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Q9GZQ4 (NMUR2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuromedin-U receptor 2

Short name=NMU-R2
Alternative name(s):
G-protein coupled receptor FM-4
G-protein coupled receptor TGR-1
Gene names
Name:NMUR2
Synonyms:NMU2R, TGR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the neuromedin-U and neuromedin-S neuropeptides By similarity. Ref.2

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Predominantly expressed in the CNS, particularly in the medulla oblongata, pontine reticular formation, spinal cord, and thalamus. High level in testis whereas lower levels are present in a variety of peripheral tissues including the gastrointestinal tract, genitourinary tract, liver, pancreas, adrenal gland, thyroid gland, lung, trachea, spleen and thymus. Ref.1 Ref.2 Ref.3 Ref.6

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.

Sequence caution

The sequence BAB13721.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of phospholipase A2 activity by calcium-mediated signaling

Inferred from direct assay Ref.2. Source: UniProtKB

arachidonic acid secretion

Inferred from direct assay Ref.1. Source: UniProtKB

calcium ion transport

Inferred from direct assay Ref.2. Source: UniProtKB

calcium-mediated signaling

Non-traceable author statement Ref.2. Source: UniProtKB

cell-cell signaling

Traceable author statement Ref.6. Source: ProtInc

central nervous system development

Inferred from expression pattern Ref.2. Source: UniProtKB

chloride transmembrane transport

Inferred from direct assay Ref.2. Source: GOC

chloride transport

Inferred from direct assay Ref.2. Source: GOC

feeding behavior

Traceable author statement Ref.6. Source: ProtInc

grooming behavior

Inferred from electronic annotation. Source: Ensembl

inositol phosphate-mediated signaling

Inferred from direct assay Ref.2. Source: UniProtKB

neuropeptide signaling pathway

Traceable author statement Ref.6. Source: ProtInc

phospholipase C-activating G-protein coupled receptor signaling pathway

Inferred from direct assay Ref.2. Source: UniProtKB

positive regulation of cytosolic calcium ion concentration

Inferred from direct assay Ref.2. Source: UniProtKB

reduction of food intake in response to dietary excess

Inferred from electronic annotation. Source: Ensembl

regulation of smooth muscle contraction

Non-traceable author statement Ref.1. Source: UniProtKB

response to pain

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from direct assay Ref.2. Source: UniProtKB

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionG-protein coupled receptor activity

Traceable author statement Ref.6. Source: ProtInc

GTP binding

Inferred from direct assay Ref.2. Source: UniProtKB

intracellular calcium activated chloride channel activity

Inferred from direct assay Ref.2. Source: UniProtKB

neuromedin U binding

Inferred from direct assay Ref.2. Source: UniProtKB

neuromedin U receptor activity

Inferred from direct assay Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415Neuromedin-U receptor 2
PRO_0000069910

Regions

Topological domain1 – 4949Extracellular Potential
Transmembrane50 – 7021Helical; Name=1; Potential
Topological domain71 – 8212Cytoplasmic Potential
Transmembrane83 – 10321Helical; Name=2; Potential
Topological domain104 – 12320Extracellular Potential
Transmembrane124 – 14623Helical; Name=3; Potential
Topological domain147 – 16519Cytoplasmic Potential
Transmembrane166 – 18621Helical; Name=4; Potential
Topological domain187 – 21428Extracellular Potential
Transmembrane215 – 23521Helical; Name=5; Potential
Topological domain236 – 26530Cytoplasmic Potential
Transmembrane266 – 28621Helical; Name=6; Potential
Topological domain287 – 30115Extracellular Potential
Transmembrane302 – 32221Helical; Name=7; Potential
Topological domain323 – 41593Cytoplasmic Potential

Amino acid modifications

Glycosylation91N-linked (GlcNAc...) Potential
Glycosylation271N-linked (GlcNAc...) Potential
Glycosylation1941N-linked (GlcNAc...) Potential
Disulfide bond119 ↔ 204 By similarity

Natural variations

Natural variant2981S → T.
Corresponds to variant rs4958535 [ dbSNP | Ensembl ].
VAR_023941
Natural variant3151F → L.
Corresponds to variant rs1895245 [ dbSNP | Ensembl ].
VAR_023942
Natural variant3831P → L.
Corresponds to variant rs4958532 [ dbSNP | Ensembl ].
VAR_032770
Natural variant3881M → V.
Corresponds to variant rs4958531 [ dbSNP | Ensembl ].
VAR_023943
Natural variant3951A → T. Ref.1 Ref.2 Ref.3 Ref.5 Ref.6
Corresponds to variant rs1363422 [ dbSNP | Ensembl ].
VAR_023944

Experimental info

Sequence conflict2041C → F in AAH16938. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q9GZQ4 [UniParc].

