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Protein

ATP-dependent RNA helicase DDX24

Gene

DDX24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

ATP-dependent RNA helicase.Curated

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi237 – 244ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: GO_Central
  • poly(A) RNA binding Source: UniProtKB
  • RNA helicase activity Source: UniProtKB

GO - Biological processi

  • RNA metabolic process Source: UniProtKB
  • RNA secondary structure unwinding Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089737-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DDX24 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 24
Gene namesi
Name:DDX24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:13266. DDX24.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
  • nucleolus Source: LIFEdb
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000089737.
ENSG00000273761.
PharmGKBiPA27211.

Polymorphism and mutation databases

BioMutaiDDX24.
DMDMi18202929.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550291 – 859ATP-dependent RNA helicase DDX24Add BLAST859

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17N6-acetyllysineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei71N6-acetyllysineCombined sources1
Modified residuei82PhosphoserineCombined sources1
Modified residuei94PhosphoserineCombined sources1
Modified residuei287PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Modified residuei302PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9GZR7.
MaxQBiQ9GZR7.
PaxDbiQ9GZR7.
PeptideAtlasiQ9GZR7.
PRIDEiQ9GZR7.

2D gel databases

SWISS-2DPAGEQ9GZR7.

PTM databases

iPTMnetiQ9GZR7.
PhosphoSitePlusiQ9GZR7.

Expressioni

Tissue specificityi

Ubiquitous. Most abundant in heart and brain, but with lowest levels in thymus and small intestine.

Gene expression databases

BgeeiENSG00000089737.
CleanExiHS_DDX24.
ExpressionAtlasiQ9GZR7. baseline and differential.
GenevisibleiQ9GZR7. HS.

Organism-specific databases

HPAiHPA002554.
HPA061434.

Interactioni

Protein-protein interaction databases

BioGridi121353. 150 interactors.
DIPiDIP-47301N.
IntActiQ9GZR7. 48 interactors.
MINTiMINT-1378437.
STRINGi9606.ENSP00000328690.

Structurei

3D structure databases

ProteinModelPortaliQ9GZR7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini224 – 528Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST305
Domaini578 – 723Helicase C-terminalPROSITE-ProRule annotationAdd BLAST146

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi192 – 220Q motifAdd BLAST29
Motifi471 – 474DEAD box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi83 – 89Poly-Glu7
Compositional biasi153 – 161Poly-Lys9
Compositional biasi835 – 845Poly-LysAdd BLAST11

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0347. Eukaryota.
ENOG410XS03. LUCA.
GeneTreeiENSGT00550000074847.
HOGENOMiHOG000290702.
HOVERGENiHBG104200.
InParanoidiQ9GZR7.
KOiK14805.
OMAiVPKQNEN.
OrthoDBiEOG091G078Q.
PhylomeDBiQ9GZR7.
TreeFamiTF105837.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9GZR7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLKDTKSRP KQSSCGKFQT KGIKVVGKWK EVKIDPNMFA DGQMDDLVCF
60 70 80 90 100
EELTDYQLVS PAKNPSSLFS KEAPKRKAQA VSEEEEEEEG KSSSPKKKIK
110 120 130 140 150
LKKSKNVATE GTSTQKEFEV KDPELEAQGD DMVCDDPEAG EMTSENLVQT
160 170 180 190 200
APKKKKNKGK KGLEPSQSTA AKVPKKAKTW IPEVHDQKAD VSAWKDLFVP
210 220 230 240 250
RPVLRALSFL GFSAPTPIQA LTLAPAIRDK LDILGAAETG SGKTLAFAIP
260 270 280 290 300
MIHAVLQWQK RNAAPPPSNT EAPPGETRTE AGAETRSPGK AEAESDALPD
310 320 330 340 350
DTVIESEALP SDIAAEARAK TGGTVSDQAL LFGDDDAGEG PSSLIREKPV
360 370 380 390 400
PKQNENEEEN LDKEQTGNLK QELDDKSATC KAYPKRPLLG LVLTPTRELA
410 420 430 440 450
VQVKQHIDAV ARFTGIKTAI LVGGMSTQKQ QRMLNRRPEI VVATPGRLWE
460 470 480 490 500
LIKEKHYHLR NLRQLRCLVV DEADRMVEKG HFAELSQLLE MLNDSQYNPK
510 520 530 540 550
RQTLVFSATL TLVHQAPARI LHKKHTKKMD KTAKLDLLMQ KIGMRGKPKV
560 570 580 590 600
IDLTRNEATV ETLTETKIHC ETDEKDFYLY YFLMQYPGRS LVFANSISCI
610 620 630 640 650
KRLSGLLKVL DIMPLTLHAC MHQKQRLRNL EQFARLEDCV LLATDVAARG
660 670 680 690 700
LDIPKVQHVI HYQVPRTSEI YVHRSGRTAR ATNEGLSLML IGPEDVINFK
710 720 730 740 750
KIYKTLKKDE DIPLFPVQTK YMDVVKERIR LARQIEKSEY RNFQACLHNS
760 770 780 790 800
WIEQAAAALE IELEEDMYKG GKADQQEERR RQKQMKVLKK ELRHLLSQPL
810 820 830 840 850
FTESQKTKYP TQSGKPPLLV SAPSKSESAL SCLSKQKKKK TKKPKEPQPE

QPQPSTSAN
Length:859
Mass (Da):96,332
Last modified:March 1, 2001 - v1
Checksum:iB01B1170B2CFA0F7
GO
Isoform 2 (identifier: Q9GZR7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-225: Missing.

