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Q9GZN8

- CT027_HUMAN

UniProt

Q9GZN8 - CT027_HUMAN

Protein

UPF0687 protein C20orf27

Gene

C20orf27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UPF0687 protein C20orf27
    Gene namesi
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15873. C20orf27.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25742.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 174173UPF0687 protein C20orf27PRO_0000079419Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9GZN8.
    PaxDbiQ9GZN8.
    PRIDEiQ9GZN8.

    PTM databases

    PhosphoSiteiQ9GZN8.

    Expressioni

    Gene expression databases

    BgeeiQ9GZN8.
    CleanExiHS_C20orf27.
    GenevestigatoriQ9GZN8.

    Organism-specific databases

    HPAiHPA047483.

    Interactioni

    Protein-protein interaction databases

    BioGridi120312. 6 interactions.
    IntActiQ9GZN8. 3 interactions.
    STRINGi9606.ENSP00000217195.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9GZN8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPF0687 family.Curated

    Phylogenomic databases

    eggNOGiNOG78857.
    HOGENOMiHOG000231708.
    HOVERGENiHBG051155.
    OMAiKGTPMLR.
    PhylomeDBiQ9GZN8.
    TreeFamiTF323780.

    Family and domain databases

    InterProiIPR026794. UPF0687.
    [Graphical view]
    PANTHERiPTHR13287. PTHR13287. 1 hit.
    PfamiPF15006. DUF4517. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9GZN8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAANKGNKP RVRSIRFAAG HDAEGSHSHV HFDEKLHDSV VMVTQESDSS    50
    FLVKVGFLKI LHRYEITFTL PPVHRLSKDV REAPVPSLHL KLLSVVPVPE 100
    GYSVKCEYSA HKEGVLKEEI LLACEGGTGT CVRVTVQARV MDRHHGTPML 150
    LDGVKCVGAE LEYDSEHSDW HGFD 174
    Length:174
    Mass (Da):19,291
    Last modified:January 23, 2007 - v3
    Checksum:iDD114F2C1A7D8B97
    GO
    Isoform 2 (identifier: Q9GZN8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         6-6: K → KGKCLPGVVGLAQALPVGPGRRAIAA

    Show »
    Length:199
    Mass (Da):21,645
    Checksum:iB3D49626EDF72968
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141S → G in BAA91252. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei6 – 61K → KGKCLPGVVGLAQALPVGPG RRAIAA in isoform 2. 1 PublicationVSP_040293

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000557 mRNA. Translation: BAA91252.1.
    AK024220 mRNA. Translation: BAB14854.1.
    AK097645 mRNA. Translation: BAG53501.1.
    AK290955 mRNA. Translation: BAF83644.1.
    CR615129 mRNA. No translation available.
    AL109804 Genomic DNA. Translation: CAC17545.1.
    AL109804 Genomic DNA. Translation: CAI18843.1.
    CH471133 Genomic DNA. Translation: EAX10508.1.
    CH471133 Genomic DNA. Translation: EAX10510.1.
    CH471133 Genomic DNA. Translation: EAX10511.1.
    BC012196 mRNA. Translation: AAH12196.1.
    BC024036 mRNA. Translation: AAH24036.1.
    CCDSiCCDS33436.1. [Q9GZN8-2]
    CCDS58763.1. [Q9GZN8-1]
    RefSeqiNP_001034229.1. NM_001039140.2. [Q9GZN8-2]
    NP_001245358.1. NM_001258429.1. [Q9GZN8-1]
    NP_001245359.1. NM_001258430.1. [Q9GZN8-1]
    UniGeneiHs.274422.

    Genome annotation databases

    EnsembliENST00000217195; ENSP00000217195; ENSG00000101220. [Q9GZN8-2]
    ENST00000379772; ENSP00000369097; ENSG00000101220. [Q9GZN8-1]
    ENST00000399672; ENSP00000382580; ENSG00000101220. [Q9GZN8-1]
    GeneIDi54976.
    KEGGihsa:54976.
    UCSCiuc002wjf.1. human. [Q9GZN8-2]
    uc002wji.2. human. [Q9GZN8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000557 mRNA. Translation: BAA91252.1 .
    AK024220 mRNA. Translation: BAB14854.1 .
    AK097645 mRNA. Translation: BAG53501.1 .
    AK290955 mRNA. Translation: BAF83644.1 .
    CR615129 mRNA. No translation available.
    AL109804 Genomic DNA. Translation: CAC17545.1 .
    AL109804 Genomic DNA. Translation: CAI18843.1 .
    CH471133 Genomic DNA. Translation: EAX10508.1 .
    CH471133 Genomic DNA. Translation: EAX10510.1 .
    CH471133 Genomic DNA. Translation: EAX10511.1 .
    BC012196 mRNA. Translation: AAH12196.1 .
    BC024036 mRNA. Translation: AAH24036.1 .
    CCDSi CCDS33436.1. [Q9GZN8-2 ]
    CCDS58763.1. [Q9GZN8-1 ]
    RefSeqi NP_001034229.1. NM_001039140.2. [Q9GZN8-2 ]
    NP_001245358.1. NM_001258429.1. [Q9GZN8-1 ]
    NP_001245359.1. NM_001258430.1. [Q9GZN8-1 ]
    UniGenei Hs.274422.

    3D structure databases

    ProteinModelPortali Q9GZN8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120312. 6 interactions.
    IntActi Q9GZN8. 3 interactions.
    STRINGi 9606.ENSP00000217195.

    PTM databases

    PhosphoSitei Q9GZN8.

    Proteomic databases

    MaxQBi Q9GZN8.
    PaxDbi Q9GZN8.
    PRIDEi Q9GZN8.

    Protocols and materials databases

    DNASUi 54976.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000217195 ; ENSP00000217195 ; ENSG00000101220 . [Q9GZN8-2 ]
    ENST00000379772 ; ENSP00000369097 ; ENSG00000101220 . [Q9GZN8-1 ]
    ENST00000399672 ; ENSP00000382580 ; ENSG00000101220 . [Q9GZN8-1 ]
    GeneIDi 54976.
    KEGGi hsa:54976.
    UCSCi uc002wjf.1. human. [Q9GZN8-2 ]
    uc002wji.2. human. [Q9GZN8-1 ]

    Organism-specific databases

    CTDi 54976.
    GeneCardsi GC20M003734.
    H-InvDB HIX0015601.
    HGNCi HGNC:15873. C20orf27.
    HPAi HPA047483.
    neXtProti NX_Q9GZN8.
    PharmGKBi PA25742.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG78857.
    HOGENOMi HOG000231708.
    HOVERGENi HBG051155.
    OMAi KGTPMLR.
    PhylomeDBi Q9GZN8.
    TreeFami TF323780.

    Miscellaneous databases

    ChiTaRSi C20orf27. human.
    GeneWikii C20orf27.
    GenomeRNAii 54976.
    NextBioi 58230.

    Gene expression databases

    Bgeei Q9GZN8.
    CleanExi HS_C20orf27.
    Genevestigatori Q9GZN8.

    Family and domain databases

    InterProi IPR026794. UPF0687.
    [Graphical view ]
    PANTHERi PTHR13287. PTHR13287. 1 hit.
    Pfami PF15006. DUF4517. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Gastric carcinoma, Teratocarcinoma and Testis.
    2. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Lung.
    6. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-11 (ISOFORM 1).
      Tissue: Platelet.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCT027_HUMAN
    AccessioniPrimary (citable) accession number: Q9GZN8
    Secondary accession number(s): A8K4J0
    , D3DVX8, Q5JX81, Q9NWX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 95 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3