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Q9GZP7

- VN1R1_HUMAN

UniProt

Q9GZP7 - VN1R1_HUMAN

Protein

Vomeronasal type-1 receptor 1

Gene

VN1R1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Putative pheromone receptor.

    GO - Molecular functioni

    1. pheromone receptor activity Source: InterPro

    GO - Biological processi

    1. response to pheromone Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Pheromone response

    Protein family/group databases

    TCDBi9.A.14.12.1. the g-protein-coupled receptor (gpcr) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vomeronasal type-1 receptor 1
    Alternative name(s):
    G-protein coupled receptor GPCR24
    Short name:
    hGPCR24
    V1r-like receptor 1
    V3r-related gene protein
    Vomeronasal olfactory receptor chromosome 19 subtype I member 1
    Gene namesi
    Name:VN1R1
    Synonyms:V1RL1, VNR19I1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:13548. VN1R1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134957891.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 353353Vomeronasal type-1 receptor 1PRO_0000070213Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9GZP7.
    PRIDEiQ9GZP7.

    PTM databases

    PhosphoSiteiQ9GZP7.

    Expressioni

    Tissue specificityi

    Expressed in the olfactory mucosa, very low expression in brain, lung and kidney.1 Publication

    Gene expression databases

    BgeeiQ9GZP7.
    CleanExiHS_VN1R1.
    GenevestigatoriQ9GZP7.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000322339.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GZP7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5656ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini78 – 847CytoplasmicSequence Analysis
    Topological domaini106 – 13227ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini154 – 16916CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini191 – 22636ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini248 – 27427CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini296 – 3038ExtracellularSequence Analysis
    Topological domaini325 – 35329CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei57 – 7721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei133 – 15321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei227 – 24721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei275 – 29521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG113005.
    HOGENOMiHOG000231675.
    HOVERGENiHBG073430.
    InParanoidiQ9GZP7.
    KOiK04614.
    OMAiMEIKIRS.
    OrthoDBiEOG722J92.
    PhylomeDBiQ9GZP7.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR017452. GPCR_Rhodpsn_7TM.
    IPR004072. Vmron_rcpt_1.
    [Graphical view]
    PfamiPF03402. V1R. 1 hit.
    [Graphical view]
    PRINTSiPR01534. VOMERONASL1R.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9GZP7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVGDTLKLLS PLMTRYFFLL FYSTDSSDLN ENQHPLDFDE MAFGKVKSGI    50
    SFLIQTGVGI LGNSFLLCFY NLILFTGHKL RPTDLILSQL ALANSMVLFF 100
    KGIPQTMAAF GLKYLLNDTG CKFVFYYHRV GTRVSLSTIC LLNGFQAIKL 150
    NPSICRWMEI KIRSPRFIDF CCLLCWAPHV LMNASVLLLV NGPLNSKNSS 200
    AKNNYGYCSY KASKRFSSLH AVLYFSPDFM SLGFMVWASG SMVFFLYRHK 250
    QQVQHNHSNR LSCRPSQEAR ATHTIMVLVS SFFVFYSVHS FLTIWTTVVA 300
    NPGQWIVTNS VLVASCFPAR SPFVLIMSDT HISQFCFACR TRKTLFPNLV 350
    VMP 353
    Length:353
    Mass (Da):40,021
    Last modified:March 1, 2001 - v1
    Checksum:iCCB0E9BAFA5EC021
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti103 – 1031I → M.
    Corresponds to variant rs3746223 [ dbSNP | Ensembl ].
    VAR_049452
    Natural varianti139 – 1391I → T in allele VN1R1*2. 1 Publication
    VAR_022795
    Natural varianti241 – 2411S → F in allele VN1R1*3. 2 Publications
    Corresponds to variant rs28649880 [ dbSNP | Ensembl ].
    VAR_022796
    Natural varianti269 – 2691A → D in allele VN1R1*3. 2 Publications
    Corresponds to variant rs61744949 [ dbSNP | Ensembl ].
    VAR_022797