Note: No experimental confirmation available.
Show »
Length:804
Mass (Da):90,298
Checksum:iD8956E22F02B6589
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052162316E → K.Corresponds to variant rs35413935dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053881171 – 225Missing in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214731 mRNA. Translation: AAG02169.1.
AL136886 mRNA. Translation: CAB66820.1.
AK025162 mRNA. Translation: BAB15079.1.
BC008847 mRNA. Translation: AAH08847.1.
BC009406 mRNA. Translation: AAH09406.1.
BC096826 mRNA. Translation: AAH96826.1.
CCDSiCCDS9918.1. [Q9GZR7-1]
RefSeqiNP_065147.1. NM_020414.3. [Q9GZR7-1]
UniGeneiHs.510328.

Genome annotation databases

EnsembliENST00000330836; ENSP00000328690; ENSG00000089737. [Q9GZR7-2]
ENST00000613280; ENSP00000482106; ENSG00000273761. [Q9GZR7-1]
ENST00000618456; ENSP00000478630; ENSG00000273761. [Q9GZR7-2]
ENST00000621632; ENSP00000481495; ENSG00000089737. [Q9GZR7-1]
GeneIDi57062.
KEGGihsa:57062.
UCSCiuc001ycj.4. human. [Q9GZR7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214731 mRNA. Translation: AAG02169.1.
AL136886 mRNA. Translation: CAB66820.1.
AK025162 mRNA. Translation: BAB15079.1.
BC008847 mRNA. Translation: AAH08847.1.
BC009406 mRNA. Translation: AAH09406.1.
BC096826 mRNA. Translation: AAH96826.1.
CCDSiCCDS9918.1. [Q9GZR7-1]
RefSeqiNP_065147.1. NM_020414.3. [Q9GZR7-1]
UniGeneiHs.510328.

3D structure databases

ProteinModelPortaliQ9GZR7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121353. 150 interactors.
DIPiDIP-47301N.
IntActiQ9GZR7. 48 interactors.
MINTiMINT-1378437.
STRINGi9606.ENSP00000328690.

PTM databases

iPTMnetiQ9GZR7.
PhosphoSitePlusiQ9GZR7.

Polymorphism and mutation databases

BioMutaiDDX24.
DMDMi18202929.

2D gel databases

SWISS-2DPAGEQ9GZR7.

Proteomic databases

EPDiQ9GZR7.
MaxQBiQ9GZR7.
PaxDbiQ9GZR7.
PeptideAtlasiQ9GZR7.
PRIDEiQ9GZR7.

Protocols and materials databases

DNASUi57062.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330836; ENSP00000328690; ENSG00000089737. [Q9GZR7-2]
ENST00000613280; ENSP00000482106; ENSG00000273761. [Q9GZR7-1]
ENST00000618456; ENSP00000478630; ENSG00000273761. [Q9GZR7-2]
ENST00000621632; ENSP00000481495; ENSG00000089737. [Q9GZR7-1]
GeneIDi57062.
KEGGihsa:57062.
UCSCiuc001ycj.4. human. [Q9GZR7-1]

Organism-specific databases

CTDi57062.
GeneCardsiDDX24.
HGNCiHGNC:13266. DDX24.
HPAiHPA002554.
HPA061434.
MIMi606181. gene.
neXtProtiNX_Q9GZR7.
OpenTargetsiENSG00000089737.
ENSG00000273761.
PharmGKBiPA27211.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0347. Eukaryota.
ENOG410XS03. LUCA.
GeneTreeiENSGT00550000074847.
HOGENOMiHOG000290702.
HOVERGENiHBG104200.
InParanoidiQ9GZR7.
KOiK14805.
OMAiVPKQNEN.
OrthoDBiEOG091G078Q.
PhylomeDBiQ9GZR7.
TreeFamiTF105837.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000089737-MONOMER.

Miscellaneous databases

ChiTaRSiDDX24. human.
GeneWikiiDDX24.
GenomeRNAii57062.
PROiQ9GZR7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000089737.
CleanExiHS_DDX24.
ExpressionAtlasiQ9GZR7. baseline and differential.
GenevisibleiQ9GZR7. HS.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDX24_HUMAN
AccessioniPrimary (citable) accession number: Q9GZR7
Secondary accession number(s): E7EMJ4, Q4V9L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 159 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.