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Q9GZQ4

- NMUR2_HUMAN

UniProt

Q9GZQ4 - NMUR2_HUMAN

Protein

Neuromedin-U receptor 2

Gene

NMUR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Receptor for the neuromedin-U and neuromedin-S neuropeptides.By similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: ProtInc
    2. GTP binding Source: UniProtKB
    3. intracellular calcium activated chloride channel activity Source: UniProtKB
    4. neuromedin U binding Source: UniProtKB
    5. neuromedin U receptor activity Source: UniProtKB

    GO - Biological processi

    1. activation of phospholipase A2 activity by calcium-mediated signaling Source: UniProtKB
    2. arachidonic acid secretion Source: UniProtKB
    3. calcium ion transport Source: UniProtKB
    4. calcium-mediated signaling Source: UniProtKB
    5. cell-cell signaling Source: ProtInc
    6. central nervous system development Source: UniProtKB
    7. chloride transmembrane transport Source: GOC
    8. chloride transport Source: GOC
    9. feeding behavior Source: ProtInc
    10. grooming behavior Source: Ensembl
    11. inositol phosphate-mediated signaling Source: UniProtKB
    12. neuropeptide signaling pathway Source: ProtInc
    13. phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
    14. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
    15. reduction of food intake in response to dietary excess Source: Ensembl
    16. regulation of smooth muscle contraction Source: UniProtKB
    17. response to pain Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuromedin-U receptor 2
    Short name:
    NMU-R2
    Alternative name(s):
    G-protein coupled receptor FM-4
    G-protein coupled receptor TGR-1
    Gene namesi
    Name:NMUR2
    Synonyms:NMU2R, TGR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:16454. NMUR2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31664.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 415415Neuromedin-U receptor 2PRO_0000069910Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi119 ↔ 204PROSITE-ProRule annotation
    Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9GZQ4.
    PRIDEiQ9GZQ4.

    PTM databases

    PhosphoSiteiQ9GZQ4.

    Expressioni

    Tissue specificityi

    Predominantly expressed in the CNS, particularly in the medulla oblongata, pontine reticular formation, spinal cord, and thalamus. High level in testis whereas lower levels are present in a variety of peripheral tissues including the gastrointestinal tract, genitourinary tract, liver, pancreas, adrenal gland, thyroid gland, lung, trachea, spleen and thymus.4 Publications

    Gene expression databases

    BgeeiQ9GZQ4.
    CleanExiHS_NMUR2.
    GenevestigatoriQ9GZQ4.

    Organism-specific databases

    HPAiHPA045836.

    Interactioni

    Protein-protein interaction databases

    BioGridi121250. 2 interactions.
    STRINGi9606.ENSP00000255262.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GZQ4.
    SMRiQ9GZQ4. Positions 48-338.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4949ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini71 – 8212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini104 – 12320ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini147 – 16519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini187 – 21428ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini236 – 26530CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini287 – 30115ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini323 – 41593CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei50 – 7021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei83 – 10321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei124 – 14623Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei166 – 18621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei215 – 23521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei302 – 32221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG308321.
    HOGENOMiHOG000113804.
    HOVERGENiHBG103506.
    InParanoidiQ9GZQ4.
    KOiK05053.
    OMAiLFYILPM.
    OrthoDBiEOG7GXPBG.
    PhylomeDBiQ9GZQ4.
    TreeFamiTF318522.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR005390. NeuromedU_rcpt.
    IPR005392. NeuromedU_rcpt_2.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01565. NEUROMEDINUR.
    PR01567. NEUROMEDNU2R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9GZQ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGMEKLQNA SWIYQQKLED PFQKHLNSTE EYLAFLCGPR RSHFFLPVSV    50
    VYVPIFVVGV IGNVLVCLVI LQHQAMKTPT NYYLFSLAVS DLLVLLLGMP 100
    LEVYEMWRNY PFLFGPVGCY FKTALFETVC FASILSITTV SVERYVAILH 150
    PFRAKLQSTR RRALRILGIV WGFSVLFSLP NTSIHGIKFH YFPNGSLVPG 200
    SATCTVIKPM WIYNFIIQVT SFLFYLLPMT VISVLYYLMA LRLKKDKSLE 250
    ADEGNANIQR PCRKSVNKML FVLVLVFAIC WAPFHIDRLF FSFVEEWSES 300
    LAAVFNLVHV VSGVFFYLSS AVNPIIYNLL SRRFQAAFQN VISSFHKQWH 350
    SQHDPQLPPA QRNIFLTECH FVELTEDIGP QFPCQSSMHN SHLPAALSSE 400
    QMSRTNYQSF HFNKT 415
    Length:415
    Mass (Da):47,696
    Last modified:November 2, 2010 - v2
    Checksum:iC2BACD84A812890F
    GO

