Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neurensin-2

Gene

NRSN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in maintenance and/or transport of vesicles.

Protein family/group databases

TCDBi9.B.189.1.2. the vesicular membrane neurensin (neurensin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurensin-2
Gene namesi
Name:NRSN2
Synonyms:C20orf98
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16229. NRSN2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei66 – 8621HelicalSequence analysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25805.

Polymorphism and mutation databases

BioMutaiNRSN2.
DMDMi25008324.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204Neurensin-2PRO_0000221675Add
BLAST

Proteomic databases

EPDiQ9GZP1.
PaxDbiQ9GZP1.
PeptideAtlasiQ9GZP1.
PRIDEiQ9GZP1.

PTM databases

iPTMnetiQ9GZP1.
PhosphoSiteiQ9GZP1.
SwissPalmiQ9GZP1.

Expressioni

Gene expression databases

BgeeiENSG00000125841.
CleanExiHS_NRSN2.
ExpressionAtlasiQ9GZP1. baseline and differential.
GenevisibleiQ9GZP1. HS.

Organism-specific databases

HPAiHPA015967.

Interactioni

Protein-protein interaction databases

BioGridi123077. 5 interactions.
IntActiQ9GZP1. 2 interactions.
MINTiMINT-1424241.
STRINGi9606.ENSP00000371722.

Structurei

3D structure databases

ProteinModelPortaliQ9GZP1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the VMP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHGJ. Eukaryota.
ENOG4111B0E. LUCA.
GeneTreeiENSGT00530000063877.
HOGENOMiHOG000231873.
HOVERGENiHBG080467.
InParanoidiQ9GZP1.
OMAiSWFSPPA.
OrthoDBiEOG091G0K9J.
PhylomeDBiQ9GZP1.
TreeFamiTF332090.

Family and domain databases

InterProiIPR024883. Neurensin.
IPR029701. Nrsn2.
[Graphical view]
PANTHERiPTHR14796. PTHR14796. 1 hit.
PTHR14796:SF5. PTHR14796:SF5. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9GZP1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPSCNRSCS CSRGPSVEDG KWYGVRSYLH LFYEDCAGTA LSDDPEGPPV
60 70 80 90 100
LCPRRPWPSL CWKISLSSGT LLLLLGVAAL TTGYAVPPKL EGIGEGEFLV
110 120 130 140 150
LDQRAADYNQ ALGTCRLAGT ALCVAAGVLL AICLFWAMIG WLSQDTKAEP
160 170 180 190 200
LDPEADSHVE VFGDEPEQQL SPIFRNASGQ SWFSPPASPF GQSSVQTIQP

KRDS
Length:204
Mass (Da):21,983
Last modified:March 1, 2001 - v1
Checksum:iD20FAAE67C0FF16D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411L → V.
Corresponds to variant rs11556643 [ dbSNP | Ensembl ].
VAR_053738
Natural varianti65 – 651S → C.
Corresponds to variant rs17762763 [ dbSNP | Ensembl ].
VAR_053739
Natural varianti160 – 1601E → Q.
Corresponds to variant rs35731713 [ dbSNP | Ensembl ].
VAR_062158

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136915 mRNA. Translation: CAB66849.1.
AK026982 mRNA. Translation: BAB15613.1.
AK290527 mRNA. Translation: BAF83216.1.
CR533441 mRNA. Translation: CAG38472.1.
AL034548 Genomic DNA. Translation: CAI19176.1.
CH471133 Genomic DNA. Translation: EAX10680.1.
BC001963 mRNA. Translation: AAH01963.1.
CCDSiCCDS12996.1.
RefSeqiNP_001310608.1. NM_001323679.1.
NP_001310609.1. NM_001323680.1.
NP_001310610.1. NM_001323681.1.
NP_001310611.1. NM_001323682.1.
NP_001310612.1. NM_001323683.1.
NP_001310613.1. NM_001323684.1.
NP_001310614.1. NM_001323685.1.
NP_079234.1. NM_024958.2.
XP_006723693.1. XM_006723630.3.
XP_011527662.1. XM_011529360.1.
XP_011527664.1. XM_011529362.2.
XP_011527665.1. XM_011529363.2.
UniGeneiHs.416024.

