Q9GZP7 (VN1R1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vomeronasal type-1 receptor 1

Alternative name(s):
G-protein coupled receptor GPCR24
Short name=hGPCR24
V1r-like receptor 1
V3r-related gene protein
Vomeronasal olfactory receptor chromosome 19 subtype I member 1

Gene names

Name:	VN1R1
Synonyms:	V1RL1, VNR19I1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative pheromone receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in the olfactory mucosa, very low expression in brain, lung and kidney. Ref.1
Miscellaneous	The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Pheromone response
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to pheromone Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW membrane Non-traceable author statement. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	pheromone receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 353	353	Vomeronasal type-1 receptor 1		PRO_0000070213
Regions
	Topological domain	1 – 56	56	Extracellular Potential
	Transmembrane	57 – 77	21	Helical; Name=1; Potential
	Topological domain	78 – 84	7	Cytoplasmic Potential
	Transmembrane	85 – 105	21	Helical; Name=2; Potential
	Topological domain	106 – 132	27	Extracellular Potential
	Transmembrane	133 – 153	21	Helical; Name=3; Potential
	Topological domain	154 – 169	16	Cytoplasmic Potential
	Transmembrane	170 – 190	21	Helical; Name=4; Potential
	Topological domain	191 – 226	36	Extracellular Potential
	Transmembrane	227 – 247	21	Helical; Name=5; Potential
	Topological domain	248 – 274	27	Cytoplasmic Potential
	Transmembrane	275 – 295	21	Helical; Name=6; Potential
	Topological domain	296 – 303	8	Extracellular Potential
	Transmembrane	304 – 324	21	Helical; Name=7; Potential
	Topological domain	325 – 353	29	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	117	1	N-linked (GlcNAc...) Potential
	Glycosylation	198	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	103	1	I → M. Corresponds to variant rs3746223 [ dbSNP | Ensembl ].		VAR_049452
	Natural variant	139	1	I → T in allele VN1R1*2. Ref.3		VAR_022795
	Natural variant	241	1	S → F in allele VN1R1*3. Ref.1 Ref.3 Corresponds to variant rs28649880 [ dbSNP | Ensembl ].		VAR_022796
	Natural variant	269	1	A → D in allele VN1R1*3. Ref.1 Ref.3		VAR_022797

Sequences

	Sequence		Length	Mass (Da)
	Q9GZP7 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: CCB0E9BAFA5EC021	FASTA	353	40,021
	10 20 30 40 50 60 MVGDTLKLLS PLMTRYFFLL FYSTDSSDLN ENQHPLDFDE MAFGKVKSGI SFLIQTGVGI 70 80 90 100 110 120 LGNSFLLCFY NLILFTGHKL RPTDLILSQL ALANSMVLFF KGIPQTMAAF GLKYLLNDTG 130 140 150 160 170 180 CKFVFYYHRV GTRVSLSTIC LLNGFQAIKL NPSICRWMEI KIRSPRFIDF CCLLCWAPHV 190 200 210 220 230 240 LMNASVLLLV NGPLNSKNSS AKNNYGYCSY KASKRFSSLH AVLYFSPDFM SLGFMVWASG 250 260 270 280 290 300 SMVFFLYRHK QQVQHNHSNR LSCRPSQEAR ATHTIMVLVS SFFVFYSVHS FLTIWTTVVA 310 320 330 340 350 NPGQWIVTNS VLVASCFPAR SPFVLIMSDT HISQFCFACR TRKTLFPNLV VMP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A putative pheromone receptor gene expressed in human olfactory mucosa." Rodriguez I., Greer C.A., Mok M.Y., Mombaerts P. Nat. Genet. 26:18-19(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS PHE-241 AND ASP-269.
[2]	"Human pheromone receptor ortholog subtype I member 1." Holloway J., Lofton-Day C., Lok S. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates." Zhang J., Webb D.M. Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-139; PHE-241 AND ASP-269.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum.
[5]	"Identification of G protein-coupled receptor genes from the human genome sequence." Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S. FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Web resources

Protein Spotlight

No one nose - Issue 61 of August 2005

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF255342 mRNA. Translation: AAG10698.1. AF302903 mRNA. Translation: AAG22545.1. AY312477 Genomic DNA. Translation: AAP85612.1. AY312478 Genomic DNA. Translation: AAP85613.1. AY312479 Genomic DNA. Translation: AAP85614.1. AK094452 mRNA. Translation: BAG52867.1. AB083606 Genomic DNA. Translation: BAB89319.1. CH471135 Genomic DNA. Translation: EAW72503.1. BC095508 mRNA. Translation: AAH95508.1.
IPI	IPI00009853.
RefSeq	NP_065684.1. NM_020633.3.
UniGene	Hs.677423. Hs.736494.
3D structure databases
ProteinModelPortal	Q9GZP7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000322339.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9GZP7.
Polymorphism databases
DMDM	71153399.
Proteomic databases
PaxDb	Q9GZP7.
PRIDE	Q9GZP7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000321039; ENSP00000322339; ENSG00000178201.
GeneID	57191.
KEGG	hsa:57191.
UCSC	uc002qos.2. human.
Organism-specific databases
CTD	57191.
GeneCards	GC19M057966.
HGNC	HGNC:13548. VN1R1.
MIM	605234. gene.
neXtProt	NX_Q9GZP7.
PharmGKB	PA134957891.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG113005.
HOGENOM	HOG000231675.
HOVERGEN	HBG073430.
InParanoid	Q9GZP7.
KO	K04614.
OMA	MEIKIRS.
OrthoDB	EOG45DWQ9.
PhylomeDB	Q9GZP7.
Gene expression databases
Bgee	Q9GZP7.
CleanEx	HS_VN1R1.
Genevestigator	Q9GZP7.
GermOnline	ENSG00000178201. Homo sapiens.
Family and domain databases
InterPro	IPR017452. GPCR_Rhodpsn_7TM. IPR004072. Vmron_rcpt_1. [Graphical view]
Pfam	PF03402. V1R. 1 hit. [Graphical view]
PRINTS	PR01534. VOMERONASL1R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	57191.
NextBio	63274.
SOURCE	Search...

Entry information

Entry name

VN1R1_HUMAN

Accession

Primary (citable) accession number: Q9GZP7
Secondary accession number(s): B3KSV5, Q7Z5H8, Q7Z5H9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.