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Q9GZN8

- CT027_HUMAN

UniProt

Q9GZN8 - CT027_HUMAN

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Protein

UPF0687 protein C20orf27

Gene

C20orf27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0687 protein C20orf27
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15873. C20orf27.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25742.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 174173UPF0687 protein C20orf27PRO_0000079419Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9GZN8.
PaxDbiQ9GZN8.
PRIDEiQ9GZN8.

PTM databases

PhosphoSiteiQ9GZN8.

Expressioni

Gene expression databases

BgeeiQ9GZN8.
CleanExiHS_C20orf27.
GenevestigatoriQ9GZN8.

Organism-specific databases

HPAiHPA047483.

Interactioni

Protein-protein interaction databases

BioGridi120312. 8 interactions.
IntActiQ9GZN8. 3 interactions.
STRINGi9606.ENSP00000217195.

Structurei

3D structure databases

ProteinModelPortaliQ9GZN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0687 family.Curated

Phylogenomic databases

eggNOGiNOG78857.
GeneTreeiENSGT00390000008711.
HOGENOMiHOG000231708.
HOVERGENiHBG051155.
InParanoidiQ9GZN8.
OMAiKGTPMLR.
PhylomeDBiQ9GZN8.
TreeFamiTF323780.

Family and domain databases

InterProiIPR026794. UPF0687.
[Graphical view]
PANTHERiPTHR13287. PTHR13287. 1 hit.
PfamiPF15006. DUF4517. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9GZN8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAANKGNKP RVRSIRFAAG HDAEGSHSHV HFDEKLHDSV VMVTQESDSS
60 70 80 90 100
FLVKVGFLKI LHRYEITFTL PPVHRLSKDV REAPVPSLHL KLLSVVPVPE
110 120 130 140 150
GYSVKCEYSA HKEGVLKEEI LLACEGGTGT CVRVTVQARV MDRHHGTPML
160 170
LDGVKCVGAE LEYDSEHSDW HGFD
Length:174
Mass (Da):19,291
Last modified:January 23, 2007 - v3
Checksum:iDD114F2C1A7D8B97
GO
Isoform 2 (identifier: Q9GZN8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-6: K → KGKCLPGVVGLAQALPVGPGRRAIAA

Show »
Length:199
Mass (Da):21,645
Checksum:iB3D49626EDF72968
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141S → G in BAA91252. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei6 – 61K → KGKCLPGVVGLAQALPVGPG RRAIAA in isoform 2. 1 PublicationVSP_040293

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000557 mRNA. Translation: BAA91252.1.
AK024220 mRNA. Translation: BAB14854.1.
AK097645 mRNA. Translation: BAG53501.1.
AK290955 mRNA. Translation: BAF83644.1.
CR615129 mRNA. No translation available.
AL109804 Genomic DNA. Translation: CAC17545.1.
AL109804 Genomic DNA. Translation: CAI18843.1.
CH471133 Genomic DNA. Translation: EAX10508.1.
CH471133 Genomic DNA. Translation: EAX10510.1.
CH471133 Genomic DNA. Translation: EAX10511.1.
BC012196 mRNA. Translation: AAH12196.1.
BC024036 mRNA. Translation: AAH24036.1.
CCDSiCCDS33436.1. [Q9GZN8-2]
CCDS58763.1. [Q9GZN8-1]
RefSeqiNP_001034229.1. NM_001039140.2. [Q9GZN8-2]
NP_001245358.1. NM_001258429.1. [Q9GZN8-1]
NP_001245359.1. NM_001258430.1. [Q9GZN8-1]
UniGeneiHs.274422.

Genome annotation databases

EnsembliENST00000217195; ENSP00000217195; ENSG00000101220. [Q9GZN8-2]
ENST00000379772; ENSP00000369097; ENSG00000101220. [Q9GZN8-1]
ENST00000399672; ENSP00000382580; ENSG00000101220. [Q9GZN8-1]
GeneIDi54976.
KEGGihsa:54976.
UCSCiuc002wjf.1. human. [Q9GZN8-2]
uc002wji.2. human. [Q9GZN8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000557 mRNA. Translation: BAA91252.1 .
AK024220 mRNA. Translation: BAB14854.1 .
AK097645 mRNA. Translation: BAG53501.1 .
AK290955 mRNA. Translation: BAF83644.1 .
CR615129 mRNA. No translation available.
AL109804 Genomic DNA. Translation: CAC17545.1 .
AL109804 Genomic DNA. Translation: CAI18843.1 .
CH471133 Genomic DNA. Translation: EAX10508.1 .
CH471133 Genomic DNA. Translation: EAX10510.1 .
CH471133 Genomic DNA. Translation: EAX10511.1 .
BC012196 mRNA. Translation: AAH12196.1 .
BC024036 mRNA. Translation: AAH24036.1 .
CCDSi CCDS33436.1. [Q9GZN8-2 ]
CCDS58763.1. [Q9GZN8-1 ]
RefSeqi NP_001034229.1. NM_001039140.2. [Q9GZN8-2 ]
NP_001245358.1. NM_001258429.1. [Q9GZN8-1 ]
NP_001245359.1. NM_001258430.1. [Q9GZN8-1 ]
UniGenei Hs.274422.

3D structure databases

ProteinModelPortali Q9GZN8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120312. 8 interactions.
IntActi Q9GZN8. 3 interactions.
STRINGi 9606.ENSP00000217195.

PTM databases

PhosphoSitei Q9GZN8.

Proteomic databases

MaxQBi Q9GZN8.
PaxDbi Q9GZN8.
PRIDEi Q9GZN8.

Protocols and materials databases

DNASUi 54976.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000217195 ; ENSP00000217195 ; ENSG00000101220 . [Q9GZN8-2 ]
ENST00000379772 ; ENSP00000369097 ; ENSG00000101220 . [Q9GZN8-1 ]
ENST00000399672 ; ENSP00000382580 ; ENSG00000101220 . [Q9GZN8-1 ]
GeneIDi 54976.
KEGGi hsa:54976.
UCSCi uc002wjf.1. human. [Q9GZN8-2 ]
uc002wji.2. human. [Q9GZN8-1 ]

Organism-specific databases

CTDi 54976.
GeneCardsi GC20M003734.
H-InvDB HIX0015601.
HGNCi HGNC:15873. C20orf27.
HPAi HPA047483.
neXtProti NX_Q9GZN8.
PharmGKBi PA25742.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG78857.
GeneTreei ENSGT00390000008711.
HOGENOMi HOG000231708.
HOVERGENi HBG051155.
InParanoidi Q9GZN8.
OMAi KGTPMLR.
PhylomeDBi Q9GZN8.
TreeFami TF323780.

Miscellaneous databases

ChiTaRSi C20orf27. human.
GeneWikii C20orf27.
GenomeRNAii 54976.
NextBioi 58230.

Gene expression databases

Bgeei Q9GZN8.
CleanExi HS_C20orf27.
Genevestigatori Q9GZN8.

Family and domain databases

InterProi IPR026794. UPF0687.
[Graphical view ]
PANTHERi PTHR13287. PTHR13287. 1 hit.
Pfami PF15006. DUF4517. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Gastric carcinoma, Teratocarcinoma and Testis.
  2. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Lung.
  6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-11 (ISOFORM 1).
    Tissue: Platelet.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCT027_HUMAN
AccessioniPrimary (citable) accession number: Q9GZN8
Secondary accession number(s): A8K4J0
, D3DVX8, Q5JX81, Q9NWX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3