Q9GZQ3 (COMD5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
COMM domain-containing protein 5

Alternative name(s):
Hypertension-related calcium-regulated gene protein
Short name=HCaRG

Gene names

Name:	COMMD5
ORF Names:	HT002

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Down-regulates activation of NF-kappa-B. Ref.6
Subunit structure	Interacts (via COMM domain) with COMMD1 (via COMM domain). Ref.6
Subcellular location	Nucleus By similarity.
Tissue specificity	Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver. Ref.1 Ref.6
Sequence similarities	Contains 1 COMM domain.
Sequence caution	The sequence AAF14877.1 differs from that shown. Reason: Frameshift at positions 66, 84, 112 and 136.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction Ref.6. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	COMM domain-containing protein 5		PRO_0000077395
Regions
	Domain	151 – 215	65	COMM
Natural variations
	Natural variant	6	1	A → T. Ref.2 Corresponds to variant rs1209879 [ dbSNP | Ensembl ].		VAR_020130
	Natural variant	69	1	Q → H. Corresponds to variant rs421427 [ dbSNP | Ensembl ].		VAR_048812
Experimental info
	Sequence conflict	108	1	T → I in BAA91714. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9GZQ3 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: C4CC0563B9FA3240	FASTA	224	24,670
	10 20 30 40 50 60 MSAVGAATPY LHHPGDSHSG RVSFLGAQLP PEVAAMARLL GDLDRSTFRK LLKFVVSSLQ 70 80 90 100 110 120 GEDCREAVQR LGVSANLPEE QLGALLAGMH TLLQQALRLP PTSLKPDTFR DQLQELCIPQ 130 140 150 160 170 180 DLVGDLASVV FGSQRPLLDS VAQQQGAWLP HVADFRWRVD VAISTSALAR SLQPSVLMQL 190 200 210 220 KLSDGSAYRF EVPTAKFQEL RYSVALVLKE MADLEKRCER RLQD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"HCaRG, a novel calcium-regulated gene coding for a nuclear protein, is potentially involved in the regulation of cell proliferation." Solban N., Jia H.-P., Richard S., Tremblay S., Devlin A.M., Peng J., Gossard F., Guo D.-F., Morel G., Hamet P., Lewanczuk R., Tremblay J. J. Biol. Chem. 275:32234-32243(2000) [PubMed: 10918053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Parathyroid.
[2]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-6. Tissue: Hypothalamus.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin and Uterus.
[6]	"COMMD proteins, a novel family of structural and functional homologs of MURR1." Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A., Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S. J. Biol. Chem. 280:22222-22232(2005) [PubMed: 15799966] [Abstract] Cited for: FUNCTION, INTERACTION WITH COMMD1, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF290195 mRNA. Translation: AAG09915.1. AF113540 mRNA. Translation: AAF14877.1. Frameshift. AK001477 mRNA. Translation: BAA91714.1. AK023070 mRNA. Translation: BAB14389.1. CH471162 Genomic DNA. Translation: EAW82033.1. CH471162 Genomic DNA. Translation: EAW82034.1. CH471162 Genomic DNA. Translation: EAW82035.1. CH471162 Genomic DNA. Translation: EAW82036.1. CH471162 Genomic DNA. Translation: EAW82037.1. BC002672 mRNA. Translation: AAH02672.1. BC003055 mRNA. Translation: AAH03055.1. BC065729 mRNA. Translation: AAH65729.1.
IPI	IPI00101106.
RefSeq	NP_001074472.1. NM_001081003.1. NP_001074473.1. NM_001081004.1. NP_054785.2. NM_014066.3.
UniGene	Hs.631856.
3D structure databases
ProteinModelPortal	Q9GZQ3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9GZQ3. 4 interactions.
STRING	Q9GZQ3.
Polymorphism databases
DMDM	51316093.
Proteomic databases
PeptideAtlas	Q9GZQ3.
PRIDE	Q9GZQ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000305103; ENSP00000304544; ENSG00000170619. ENST00000402718; ENSP00000385793; ENSG00000170619. ENST00000450361; ENSP00000394331; ENSG00000170619.
GeneID	28991.
KEGG	hsa:28991.
UCSC	uc003zem.1. human.
Organism-specific databases
CTD	28991.
GeneCards	GC08M146075.
HGNC	HGNC:17902. COMMD5.
MIM	608216. gene.
neXtProt	NX_Q9GZQ3.
PharmGKB	PA134873412.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11611.
GeneTree	ENSGT00390000013770.
HOGENOM	HBG506691.
HOVERGEN	HBG051070.
InParanoid	Q9GZQ3.
OMA	DFRWRVD.
OrthoDB	EOG4VQ9Q5.
PhylomeDB	Q9GZQ3.
Gene expression databases
ArrayExpress	Q9GZQ3.
Bgee	Q9GZQ3.
CleanEx	HS_COMMD5.
Genevestigator	Q9GZQ3.
GermOnline	ENSG00000170619. Homo sapiens.
Family and domain databases
InterPro	IPR017920. COMM. IPR009886. HCaRG. [Graphical view]
Pfam	PF07258. HCaRG. 1 hit. [Graphical view]
PROSITE	PS51269. COMM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	51913.
SOURCE	Search...

Entry information

Entry name

COMD5_HUMAN

Accession

Primary (citable) accession number: Q9GZQ3
Secondary accession number(s): D3DWN7, Q9NVN6, Q9UHX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	March 1, 2001
Last modified:	January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.