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Q9GZP7

- VN1R1_HUMAN

UniProt

Q9GZP7 - VN1R1_HUMAN

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Protein

Vomeronasal type-1 receptor 1

Gene

VN1R1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Putative pheromone receptor.

GO - Molecular functioni

  1. pheromone receptor activity Source: InterPro

GO - Biological processi

  1. response to pheromone Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Pheromone response

Protein family/group databases

TCDBi9.A.14.12.1. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-1 receptor 1
Alternative name(s):
G-protein coupled receptor GPCR24
Short name:
hGPCR24
V1r-like receptor 1
V3r-related gene protein
Vomeronasal olfactory receptor chromosome 19 subtype I member 1
Gene namesi
Name:VN1R1
Synonyms:V1RL1, VNR19I1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:13548. VN1R1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134957891.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 353353Vomeronasal type-1 receptor 1PRO_0000070213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9GZP7.
PRIDEiQ9GZP7.

PTM databases

PhosphoSiteiQ9GZP7.

Expressioni

Tissue specificityi

Expressed in the olfactory mucosa, very low expression in brain, lung and kidney.1 Publication

Gene expression databases

BgeeiQ9GZP7.
CleanExiHS_VN1R1.
GenevestigatoriQ9GZP7.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322339.

Structurei

3D structure databases

ProteinModelPortaliQ9GZP7.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5656ExtracellularSequence AnalysisAdd
BLAST
Topological domaini78 – 847CytoplasmicSequence Analysis
Topological domaini106 – 13227ExtracellularSequence AnalysisAdd
BLAST
Topological domaini154 – 16916CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini191 – 22636ExtracellularSequence AnalysisAdd
BLAST
Topological domaini248 – 27427CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini296 – 3038ExtracellularSequence Analysis
Topological domaini325 – 35329CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei57 – 7721Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei85 – 10521Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei133 – 15321Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei170 – 19021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei227 – 24721Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei275 – 29521Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei304 – 32421Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG113005.
GeneTreeiENSGT00760000118911.
HOGENOMiHOG000231675.
HOVERGENiHBG073430.
InParanoidiQ9GZP7.
KOiK04614.
OMAiMEIKIRS.
OrthoDBiEOG722J92.
PhylomeDBiQ9GZP7.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GZP7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVGDTLKLLS PLMTRYFFLL FYSTDSSDLN ENQHPLDFDE MAFGKVKSGI
60 70 80 90 100
SFLIQTGVGI LGNSFLLCFY NLILFTGHKL RPTDLILSQL ALANSMVLFF
110 120 130 140 150
KGIPQTMAAF GLKYLLNDTG CKFVFYYHRV GTRVSLSTIC LLNGFQAIKL
160 170 180 190 200
NPSICRWMEI KIRSPRFIDF CCLLCWAPHV LMNASVLLLV NGPLNSKNSS
210 220 230 240 250
AKNNYGYCSY KASKRFSSLH AVLYFSPDFM SLGFMVWASG SMVFFLYRHK
260 270 280 290 300
QQVQHNHSNR LSCRPSQEAR ATHTIMVLVS SFFVFYSVHS FLTIWTTVVA
310 320 330 340 350
NPGQWIVTNS VLVASCFPAR SPFVLIMSDT HISQFCFACR TRKTLFPNLV

VMP
Length:353
Mass (Da):40,021
Last modified:March 1, 2001 - v1
Checksum:iCCB0E9BAFA5EC021
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti103 – 1031I → M.
Corresponds to variant rs3746223 [ dbSNP | Ensembl ].
VAR_049452
Natural varianti139 – 1391I → T in allele VN1R1*2. 1 Publication
VAR_022795
Natural varianti241 – 2411S → F in allele VN1R1*3. 2 Publications
Corresponds to variant rs28649880 [ dbSNP | Ensembl ].
VAR_022796
Natural varianti269 – 2691A → D in allele VN1R1*3. 2 Publications
Corresponds to variant rs61744949 [ dbSNP | Ensembl ].
VAR_022797

