Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9GZP7 (VN1R1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vomeronasal type-1 receptor 1
Alternative name(s):
G-protein coupled receptor GPCR24
Short name=hGPCR24
V1r-like receptor 1
V3r-related gene protein
Vomeronasal olfactory receptor chromosome 19 subtype I member 1
Gene names
Name:VN1R1
Synonyms:V1RL1, VNR19I1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative pheromone receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed in the olfactory mucosa, very low expression in brain, lung and kidney. Ref.1

Miscellaneous

The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Biological processPheromone response
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to pheromone

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpheromone receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353Vomeronasal type-1 receptor 1
PRO_0000070213

Regions

Topological domain1 – 5656Extracellular Potential
Transmembrane57 – 7721Helical; Name=1; Potential
Topological domain78 – 847Cytoplasmic Potential
Transmembrane85 – 10521Helical; Name=2; Potential
Topological domain106 – 13227Extracellular Potential
Transmembrane133 – 15321Helical; Name=3; Potential
Topological domain154 – 16916Cytoplasmic Potential
Transmembrane170 – 19021Helical; Name=4; Potential
Topological domain191 – 22636Extracellular Potential
Transmembrane227 – 24721Helical; Name=5; Potential
Topological domain248 – 27427Cytoplasmic Potential
Transmembrane275 – 29521Helical; Name=6; Potential
Topological domain296 – 3038Extracellular Potential
Transmembrane304 – 32421Helical; Name=7; Potential
Topological domain325 – 35329Cytoplasmic Potential

Amino acid modifications

Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation1981N-linked (GlcNAc...) Potential

Natural variations

Natural variant1031I → M.
Corresponds to variant rs3746223 [ dbSNP | Ensembl ].
VAR_049452
Natural variant1391I → T in allele VN1R1*2. Ref.3
VAR_022795
Natural variant2411S → F in allele VN1R1*3. Ref.1 Ref.3
Corresponds to variant rs28649880 [ dbSNP | Ensembl ].
VAR_022796
Natural variant2691A → D in allele VN1R1*3. Ref.1 Ref.3
Corresponds to variant rs61744949 [ dbSNP | Ensembl ].
VAR_022797

Sequences

Sequence LengthMass (Da)Tools
Q9GZP7 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: CCB0E9BAFA5EC021

FASTA35340,021
        10         20         30         40         50         60 
MVGDTLKLLS PLMTRYFFLL FYSTDSSDLN ENQHPLDFDE MAFGKVKSGI SFLIQTGVGI 

        70         80         90        100        110        120 
LGNSFLLCFY NLILFTGHKL RPTDLILSQL ALANSMVLFF KGIPQTMAAF GLKYLLNDTG 

       130        140        150        160        170        180 
CKFVFYYHRV GTRVSLSTIC LLNGFQAIKL NPSICRWMEI KIRSPRFIDF CCLLCWAPHV 

       190        200        210        220        230        240 
LMNASVLLLV NGPLNSKNSS AKNNYGYCSY KASKRFSSLH AVLYFSPDFM SLGFMVWASG 

       250        260        270        280        290        300 
SMVFFLYRHK QQVQHNHSNR LSCRPSQEAR ATHTIMVLVS SFFVFYSVHS FLTIWTTVVA 

       310        320        330        340        350 
NPGQWIVTNS VLVASCFPAR SPFVLIMSDT HISQFCFACR TRKTLFPNLV VMP 

« Hide

References

« Hide 'large scale' references
[1]"A putative pheromone receptor gene expressed in human olfactory mucosa."
Rodriguez I., Greer C.A., Mok M.Y., Mombaerts P.
Nat. Genet. 26:18-19(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS PHE-241 AND ASP-269.
[2]"Human pheromone receptor ortholog subtype I member 1."
Holloway J., Lofton-Day C., Lok S.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."
Zhang J., Webb D.M.
Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-139; PHE-241 AND ASP-269.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.
[5]"Identification of G protein-coupled receptor genes from the human genome sequence."
Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Web resources

Protein Spotlight

No one nose - Issue 61 of August 2005

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF255342 mRNA. Translation: AAG10698.1.
AF302903 mRNA. Translation: AAG22545.1.
AY312477 Genomic DNA. Translation: AAP85612.1.
AY312478 Genomic DNA. Translation: AAP85613.1.
AY312479 Genomic DNA. Translation: AAP85614.1.
AK094452 mRNA. Translation: BAG52867.1.
AB083606 Genomic DNA. Translation: BAB89319.1.
CH471135 Genomic DNA. Translation: EAW72503.1.
BC095508 mRNA. Translation: AAH95508.1.
CCDSCCDS12951.1.
RefSeqNP_065684.1. NM_020633.3.
UniGeneHs.677423.
Hs.736494.

3D structure databases

ProteinModelPortalQ9GZP7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000322339.

Protein family/group databases

TCDB9.A.14.12.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBSearch...

PTM databases

PhosphoSiteQ9GZP7.

Polymorphism databases

DMDM71153399.

Proteomic databases

PaxDbQ9GZP7.
PRIDEQ9GZP7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000321039; ENSP00000322339; ENSG00000178201.
GeneID57191.
KEGGhsa:57191.
UCSCuc002qos.2. human.

Organism-specific databases

CTD57191.
GeneCardsGC19M057966.
HGNCHGNC:13548. VN1R1.
MIM605234. gene.
neXtProtNX_Q9GZP7.
PharmGKBPA134957891.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG113005.
HOGENOMHOG000231675.
HOVERGENHBG073430.
InParanoidQ9GZP7.
KOK04614.
OMAMEIKIRS.
OrthoDBEOG722J92.
PhylomeDBQ9GZP7.

Gene expression databases

BgeeQ9GZP7.
CleanExHS_VN1R1.
GenevestigatorQ9GZP7.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamPF03402. V1R. 1 hit.
[Graphical view]
PRINTSPR01534. VOMERONASL1R.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiVN1R1.
GenomeRNAi57191.
NextBio63274.
PROQ9GZP7.
SOURCESearch...

Entry information

Entry nameVN1R1_HUMAN
AccessionPrimary (citable) accession number: Q9GZP7
Secondary accession number(s): B3KSV5, Q7Z5H8, Q7Z5H9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries