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Protein

SRA stem-loop-interacting RNA-binding protein, mitochondrial

Gene

SLIRP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation.1 Publication

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRepressor, RNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SRA stem-loop-interacting RNA-binding protein, mitochondrial
Gene namesi
Name:SLIRP
Synonyms:C14orf156
ORF Names:DC23, DC50, PD04872
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20495. SLIRP.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi7R → A: Impairs corepressor activity; when associated with 13-A-A-14. 1 Publication1
Mutagenesisi13 – 14RR → AA: Impairs corepressor activity; when associated with A-7. 1 Publication2
Mutagenesisi24 – 25RR → AA: Impairs SRA-mediated repression; when associated with A-62. 1 Publication2
Mutagenesisi62L → A: Impairs SRA-mediated repression; when associated with 24-A-A-25. 1 Publication1

Organism-specific databases

DisGeNETi81892.
OpenTargetsiENSG00000119705.
PharmGKBiPA134892132.

Polymorphism and mutation databases

BioMutaiSLIRP.
DMDMi74762723.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000247051? – 109SRA stem-loop-interacting RNA-binding protein, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineCombined sources1
Modified residuei101PhosphothreonineCombined sources1
Modified residuei102PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9GZT3.
MaxQBiQ9GZT3.
PaxDbiQ9GZT3.
PeptideAtlasiQ9GZT3.
PRIDEiQ9GZT3.
TopDownProteomicsiQ9GZT3-1. [Q9GZT3-1]

PTM databases

iPTMnetiQ9GZT3.
PhosphoSitePlusiQ9GZT3.
SwissPalmiQ9GZT3.

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest level in heart, liver, skeletal muscle and testis.1 Publication

Gene expression databases

BgeeiENSG00000119705.
CleanExiHS_C14orf156.
ExpressionAtlasiQ9GZT3. baseline and differential.
GenevisibleiQ9GZT3. HS.

Organism-specific databases

HPAiHPA020291.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123624. 44 interactors.
IntActiQ9GZT3. 26 interactors.
STRINGi9606.ENSP00000450909.

Structurei

3D structure databases

ProteinModelPortaliQ9GZT3.
SMRiQ9GZT3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 103RRMPROSITE-ProRule annotationAdd BLAST85

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00390000008624.
HOGENOMiHOG000276232.
HOVERGENiHBG079935.
InParanoidiQ9GZT3.
PhylomeDBiQ9GZT3.
TreeFamiTF319527.

Family and domain databases

CDDicd12242. RRM_SLIRP. 1 hit.
InterProiView protein in InterPro
IPR000504. RRM_dom.
IPR034152. SLIRP_RRM.
PfamiView protein in Pfam
PF00076. RRM_1. 1 hit.
SMARTiView protein in SMART
SM00360. RRM. 1 hit.
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS50102. RRM. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9GZT3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASAARGAA ALRRSINQPV AFVRRIPWTA ASSQLKEHFA QFGHVRRCIL
60 70 80 90 100
PFDKETGFHR GLGWVQFSSE EGLRNALQQE NHIIDGVKVQ VHTRRPKLPQ

TSDDEKKDF
Length:109
Mass (Da):12,349
Last modified:March 1, 2001 - v1
Checksum:i8BDCB6EA244F17B8
GO
Isoform 2 (identifier: Q9GZT3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-90: Missing.

Note: No experimental confirmation available.
Show »
Length:107
Mass (Da):12,122
Checksum:iFAD9DF3AF5282FBD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44H → R in BU535760 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04735089 – 90Missing in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY860853 mRNA. Translation: AAX58600.1.
AJ272055 mRNA. Translation: CAC81241.1.
AF253980 mRNA. Translation: AAG44629.1.
AF271779 mRNA. Translation: AAG44790.1.
BC017895 mRNA. Translation: AAH17895.1.
BU535760 mRNA. No translation available.
CCDSiCCDS58331.1. [Q9GZT3-2]
CCDS9866.1. [Q9GZT3-1]
RefSeqiNP_001254792.1. NM_001267863.1. [Q9GZT3-2]
NP_001254793.1. NM_001267864.1.
NP_112487.1. NM_031210.5. [Q9GZT3-1]
UniGeneiHs.655105.

Genome annotation databases

EnsembliENST00000238688; ENSP00000238688; ENSG00000119705. [Q9GZT3-2]
ENST00000557342; ENSP00000450909; ENSG00000119705. [Q9GZT3-1]
GeneIDi81892.
KEGGihsa:81892.
UCSCiuc001xue.7. human. [Q9GZT3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSLIRP_HUMAN
AccessioniPrimary (citable) accession number: Q9GZT3
Secondary accession number(s): J3KMY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2001
Last modified: June 7, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot