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Protein

UPF0687 protein C20orf27

Gene

C20orf27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0687 protein C20orf27
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15873. C20orf27.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25742.

Polymorphism and mutation databases

BioMutaiC20orf27.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 174173UPF0687 protein C20orf27PRO_0000079419Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9GZN8.
PaxDbiQ9GZN8.
PRIDEiQ9GZN8.

PTM databases

PhosphoSiteiQ9GZN8.

Expressioni

Gene expression databases

BgeeiQ9GZN8.
CleanExiHS_C20orf27.
ExpressionAtlasiQ9GZN8. baseline and differential.
GenevisibleiQ9GZN8. HS.

Organism-specific databases

HPAiHPA047483.

Interactioni

Protein-protein interaction databases

BioGridi120312. 5 interactions.
IntActiQ9GZN8. 3 interactions.
STRINGi9606.ENSP00000217195.

Structurei

3D structure databases

ProteinModelPortaliQ9GZN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0687 family.Curated

Phylogenomic databases

eggNOGiNOG78857.
GeneTreeiENSGT00390000008711.
HOGENOMiHOG000231708.
HOVERGENiHBG051155.
InParanoidiQ9GZN8.
OMAiLQINHRY.
PhylomeDBiQ9GZN8.
TreeFamiTF323780.

Family and domain databases

InterProiIPR026794. UPF0687.
[Graphical view]
PANTHERiPTHR13287. PTHR13287. 1 hit.
PfamiPF15006. DUF4517. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9GZN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAANKGNKP RVRSIRFAAG HDAEGSHSHV HFDEKLHDSV VMVTQESDSS
60 70 80 90 100
FLVKVGFLKI LHRYEITFTL PPVHRLSKDV REAPVPSLHL KLLSVVPVPE
110 120 130 140 150
GYSVKCEYSA HKEGVLKEEI LLACEGGTGT CVRVTVQARV MDRHHGTPML
160 170
LDGVKCVGAE LEYDSEHSDW HGFD
Length:174
Mass (Da):19,291
Last modified:January 23, 2007 - v3
Checksum:iDD114F2C1A7D8B97
GO
Isoform 2 (identifier: Q9GZN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-6: K → KGKCLPGVVGLAQALPVGPGRRAIAA

Show »
Length:199
Mass (Da):21,645
Checksum:iB3D49626EDF72968
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141S → G in BAA91252 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei6 – 61K → KGKCLPGVVGLAQALPVGPG RRAIAA in isoform 2. 1 PublicationVSP_040293

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000557 mRNA. Translation: BAA91252.1.
AK024220 mRNA. Translation: BAB14854.1.
AK097645 mRNA. Translation: BAG53501.1.
AK290955 mRNA. Translation: BAF83644.1.
CR615129 mRNA. No translation available.
AL109804 Genomic DNA. Translation: CAC17545.1.
AL109804 Genomic DNA. Translation: CAI18843.1.
CH471133 Genomic DNA. Translation: EAX10508.1.
CH471133 Genomic DNA. Translation: EAX10510.1.
CH471133 Genomic DNA. Translation: EAX10511.1.
BC012196 mRNA. Translation: AAH12196.1.
BC024036 mRNA. Translation: AAH24036.1.
CCDSiCCDS33436.1. [Q9GZN8-2]
CCDS58763.1. [Q9GZN8-1]
RefSeqiNP_001034229.1. NM_001039140.2. [Q9GZN8-2]
NP_001245358.1. NM_001258429.1. [Q9GZN8-1]
NP_001245359.1. NM_001258430.1. [Q9GZN8-1]
UniGeneiHs.274422.

Genome annotation databases

EnsembliENST00000217195; ENSP00000217195; ENSG00000101220. [Q9GZN8-2]
ENST00000379772; ENSP00000369097; ENSG00000101220.
ENST00000399672; ENSP00000382580; ENSG00000101220.
GeneIDi54976.
KEGGihsa:54976.
UCSCiuc002wjf.1. human. [Q9GZN8-2]
uc002wji.2. human. [Q9GZN8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000557 mRNA. Translation: BAA91252.1.
AK024220 mRNA. Translation: BAB14854.1.
AK097645 mRNA. Translation: BAG53501.1.
AK290955 mRNA. Translation: BAF83644.1.
CR615129 mRNA. No translation available.
AL109804 Genomic DNA. Translation: CAC17545.1.
AL109804 Genomic DNA. Translation: CAI18843.1.
CH471133 Genomic DNA. Translation: EAX10508.1.
CH471133 Genomic DNA. Translation: EAX10510.1.
CH471133 Genomic DNA. Translation: EAX10511.1.
BC012196 mRNA. Translation: AAH12196.1.
BC024036 mRNA. Translation: AAH24036.1.
CCDSiCCDS33436.1. [Q9GZN8-2]
CCDS58763.1. [Q9GZN8-1]
RefSeqiNP_001034229.1. NM_001039140.2. [Q9GZN8-2]
NP_001245358.1. NM_001258429.1. [Q9GZN8-1]
NP_001245359.1. NM_001258430.1. [Q9GZN8-1]
UniGeneiHs.274422.

3D structure databases

ProteinModelPortaliQ9GZN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120312. 5 interactions.
IntActiQ9GZN8. 3 interactions.
STRINGi9606.ENSP00000217195.

PTM databases

PhosphoSiteiQ9GZN8.

Polymorphism and mutation databases

BioMutaiC20orf27.

Proteomic databases

MaxQBiQ9GZN8.
PaxDbiQ9GZN8.
PRIDEiQ9GZN8.

Protocols and materials databases

DNASUi54976.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217195; ENSP00000217195; ENSG00000101220. [Q9GZN8-2]
ENST00000379772; ENSP00000369097; ENSG00000101220.
ENST00000399672; ENSP00000382580; ENSG00000101220.
GeneIDi54976.
KEGGihsa:54976.
UCSCiuc002wjf.1. human. [Q9GZN8-2]
uc002wji.2. human. [Q9GZN8-1]

Organism-specific databases

CTDi54976.
GeneCardsiGC20M003734.
H-InvDBHIX0015601.
HGNCiHGNC:15873. C20orf27.
HPAiHPA047483.
neXtProtiNX_Q9GZN8.
PharmGKBiPA25742.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG78857.
GeneTreeiENSGT00390000008711.
HOGENOMiHOG000231708.
HOVERGENiHBG051155.
InParanoidiQ9GZN8.
OMAiLQINHRY.
PhylomeDBiQ9GZN8.
TreeFamiTF323780.

Miscellaneous databases

ChiTaRSiC20orf27. human.
GeneWikiiC20orf27.
GenomeRNAii54976.
NextBioi58230.
PROiQ9GZN8.

Gene expression databases

BgeeiQ9GZN8.
CleanExiHS_C20orf27.
ExpressionAtlasiQ9GZN8. baseline and differential.
GenevisibleiQ9GZN8. HS.

Family and domain databases

InterProiIPR026794. UPF0687.
[Graphical view]
PANTHERiPTHR13287. PTHR13287. 1 hit.
PfamiPF15006. DUF4517. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Gastric carcinoma, Teratocarcinoma and Testis.
  2. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Lung.
  6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-11 (ISOFORM 1).
    Tissue: Platelet.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCT027_HUMAN
AccessioniPrimary (citable) accession number: Q9GZN8
Secondary accession number(s): A8K4J0
, D3DVX8, Q5JX81, Q9NWX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.