Last modified November 2, 2010. Version 2.
Checksum: C2BACD84A812890F

FASTA41547,696
        10         20         30         40         50         60 
MSGMEKLQNA SWIYQQKLED PFQKHLNSTE EYLAFLCGPR RSHFFLPVSV VYVPIFVVGV 

        70         80         90        100        110        120 
IGNVLVCLVI LQHQAMKTPT NYYLFSLAVS DLLVLLLGMP LEVYEMWRNY PFLFGPVGCY 

       130        140        150        160        170        180 
FKTALFETVC FASILSITTV SVERYVAILH PFRAKLQSTR RRALRILGIV WGFSVLFSLP 

       190        200        210        220        230        240 
NTSIHGIKFH YFPNGSLVPG SATCTVIKPM WIYNFIIQVT SFLFYLLPMT VISVLYYLMA 

       250        260        270        280        290        300 
LRLKKDKSLE ADEGNANIQR PCRKSVNKML FVLVLVFAIC WAPFHIDRLF FSFVEEWSES 

       310        320        330        340        350        360 
LAAVFNLVHV VSGVFFYLSS AVNPIIYNLL SRRFQAAFQN VISSFHKQWH SQHDPQLPPA 

       370        380        390        400        410 
QRNIFLTECH FVELTEDIGP QFPCQSSMHN SHLPAALSSE QMSRTNYQSF HFNKT 

« Hide

References

« Hide 'large scale' references
[1]"Identification and functional characterization of a novel subtype of neuromedin U receptor."
Hosoya M., Moriya T., Kawamata Y., Ohkubo S., Fujii R., Matsui H., Shintani Y., Fukusumi S., Habata Y., Hinuma S., Onda H., Nishimura O., Fujino M.
J. Biol. Chem. 275:29528-29532(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT THR-395.
[2]"Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system."
Raddatz R., Wilson A.E., Artymyshyn R., Bonini J.A., Borowsky B., Boteju L.W., Zhou S., Kouranova E.V., Nagorny R., Guevarra M.S., Dai M., Lerman G.S., Vaysse P.J., Branchek T.A., Gerald C., Forray C., Adham N.
J. Biol. Chem. 275:32452-32459(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANT THR-395.
[3]"Identification of a novel neuromedin U receptor subtype expressed in the central nervous system."
Shan L., Qiao X., Crona J.H., Behan J., Wang S., Laz T., Bayne M., Gustafson E.L., Monsma F.J. Jr., Hedrick J.A.
J. Biol. Chem. 275:39482-39486(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT THR-395.
[4]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-395.
Tissue: Colon and Placenta.
[6]"Identification of receptors for neuromedin U and its role in feeding."
Howard A.D., Wang R., Pong S.-S., Mellin T.N., Strack A., Guan X.-M., Zeng Z., Williams D.L., Feighner S.D., Nunes C.N., Murphy B., Stair J.N., Yu H., Jiang Q., Clements M.K., Tan C.P., Mckee K.K., Hreniuk D.L. expand/collapse author list , Mcdonald T.P., Lynch K.R., Evans J.F., Austin C.P., Caskey T., van der Ploeg L.H.T., Liu Q.
Nature 406:70-74(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-415, TISSUE SPECIFICITY, VARIANT THR-395.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB041228 mRNA. Translation: BAB13721.1. Different initiation.
AF272363 mRNA. Translation: AAG24794.1.
AF292402 mRNA. Translation: AAG03064.1.
AC008571 Genomic DNA. No translation available.
BC016938 mRNA. Translation: AAH16938.1.
BC067776 mRNA. Translation: AAH67776.1.
AF242874 mRNA. Translation: AAF82755.1.
RefSeqNP_064552.3. NM_020167.4.
UniGeneHs.731911.

3D structure databases

ProteinModelPortalQ9GZQ4.
SMRQ9GZQ4. Positions 48-343.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121250. 2 interactions.
STRING9606.ENSP00000255262.

Chemistry

ChEMBLCHEMBL1075144.
GuidetoPHARMACOLOGY299.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9GZQ4.

Polymorphism databases

DMDM311033403.

Proteomic databases

PaxDbQ9GZQ4.
PRIDEQ9GZQ4.

Protocols and materials databases

DNASU56923.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000255262; ENSP00000255262; ENSG00000132911.
GeneID56923.
KEGGhsa:56923.
UCSCuc003luv.2. human.

Organism-specific databases

CTD56923.
GeneCardsGC05M151751.
H-InvDBHIX0005335.
HGNCHGNC:16454. NMUR2.
HPAHPA045836.
MIM605108. gene.
neXtProtNX_Q9GZQ4.
PharmGKBPA31664.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG308321.
HOGENOMHOG000113804.
HOVERGENHBG103506.
InParanoidQ9GZQ4.
KOK05053.
OMALFYILPM.
OrthoDBEOG7GXPBG.
PhylomeDBQ9GZQ4.
TreeFamTF318522.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ9GZQ4.
CleanExHS_NMUR2.
GenevestigatorQ9GZQ4.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005390. NeuromedU_rcpt.
IPR005392. NeuromedU_rcpt_2.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01567. NEUROMEDNU2R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiNeuromedin_U_receptor_2.
GenomeRNAi56923.
NextBio62432.
PROQ9GZQ4.
SOURCESearch...

Entry information

Entry nameNMUR2_HUMAN
AccessionPrimary (citable) accession number: Q9GZQ4
Secondary accession number(s): Q7LC54, Q96AM5, Q9NRA6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 2, 2010
Last modified: April 16, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries