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Protein

UPF0687 protein C20orf27

Gene

C20orf27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0687 protein C20orf27
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15873. C20orf27.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101220.
PharmGKBiPA25742.

Polymorphism and mutation databases

BioMutaiC20orf27.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000794192 – 174UPF0687 protein C20orf27Add BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei147PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9GZN8.
MaxQBiQ9GZN8.
PaxDbiQ9GZN8.
PeptideAtlasiQ9GZN8.
PRIDEiQ9GZN8.

PTM databases

iPTMnetiQ9GZN8.
PhosphoSitePlusiQ9GZN8.

Expressioni

Gene expression databases

BgeeiENSG00000101220.
CleanExiHS_C20orf27.
ExpressionAtlasiQ9GZN8. baseline and differential.
GenevisibleiQ9GZN8. HS.

Organism-specific databases

HPAiHPA047483.

Interactioni

Protein-protein interaction databases

BioGridi120312. 6 interactors.
IntActiQ9GZN8. 6 interactors.
STRINGi9606.ENSP00000217195.

Structurei

3D structure databases

ProteinModelPortaliQ9GZN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0687 family.Curated

Phylogenomic databases

eggNOGiENOG410IXFR. Eukaryota.
ENOG4111MWE. LUCA.
GeneTreeiENSGT00390000008711.
HOGENOMiHOG000231708.
HOVERGENiHBG051155.
InParanoidiQ9GZN8.
OMAiVCVKVKV.
OrthoDBiEOG091G0QBP.
PhylomeDBiQ9GZN8.
TreeFamiTF323780.

Family and domain databases

InterProiIPR026794. UPF0687.
[Graphical view]
PANTHERiPTHR13287. PTHR13287. 1 hit.
PfamiPF15006. DUF4517. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9GZN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAANKGNKP RVRSIRFAAG HDAEGSHSHV HFDEKLHDSV VMVTQESDSS
60 70 80 90 100
FLVKVGFLKI LHRYEITFTL PPVHRLSKDV REAPVPSLHL KLLSVVPVPE
110 120 130 140 150
GYSVKCEYSA HKEGVLKEEI LLACEGGTGT CVRVTVQARV MDRHHGTPML
160 170
LDGVKCVGAE LEYDSEHSDW HGFD
Length:174
Mass (Da):19,291
Last modified:January 23, 2007 - v3
Checksum:iDD114F2C1A7D8B97
GO
Isoform 2 (identifier: Q9GZN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-6: K → KGKCLPGVVGLAQALPVGPGRRAIAA

Show »
Length:199
Mass (Da):21,645
Checksum:iB3D49626EDF72968
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14S → G in BAA91252 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0402936K → KGKCLPGVVGLAQALPVGPG RRAIAA in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000557 mRNA. Translation: BAA91252.1.
AK024220 mRNA. Translation: BAB14854.1.
AK097645 mRNA. Translation: BAG53501.1.
AK290955 mRNA. Translation: BAF83644.1.
CR615129 mRNA. No translation available.
AL109804 Genomic DNA. Translation: CAC17545.1.
AL109804 Genomic DNA. Translation: CAI18843.1.
CH471133 Genomic DNA. Translation: EAX10508.1.
CH471133 Genomic DNA. Translation: EAX10510.1.
CH471133 Genomic DNA. Translation: EAX10511.1.
BC012196 mRNA. Translation: AAH12196.1.
BC024036 mRNA. Translation: AAH24036.1.
CCDSiCCDS33436.1. [Q9GZN8-2]
CCDS58763.1. [Q9GZN8-1]
RefSeqiNP_001034229.1. NM_001039140.2. [Q9GZN8-2]
NP_001245358.1. NM_001258429.1. [Q9GZN8-1]
NP_001245359.1. NM_001258430.1. [Q9GZN8-1]
UniGeneiHs.274422.

