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Q9GZP4

- PITH1_HUMAN

UniProt

Q9GZP4 - PITH1_HUMAN

Protein

PITH domain-containing protein 1

Gene

PITHD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PITH domain-containing protein 1
    Gene namesi
    Name:PITHD1
    Synonyms:C1orf128
    ORF Names:AD039, HT014, PP603
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25022. PITHD1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672446.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 211211PITH domain-containing protein 1PRO_0000285032Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei189 – 1891Phosphotyrosine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9GZP4.
    PaxDbiQ9GZP4.
    PeptideAtlasiQ9GZP4.
    PRIDEiQ9GZP4.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00015351.

    PTM databases

    PhosphoSiteiQ9GZP4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9GZP4.
    BgeeiQ9GZP4.
    CleanExiHS_C1orf128.
    GenevestigatoriQ9GZP4.

    Organism-specific databases

    HPAiHPA016936.

    Interactioni

    Protein-protein interaction databases

    BioGridi121363. 6 interactions.
    IntActiQ9GZP4. 1 interaction.
    STRINGi9606.ENSP00000246151.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GZP4.
    SMRiQ9GZP4. Positions 41-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 192173PITHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi8 – 114Poly-Gly

    Sequence similaritiesi

    Belongs to the PITHD1 family.Curated
    Contains 1 PITH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG283555.
    HOVERGENiHBG104505.
    InParanoidiQ9GZP4.
    OMAiYPTKIAR.
    OrthoDBiEOG7V1FRS.
    PhylomeDBiQ9GZP4.
    TreeFamiTF314669.

    Family and domain databases

    Gene3Di2.60.120.470. 1 hit.
    InterProiIPR008979. Galactose-bd-like.
    IPR010400. PITH_dom.
    [Graphical view]
    PfamiPF06201. PITH. 1 hit.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 1 hit.
    PROSITEiPS51532. PITH. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9GZP4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSHGHSHGGG GCRCAAEREE PPEQRGLAYG LYLRIDLERL QCLNESREGS    50
    GRGVFKPWEE RTDRSKFVES DADEELLFNI PFTGNVKLKG IIIMGEDDDS 100
    HPSEMRLYKN IPQMSFDDTE REPDQTFSLN RDLTGELEYA TKISRFSNVY 150
    HLSIHISKNF GADTTKVFYI GLRGEWTELR RHEVTICNYE ASANPADHRV 200
    HQVTPQTHFI S 211
    Length:211
    Mass (Da):24,178
    Last modified:March 1, 2001 - v1
    Checksum:iCFB3B6A0D75685FA
    GO
    Isoform 2 (identifier: Q9GZP4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         53-53: Missing.

    Show »
    Length:210
    Mass (Da):24,121
    Checksum:iA4405E4BEE78F352
    GO

    Sequence cautioni

    The sequence CAI23142.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei53 – 531Missing in isoform 2. 1 PublicationVSP_024807

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF271784 mRNA. Translation: AAG44795.1.
    AF221595 mRNA. Translation: AAF91232.1.
    AF218024 mRNA. Translation: AAG17266.1.
    AK313005 mRNA. Translation: BAG35841.1.
    AL031295 Genomic DNA. Translation: CAI23140.1.
    AL031295 Genomic DNA. Translation: CAI23141.1.
    AL031295 Genomic DNA. Translation: CAI23142.1. Sequence problems.
    CH471134 Genomic DNA. Translation: EAW95075.1.
    BC017208 mRNA. Translation: AAH17208.1.
    CCDSiCCDS240.1. [Q9GZP4-1]
    RefSeqiNP_065095.2. NM_020362.4. [Q9GZP4-1]
    UniGeneiHs.31819.

    Genome annotation databases

    EnsembliENST00000246151; ENSP00000246151; ENSG00000057757. [Q9GZP4-1]
    GeneIDi57095.
    KEGGihsa:57095.
    UCSCiuc001bhq.3. human. [Q9GZP4-1]

    Polymorphism databases

    DMDMi74752536.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF271784 mRNA. Translation: AAG44795.1 .
    AF221595 mRNA. Translation: AAF91232.1 .
    AF218024 mRNA. Translation: AAG17266.1 .
    AK313005 mRNA. Translation: BAG35841.1 .
    AL031295 Genomic DNA. Translation: CAI23140.1 .
    AL031295 Genomic DNA. Translation: CAI23141.1 .
    AL031295 Genomic DNA. Translation: CAI23142.1 . Sequence problems.
    CH471134 Genomic DNA. Translation: EAW95075.1 .
    BC017208 mRNA. Translation: AAH17208.1 .
    CCDSi CCDS240.1. [Q9GZP4-1 ]
    RefSeqi NP_065095.2. NM_020362.4. [Q9GZP4-1 ]
    UniGenei Hs.31819.

    3D structure databases

    ProteinModelPortali Q9GZP4.
    SMRi Q9GZP4. Positions 41-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121363. 6 interactions.
    IntActi Q9GZP4. 1 interaction.
    STRINGi 9606.ENSP00000246151.

    PTM databases

    PhosphoSitei Q9GZP4.

    Polymorphism databases

    DMDMi 74752536.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00015351.

    Proteomic databases

    MaxQBi Q9GZP4.
    PaxDbi Q9GZP4.
    PeptideAtlasi Q9GZP4.
    PRIDEi Q9GZP4.

    Protocols and materials databases

    DNASUi 57095.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000246151 ; ENSP00000246151 ; ENSG00000057757 . [Q9GZP4-1 ]
    GeneIDi 57095.
    KEGGi hsa:57095.
    UCSCi uc001bhq.3. human. [Q9GZP4-1 ]

    Organism-specific databases

    CTDi 57095.
    GeneCardsi GC01P024105.
    HGNCi HGNC:25022. PITHD1.
    HPAi HPA016936.
    neXtProti NX_Q9GZP4.
    PharmGKBi PA142672446.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG283555.
    HOVERGENi HBG104505.
    InParanoidi Q9GZP4.
    OMAi YPTKIAR.
    OrthoDBi EOG7V1FRS.
    PhylomeDBi Q9GZP4.
    TreeFami TF314669.

    Miscellaneous databases

    ChiTaRSi PITHD1. human.
    GenomeRNAii 57095.
    NextBioi 62913.
    PROi Q9GZP4.

    Gene expression databases

    ArrayExpressi Q9GZP4.
    Bgeei Q9GZP4.
    CleanExi HS_C1orf128.
    Genevestigatori Q9GZP4.

    Family and domain databases

    Gene3Di 2.60.120.470. 1 hit.
    InterProi IPR008979. Galactose-bd-like.
    IPR010400. PITH_dom.
    [Graphical view ]
    Pfami PF06201. PITH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 1 hit.
    PROSITEi PS51532. PITH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Adrenal gland.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Hypothalamus.
    3. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Cerebellum.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Lung.
    8. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-189, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPITH1_HUMAN
    AccessioniPrimary (citable) accession number: Q9GZP4
    Secondary accession number(s): B2R7J4
    , Q5QPN6, Q5QPN7, Q9NRI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3