    Sequence cautioni

    The sequence BAB13721.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti204 – 2041C → F in AAH16938. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti298 – 2981S → T.
    Corresponds to variant rs4958535 [ dbSNP | Ensembl ].
    VAR_023941
    Natural varianti315 – 3151F → L.
    Corresponds to variant rs1895245 [ dbSNP | Ensembl ].
    VAR_023942
    Natural varianti383 – 3831P → L.
    Corresponds to variant rs4958532 [ dbSNP | Ensembl ].
    VAR_032770
    Natural varianti388 – 3881M → V.
    Corresponds to variant rs4958531 [ dbSNP | Ensembl ].
    VAR_023943
    Natural varianti395 – 3951A → T.5 Publications
    Corresponds to variant rs1363422 [ dbSNP | Ensembl ].
    VAR_023944

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB041228 mRNA. Translation: BAB13721.1. Different initiation.
    AF272363 mRNA. Translation: AAG24794.1.
    AF292402 mRNA. Translation: AAG03064.1.
    AC008571 Genomic DNA. No translation available.
    BC016938 mRNA. Translation: AAH16938.1.
    BC067776 mRNA. Translation: AAH67776.1.
    AF242874 mRNA. Translation: AAF82755.1.
    CCDSiCCDS4321.1.
    RefSeqiNP_064552.3. NM_020167.4.
    UniGeneiHs.731911.

    Genome annotation databases

    EnsembliENST00000255262; ENSP00000255262; ENSG00000132911.
    GeneIDi56923.
    KEGGihsa:56923.
    UCSCiuc003luv.2. human.

    Polymorphism databases

    DMDMi311033403.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB041228 mRNA. Translation: BAB13721.1 . Different initiation.
    AF272363 mRNA. Translation: AAG24794.1 .
    AF292402 mRNA. Translation: AAG03064.1 .
    AC008571 Genomic DNA. No translation available.
    BC016938 mRNA. Translation: AAH16938.1 .
    BC067776 mRNA. Translation: AAH67776.1 .
    AF242874 mRNA. Translation: AAF82755.1 .
    CCDSi CCDS4321.1.
    RefSeqi NP_064552.3. NM_020167.4.
    UniGenei Hs.731911.

    3D structure databases

    ProteinModelPortali Q9GZQ4.
    SMRi Q9GZQ4. Positions 48-338.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121250. 2 interactions.
    STRINGi 9606.ENSP00000255262.

    Chemistry

    ChEMBLi CHEMBL1075144.
    GuidetoPHARMACOLOGYi 299.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9GZQ4.

    Polymorphism databases

    DMDMi 311033403.

    Proteomic databases

    PaxDbi Q9GZQ4.
    PRIDEi Q9GZQ4.

    Protocols and materials databases

    DNASUi 56923.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000255262 ; ENSP00000255262 ; ENSG00000132911 .
    GeneIDi 56923.
    KEGGi hsa:56923.
    UCSCi uc003luv.2. human.

    Organism-specific databases

    CTDi 56923.
    GeneCardsi GC05M151751.
    H-InvDB HIX0005335.
    HGNCi HGNC:16454. NMUR2.
    HPAi HPA045836.
    MIMi 605108. gene.
    neXtProti NX_Q9GZQ4.
    PharmGKBi PA31664.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG308321.
    HOGENOMi HOG000113804.
    HOVERGENi HBG103506.
    InParanoidi Q9GZQ4.
    KOi K05053.
    OMAi LFYILPM.
    OrthoDBi EOG7GXPBG.
    PhylomeDBi Q9GZQ4.
    TreeFami TF318522.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii Neuromedin_U_receptor_2.
    GenomeRNAii 56923.
    NextBioi 62432.
    PROi Q9GZQ4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9GZQ4.
    CleanExi HS_NMUR2.
    Genevestigatori Q9GZQ4.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR005390. NeuromedU_rcpt.
    IPR005392. NeuromedU_rcpt_2.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01565. NEUROMEDINUR.
    PR01567. NEUROMEDNU2R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and functional characterization of a novel subtype of neuromedin U receptor."
      Hosoya M., Moriya T., Kawamata Y., Ohkubo S., Fujii R., Matsui H., Shintani Y., Fukusumi S., Habata Y., Hinuma S., Onda H., Nishimura O., Fujino M.
      J. Biol. Chem. 275:29528-29532(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT THR-395.
    2. "Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system."
      Raddatz R., Wilson A.E., Artymyshyn R., Bonini J.A., Borowsky B., Boteju L.W., Zhou S., Kouranova E.V., Nagorny R., Guevarra M.S., Dai M., Lerman G.S., Vaysse P.J., Branchek T.A., Gerald C., Forray C., Adham N.
      J. Biol. Chem. 275:32452-32459(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANT THR-395.
    3. "Identification of a novel neuromedin U receptor subtype expressed in the central nervous system."
      Shan L., Qiao X., Crona J.H., Behan J., Wang S., Laz T., Bayne M., Gustafson E.L., Monsma F.J. Jr., Hedrick J.A.
      J. Biol. Chem. 275:39482-39486(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT THR-395.
    4. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-395.
      Tissue: Colon and Placenta.
    6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-415, TISSUE SPECIFICITY, VARIANT THR-395.

    Entry informationi

    Entry nameiNMUR2_HUMAN
    AccessioniPrimary (citable) accession number: Q9GZQ4
    Secondary accession number(s): Q7LC54, Q96AM5, Q9NRA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-4 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3