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Protein

Neuromedin-U receptor 2

Gene

NMUR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the neuromedin-U and neuromedin-S neuropeptides.By similarity1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • GTP binding Source: UniProtKB
  • intracellular calcium activated chloride channel activity Source: UniProtKB
  • neuromedin U binding Source: UniProtKB
  • neuromedin U receptor activity Source: UniProtKB

GO - Biological processi

  • activation of phospholipase A2 activity by calcium-mediated signaling Source: UniProtKB
  • arachidonic acid secretion Source: UniProtKB
  • calcium ion transport Source: UniProtKB
  • calcium-mediated signaling Source: UniProtKB
  • cell-cell signaling Source: ProtInc
  • central nervous system development Source: UniProtKB
  • feeding behavior Source: ProtInc
  • grooming behavior Source: Ensembl
  • inositol phosphate-mediated signaling Source: UniProtKB
  • neuropeptide signaling pathway Source: ProtInc
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  • positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  • reduction of food intake in response to dietary excess Source: Ensembl
  • regulation of smooth muscle contraction Source: UniProtKB
  • response to pain Source: Ensembl

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiQ9GZQ4.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U receptor 2
Short name:
NMU-R2
Alternative name(s):
G-protein coupled receptor FM-4
G-protein coupled receptor TGR-1
Gene namesi
Name:NMUR2
Synonyms:NMU2R, TGR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:16454. NMUR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49ExtracellularSequence analysisAdd BLAST49
Transmembranei50 – 70Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini71 – 82CytoplasmicSequence analysisAdd BLAST12
Transmembranei83 – 103Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini104 – 123ExtracellularSequence analysisAdd BLAST20
Transmembranei124 – 146Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini147 – 165CytoplasmicSequence analysisAdd BLAST19
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini187 – 214ExtracellularSequence analysisAdd BLAST28
Transmembranei215 – 235Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini236 – 265CytoplasmicSequence analysisAdd BLAST30
Transmembranei266 – 286Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini287 – 301ExtracellularSequence analysisAdd BLAST15
Transmembranei302 – 322Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini323 – 415CytoplasmicSequence analysisAdd BLAST93

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • intracellular Source: GOC
  • plasma membrane Source: Reactome

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56923.
OpenTargetsiENSG00000132911.
PharmGKBiPA31664.

Chemistry databases

ChEMBLiCHEMBL1075144.
GuidetoPHARMACOLOGYi299.

Polymorphism and mutation databases

BioMutaiNMUR2.
DMDMi311033403.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699101 – 415Neuromedin-U receptor 2Add BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi119 ↔ 204PROSITE-ProRule annotation
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9GZQ4.
PaxDbiQ9GZQ4.
PeptideAtlasiQ9GZQ4.
PRIDEiQ9GZQ4.

PTM databases

iPTMnetiQ9GZQ4.
PhosphoSitePlusiQ9GZQ4.

Expressioni

Tissue specificityi

Predominantly expressed in the CNS, particularly in the medulla oblongata, pontine reticular formation, spinal cord, and thalamus. High level in testis whereas lower levels are present in a variety of peripheral tissues including the gastrointestinal tract, genitourinary tract, liver, pancreas, adrenal gland, thyroid gland, lung, trachea, spleen and thymus.4 Publications

Gene expression databases

BgeeiENSG00000132911.
CleanExiHS_NMUR2.
GenevisibleiQ9GZQ4. HS.

Organism-specific databases

HPAiHPA045836.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi121250. 25 interactors.
IntActiQ9GZQ4. 4 interactors.
STRINGi9606.ENSP00000255262.

Chemistry databases

BindingDBiQ9GZQ4.

Structurei

3D structure databases

ProteinModelPortaliQ9GZQ4.
SMRiQ9GZQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000113804.
HOVERGENiHBG103506.
InParanoidiQ9GZQ4.
KOiK05053.
OMAiSQYAMIN.
OrthoDBiEOG091G0ZDG.
PhylomeDBiQ9GZQ4.
TreeFamiTF318522.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005390. NeuromedU_rcpt.
IPR005392. NeuromedU_rcpt_2.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01567. NEUROMEDNU2R.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9GZQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGMEKLQNA SWIYQQKLED PFQKHLNSTE EYLAFLCGPR RSHFFLPVSV
60 70 80 90 100
VYVPIFVVGV IGNVLVCLVI LQHQAMKTPT NYYLFSLAVS DLLVLLLGMP
110 120 130 140 150
LEVYEMWRNY PFLFGPVGCY FKTALFETVC FASILSITTV SVERYVAILH
160 170 180 190 200
PFRAKLQSTR RRALRILGIV WGFSVLFSLP NTSIHGIKFH YFPNGSLVPG
210 220 230 240 250
SATCTVIKPM WIYNFIIQVT SFLFYLLPMT VISVLYYLMA LRLKKDKSLE
260 270 280 290 300
ADEGNANIQR PCRKSVNKML FVLVLVFAIC WAPFHIDRLF FSFVEEWSES
310 320 330 340 350
LAAVFNLVHV VSGVFFYLSS AVNPIIYNLL SRRFQAAFQN VISSFHKQWH
360 370 380 390 400
SQHDPQLPPA QRNIFLTECH FVELTEDIGP QFPCQSSMHN SHLPAALSSE
410
QMSRTNYQSF HFNKT
Length:415
Mass (Da):47,696
Last modified:November 2, 2010 - v2
Checksum:iC2BACD84A812890F
GO

Sequence cautioni

The sequence BAB13721 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204C → F in AAH16938 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023941298S → T. Corresponds to variant dbSNP:rs4958535Ensembl.1
Natural variantiVAR_023942315F → L. Corresponds to variant dbSNP:rs1895245Ensembl.1
Natural variantiVAR_032770383P → L. Corresponds to variant dbSNP:rs4958532Ensembl.1
Natural variantiVAR_023943388M → V. Corresponds to variant dbSNP:rs4958531Ensembl.1
Natural variantiVAR_023944395A → T5 PublicationsCorresponds to variant dbSNP:rs1363422Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041228 mRNA. Translation: BAB13721.1. Different initiation.
AF272363 mRNA. Translation: AAG24794.1.
AF292402 mRNA. Translation: AAG03064.1.
AC008571 Genomic DNA. No translation available.
BC016938 mRNA. Translation: AAH16938.1.
BC067776 mRNA. Translation: AAH67776.1.
AF242874 mRNA. Translation: AAF82755.1.
CCDSiCCDS4321.1.
RefSeqiNP_064552.3. NM_020167.4.
UniGeneiHs.731911.

Genome annotation databases

EnsembliENST00000255262; ENSP00000255262; ENSG00000132911.
GeneIDi56923.
KEGGihsa:56923.
UCSCiuc003luv.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNMUR2_HUMAN
AccessioniPrimary (citable) accession number: Q9GZQ4
Secondary accession number(s): Q7LC54, Q96AM5, Q9NRA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 2, 2010
Last modified: June 7, 2017
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families