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Protein

Neuropeptide FF receptor 1

Gene

NPFFR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GO_Central
  • neuropeptide receptor activity Source: UniProtKB
  • peptide binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiQ9GZQ6

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide FF receptor 1
Alternative name(s):
G-protein coupled receptor 147
RFamide-related peptide receptor OT7T022
Gene namesi
Name:NPFFR1
Synonyms:GPR147, NPFF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148734.7
HGNCiHGNC:17425 NPFFR1
MIMi607448 gene
neXtProtiNX_Q9GZQ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43ExtracellularSequence analysisAdd BLAST43
Transmembranei44 – 64Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini65 – 80CytoplasmicSequence analysisAdd BLAST16
Transmembranei81 – 101Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini102 – 117ExtracellularSequence analysisAdd BLAST16
Transmembranei118 – 138Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini139 – 158CytoplasmicSequence analysisAdd BLAST20
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini180 – 214ExtracellularSequence analysisAdd BLAST35
Transmembranei215 – 235Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini236 – 271CytoplasmicSequence analysisAdd BLAST36
Transmembranei272 – 292Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini293 – 307ExtracellularSequence analysisAdd BLAST15
Transmembranei308 – 328Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini329 – 430CytoplasmicSequence analysisAdd BLAST102

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64106
OpenTargetsiENSG00000148734
PharmGKBiPA134934991

Chemistry databases

ChEMBLiCHEMBL5951
GuidetoPHARMACOLOGYi300

Polymorphism and mutation databases

BioMutaiNPFFR1
DMDMi13878599

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699131 – 430Neuropeptide FF receptor 1Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi116 ↔ 203PROSITE-ProRule annotation
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZQ6
PeptideAtlasiQ9GZQ6
PRIDEiQ9GZQ6

PTM databases

iPTMnetiQ9GZQ6
PhosphoSitePlusiQ9GZQ6

Expressioni

Gene expression databases

BgeeiENSG00000148734
CleanExiHS_NPFFR1
GenevisibleiQ9GZQ6 HS

Organism-specific databases

HPAiHPA037521

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000277942

Chemistry databases

BindingDBiQ9GZQ6

Structurei

3D structure databases

ProteinModelPortaliQ9GZQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00900000140797
HOGENOMiHOG000041285
HOVERGENiHBG099624
InParanoidiQ9GZQ6
KOiK04240
OMAiMCPSAIT
OrthoDBiEOG091G098F
PhylomeDBiQ9GZQ6
TreeFamiTF315303

Family and domain databases

CDDicd15981 7tmA_NPFFR1, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR005395 NPFF_rcpt
IPR005396 NPFF_rcpt_1
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01570 NPFFRECEPTOR
PR01571 NPFFRECEPTR1
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9GZQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGEPSQPPN SSWPLSQNGT NTEATPATNL TFSSYYQHTS PVAAMFIVAY
60 70 80 90 100
ALIFLLCMVG NTLVCFIVLK NRHMHTVTNM FILNLAVSDL LVGIFCMPTT
110 120 130 140 150
LVDNLITGWP FDNATCKMSG LVQGMSVSAS VFTLVAIAVE RFRCIVHPFR
160 170 180 190 200
EKLTLRKALV TIAVIWALAL LIMCPSAVTL TVTREEHHFM VDARNRSYPL
210 220 230 240 250
YSCWEAWPEK GMRRVYTTVL FSHIYLAPLA LIVVMYARIA RKLCQAPGPA
260 270 280 290 300
PGGEEAADPR ASRRRARVVH MLVMVALFFT LSWLPLWALL LLIDYGQLSA
310 320 330 340 350
PQLHLVTVYA FPFAHWLAFF NSSANPIIYG YFNENFRRGF QAAFRARLCP
360 370 380 390 400
RPSGSHKEAY SERPGGLLHR RVFVVVRPSD SGLPSESGPS SGAPRPGRLP
410 420 430
LRNGRVAHHG LPREGPGCSH LPLTIPAWDI
Length:430
Mass (Da):47,819
Last modified:March 1, 2001 - v1
Checksum:iBBB0146281B2B9A0
GO

Sequence cautioni

The sequence BAC05950 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti376V → A in AAK94199 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059327145I → L. Corresponds to variant dbSNP:rs3812694Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268898 mRNA Translation: AAG41397.1
AB040104 mRNA Translation: BAB17677.1
AF330055 mRNA Translation: AAK94199.1
AB065729 Genomic DNA Translation: BAC05950.1 Sequence problems.
EU432128 mRNA Translation: ABY87927.1
BC131580 mRNA Translation: AAI31581.1
CCDSiCCDS53539.1
RefSeqiNP_071429.1, NM_022146.4
UniGeneiHs.302026

Genome annotation databases

EnsembliENST00000277942; ENSP00000277942; ENSG00000148734
GeneIDi64106
KEGGihsa:64106
UCSCiuc021psj.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNPFF1_HUMAN
AccessioniPrimary (citable) accession number: Q9GZQ6
Secondary accession number(s): A2RRF0, Q8NGR0, Q96RN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: February 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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