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF255342 mRNA. Translation: AAG10698.1.
AF302903 mRNA. Translation: AAG22545.1.
AY312477 Genomic DNA. Translation: AAP85612.1.
AY312478 Genomic DNA. Translation: AAP85613.1.
AY312479 Genomic DNA. Translation: AAP85614.1.
AK094452 mRNA. Translation: BAG52867.1.
AB083606 Genomic DNA. Translation: BAB89319.1.
CH471135 Genomic DNA. Translation: EAW72503.1.
BC095508 mRNA. Translation: AAH95508.1.
CCDSiCCDS12951.1.
RefSeqiNP_065684.1. NM_020633.3.
UniGeneiHs.677423.
Hs.736494.

Genome annotation databases

EnsembliENST00000321039; ENSP00000322339; ENSG00000178201.
GeneIDi57191.
KEGGihsa:57191.
UCSCiuc002qos.2. human.

Polymorphism databases

DMDMi71153399.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

No one nose - Issue 61 of August 2005

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF255342 mRNA. Translation: AAG10698.1 .
AF302903 mRNA. Translation: AAG22545.1 .
AY312477 Genomic DNA. Translation: AAP85612.1 .
AY312478 Genomic DNA. Translation: AAP85613.1 .
AY312479 Genomic DNA. Translation: AAP85614.1 .
AK094452 mRNA. Translation: BAG52867.1 .
AB083606 Genomic DNA. Translation: BAB89319.1 .
CH471135 Genomic DNA. Translation: EAW72503.1 .
BC095508 mRNA. Translation: AAH95508.1 .
CCDSi CCDS12951.1.
RefSeqi NP_065684.1. NM_020633.3.
UniGenei Hs.677423.
Hs.736494.

3D structure databases

ProteinModelPortali Q9GZP7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000322339.

Protein family/group databases

TCDBi 9.A.14.12.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBi Search...

PTM databases

PhosphoSitei Q9GZP7.

Polymorphism databases

DMDMi 71153399.

Proteomic databases

PaxDbi Q9GZP7.
PRIDEi Q9GZP7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000321039 ; ENSP00000322339 ; ENSG00000178201 .
GeneIDi 57191.
KEGGi hsa:57191.
UCSCi uc002qos.2. human.

Organism-specific databases

CTDi 57191.
GeneCardsi GC19M057966.
HGNCi HGNC:13548. VN1R1.
MIMi 605234. gene.
neXtProti NX_Q9GZP7.
PharmGKBi PA134957891.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG113005.
GeneTreei ENSGT00760000118911.
HOGENOMi HOG000231675.
HOVERGENi HBG073430.
InParanoidi Q9GZP7.
KOi K04614.
OMAi MEIKIRS.
OrthoDBi EOG722J92.
PhylomeDBi Q9GZP7.

Miscellaneous databases

GeneWikii VN1R1.
GenomeRNAii 57191.
NextBioi 63274.
PROi Q9GZP7.
SOURCEi Search...

Gene expression databases

Bgeei Q9GZP7.
CleanExi HS_VN1R1.
Genevestigatori Q9GZP7.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view ]
Pfami PF03402. V1R. 1 hit.
[Graphical view ]
PRINTSi PR01534. VOMERONASL1R.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A putative pheromone receptor gene expressed in human olfactory mucosa."
    Rodriguez I., Greer C.A., Mok M.Y., Mombaerts P.
    Nat. Genet. 26:18-19(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANTS PHE-241 AND ASP-269.
  2. "Human pheromone receptor ortholog subtype I member 1."
    Holloway J., Lofton-Day C., Lok S.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates."
    Zhang J., Webb D.M.
    Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS THR-139; PHE-241 AND ASP-269.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  5. "Identification of G protein-coupled receptor genes from the human genome sequence."
    Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.
    FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiVN1R1_HUMAN
AccessioniPrimary (citable) accession number: Q9GZP7
Secondary accession number(s): B3KSV5, Q7Z5H8, Q7Z5H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3