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF255342 mRNA. Translation: AAG10698.1.
    AF302903 mRNA. Translation: AAG22545.1.
    AY312477 Genomic DNA. Translation: AAP85612.1.
    AY312478 Genomic DNA. Translation: AAP85613.1.
    AY312479 Genomic DNA. Translation: AAP85614.1.
    AK094452 mRNA. Translation: BAG52867.1.
    AB083606 Genomic DNA. Translation: BAB89319.1.
    CH471135 Genomic DNA. Translation: EAW72503.1.
    BC095508 mRNA. Translation: AAH95508.1.
    CCDSiCCDS12951.1.
    RefSeqiNP_065684.1. NM_020633.3.
    UniGeneiHs.677423.
    Hs.736494.

    Genome annotation databases

    EnsembliENST00000321039; ENSP00000322339; ENSG00000178201.
    GeneIDi57191.
    KEGGihsa:57191.
    UCSCiuc002qos.2. human.

    Polymorphism databases

    DMDMi71153399.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    No one nose - Issue 61 of August 2005

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF255342 mRNA. Translation: AAG10698.1 .
    AF302903 mRNA. Translation: AAG22545.1 .
    AY312477 Genomic DNA. Translation: AAP85612.1 .
    AY312478 Genomic DNA. Translation: AAP85613.1 .
    AY312479 Genomic DNA. Translation: AAP85614.1 .
    AK094452 mRNA. Translation: BAG52867.1 .
    AB083606 Genomic DNA. Translation: BAB89319.1 .
    CH471135 Genomic DNA. Translation: EAW72503.1 .
    BC095508 mRNA. Translation: AAH95508.1 .
    CCDSi CCDS12951.1.
    RefSeqi NP_065684.1. NM_020633.3.
    UniGenei Hs.677423.
    Hs.736494.

    3D structure databases

    ProteinModelPortali Q9GZP7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000322339.

    Protein family/group databases

    TCDBi 9.A.14.12.1. the g-protein-coupled receptor (gpcr) family.
    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9GZP7.

    Polymorphism databases

    DMDMi 71153399.

    Proteomic databases

    PaxDbi Q9GZP7.
    PRIDEi Q9GZP7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000321039 ; ENSP00000322339 ; ENSG00000178201 .
    GeneIDi 57191.
    KEGGi hsa:57191.
    UCSCi uc002qos.2. human.

    Organism-specific databases

    CTDi 57191.
    GeneCardsi GC19M057966.
    HGNCi HGNC:13548. VN1R1.
    MIMi 605234. gene.
    neXtProti NX_Q9GZP7.
    PharmGKBi PA134957891.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG113005.
    HOGENOMi HOG000231675.
    HOVERGENi HBG073430.
    InParanoidi Q9GZP7.
    KOi K04614.
    OMAi MEIKIRS.
    OrthoDBi EOG722J92.
    PhylomeDBi Q9GZP7.

    Miscellaneous databases

    GeneWikii VN1R1.
    GenomeRNAii 57191.
    NextBioi 63274.
    PROi Q9GZP7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9GZP7.
    CleanExi HS_VN1R1.
    Genevestigatori Q9GZP7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR017452. GPCR_Rhodpsn_7TM.
    IPR004072. Vmron_rcpt_1.
    [Graphical view ]
    Pfami PF03402. V1R. 1 hit.
    [Graphical view ]
    PRINTSi PR01534. VOMERONASL1R.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A putative pheromone receptor gene expressed in human olfactory mucosa."
      Rodriguez I., Greer C.A., Mok M.Y., Mombaerts P.
      Nat. Genet. 26:18-19(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS PHE-241 AND ASP-269.
    2. "Human pheromone receptor ortholog subtype I member 1."
      Holloway J., Lofton-Day C., Lok S.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."
      Zhang J., Webb D.M.
      Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-139; PHE-241 AND ASP-269.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    5. "Identification of G protein-coupled receptor genes from the human genome sequence."
      Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
      FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiVN1R1_HUMAN
    AccessioniPrimary (citable) accession number: Q9GZP7
    Secondary accession number(s): B3KSV5, Q7Z5H8, Q7Z5H9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3