Genome annotation databases

EnsembliENST00000382285; ENSP00000371722; ENSG00000125841.
ENST00000382291; ENSP00000371728; ENSG00000125841.
ENST00000621012; ENSP00000482706; ENSG00000125841.
GeneIDi80023.
KEGGihsa:80023.
UCSCiuc002wdi.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136915 mRNA. Translation: CAB66849.1.
AK026982 mRNA. Translation: BAB15613.1.
AK290527 mRNA. Translation: BAF83216.1.
CR533441 mRNA. Translation: CAG38472.1.
AL034548 Genomic DNA. Translation: CAI19176.1.
CH471133 Genomic DNA. Translation: EAX10680.1.
BC001963 mRNA. Translation: AAH01963.1.
CCDSiCCDS12996.1.
RefSeqiNP_001310608.1. NM_001323679.1.
NP_001310609.1. NM_001323680.1.
NP_001310610.1. NM_001323681.1.
NP_001310611.1. NM_001323682.1.
NP_001310612.1. NM_001323683.1.
NP_001310613.1. NM_001323684.1.
NP_001310614.1. NM_001323685.1.
NP_079234.1. NM_024958.2.
XP_006723693.1. XM_006723630.3.
XP_011527662.1. XM_011529360.1.
XP_011527664.1. XM_011529362.2.
XP_011527665.1. XM_011529363.2.
UniGeneiHs.416024.

3D structure databases

ProteinModelPortaliQ9GZP1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123077. 5 interactions.
IntActiQ9GZP1. 2 interactions.
MINTiMINT-1424241.
STRINGi9606.ENSP00000371722.

Protein family/group databases

TCDBi9.B.189.1.2. the vesicular membrane neurensin (neurensin) family.

PTM databases

iPTMnetiQ9GZP1.
PhosphoSiteiQ9GZP1.
SwissPalmiQ9GZP1.

Polymorphism and mutation databases

BioMutaiNRSN2.
DMDMi25008324.

Proteomic databases

EPDiQ9GZP1.
PaxDbiQ9GZP1.
PeptideAtlasiQ9GZP1.
PRIDEiQ9GZP1.

Protocols and materials databases

DNASUi80023.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382285; ENSP00000371722; ENSG00000125841.
ENST00000382291; ENSP00000371728; ENSG00000125841.
ENST00000621012; ENSP00000482706; ENSG00000125841.
GeneIDi80023.
KEGGihsa:80023.
UCSCiuc002wdi.5. human.

Organism-specific databases

CTDi80023.
GeneCardsiNRSN2.
HGNCiHGNC:16229. NRSN2.
HPAiHPA015967.
MIMi610666. gene.
neXtProtiNX_Q9GZP1.
PharmGKBiPA25805.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHGJ. Eukaryota.
ENOG4111B0E. LUCA.
GeneTreeiENSGT00530000063877.
HOGENOMiHOG000231873.
HOVERGENiHBG080467.
InParanoidiQ9GZP1.
OMAiSWFSPPA.
OrthoDBiEOG091G0K9J.
PhylomeDBiQ9GZP1.
TreeFamiTF332090.

Miscellaneous databases

ChiTaRSiNRSN2. human.
GeneWikiiNRSN2.
GenomeRNAii80023.
PROiQ9GZP1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125841.
CleanExiHS_NRSN2.
ExpressionAtlasiQ9GZP1. baseline and differential.
GenevisibleiQ9GZP1. HS.

Family and domain databases

InterProiIPR024883. Neurensin.
IPR029701. Nrsn2.
[Graphical view]
PANTHERiPTHR14796. PTHR14796. 1 hit.
PTHR14796:SF5. PTHR14796:SF5. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNRSN2_HUMAN
AccessioniPrimary (citable) accession number: Q9GZP1
Secondary accession number(s): A8K3B2, Q6FII5, Q9NUD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.