Genome annotation databases

EnsembliENST00000217195; ENSP00000217195; ENSG00000101220. [Q9GZN8-2]
ENST00000379772; ENSP00000369097; ENSG00000101220. [Q9GZN8-1]
ENST00000399672; ENSP00000382580; ENSG00000101220. [Q9GZN8-1]
GeneIDi54976.
KEGGihsa:54976.
UCSCiuc002wjh.3. human. [Q9GZN8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000557 mRNA. Translation: BAA91252.1.
AK024220 mRNA. Translation: BAB14854.1.
AK097645 mRNA. Translation: BAG53501.1.
AK290955 mRNA. Translation: BAF83644.1.
CR615129 mRNA. No translation available.
AL109804 Genomic DNA. Translation: CAC17545.1.
AL109804 Genomic DNA. Translation: CAI18843.1.
CH471133 Genomic DNA. Translation: EAX10508.1.
CH471133 Genomic DNA. Translation: EAX10510.1.
CH471133 Genomic DNA. Translation: EAX10511.1.
BC012196 mRNA. Translation: AAH12196.1.
BC024036 mRNA. Translation: AAH24036.1.
CCDSiCCDS33436.1. [Q9GZN8-2]
CCDS58763.1. [Q9GZN8-1]
RefSeqiNP_001034229.1. NM_001039140.2. [Q9GZN8-2]
NP_001245358.1. NM_001258429.1. [Q9GZN8-1]
NP_001245359.1. NM_001258430.1. [Q9GZN8-1]
UniGeneiHs.274422.

3D structure databases

ProteinModelPortaliQ9GZN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120312. 6 interactors.
IntActiQ9GZN8. 6 interactors.
STRINGi9606.ENSP00000217195.

PTM databases

iPTMnetiQ9GZN8.
PhosphoSitePlusiQ9GZN8.

Polymorphism and mutation databases

BioMutaiC20orf27.

Proteomic databases

EPDiQ9GZN8.
MaxQBiQ9GZN8.
PaxDbiQ9GZN8.
PeptideAtlasiQ9GZN8.
PRIDEiQ9GZN8.

Protocols and materials databases

DNASUi54976.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217195; ENSP00000217195; ENSG00000101220. [Q9GZN8-2]
ENST00000379772; ENSP00000369097; ENSG00000101220. [Q9GZN8-1]
ENST00000399672; ENSP00000382580; ENSG00000101220. [Q9GZN8-1]
GeneIDi54976.
KEGGihsa:54976.
UCSCiuc002wjh.3. human. [Q9GZN8-1]

Organism-specific databases

CTDi54976.
GeneCardsiC20orf27.
H-InvDBHIX0015601.
HGNCiHGNC:15873. C20orf27.
HPAiHPA047483.
neXtProtiNX_Q9GZN8.
OpenTargetsiENSG00000101220.
PharmGKBiPA25742.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXFR. Eukaryota.
ENOG4111MWE. LUCA.
GeneTreeiENSGT00390000008711.
HOGENOMiHOG000231708.
HOVERGENiHBG051155.
InParanoidiQ9GZN8.
OMAiVCVKVKV.
OrthoDBiEOG091G0QBP.
PhylomeDBiQ9GZN8.
TreeFamiTF323780.

Miscellaneous databases

ChiTaRSiC20orf27. human.
GeneWikiiC20orf27.
GenomeRNAii54976.
PROiQ9GZN8.

Gene expression databases

BgeeiENSG00000101220.
CleanExiHS_C20orf27.
ExpressionAtlasiQ9GZN8. baseline and differential.
GenevisibleiQ9GZN8. HS.

Family and domain databases

InterProiIPR026794. UPF0687.
[Graphical view]
PANTHERiPTHR13287. PTHR13287. 1 hit.
PfamiPF15006. DUF4517. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCT027_HUMAN
AccessioniPrimary (citable) accession number: Q9GZN8
Secondary accession number(s): A8K4J0
, D3DVX8, Q5JX81, Q9NWX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.