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Q9GZR2 (REXO4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA exonuclease 4

EC=3.1.-.-
Alternative name(s):
Exonuclease XPMC2
Prevents mitotic catastrophe 2 protein homolog
Short name=hPMC2
Gene names
Name:REXO4
Synonyms:PMC2, XPMC2H
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Can bind ESR1 and ESR2. This interaction is abrogated by estrogen and augmented by tamoxifen treatment.

Subcellular location

Nucleusnucleolus Ref.2 Ref.8.

Sequence similarities

Belongs to the REXO4 family.

Contains 1 exonuclease domain.

Sequence caution

The sequence CAI12845.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI12847.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI12848.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9GZR2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9GZR2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     76-132: WLLKQKSQAP...KDQEASRGSV → VPRWTGGRQY...RRQPQPHPPR
     133-304: Missing.
Note: Gene prediction based on EST data. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422RNA exonuclease 4
PRO_0000131703

Regions

Domain243 – 394152Exonuclease

Amino acid modifications

Modified residue151Phosphoserine Ref.9

Natural variations

Alternative sequence76 – 13257WLLKQ…SRGSV → VPRWTGGRQYLAPRPVEQST IRKEPRKGQMVILFQNEGTS SIRSGKLRRQPQPHPPR in isoform 2.
VSP_014796
Alternative sequence133 – 304172Missing in isoform 2.
VSP_014797
Natural variant1411R → K.
Corresponds to variant rs6597630 [ dbSNP | Ensembl ].
VAR_023067
Natural variant2831T → A. Ref.1
Corresponds to variant rs2285487 [ dbSNP | Ensembl ].
VAR_023068

Experimental info

Sequence conflict2021A → P Ref.1
Sequence conflict2021A → P Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 19, 2005. Version 2.
Checksum: 5994D59678B17C21

FASTA42246,672
        10         20         30         40         50         60 
MGKAKVPASK RAPSSPVAKP GPVKTLTRKK NKKKKRFWKS KAREVSKKPA SGPGAVVRPP 

        70         80         90        100        110        120 
KAPEDFSQNW KALQEWLLKQ KSQAPEKPLV ISQMGSKKKP KIIQQNKKET SPQVKGEEMP 

       130        140        150        160        170        180 
AGKDQEASRG SVPSGSKMDR RAPVPRTKAS GTEHNKKGTK ERTNGDIVPE RGDIEHKKRK 

       190        200        210        220        230        240 
AKEAAPAPPT EEDIWFDDVD PADIEAAIGP EAAKIARKQL GQSEGSVSLS LVKEQAFGGL 

       250        260        270        280        290        300 
TRALALDCEM VGVGPKGEES MAARVSIVNQ YGKCVYDKYV KPTEPVTDYR TAVSGIRPEN 

       310        320        330        340        350        360 
LKQGEELEVV QKEVAEMLKG RILVGHALHN DLKVLFLDHP KKKIRDTQKY KPFKSQVKSG 

       370        380        390        400        410        420 
RPSLRLLSEK ILGLQVQQAE HCSIQDAQAA MRLYVMVKKE WESMARDRRP LLTAPDHCSD 


DA 

« Hide

Isoform 2 [UniParc].

Checksum: F2F05F07242D6EFE
Show »

FASTA25028,390

References

« Hide 'large scale' references
[1]"Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1."
Kwiatkowska J., Slomski R., Jozwiak S., Short M.P., Kwiatkowski D.J.
Genomics 44:350-354(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ALA-283.
[2]"Identification and characterization of a novel factor that regulates quinone reductase gene transcriptional activity."
Montano M.M., Wittmann B.M., Bianco N.R.
J. Biol. Chem. 275:34306-34313(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, INTERACTION WITH ESR1 AND ESR2.
[3]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Testis.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 2).
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[8]"Functional proteomic analysis of human nucleolus."
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF295774 mRNA. Translation: AAG02123.1.
AF273304 mRNA. Translation: AAF98162.1.
AL136894 mRNA. Translation: CAB66828.1.
AK025493 mRNA. Translation: BAB15152.1.
AK314333 mRNA. Translation: BAG36979.1.
AL158826 Genomic DNA. Translation: CAI12845.1. Sequence problems.
AL158826 Genomic DNA. Translation: CAI12847.1. Sequence problems.
AL158826 Genomic DNA. Translation: CAI12848.1. Sequence problems.
AL158826 Genomic DNA. Translation: CAI12849.1.
CH471090 Genomic DNA. Translation: EAW88082.1.
BC009274 mRNA. Translation: AAH09274.1.
RefSeqNP_001266278.1. NM_001279349.1.
NP_001266279.1. NM_001279350.1.
NP_001266280.1. NM_001279351.1.
NP_065118.2. NM_020385.3.
UniGeneHs.438409.

3D structure databases

ProteinModelPortalQ9GZR2.
SMRQ9GZR2. Positions 244-399.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121375. 4 interactions.
IntActQ9GZR2. 1 interaction.
MINTMINT-3065177.
STRING9606.ENSP00000361010.

PTM databases

PhosphoSiteQ9GZR2.

Polymorphism databases

DMDM71153418.

2D gel databases

SWISS-2DPAGEQ9GZR2.

Proteomic databases

PaxDbQ9GZR2.
PRIDEQ9GZR2.

Protocols and materials databases

DNASU57109.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371935; ENSP00000361003; ENSG00000148300. [Q9GZR2-2]
ENST00000371942; ENSP00000361010; ENSG00000148300. [Q9GZR2-1]
ENST00000445916; ENSP00000391534; ENSG00000148300.
ENST00000454825; ENSP00000394229; ENSG00000148300.
ENST00000562216; ENSP00000457846; ENSG00000261493.
ENST00000568937; ENSP00000456472; ENSG00000261493. [Q9GZR2-1]
ENST00000569763; ENSP00000454220; ENSG00000261493.
ENST00000570226; ENSP00000456823; ENSG00000261493.
GeneID57109.
KEGGhsa:57109.
UCSCuc004cdm.3. human. [Q9GZR2-1]

Organism-specific databases

CTD57109.
GeneCardsGC09M136271.
HGNCHGNC:12820. REXO4.
HPAHPA047006.
MIM602930. gene.
neXtProtNX_Q9GZR2.
PharmGKBPA37414.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0847.
HOGENOMHOG000231626.
HOVERGENHBG000999.
InParanoidQ9GZR2.
KOK01175.
OMADHCSDDA.
OrthoDBEOG7WHHB0.
PhylomeDBQ9GZR2.
TreeFamTF313504.

Gene expression databases

ArrayExpressQ9GZR2.
BgeeQ9GZR2.
CleanExHS_REXO4.
GenevestigatorQ9GZR2.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
InterProIPR006055. Exonuclease.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamPF00929. RNase_T. 1 hit.
[Graphical view]
SMARTSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMSSF53098. SSF53098. 1 hit.
ProtoNetSearch...

Other

GeneWikiREXO4.
GenomeRNAi57109.
NextBio62959.
PROQ9GZR2.
SOURCESearch...

Entry information

Entry nameREXO4_HUMAN
AccessionPrimary (citable) accession number: Q9GZR2
Secondary accession number(s): B2RAT2 expand/collapse secondary AC list , Q5T8S4, Q5T8S5, Q5T8S6, Q9GZW3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: April 16, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM