Q9GZN8 (CT027_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UPF0687 protein C20orf27

Gene names

Name:

C20orf27

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the UPF0687 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9GZN8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9GZN8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     6-6: K → KGKCLPGVVGLAQALPVGPGRRAIAA

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.6
	Chain	2 – 174	173	UPF0687 protein C20orf27		PRO_0000079419
Natural variations
	Alternative sequence	6	1	K → KGKCLPGVVGLAQALPVGPG RRAIAA in isoform 2.		VSP_040293
Experimental info
	Sequence conflict	14	1	S → G in BAA91252. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: DD114F2C1A7D8B97	FASTA	174	19,291
	10 20 30 40 50 60 MAAANKGNKP RVRSIRFAAG HDAEGSHSHV HFDEKLHDSV VMVTQESDSS FLVKVGFLKI 70 80 90 100 110 120 LHRYEITFTL PPVHRLSKDV REAPVPSLHL KLLSVVPVPE GYSVKCEYSA HKEGVLKEEI 130 140 150 160 170 LLACEGGTGT CVRVTVQARV MDRHHGTPML LDGVKCVGAE LEYDSEHSDW HGFD
	Isoform 2 [UniParc]. Checksum: B3D49626EDF72968	FASTA	199	21,645
	10 20 30 40 50 60 MAAANKGKCL PGVVGLAQAL PVGPGRRAIA AGNKPRVRSI RFAAGHDAEG SHSHVHFDEK 70 80 90 100 110 120 LHDSVVMVTQ ESDSSFLVKV GFLKILHRYE ITFTLPPVHR LSKDVREAPV PSLHLKLLSV 130 140 150 160 170 180 VPVPEGYSVK CEYSAHKEGV LKEEILLACE GGTGTCVRVT VQARVMDRHH GTPMLLDGVK 190 CVGAELEYDS EHSDWHGFD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Gastric carcinoma, Teratocarcinoma and Testis.
[2]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Lung.
[6]	"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J. Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-11 (ISOFORM 1). Tissue: Platelet.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK000557 mRNA. Translation: BAA91252.1. AK024220 mRNA. Translation: BAB14854.1. AK097645 mRNA. Translation: BAG53501.1. AK290955 mRNA. Translation: BAF83644.1. CR615129 mRNA. No translation available. AL109804 Genomic DNA. Translation: CAC17545.1. AL109804 Genomic DNA. Translation: CAI18843.1. CH471133 Genomic DNA. Translation: EAX10508.1. CH471133 Genomic DNA. Translation: EAX10510.1. CH471133 Genomic DNA. Translation: EAX10511.1. BC012196 mRNA. Translation: AAH12196.1. BC024036 mRNA. Translation: AAH24036.1.
IPI	IPI00101095. IPI00552634.
RefSeq	NP_001034229.1. NM_001039140.2. NP_001245358.1. NM_001258429.1. NP_001245359.1. NM_001258430.1.
UniGene	Hs.274422.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9GZN8. 2 interactions.
STRING	9606.ENSP00000217195.
PTM databases
PhosphoSite	Q9GZN8.
Polymorphism databases
DMDM	27734252.
Proteomic databases
PaxDb	Q9GZN8.
PRIDE	Q9GZN8.
Protocols and materials databases
DNASU	54976.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000217195; ENSP00000217195; ENSG00000101220. ENST00000379772; ENSP00000369097; ENSG00000101220. ENST00000399672; ENSP00000382580; ENSG00000101220.
GeneID	54976.
KEGG	hsa:54976.
UCSC	uc002wjf.1. human. uc002wji.1. human.
Organism-specific databases
CTD	54976.
GeneCards	GC20M003734.
H-InvDB	HIX0015601.
HGNC	HGNC:15873. C20orf27.
HPA	HPA047483.
neXtProt	NX_Q9GZN8.
PharmGKB	PA25742.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG78857.
HOGENOM	HOG000231708.
HOVERGEN	HBG051155.
OMA	KGTPMLR.
OrthoDB	EOG4640D6.
Gene expression databases
ArrayExpress	Q9GZN8.
Bgee	Q9GZN8.
CleanEx	HS_C20orf27.
Genevestigator	Q9GZN8.
GermOnline	ENSG00000101220. Homo sapiens.
Family and domain databases
InterPro	IPR026794. UPF0687. [Graphical view]
PANTHER	PTHR13287. PTHR13287. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	C20orf27. human.
GenomeRNAi	54976.
NextBio	58230.

Entry information

Entry name

CT027_HUMAN

Accession

Primary (citable) accession number: Q9GZN8
Secondary accession number(s): A8K4J0 , D3DVX8, Q5JX81, Q9NWX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 84 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.