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Q9GZQ4

- NMUR2_HUMAN

UniProt

Q9GZQ4 - NMUR2_HUMAN

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Protein

Neuromedin-U receptor 2

Gene

NMUR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for the neuromedin-U and neuromedin-S neuropeptides.By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: ProtInc
  2. GTP binding Source: UniProtKB
  3. intracellular calcium activated chloride channel activity Source: UniProtKB
  4. neuromedin U binding Source: UniProtKB
  5. neuromedin U receptor activity Source: UniProtKB

GO - Biological processi

  1. activation of phospholipase A2 activity by calcium-mediated signaling Source: UniProtKB
  2. arachidonic acid secretion Source: UniProtKB
  3. calcium ion transport Source: UniProtKB
  4. calcium-mediated signaling Source: UniProtKB
  5. cell-cell signaling Source: ProtInc
  6. central nervous system development Source: UniProtKB
  7. chloride transmembrane transport Source: GOC
  8. chloride transport Source: GOC
  9. feeding behavior Source: ProtInc
  10. grooming behavior Source: Ensembl
  11. inositol phosphate-mediated signaling Source: UniProtKB
  12. neuropeptide signaling pathway Source: ProtInc
  13. phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  14. positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  15. reduction of food intake in response to dietary excess Source: Ensembl
  16. regulation of smooth muscle contraction Source: UniProtKB
  17. response to pain Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U receptor 2
Short name:
NMU-R2
Alternative name(s):
G-protein coupled receptor FM-4
G-protein coupled receptor TGR-1
Gene namesi
Name:NMUR2
Synonyms:NMU2R, TGR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:16454. NMUR2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31664.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Neuromedin-U receptor 2PRO_0000069910Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi119 ↔ 204PROSITE-ProRule annotation
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9GZQ4.
PRIDEiQ9GZQ4.

PTM databases

PhosphoSiteiQ9GZQ4.

Expressioni

Tissue specificityi

Predominantly expressed in the CNS, particularly in the medulla oblongata, pontine reticular formation, spinal cord, and thalamus. High level in testis whereas lower levels are present in a variety of peripheral tissues including the gastrointestinal tract, genitourinary tract, liver, pancreas, adrenal gland, thyroid gland, lung, trachea, spleen and thymus.4 Publications

Gene expression databases

BgeeiQ9GZQ4.
CleanExiHS_NMUR2.
GenevestigatoriQ9GZQ4.

Organism-specific databases

HPAiHPA045836.

Interactioni

Protein-protein interaction databases

BioGridi121250. 2 interactions.
STRINGi9606.ENSP00000255262.

Structurei

3D structure databases

ProteinModelPortaliQ9GZQ4.
SMRiQ9GZQ4. Positions 48-338.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949ExtracellularSequence AnalysisAdd
BLAST
Topological domaini71 – 8212CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini104 – 12320ExtracellularSequence AnalysisAdd
BLAST
Topological domaini147 – 16519CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini187 – 21428ExtracellularSequence AnalysisAdd
BLAST
Topological domaini236 – 26530CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini287 – 30115ExtracellularSequence AnalysisAdd
BLAST
Topological domaini323 – 41593CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei50 – 7021Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei83 – 10321Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei124 – 14623Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei166 – 18621Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei215 – 23521Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei266 – 28621Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei302 – 32221Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG308321.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000113804.
HOVERGENiHBG103506.
InParanoidiQ9GZQ4.
KOiK05053.
OMAiLFYILPM.
OrthoDBiEOG7GXPBG.
PhylomeDBiQ9GZQ4.
TreeFamiTF318522.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005390. NeuromedU_rcpt.
IPR005392. NeuromedU_rcpt_2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01567. NEUROMEDNU2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GZQ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGMEKLQNA SWIYQQKLED PFQKHLNSTE EYLAFLCGPR RSHFFLPVSV
60 70 80 90 100
VYVPIFVVGV IGNVLVCLVI LQHQAMKTPT NYYLFSLAVS DLLVLLLGMP
110 120 130 140 150
LEVYEMWRNY PFLFGPVGCY FKTALFETVC FASILSITTV SVERYVAILH
160 170 180 190 200
PFRAKLQSTR RRALRILGIV WGFSVLFSLP NTSIHGIKFH YFPNGSLVPG
210 220 230 240 250
SATCTVIKPM WIYNFIIQVT SFLFYLLPMT VISVLYYLMA LRLKKDKSLE
260 270 280 290 300
ADEGNANIQR PCRKSVNKML FVLVLVFAIC WAPFHIDRLF FSFVEEWSES
310 320 330 340 350
LAAVFNLVHV VSGVFFYLSS AVNPIIYNLL SRRFQAAFQN VISSFHKQWH
360 370 380 390 400
SQHDPQLPPA QRNIFLTECH FVELTEDIGP QFPCQSSMHN SHLPAALSSE
410
QMSRTNYQSF HFNKT
Length:415
Mass (Da):47,696
Last modified:November 2, 2010 - v2
Checksum:iC2BACD84A812890F
GO

