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Protein

Neuropeptide FF receptor 1

Gene

NPFFR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB
  • neuropeptide receptor activity Source: UniProtKB
  • peptide binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148734-MONOMER.
ReactomeiR-HSA-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiQ9GZQ6.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide FF receptor 1
Alternative name(s):
G-protein coupled receptor 147
RFamide-related peptide receptor OT7T022
Gene namesi
Name:NPFFR1
Synonyms:GPR147, NPFF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:17425. NPFFR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 64Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini65 – 80CytoplasmicSequence analysisAdd BLAST16
Transmembranei81 – 101Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini102 – 117ExtracellularSequence analysisAdd BLAST16
Transmembranei118 – 138Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini139 – 158CytoplasmicSequence analysisAdd BLAST20
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini180 – 214ExtracellularSequence analysisAdd BLAST35
Transmembranei215 – 235Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini236 – 271CytoplasmicSequence analysisAdd BLAST36
Transmembranei272 – 292Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini293 – 307ExtracellularSequence analysisAdd BLAST15
Transmembranei308 – 328Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini329 – 430CytoplasmicSequence analysisAdd BLAST102

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64106.
OpenTargetsiENSG00000148734.
PharmGKBiPA134934991.

Chemistry databases

ChEMBLiCHEMBL5951.
GuidetoPHARMACOLOGYi300.

Polymorphism and mutation databases

BioMutaiNPFFR1.
DMDMi13878599.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699131 – 430Neuropeptide FF receptor 1Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi116 ↔ 203PROSITE-ProRule annotation
Glycosylationi195N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZQ6.
PRIDEiQ9GZQ6.

PTM databases

iPTMnetiQ9GZQ6.
PhosphoSitePlusiQ9GZQ6.

Expressioni

Gene expression databases

BgeeiENSG00000148734.
CleanExiHS_NPFFR1.
GenevisibleiQ9GZQ6. HS.

Organism-specific databases

HPAiHPA037521.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000277942.

Chemistry databases

BindingDBiQ9GZQ6.

Structurei

3D structure databases

ProteinModelPortaliQ9GZQ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000041285.
HOVERGENiHBG099624.
InParanoidiQ9GZQ6.
KOiK04240.
OMAiWEAWPET.
OrthoDBiEOG091G098F.
PhylomeDBiQ9GZQ6.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005395. NPFF_rcpt.
IPR005396. NPFF_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01570. NPFFRECEPTOR.
PR01571. NPFFRECEPTR1.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GZQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGEPSQPPN SSWPLSQNGT NTEATPATNL TFSSYYQHTS PVAAMFIVAY
60 70 80 90 100
ALIFLLCMVG NTLVCFIVLK NRHMHTVTNM FILNLAVSDL LVGIFCMPTT
110 120 130 140 150
LVDNLITGWP FDNATCKMSG LVQGMSVSAS VFTLVAIAVE RFRCIVHPFR
160 170 180 190 200
EKLTLRKALV TIAVIWALAL LIMCPSAVTL TVTREEHHFM VDARNRSYPL
210 220 230 240 250
YSCWEAWPEK GMRRVYTTVL FSHIYLAPLA LIVVMYARIA RKLCQAPGPA
260 270 280 290 300
PGGEEAADPR ASRRRARVVH MLVMVALFFT LSWLPLWALL LLIDYGQLSA
310 320 330 340 350
PQLHLVTVYA FPFAHWLAFF NSSANPIIYG YFNENFRRGF QAAFRARLCP
360 370 380 390 400
RPSGSHKEAY SERPGGLLHR RVFVVVRPSD SGLPSESGPS SGAPRPGRLP
410 420 430
LRNGRVAHHG LPREGPGCSH LPLTIPAWDI
Length:430
Mass (Da):47,819
Last modified:March 1, 2001 - v1
Checksum:iBBB0146281B2B9A0
GO

Sequence cautioni

The sequence BAC05950 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti376V → A in AAK94199 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059327145I → L.Corresponds to variant rs3812694dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268898 mRNA. Translation: AAG41397.1.
AB040104 mRNA. Translation: BAB17677.1.
AF330055 mRNA. Translation: AAK94199.1.
AB065729 Genomic DNA. Translation: BAC05950.1. Sequence problems.
EU432128 mRNA. Translation: ABY87927.1.
BC131580 mRNA. Translation: AAI31581.1.
CCDSiCCDS53539.1.
RefSeqiNP_071429.1. NM_022146.4.
UniGeneiHs.302026.

Genome annotation databases

EnsembliENST00000277942; ENSP00000277942; ENSG00000148734.
GeneIDi64106.
KEGGihsa:64106.
UCSCiuc021psj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268898 mRNA. Translation: AAG41397.1.
AB040104 mRNA. Translation: BAB17677.1.
AF330055 mRNA. Translation: AAK94199.1.
AB065729 Genomic DNA. Translation: BAC05950.1. Sequence problems.
EU432128 mRNA. Translation: ABY87927.1.
BC131580 mRNA. Translation: AAI31581.1.
CCDSiCCDS53539.1.
RefSeqiNP_071429.1. NM_022146.4.
UniGeneiHs.302026.

3D structure databases

ProteinModelPortaliQ9GZQ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000277942.

Chemistry databases

BindingDBiQ9GZQ6.
ChEMBLiCHEMBL5951.
GuidetoPHARMACOLOGYi300.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9GZQ6.
PhosphoSitePlusiQ9GZQ6.

Polymorphism and mutation databases

BioMutaiNPFFR1.
DMDMi13878599.

Proteomic databases

PaxDbiQ9GZQ6.
PRIDEiQ9GZQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277942; ENSP00000277942; ENSG00000148734.
GeneIDi64106.
KEGGihsa:64106.
UCSCiuc021psj.2. human.

Organism-specific databases

CTDi64106.
DisGeNETi64106.
GeneCardsiNPFFR1.
HGNCiHGNC:17425. NPFFR1.
HPAiHPA037521.
MIMi607448. gene.
neXtProtiNX_Q9GZQ6.
OpenTargetsiENSG00000148734.
PharmGKBiPA134934991.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000041285.
HOVERGENiHBG099624.
InParanoidiQ9GZQ6.
KOiK04240.
OMAiWEAWPET.
OrthoDBiEOG091G098F.
PhylomeDBiQ9GZQ6.
TreeFamiTF315303.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148734-MONOMER.
ReactomeiR-HSA-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiQ9GZQ6.

Miscellaneous databases

GeneWikiiNeuropeptide_FF_receptor_1.
GenomeRNAii64106.
PROiQ9GZQ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148734.
CleanExiHS_NPFFR1.
GenevisibleiQ9GZQ6. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005395. NPFF_rcpt.
IPR005396. NPFF_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01570. NPFFRECEPTOR.
PR01571. NPFFRECEPTR1.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPFF1_HUMAN
AccessioniPrimary (citable) accession number: Q9GZQ6
Secondary accession number(s): A2RRF0, Q8NGR0, Q96RN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.