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Protein

Microtubule-associated proteins 1A/1B light chain 3B

Gene

MAP1LC3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei120 – 1212Cleavage; by ATG4BBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated proteins 1A/1B light chain 3B
Alternative name(s):
Autophagy-related protein LC3 B
Autophagy-related ubiquitin-like modifier LC3 B
MAP1 light chain 3-like protein 2
MAP1A/MAP1B light chain 3 B
Short name:
MAP1A/MAP1B LC3 B
Microtubule-associated protein 1 light chain 3 beta
Gene namesi
Name:MAP1LC3B
Synonyms:MAP1ALC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:13352. MAP1LC3B.

Subcellular locationi

GO - Cellular componenti

  • autophagic vacuole Source: UniProtKB
  • autophagic vacuole membrane Source: GO_Central
  • axoneme Source: UniProtKB
  • cytoplasmic vesicle Source: UniProtKB-KW
  • cytosol Source: GO_Central
  • endomembrane system Source: UniProtKB-SubCell
  • extrinsic component of membrane Source: GO_Central
  • intracellular Source: LIFEdb
  • microtubule Source: UniProtKB-KW
  • mitochondrion Source: ParkinsonsUK-UCL
  • organelle membrane Source: UniProtKB
  • pre-autophagosomal structure Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi52 – 532FL → AA: No effect on interaction with TECPR2. 1 Publication
Mutagenesisi68 – 681R → A: Impairs cleavage by ATG4B. 1 Publication
Mutagenesisi70 – 701R → A: Abolishes interaction with TECPR2. 1 Publication
Mutagenesisi120 – 1201G → A: No processing of precursor. 1 Publication
Mutagenesisi122 – 1221K → A: No effect on processing of precursor. 1 Publication

Organism-specific databases

PharmGKBiPA134923100.

Polymorphism and mutation databases

BioMutaiMAP1LC3B.
DMDMi17433141.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 120119Microtubule-associated proteins 1A/1B light chain 3BPRO_0000017198Add
BLAST
Propeptidei121 – 1255Removed in mature formPRO_0000017199

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121Phosphothreonine; by PKABy similarity
Lipidationi120 – 1201Phosphatidylethanolamine amidated glycine1 Publication

Post-translational modificationi

The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II (PubMed:15187094).1 Publication
The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.
Phosphorylation at Thr-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE) (By similarity). Interaction with MAPK15 reduces the inhibitory phosphorylation and increases autophagy activity.By similarity2 Publications

Keywords - PTMi

Lipoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9GZQ8.
PaxDbiQ9GZQ8.
PRIDEiQ9GZQ8.

PTM databases

PhosphoSiteiQ9GZQ8.

Miscellaneous databases

PMAP-CutDBQ9GZQ8.

Expressioni

Tissue specificityi

Most abundant in heart, brain, skeletal muscle and testis. Little expression observed in liver.1 Publication

Gene expression databases

BgeeiQ9GZQ8.
CleanExiHS_MAP1LC3B.
ExpressionAtlasiQ9GZQ8. baseline and differential.
GenevisibleiQ9GZQ8. HS.

Organism-specific databases

HPAiCAB037216.
HPA052474.
HPA052484.
HPA053767.

Interactioni

Subunit structurei

3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins (By similarity). Interacts at microtubules with CABP1 (via EF-hands 1 and 2) but not with calmodulin. Interacts with FYCO1 (via C-terminus). Interacts with TP53INP1 and TP53INP2. Interacts with TBC1D25. Directly interacts with SQSTM1; this interaction leads to MAP1LC3B recruitment to inclusion bodies containing polyubiquitinated protein aggregates and to inclusion body degradation by autophagy. Interacts with ATG4B, MAPK15 and BNIP3. Interacts with MAPB1, KEAP1, PCM1, OFD1, CEP131, and TECPR2. Interacts with TBC1D5 (PubMed:22354992). Found in a complex with UBQLN1 and UBQLN2. Interacts with UBQLN4 (via STI1 1 and 2 domains). Interacts with UBQLN1 in the presence of UBQLN4.By similarity13 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATG13O751432EBI-373144,EBI-2798775
ATG16L1Q676U52EBI-373144,EBI-535909
ATG2AQ2TAZ02EBI-373144,EBI-2514077
ATG3Q9NT627EBI-373144,EBI-988094
ATG4BQ9Y4P111EBI-373144,EBI-712014
ATG5Q9H1Y02EBI-373144,EBI-1047414
ATG7O953527EBI-373144,EBI-987834
Bnip3lQ9Z2F75EBI-373144,EBI-1774669From a different organism.
CLINT1Q146772EBI-373144,EBI-1171113
CTNNB1P352225EBI-373144,EBI-491549
FUNDC1Q8IVP58EBI-373144,EBI-3059266
FYCO1Q9BQS87EBI-373144,EBI-2869338
GBASO753234EBI-373144,EBI-307133
GORASP2Q9H8Y83EBI-373144,EBI-739467
HADHAP409394EBI-373144,EBI-356720
IPO5O004102EBI-373144,EBI-356424
KBTBD6Q86V972EBI-373144,EBI-2514778
KBTBD7Q8WVZ94EBI-373144,EBI-473695
KXD1Q9BQD34EBI-373144,EBI-739657
LUC7L2Q9Y3833EBI-373144,EBI-352851
NBR1Q145968EBI-373144,EBI-742698
Nbr1P974322EBI-373144,EBI-642554From a different organism.
NEK9Q8TD192EBI-373144,EBI-1044009
PINK1Q9BXM73EBI-373144,EBI-2846068
RASSF1Q9NS232EBI-373144,EBI-367363
RASSF5Q8WWW05EBI-373144,EBI-367390
SAFBQ154243EBI-373144,EBI-348298
SAFB2Q141513EBI-373144,EBI-352869
SQSTM1Q1350117EBI-373144,EBI-307104
Sqstm1Q643376EBI-373144,EBI-645025From a different organism.
STBD1O952102EBI-373144,EBI-2947137
STK3Q131885EBI-373144,EBI-992580
STK4Q130437EBI-373144,EBI-367376
TBC1D15Q8TC072EBI-373144,EBI-1048247
TBC1D2BQ9UPU73EBI-373144,EBI-2947180
TNIP1Q150253EBI-373144,EBI-357849
UBA5Q9GZZ92EBI-373144,EBI-747805
ULK1O753852EBI-373144,EBI-908831
WDFY3Q8IZQ16EBI-373144,EBI-1569256

Protein-protein interaction databases

BioGridi123565. 83 interactions.
DIPiDIP-29760N.
IntActiQ9GZQ8. 363 interactions.
MINTiMINT-1369587.
STRINGi9606.ENSP00000268607.

Structurei

Secondary structure

1
125
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 43Combined sources
Helixi7 – 104Combined sources
Helixi13 – 2614Combined sources
Beta strandi30 – 378Combined sources
Beta strandi42 – 443Combined sources
Beta strandi51 – 555Combined sources
Helixi60 – 7112Combined sources
Turni75 – 773Combined sources
Beta strandi79 – 835Combined sources
Turni84 – 863Combined sources
Turni89 – 913Combined sources
Helixi95 – 1028Combined sources
Beta strandi109 – 1157Combined sources
Helixi116 – 1216Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V49NMR-A1-120[»]
2LUENMR-A5-119[»]
2ZJDX-ray1.56A/C1-125[»]
3VTUX-ray1.60A2-119[»]
3VTVX-ray1.70A2-119[»]
3VTWX-ray2.52A/B/C2-119[»]
3WAOX-ray2.60A/B/C/D2-119[»]
3X0WX-ray2.71A/B2-119[»]
ProteinModelPortaliQ9GZQ8.
SMRiQ9GZQ8. Positions 1-122.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9GZQ8.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG8 family.Curated

Phylogenomic databases

eggNOGiNOG283348.
GeneTreeiENSGT00390000012937.
HOGENOMiHOG000232034.
HOVERGENiHBG051706.
InParanoidiQ9GZQ8.
KOiK10435.
OMAiIRDQHPT.
OrthoDBiEOG7XH6RV.
PhylomeDBiQ9GZQ8.
TreeFamiTF312964.

Family and domain databases

InterProiIPR004241. Atg8_like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10969. PTHR10969. 1 hit.
PfamiPF02991. Atg8. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GZQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSEKTFKQR RTFEQRVEDV RLIREQHPTK IPVIIERYKG EKQLPVLDKT
60 70 80 90 100
KFLVPDHVNM SELIKIIRRR LQLNANQAFF LLVNGHSMVS VSTPISEVYE
110 120
SEKDEDGFLY MVYASQETFG MKLSV
Length:125
Mass (Da):14,688
Last modified:January 23, 2007 - v3
Checksum:iBB141DEC7653E83F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611S → G in AAH67797 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303888 mRNA. Translation: AAG23182.1.
AF183417 mRNA. Translation: AAG09686.1.
AF087871 mRNA. Translation: AAM10499.1.
AK025556 mRNA. Translation: BAB15169.1.
BC018634 mRNA. Translation: AAH18634.1.
BC041874 mRNA. Translation: AAH41874.1.
BC067797 mRNA. Translation: AAH67797.1.
CCDSiCCDS10960.1.
RefSeqiNP_073729.1. NM_022818.4.
UniGeneiHs.356061.

Genome annotation databases

EnsembliENST00000268607; ENSP00000268607; ENSG00000140941.
GeneIDi81631.
KEGGihsa:81631.
UCSCiuc002fjx.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF303888 mRNA. Translation: AAG23182.1.
AF183417 mRNA. Translation: AAG09686.1.
AF087871 mRNA. Translation: AAM10499.1.
AK025556 mRNA. Translation: BAB15169.1.
BC018634 mRNA. Translation: AAH18634.1.
BC041874 mRNA. Translation: AAH41874.1.
BC067797 mRNA. Translation: AAH67797.1.
CCDSiCCDS10960.1.
RefSeqiNP_073729.1. NM_022818.4.
UniGeneiHs.356061.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V49NMR-A1-120[»]
2LUENMR-A5-119[»]
2ZJDX-ray1.56A/C1-125[»]
3VTUX-ray1.60A2-119[»]
3VTVX-ray1.70A2-119[»]
3VTWX-ray2.52A/B/C2-119[»]
3WAOX-ray2.60A/B/C/D2-119[»]
3X0WX-ray2.71A/B2-119[»]
ProteinModelPortaliQ9GZQ8.
SMRiQ9GZQ8. Positions 1-122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123565. 83 interactions.
DIPiDIP-29760N.
IntActiQ9GZQ8. 363 interactions.
MINTiMINT-1369587.
STRINGi9606.ENSP00000268607.

PTM databases

PhosphoSiteiQ9GZQ8.

Polymorphism and mutation databases

BioMutaiMAP1LC3B.
DMDMi17433141.

Proteomic databases

MaxQBiQ9GZQ8.
PaxDbiQ9GZQ8.
PRIDEiQ9GZQ8.

Protocols and materials databases

DNASUi81631.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000268607; ENSP00000268607; ENSG00000140941.
GeneIDi81631.
KEGGihsa:81631.
UCSCiuc002fjx.3. human.

Organism-specific databases

CTDi81631.
GeneCardsiGC16P087425.
HGNCiHGNC:13352. MAP1LC3B.
HPAiCAB037216.
HPA052474.
HPA052484.
HPA053767.
MIMi609604. gene.
neXtProtiNX_Q9GZQ8.
PharmGKBiPA134923100.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG283348.
GeneTreeiENSGT00390000012937.
HOGENOMiHOG000232034.
HOVERGENiHBG051706.
InParanoidiQ9GZQ8.
KOiK10435.
OMAiIRDQHPT.
OrthoDBiEOG7XH6RV.
PhylomeDBiQ9GZQ8.
TreeFamiTF312964.

Miscellaneous databases

ChiTaRSiMAP1LC3B. human.
EvolutionaryTraceiQ9GZQ8.
GeneWikiiMAP1LC3B.
GenomeRNAii81631.
NextBioi72018.
PMAP-CutDBQ9GZQ8.
PROiQ9GZQ8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9GZQ8.
CleanExiHS_MAP1LC3B.
ExpressionAtlasiQ9GZQ8. baseline and differential.
GenevisibleiQ9GZQ8. HS.

