Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

COMM domain-containing protein 5

Gene

COMMD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966).By similarity1 Publication1 Publication

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 5
Alternative name(s):
Hypertension-related calcium-regulated gene protein
Short name:
HCaRG
Gene namesi
Name:COMMD5
ORF Names:HT002
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000170619.9
HGNCiHGNC:17902 COMMD5
MIMi608216 gene
neXtProtiNX_Q9GZQ3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi28991
OpenTargetsiENSG00000170619
PharmGKBiPA134873412

Polymorphism and mutation databases

BioMutaiCOMMD5
DMDMi51316093

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000773952 – 224COMM domain-containing protein 5Add BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9GZQ3
MaxQBiQ9GZQ3
PaxDbiQ9GZQ3
PeptideAtlasiQ9GZQ3
PRIDEiQ9GZQ3

PTM databases

iPTMnetiQ9GZQ3
PhosphoSitePlusiQ9GZQ3

Expressioni

Tissue specificityi

Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver.2 Publications

Gene expression databases

BgeeiENSG00000170619
CleanExiHS_COMMD5
ExpressionAtlasiQ9GZQ3 baseline and differential
GenevisibleiQ9GZQ3 HS

Organism-specific databases

HPAiHPA046905

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL2, CUL3, CUL4A, CUL4B, CUL7.5 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi11881220 interactors.
CORUMiQ9GZQ3
IntActiQ9GZQ3 9 interactors.
STRINGi9606.ENSP00000304544

Structurei

3D structure databases

ProteinModelPortaliQ9GZQ3
SMRiQ9GZQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini151 – 215COMMPROSITE-ProRule annotationAdd BLAST65

Phylogenomic databases

eggNOGiENOG410IFHH Eukaryota
ENOG4111FTK LUCA
GeneTreeiENSGT00390000013770
HOGENOMiHOG000007429
HOVERGENiHBG051070
InParanoidiQ9GZQ3
OMAiFKWRVDV
OrthoDBiEOG091G0ZTA
PhylomeDBiQ9GZQ3
TreeFamiTF323880

Family and domain databases

InterProiView protein in InterPro
IPR017920 COMM
IPR037357 COMMD5
PANTHERiPTHR15666 PTHR15666, 1 hit
PfamiView protein in Pfam
PF07258 COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269 COMM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9GZQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAVGAATPY LHHPGDSHSG RVSFLGAQLP PEVAAMARLL GDLDRSTFRK
60 70 80 90 100
LLKFVVSSLQ GEDCREAVQR LGVSANLPEE QLGALLAGMH TLLQQALRLP
110 120 130 140 150
PTSLKPDTFR DQLQELCIPQ DLVGDLASVV FGSQRPLLDS VAQQQGAWLP
160 170 180 190 200
HVADFRWRVD VAISTSALAR SLQPSVLMQL KLSDGSAYRF EVPTAKFQEL
210 220
RYSVALVLKE MADLEKRCER RLQD
Length:224
Mass (Da):24,670
Last modified:March 1, 2001 - v1
Checksum:iC4CC0563B9FA3240
GO

Sequence cautioni

The sequence AAF14877 differs from that shown. Reason: Frameshift at positions 66, 84, 112 and 136.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108T → I in BAA91714 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0201306A → T1 PublicationCorresponds to variant dbSNP:rs1209879Ensembl.1
Natural variantiVAR_04881269Q → H. Corresponds to variant dbSNP:rs421427Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF290195 mRNA Translation: AAG09915.1
AF113540 mRNA Translation: AAF14877.1 Frameshift.
AK001477 mRNA Translation: BAA91714.1
AK023070 mRNA Translation: BAB14389.1
CH471162 Genomic DNA Translation: EAW82033.1
CH471162 Genomic DNA Translation: EAW82034.1
CH471162 Genomic DNA Translation: EAW82035.1
CH471162 Genomic DNA Translation: EAW82036.1
CH471162 Genomic DNA Translation: EAW82037.1
BC002672 mRNA Translation: AAH02672.1
BC003055 mRNA Translation: AAH03055.1
BC065729 mRNA Translation: AAH65729.1
CCDSiCCDS6436.1
RefSeqiNP_001074472.1, NM_001081003.2
NP_001074473.1, NM_001081004.2
NP_001274166.1, NM_001287237.1
NP_054785.2, NM_014066.3
UniGeneiHs.493218
Hs.631856

Genome annotation databases

EnsembliENST00000305103; ENSP00000304544; ENSG00000170619
ENST00000402718; ENSP00000385793; ENSG00000170619
ENST00000450361; ENSP00000394331; ENSG00000170619
ENST00000543949; ENSP00000445840; ENSG00000170619
GeneIDi28991
KEGGihsa:28991
UCSCiuc003zem.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCOMD5_HUMAN
AccessioniPrimary (citable) accession number: Q9GZQ3
Secondary accession number(s): D3DWN7, Q9NVN6, Q9UHX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome