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Protein

Neuropeptide FF receptor 1

Gene

NPFFR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB
  • neuropeptide receptor activity Source: UniProtKB
  • peptide binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiQ9GZQ6.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide FF receptor 1
Alternative name(s):
G-protein coupled receptor 147
RFamide-related peptide receptor OT7T022
Gene namesi
Name:NPFFR1
Synonyms:GPR147, NPFF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:17425. NPFFR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence analysisAdd
BLAST
Transmembranei44 – 6421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini65 – 8016CytoplasmicSequence analysisAdd
BLAST
Transmembranei81 – 10121Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini102 – 11716ExtracellularSequence analysisAdd
BLAST
Transmembranei118 – 13821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini139 – 15820CytoplasmicSequence analysisAdd
BLAST
Transmembranei159 – 17921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini180 – 21435ExtracellularSequence analysisAdd
BLAST
Transmembranei215 – 23521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini236 – 27136CytoplasmicSequence analysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini293 – 30715ExtracellularSequence analysisAdd
BLAST
Transmembranei308 – 32821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini329 – 430102CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134934991.

Chemistry

ChEMBLiCHEMBL5951.
GuidetoPHARMACOLOGYi300.

Polymorphism and mutation databases

BioMutaiNPFFR1.
DMDMi13878599.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Neuropeptide FF receptor 1PRO_0000069913Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence analysis
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence analysis
Disulfide bondi116 ↔ 203PROSITE-ProRule annotation
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZQ6.
PRIDEiQ9GZQ6.

PTM databases

iPTMnetiQ9GZQ6.
PhosphoSiteiQ9GZQ6.

Expressioni

Gene expression databases

BgeeiENSG00000148734.
CleanExiHS_NPFFR1.
GenevisibleiQ9GZQ6. HS.

Organism-specific databases

HPAiHPA037521.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000277942.

Chemistry

BindingDBiQ9GZQ6.

Structurei

3D structure databases

ProteinModelPortaliQ9GZQ6.
SMRiQ9GZQ6. Positions 5-347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000041285.
HOVERGENiHBG099624.
InParanoidiQ9GZQ6.
KOiK04240.
OMAiWEAWPET.
OrthoDBiEOG091G098F.
PhylomeDBiQ9GZQ6.
TreeFamiTF315303.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005395. NPFF_rcpt.
IPR005396. NPFF_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01570. NPFFRECEPTOR.
PR01571. NPFFRECEPTR1.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GZQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGEPSQPPN SSWPLSQNGT NTEATPATNL TFSSYYQHTS PVAAMFIVAY
60 70 80 90 100
ALIFLLCMVG NTLVCFIVLK NRHMHTVTNM FILNLAVSDL LVGIFCMPTT
110 120 130 140 150
LVDNLITGWP FDNATCKMSG LVQGMSVSAS VFTLVAIAVE RFRCIVHPFR
160 170 180 190 200
EKLTLRKALV TIAVIWALAL LIMCPSAVTL TVTREEHHFM VDARNRSYPL
210 220 230 240 250
YSCWEAWPEK GMRRVYTTVL FSHIYLAPLA LIVVMYARIA RKLCQAPGPA
260 270 280 290 300
PGGEEAADPR ASRRRARVVH MLVMVALFFT LSWLPLWALL LLIDYGQLSA
310 320 330 340 350
PQLHLVTVYA FPFAHWLAFF NSSANPIIYG YFNENFRRGF QAAFRARLCP
360 370 380 390 400
RPSGSHKEAY SERPGGLLHR RVFVVVRPSD SGLPSESGPS SGAPRPGRLP
410 420 430
LRNGRVAHHG LPREGPGCSH LPLTIPAWDI
Length:430
Mass (Da):47,819
Last modified:March 1, 2001 - v1
Checksum:iBBB0146281B2B9A0
GO

Sequence cautioni

The sequence BAC05950 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti376 – 3761V → A in AAK94199 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti145 – 1451I → L.
Corresponds to variant rs3812694 [ dbSNP | Ensembl ].
VAR_059327

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268898 mRNA. Translation: AAG41397.1.
AB040104 mRNA. Translation: BAB17677.1.
AF330055 mRNA. Translation: AAK94199.1.
AB065729 Genomic DNA. Translation: BAC05950.1. Sequence problems.
EU432128 mRNA. Translation: ABY87927.1.
BC131580 mRNA. Translation: AAI31581.1.
CCDSiCCDS53539.1.
RefSeqiNP_071429.1. NM_022146.4.
UniGeneiHs.302026.

Genome annotation databases

EnsembliENST00000277942; ENSP00000277942; ENSG00000148734.
GeneIDi64106.
KEGGihsa:64106.
UCSCiuc021psj.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268898 mRNA. Translation: AAG41397.1.
AB040104 mRNA. Translation: BAB17677.1.
AF330055 mRNA. Translation: AAK94199.1.
AB065729 Genomic DNA. Translation: BAC05950.1. Sequence problems.
EU432128 mRNA. Translation: ABY87927.1.
BC131580 mRNA. Translation: AAI31581.1.
CCDSiCCDS53539.1.
RefSeqiNP_071429.1. NM_022146.4.
UniGeneiHs.302026.

3D structure databases

ProteinModelPortaliQ9GZQ6.
SMRiQ9GZQ6. Positions 5-347.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000277942.

Chemistry

BindingDBiQ9GZQ6.
ChEMBLiCHEMBL5951.
GuidetoPHARMACOLOGYi300.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9GZQ6.
PhosphoSiteiQ9GZQ6.

Polymorphism and mutation databases

BioMutaiNPFFR1.
DMDMi13878599.

Proteomic databases

PaxDbiQ9GZQ6.
PRIDEiQ9GZQ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277942; ENSP00000277942; ENSG00000148734.
GeneIDi64106.
KEGGihsa:64106.
UCSCiuc021psj.2. human.

Organism-specific databases

CTDi64106.
GeneCardsiNPFFR1.
HGNCiHGNC:17425. NPFFR1.
HPAiHPA037521.
MIMi607448. gene.
neXtProtiNX_Q9GZQ6.
PharmGKBiPA134934991.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000041285.
HOVERGENiHBG099624.
InParanoidiQ9GZQ6.
KOiK04240.
OMAiWEAWPET.
OrthoDBiEOG091G098F.
PhylomeDBiQ9GZQ6.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-HSA-389397. Orexin and neuropeptides FF and QRFP bind to their respective receptors.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiQ9GZQ6.

Miscellaneous databases

GeneWikiiNeuropeptide_FF_receptor_1.
GenomeRNAii64106.
PROiQ9GZQ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148734.
CleanExiHS_NPFFR1.
GenevisibleiQ9GZQ6. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005395. NPFF_rcpt.
IPR005396. NPFF_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01570. NPFFRECEPTOR.
PR01571. NPFFRECEPTR1.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPFF1_HUMAN
AccessioniPrimary (citable) accession number: Q9GZQ6
Secondary accession number(s): A2RRF0, Q8NGR0, Q96RN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.