Sequence cautioni

The sequence BAB13721.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti204 – 2041C → F in AAH16938. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti298 – 2981S → T.
Corresponds to variant rs4958535 [ dbSNP | Ensembl ].
VAR_023941
Natural varianti315 – 3151F → L.
Corresponds to variant rs1895245 [ dbSNP | Ensembl ].
VAR_023942
Natural varianti383 – 3831P → L.
Corresponds to variant rs4958532 [ dbSNP | Ensembl ].
VAR_032770
Natural varianti388 – 3881M → V.
Corresponds to variant rs4958531 [ dbSNP | Ensembl ].
VAR_023943
Natural varianti395 – 3951A → T.5 Publications
Corresponds to variant rs1363422 [ dbSNP | Ensembl ].
VAR_023944

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB041228 mRNA. Translation: BAB13721.1. Different initiation.
AF272363 mRNA. Translation: AAG24794.1.
AF292402 mRNA. Translation: AAG03064.1.
AC008571 Genomic DNA. No translation available.
BC016938 mRNA. Translation: AAH16938.1.
BC067776 mRNA. Translation: AAH67776.1.
AF242874 mRNA. Translation: AAF82755.1.
CCDSiCCDS4321.1.
RefSeqiNP_064552.3. NM_020167.4.
UniGeneiHs.731911.

Genome annotation databases

EnsembliENST00000255262; ENSP00000255262; ENSG00000132911.
GeneIDi56923.
KEGGihsa:56923.
UCSCiuc003luv.2. human.

Polymorphism databases

DMDMi311033403.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB041228 mRNA. Translation: BAB13721.1 . Different initiation.
AF272363 mRNA. Translation: AAG24794.1 .
AF292402 mRNA. Translation: AAG03064.1 .
AC008571 Genomic DNA. No translation available.
BC016938 mRNA. Translation: AAH16938.1 .
BC067776 mRNA. Translation: AAH67776.1 .
AF242874 mRNA. Translation: AAF82755.1 .
CCDSi CCDS4321.1.
RefSeqi NP_064552.3. NM_020167.4.
UniGenei Hs.731911.

3D structure databases

ProteinModelPortali Q9GZQ4.
SMRi Q9GZQ4. Positions 48-338.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121250. 2 interactions.
STRINGi 9606.ENSP00000255262.

Chemistry

ChEMBLi CHEMBL1075144.
GuidetoPHARMACOLOGYi 299.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9GZQ4.

Polymorphism databases

DMDMi 311033403.

Proteomic databases

PaxDbi Q9GZQ4.
PRIDEi Q9GZQ4.

Protocols and materials databases

DNASUi 56923.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000255262 ; ENSP00000255262 ; ENSG00000132911 .
GeneIDi 56923.
KEGGi hsa:56923.
UCSCi uc003luv.2. human.

Organism-specific databases

CTDi 56923.
GeneCardsi GC05M151751.
H-InvDB HIX0005335.
HGNCi HGNC:16454. NMUR2.
HPAi HPA045836.
MIMi 605108. gene.
neXtProti NX_Q9GZQ4.
PharmGKBi PA31664.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG308321.
GeneTreei ENSGT00700000104070.
HOGENOMi HOG000113804.
HOVERGENi HBG103506.
InParanoidi Q9GZQ4.
KOi K05053.
OMAi LFYILPM.
OrthoDBi EOG7GXPBG.
PhylomeDBi Q9GZQ4.
TreeFami TF318522.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii Neuromedin_U_receptor_2.
GenomeRNAii 56923.
NextBioi 62432.
PROi Q9GZQ4.
SOURCEi Search...

Gene expression databases

Bgeei Q9GZQ4.
CleanExi HS_NMUR2.
Genevestigatori Q9GZQ4.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005390. NeuromedU_rcpt.
IPR005392. NeuromedU_rcpt_2.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01567. NEUROMEDNU2R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and functional characterization of a novel subtype of neuromedin U receptor."
    Hosoya M., Moriya T., Kawamata Y., Ohkubo S., Fujii R., Matsui H., Shintani Y., Fukusumi S., Habata Y., Hinuma S., Onda H., Nishimura O., Fujino M.
    J. Biol. Chem. 275:29528-29532(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT THR-395.
  2. "Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system."
    Raddatz R., Wilson A.E., Artymyshyn R., Bonini J.A., Borowsky B., Boteju L.W., Zhou S., Kouranova E.V., Nagorny R., Guevarra M.S., Dai M., Lerman G.S., Vaysse P.J., Branchek T.A., Gerald C., Forray C., Adham N.
    J. Biol. Chem. 275:32452-32459(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANT THR-395.
  3. "Identification of a novel neuromedin U receptor subtype expressed in the central nervous system."
    Shan L., Qiao X., Crona J.H., Behan J., Wang S., Laz T., Bayne M., Gustafson E.L., Monsma F.J. Jr., Hedrick J.A.
    J. Biol. Chem. 275:39482-39486(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT THR-395.
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-395.
    Tissue: Colon and Placenta.
  6. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-415, TISSUE SPECIFICITY, VARIANT THR-395.

Entry informationi

Entry nameiNMUR2_HUMAN
AccessioniPrimary (citable) accession number: Q9GZQ4
Secondary accession number(s): Q7LC54, Q96AM5, Q9NRA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3