT5.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR013302. Wnt10.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01893. WNT10PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9GZT5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSAHPRPWL RLRPQPQPRP ALWVLLFFLL LLAAAMPRSA PNDILDLRLP    50
    PEPVLNANTV CLTLPGLSRR QMEVCVRHPD VAASAIQGIQ IAIHECQHQF 100
    RDQRWNCSSL ETRNKIPYES PIFSRGFRES AFAYAIAAAG VVHAVSNACA 150
    LGKLKACGCD ASRRGDEEAF RRKLHRLQLD ALQRGKGLSH GVPEHPALPT 200
    ASPGLQDSWE WGGCSPDMGF GERFSKDFLD SREPHRDIHA RMRLHNNRVG 250
    RQAVMENMRR KCKCHGTSGS CQLKTCWQVT PEFRTVGALL RSRFHRATLI 300
    RPHNRNGGQL EPGPAGAPSP APGAPGPRRR ASPADLVYFE KSPDFCEREP 350
    RLDSAGTVGR LCNKSSAGSD GCGSMCCGRG HNILRQTRSE RCHCRFHWCC 400
    FVVCEECRIT EWVSVCK 417
    Length:417
    Mass (Da):46,444
    Last modified:March 1, 2001 - v1
    Checksum:i868DF5146A895319
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti52 – 521E → G in BAB55602. (PubMed:11350055)Curated
    Sequence conflicti52 – 521E → G in BAB14898. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti95 – 951E → K in STHAG4. 1 Publication
    Corresponds to variant rs318240759 [ dbSNP | Ensembl ].
    VAR_069171
    Natural varianti128 – 1281R → Q in OODD and STHAG4. 2 Publications
    Corresponds to variant rs121908121 [ dbSNP | Ensembl ].
    VAR_062510
    Natural varianti143 – 1431H → Y Probable disease-associated mutation found in a patient with hypohidrotic/anhidrotic ectodermal dysplasia. 1 Publication
    VAR_064837
    Natural varianti145 – 1451V → M Probable disease-associated mutation found in a patient with hypohidrotic/anhidrotic ectodermal dysplasia. 2 Publications
    VAR_064838
    Natural varianti163 – 1631R → W Found in a patient with hypohidrotic/anhidrotic ectodermal dysplasia. 1 Publication
    VAR_069172
    Natural varianti217 – 2171D → N in STHAG4. 1 Publication
    Corresponds to variant rs146902156 [ dbSNP | Ensembl ].
    VAR_069173
    Natural varianti228 – 2281F → I in OODD and STHAG4; also found in a patient with hypohidrotic/anhidrotic ectodermal dysplasia. 3 Publications
    Corresponds to variant rs121908120 [ dbSNP | Ensembl ].
    VAR_062511
    Natural varianti277 – 2771W → C Found in a patient with hypohidrotic/anhidrotic ectodermal dysplasia. 1 Publication
    VAR_069174
    Natural varianti302 – 3021P → T.
    Corresponds to variant rs1057306 [ dbSNP | Ensembl ].
    VAR_013239
    Natural varianti306 – 3061N → K Found in a patient with hypohidrotic/anhidrotic ectodermal dysplasia. 1 Publication
    VAR_069175
    Natural varianti360 – 3601R → C Probable disease-associated mutation found in a patient with an unclassified form of ectodermal dysplasia. 1 Publication
    VAR_064839

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY009400 mRNA. Translation: AAG38660.1.
    AF315943 Genomic DNA. Translation: AAG45153.1.
    AB059569 mRNA. Translation: BAB55602.1.
    AK024363 mRNA. Translation: BAB14898.1.
    AK315081 mRNA. Translation: BAG37548.1.
    AC073128 Genomic DNA. Translation: AAY24175.1.
    CH471063 Genomic DNA. Translation: EAW70659.1.
    BC052234 mRNA. Translation: AAH52234.1.
    CCDSiCCDS2426.1.
    PIRiJC7693.
    RefSeqiNP_079492.2. NM_025216.2.
    UniGeneiHs.121540.

    Genome annotation databases

    EnsembliENST00000258411; ENSP00000258411; ENSG00000135925.
    GeneIDi80326.
    KEGGihsa:80326.
    UCSCiuc002vjd.1. human.

    Polymorphism databases

    DMDMi14424011.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY009400 mRNA. Translation: AAG38660.1 .
    AF315943 Genomic DNA. Translation: AAG45153.1 .
    AB059569 mRNA. Translation: BAB55602.1 .
    AK024363 mRNA. Translation: BAB14898.1 .
    AK315081 mRNA. Translation: BAG37548.1 .
    AC073128 Genomic DNA. Translation: AAY24175.1 .
    CH471063 Genomic DNA. Translation: EAW70659.1 .
    BC052234 mRNA. Translation: AAH52234.1 .
    CCDSi CCDS2426.1.
    PIRi JC7693.
    RefSeqi NP_079492.2. NM_025216.2.
    UniGenei Hs.121540.

    3D structure databases

    ProteinModelPortali Q9GZT5.
    SMRi Q9GZT5. Positions 82-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9GZT5. 1 interaction.
    STRINGi 9606.ENSP00000258411.

    PTM databases

    PhosphoSitei Q9GZT5.

    Polymorphism databases

    DMDMi 14424011.

    Proteomic databases

    PaxDbi Q9GZT5.
    PRIDEi Q9GZT5.

    Protocols and materials databases

    DNASUi 80326.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258411 ; ENSP00000258411 ; ENSG00000135925 .
    GeneIDi 80326.
    KEGGi hsa:80326.
    UCSCi uc002vjd.1. human.

    Organism-specific databases

    CTDi 80326.
    GeneCardsi GC02P219745.
    HGNCi HGNC:13829. WNT10A.
    HPAi HPA013898.
    MIMi 150400. phenotype.
    224750. phenotype.
    257980. phenotype.
    606268. gene.
    neXtProti NX_Q9GZT5.
    Orphaneti 248. Autosomal recessive hypohidrotic ectodermal dysplasia.
    2227. Hypodontia.
    2721. Odonto-onycho-dermal dysplasia.
    99798. Oligodontia.
    50944. Schopf-Schulz-Passarge syndrome.
    PharmGKBi PA37817.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG240772.
    HOGENOMi HOG000039528.
    HOVERGENi HBG001595.
    InParanoidi Q9GZT5.
    KOi K01357.
    OMAi VPRSAPN.
    OrthoDBi EOG7C8GJ8.
    PhylomeDBi Q9GZT5.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).

    Miscellaneous databases

    GeneWikii WNT10A.
    GenomeRNAii 80326.
    NextBioi 70863.
    PROi Q9GZT5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9GZT5.
    Bgeei Q9GZT5.
    CleanExi HS_WNT10A.
    Genevestigatori Q9GZT5.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR013302. Wnt10.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01893. WNT10PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of six novel human WNT genes."
      Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y., Kelsell D.P., Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A., Culbert A.A., Reith A.D., Barnes M.R.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genomic sequence of the Wnt6 gene and the Wnt10a gene from human 2q35."
      Rump A., Hayes C., Brown S.D.M., Rosenthal A.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly co-expressed in SW480 cells."
      Kirikoshi H., Sekihara H., Katoh M.
      Biochem. Biophys. Res. Commun. 283:798-805(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta and Thymus.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    8. "Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia."
      Adaimy L., Chouery E., Megarbane H., Mroueh S., Delague V., Nicolas E., Belguith H., de Mazancourt P., Megarbane A.
      Am. J. Hum. Genet. 81:821-828(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN OODD.
    9. "WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes."
      Bohring A., Stamm T., Spaich C., Haase C., Spree K., Hehr U., Hoffmann M., Ledig S., Sel S., Wieacker P., Ropke A.
      Am. J. Hum. Genet. 85:97-105(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS OODD GLN-128 AND ILE-228, INVOLVEMENT IN SSPS.
    10. Cited for: INVOLVEMENT IN HYPOHIDROTIC/ANHIDROTIC ECTODERMAL DYSPLASIA, VARIANTS TYR-143; MET-145; ILE-228 AND CYS-360.
    11. Cited for: VARIANTS STHAG4 ASN-217 AND ILE-228.
    12. Cited for: VARIANTS STHAG4 LYS-95 AND GLN-128, VARIANTS MET-145; TRP-163; CYS-277 AND LYS-306.

    Entry informationi

    Entry nameiWN10A_HUMAN
    AccessioniPrimary (citable) accession number: Q9GZT5
    Secondary accession number(s): Q53S44, Q96TA7, Q9H7S8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3