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Protein

PITH domain-containing protein 1

Gene

PITHD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
PITH domain-containing protein 1
Gene namesi
Name:PITHD1
Synonyms:C1orf128
ORF Names:AD039, HT014, PP603
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25022. PITHD1.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672446.

Polymorphism and mutation databases

BioMutaiPITHD1.
DMDMi74752536.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211PITH domain-containing protein 1PRO_0000285032Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei189 – 1891Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9GZP4.
PaxDbiQ9GZP4.
PeptideAtlasiQ9GZP4.
PRIDEiQ9GZP4.

2D gel databases

REPRODUCTION-2DPAGEIPI00015351.

PTM databases

PhosphoSiteiQ9GZP4.

Expressioni

Gene expression databases

BgeeiQ9GZP4.
CleanExiHS_C1orf128.
ExpressionAtlasiQ9GZP4. baseline and differential.
GenevisibleiQ9GZP4. HS.

Organism-specific databases

HPAiHPA016936.

Interactioni

Protein-protein interaction databases

BioGridi121363. 5 interactions.
IntActiQ9GZP4. 1 interaction.
STRINGi9606.ENSP00000246151.

Structurei

3D structure databases

ProteinModelPortaliQ9GZP4.
SMRiQ9GZP4. Positions 41-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 192173PITHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi8 – 114Poly-Gly

Sequence similaritiesi

Belongs to the PITHD1 family.Curated
Contains 1 PITH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG283555.
GeneTreeiENSGT00490000043398.
HOVERGENiHBG104505.
InParanoidiQ9GZP4.
OMAiTRVYYIG.
OrthoDBiEOG7V1FRS.
PhylomeDBiQ9GZP4.
TreeFamiTF314669.

Family and domain databases

Gene3Di2.60.120.470. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR010400. PITH_dom.
[Graphical view]
PfamiPF06201. PITH. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
PROSITEiPS51532. PITH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9GZP4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSHGHSHGGG GCRCAAEREE PPEQRGLAYG LYLRIDLERL QCLNESREGS
60 70 80 90 100
GRGVFKPWEE RTDRSKFVES DADEELLFNI PFTGNVKLKG IIIMGEDDDS
110 120 130 140 150
HPSEMRLYKN IPQMSFDDTE REPDQTFSLN RDLTGELEYA TKISRFSNVY
160 170 180 190 200
HLSIHISKNF GADTTKVFYI GLRGEWTELR RHEVTICNYE ASANPADHRV
210
HQVTPQTHFI S
Length:211
Mass (Da):24,178
Last modified:March 1, 2001 - v1
Checksum:iCFB3B6A0D75685FA
GO
Isoform 2 (identifier: Q9GZP4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-53: Missing.

Show »
Length:210
Mass (Da):24,121
Checksum:iA4405E4BEE78F352
GO

Sequence cautioni

The sequence CAI23142.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei53 – 531Missing in isoform 2. 1 PublicationVSP_024807

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF271784 mRNA. Translation: AAG44795.1.
AF221595 mRNA. Translation: AAF91232.1.
AF218024 mRNA. Translation: AAG17266.1.
AK313005 mRNA. Translation: BAG35841.1.
AL031295 Genomic DNA. Translation: CAI23140.1.
AL031295 Genomic DNA. Translation: CAI23141.1.
AL031295 Genomic DNA. Translation: CAI23142.1. Sequence problems.
CH471134 Genomic DNA. Translation: EAW95075.1.
BC017208 mRNA. Translation: AAH17208.1.
CCDSiCCDS240.1. [Q9GZP4-1]
RefSeqiNP_065095.2. NM_020362.4. [Q9GZP4-1]
UniGeneiHs.31819.

Genome annotation databases

EnsembliENST00000246151; ENSP00000246151; ENSG00000057757.
GeneIDi57095.
KEGGihsa:57095.
UCSCiuc001bhq.3. human. [Q9GZP4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF271784 mRNA. Translation: AAG44795.1.
AF221595 mRNA. Translation: AAF91232.1.
AF218024 mRNA. Translation: AAG17266.1.
AK313005 mRNA. Translation: BAG35841.1.
AL031295 Genomic DNA. Translation: CAI23140.1.
AL031295 Genomic DNA. Translation: CAI23141.1.
AL031295 Genomic DNA. Translation: CAI23142.1. Sequence problems.
CH471134 Genomic DNA. Translation: EAW95075.1.
BC017208 mRNA. Translation: AAH17208.1.
CCDSiCCDS240.1. [Q9GZP4-1]
RefSeqiNP_065095.2. NM_020362.4. [Q9GZP4-1]
UniGeneiHs.31819.

3D structure databases

ProteinModelPortaliQ9GZP4.
SMRiQ9GZP4. Positions 41-174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121363. 5 interactions.
IntActiQ9GZP4. 1 interaction.
STRINGi9606.ENSP00000246151.

PTM databases

PhosphoSiteiQ9GZP4.

Polymorphism and mutation databases

BioMutaiPITHD1.
DMDMi74752536.

2D gel databases

REPRODUCTION-2DPAGEIPI00015351.

Proteomic databases

MaxQBiQ9GZP4.
PaxDbiQ9GZP4.
PeptideAtlasiQ9GZP4.
PRIDEiQ9GZP4.

Protocols and materials databases

DNASUi57095.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246151; ENSP00000246151; ENSG00000057757.
GeneIDi57095.
KEGGihsa:57095.
UCSCiuc001bhq.3. human. [Q9GZP4-1]

Organism-specific databases

CTDi57095.
GeneCardsiGC01P024108.
HGNCiHGNC:25022. PITHD1.
HPAiHPA016936.
neXtProtiNX_Q9GZP4.
PharmGKBiPA142672446.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG283555.
GeneTreeiENSGT00490000043398.
HOVERGENiHBG104505.
InParanoidiQ9GZP4.
OMAiTRVYYIG.
OrthoDBiEOG7V1FRS.
PhylomeDBiQ9GZP4.
TreeFamiTF314669.

Miscellaneous databases

ChiTaRSiPITHD1. human.
GenomeRNAii57095.
NextBioi62913.
PROiQ9GZP4.

Gene expression databases

BgeeiQ9GZP4.
CleanExiHS_C1orf128.
ExpressionAtlasiQ9GZP4. baseline and differential.
GenevisibleiQ9GZP4. HS.

Family and domain databases

Gene3Di2.60.120.470. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR010400. PITH_dom.
[Graphical view]
PfamiPF06201. PITH. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
PROSITEiPS51532. PITH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Adrenal gland.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Hypothalamus.
  3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Cerebellum.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  8. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-189, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPITH1_HUMAN
AccessioniPrimary (citable) accession number: Q9GZP4
Secondary accession number(s): B2R7J4
, Q5QPN6, Q5QPN7, Q9NRI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 1, 2001
Last modified: July 22, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.