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Protein

Vomeronasal type-1 receptor 1

Gene

VN1R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative pheromone receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Pheromone response

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178201-MONOMER.

Protein family/group databases

TCDBi9.A.14.12.1. the g-protein-coupled receptor (gpcr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Vomeronasal type-1 receptor 1
Alternative name(s):
G-protein coupled receptor GPCR24
Short name:
hGPCR24
V1r-like receptor 1
V3r-related gene protein
Vomeronasal olfactory receptor chromosome 19 subtype I member 1
Gene namesi
Name:VN1R1
Synonyms:V1RL1, VNR19I1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13548. VN1R1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 56ExtracellularSequence analysisAdd BLAST56
Transmembranei57 – 77Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini78 – 84CytoplasmicSequence analysis7
Transmembranei85 – 105Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini106 – 132ExtracellularSequence analysisAdd BLAST27
Transmembranei133 – 153Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini154 – 169CytoplasmicSequence analysisAdd BLAST16
Transmembranei170 – 190Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini191 – 226ExtracellularSequence analysisAdd BLAST36
Transmembranei227 – 247Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini248 – 274CytoplasmicSequence analysisAdd BLAST27
Transmembranei275 – 295Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini296 – 303ExtracellularSequence analysis8
Transmembranei304 – 324Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini325 – 353CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57191.
OpenTargetsiENSG00000178201.
PharmGKBiPA134957891.

Polymorphism and mutation databases

BioMutaiVN1R1.
DMDMi71153399.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702131 – 353Vomeronasal type-1 receptor 1Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9GZP7.
PRIDEiQ9GZP7.

PTM databases

iPTMnetiQ9GZP7.
PhosphoSitePlusiQ9GZP7.

Expressioni

Tissue specificityi

Expressed in the olfactory mucosa, very low expression in brain, lung and kidney.1 Publication

Gene expression databases

BgeeiENSG00000178201.
CleanExiHS_VN1R1.
GenevisibleiQ9GZP7. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322339.

Structurei

3D structure databases

ProteinModelPortaliQ9GZP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J6HZ. Eukaryota.
ENOG410Y0C1. LUCA.
GeneTreeiENSGT00760000118911.
HOGENOMiHOG000231675.
HOVERGENiHBG073430.
InParanoidiQ9GZP7.
KOiK04614.
OMAiSICRWME.
OrthoDBiEOG091G0FH6.
PhylomeDBiQ9GZP7.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9GZP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGDTLKLLS PLMTRYFFLL FYSTDSSDLN ENQHPLDFDE MAFGKVKSGI
60 70 80 90 100
SFLIQTGVGI LGNSFLLCFY NLILFTGHKL RPTDLILSQL ALANSMVLFF
110 120 130 140 150
KGIPQTMAAF GLKYLLNDTG CKFVFYYHRV GTRVSLSTIC LLNGFQAIKL
160 170 180 190 200
NPSICRWMEI KIRSPRFIDF CCLLCWAPHV LMNASVLLLV NGPLNSKNSS
210 220 230 240 250
AKNNYGYCSY KASKRFSSLH AVLYFSPDFM SLGFMVWASG SMVFFLYRHK
260 270 280 290 300
QQVQHNHSNR LSCRPSQEAR ATHTIMVLVS SFFVFYSVHS FLTIWTTVVA
310 320 330 340 350
NPGQWIVTNS VLVASCFPAR SPFVLIMSDT HISQFCFACR TRKTLFPNLV

VMP
Length:353
Mass (Da):40,021
Last modified:March 1, 2001 - v1
Checksum:iCCB0E9BAFA5EC021
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049452103I → M.Corresponds to variant rs3746223dbSNPEnsembl.1
Natural variantiVAR_022795139I → T in allele VN1R1*2. 1 PublicationCorresponds to variant rs374900565dbSNPEnsembl.1
Natural variantiVAR_022796241S → F in allele VN1R1*3. 2 PublicationsCorresponds to variant rs28649880dbSNPEnsembl.1
Natural variantiVAR_022797269A → D in allele VN1R1*3. 2 PublicationsCorresponds to variant rs61744949dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255342 mRNA. Translation: AAG10698.1.
AF302903 mRNA. Translation: AAG22545.1.
AY312477 Genomic DNA. Translation: AAP85612.1.
AY312478 Genomic DNA. Translation: AAP85613.1.
AY312479 Genomic DNA. Translation: AAP85614.1.
AK094452 mRNA. Translation: BAG52867.1.
AB083606 Genomic DNA. Translation: BAB89319.1.
CH471135 Genomic DNA. Translation: EAW72503.1.
BC095508 mRNA. Translation: AAH95508.1.
CCDSiCCDS12951.1.
RefSeqiNP_065684.1. NM_020633.3.
UniGeneiHs.677423.
Hs.736494.

Genome annotation databases

EnsembliENST00000321039; ENSP00000322339; ENSG00000178201.
GeneIDi57191.
KEGGihsa:57191.
UCSCiuc002qos.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

No one nose - Issue 61 of August 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255342 mRNA. Translation: AAG10698.1.
AF302903 mRNA. Translation: AAG22545.1.
AY312477 Genomic DNA. Translation: AAP85612.1.
AY312478 Genomic DNA. Translation: AAP85613.1.
AY312479 Genomic DNA. Translation: AAP85614.1.
AK094452 mRNA. Translation: BAG52867.1.
AB083606 Genomic DNA. Translation: BAB89319.1.
CH471135 Genomic DNA. Translation: EAW72503.1.
BC095508 mRNA. Translation: AAH95508.1.
CCDSiCCDS12951.1.
RefSeqiNP_065684.1. NM_020633.3.
UniGeneiHs.677423.
Hs.736494.

3D structure databases

ProteinModelPortaliQ9GZP7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000322339.

Protein family/group databases

TCDBi9.A.14.12.1. the g-protein-coupled receptor (gpcr) family.
GPCRDBiSearch...

PTM databases

iPTMnetiQ9GZP7.
PhosphoSitePlusiQ9GZP7.

Polymorphism and mutation databases

BioMutaiVN1R1.
DMDMi71153399.

Proteomic databases

PaxDbiQ9GZP7.
PRIDEiQ9GZP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321039; ENSP00000322339; ENSG00000178201.
GeneIDi57191.
KEGGihsa:57191.
UCSCiuc002qos.3. human.

Organism-specific databases

CTDi57191.
DisGeNETi57191.
GeneCardsiVN1R1.
HGNCiHGNC:13548. VN1R1.
MIMi605234. gene.
neXtProtiNX_Q9GZP7.
OpenTargetsiENSG00000178201.
PharmGKBiPA134957891.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J6HZ. Eukaryota.
ENOG410Y0C1. LUCA.
GeneTreeiENSGT00760000118911.
HOGENOMiHOG000231675.
HOVERGENiHBG073430.
InParanoidiQ9GZP7.
KOiK04614.
OMAiSICRWME.
OrthoDBiEOG091G0FH6.
PhylomeDBiQ9GZP7.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178201-MONOMER.

Miscellaneous databases

GeneWikiiVN1R1.
GenomeRNAii57191.
PROiQ9GZP7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178201.
CleanExiHS_VN1R1.
GenevisibleiQ9GZP7. HS.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR004072. Vmron_rcpt_1.
[Graphical view]
PfamiPF03402. V1R. 1 hit.
[Graphical view]
PRINTSiPR01534. VOMERONASL1R.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVN1R1_HUMAN
AccessioniPrimary (citable) accession number: Q9GZP7
Secondary accession number(s): B3KSV5, Q7Z5H8, Q7Z5H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.