Family and domain databases

InterProiIPR004241. Atg8_like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10969. PTHR10969. 1 hit.
PfamiPF02991. Atg8. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung carcinoma.
  2. "The gene expression profiling of sporadic pheochromocytoma and novel full-length cDNAs cloning."
    Yang Y.-S., Song H.-D., Peng Y.-D., Huang Q.-H., Li R.-Y., Zhu Z.-D., Hu R.-M., Han Z.-G., Chen J.-L.
    Endocr. Relat. Cancer 10:621-627(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pheochromocytoma.
  3. "Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B."
    He H., Dang Y., Dai F., Guo Z., Wu J., She X., Pei Y., Chen Y., Ling W., Wu C., Zhao S., Liu J.O., Yu L.
    J. Biol. Chem. 278:29278-29287(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, CLEAVAGE, TISSUE SPECIFICITY.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hepatoma.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Pancreas and Testis.
  6. "HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates."
    Tanida I., Sou Y.-S., Ezaki J., Minematsu-Ikeguchi N., Ueno T., Kominami E.
    J. Biol. Chem. 279:36268-36276(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: LIPIDATION AT GLY-120, CLEAVAGE BY ATG4B.
  7. "Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes."
    Tanida I., Ueno T., Kominami E.
    J. Biol. Chem. 279:47704-47710(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE, MUTAGENESIS OF GLY-120 AND LYS-122.
  8. Cited for: REVIEW.
  9. "Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins."
    Seidenbecher C.I., Landwehr M., Smalla K.H., Kreutz M., Dieterich D.C., Zuschratter W., Reissner C., Hammarback J.A., Bockers T.M., Gundelfinger E.D., Kreutz M.R.
    J. Mol. Biol. 336:957-970(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CABP1.
  10. "p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy."
    Pankiv S., Clausen T.H., Lamark T., Brech A., Bruun J.A., Outzen H., Overvatn A., Bjorkoy G., Johansen T.
    J. Biol. Chem. 282:24131-24145(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SQSTM1, SUBCELLULAR LOCATION.
  11. "LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis."
    Weidberg H., Shvets E., Shpilka T., Shimron F., Shinder V., Elazar Z.
    EMBO J. 29:1792-1802(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. Cited for: IDENTIFICATION IN A COMPLEX WITH UBQLN1 AND UBQLN2, SUBCELLULAR LOCATION.
  13. "FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport."
    Pankiv S., Alemu E.A., Brech A., Bruun J.A., Lamark T., Overvatn A., Bjorkoy G., Johansen T.
    J. Cell Biol. 188:253-269(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FYCO1.
  14. "Network organization of the human autophagy system."
    Behrends C., Sowa M.E., Gygi S.P., Harper J.W.
    Nature 466:68-76(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TECPR2, MUTAGENESIS OF 52-PHE-LYS-53 AND ARG-70.
  15. "OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation."
    Itoh T., Kanno E., Uemura T., Waguri S., Fukuda M.
    J. Cell Biol. 192:839-853(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TBC1D25.
  16. Cited for: INTERACTION WITH MAPK15, PHOSPHORYLATION.
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  18. "Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers."
    Popovic D., Akutsu M., Novak I., Harper J.W., Behrends C., Dikic I.
    Mol. Cell. Biol. 32:1733-1744(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TBC1D5.
  19. "DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription."
    Sancho A., Duran J., Garcia-Espana A., Mauvezin C., Alemu E.A., Lamark T., Macias M.J., Desalle R., Royo M., Sala D., Chicote J.U., Palacin M., Johansen T., Zorzano A.
    PLoS ONE 7:E34034-E34034(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TP53INP1 AND TP53INP2.
  20. "The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation."
    Choy A., Dancourt J., Mugo B., O'Connor T.J., Isberg R.R., Melia T.J., Roy C.R.
    Science 338:1072-1076(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: DECONJUGATION BY LEGIONELLA RAVZ.
  21. "Arginine68 is an essential residue for the C-terminal cleavage of human Atg8 family proteins."
    Liu C., Ma H., Wu J., Huang Q., Liu J.O., Yu L.
    BMC Cell Biol. 14:27-27(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF ARG-68, CLEAVAGE BY ATG4B.
  22. "Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery."
    Lee D.Y., Arnott D., Brown E.J.
    EMBO Rep. 14:373-381(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UBQLN1 AND UBQLN4, SUBCELLULAR LOCATION.
  23. "Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis."
    Zhu Y., Massen S., Terenzio M., Lang V., Chen-Lindner S., Eils R., Novak I., Dikic I., Hamacher-Brady A., Brady N.R.
    J. Biol. Chem. 288:1099-1113(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BNIP3, FUNCTION.
  24. "Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites."
    Tang Z., Lin M.G., Stowe T.R., Chen S., Zhu M., Stearns T., Franco B., Zhong Q.
    Nature 502:254-257(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAPB1; FYCO1; SQSTM1; KEAP1; PCM1; OFD1 AND CEP131, FUNCTION.
  25. "Solution structure of microtubule-associated protein light chain 3 and identification of its functional subdomains."
    Kouno T., Mizuguchi M., Tanida I., Ueno T., Kanematsu T., Mori Y., Shinoda H., Hirata M., Kominami E., Kawano K.
    J. Biol. Chem. 280:24610-24617(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-120.
  26. Cited for: X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) IN COMPLEX WITH AN LC3 RECOGNITION SEQUENCE (LRS).

Entry informationi

Entry nameiMLP3B_HUMAN
AccessioniPrimary (citable) accession number: Q9GZQ8
Secondary accession number(s): Q6NW02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 149 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

PubMed:12740394 has shown that the protein is cleaved at Lys-122 but PubMed:15355958 has shown that the cleavage site is at Gly-120 as in other mammalian orthologs.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.