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Protein

Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

Gene

SLC6A16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • amino acid transmembrane transport Source: GOC
  • neurotransmitter transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Protein family/group databases

TCDBi2.A.22.6.5. the neurotransmitter:sodium symporter (nss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5
Alternative name(s):
Solute carrier family 6 member 16
Gene namesi
Name:SLC6A16
Synonyms:NTT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13622. SLC6A16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 138138CytoplasmicSequence analysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei177 – 19721Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini220 – 26344ExtracellularSequence analysisAdd
BLAST
Transmembranei264 – 28421Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei290 – 31021Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei338 – 35821Helical; Name=6Sequence analysisAdd
BLAST
Transmembranei383 – 40321Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini404 – 49592ExtracellularSequence analysisAdd
BLAST
Transmembranei496 – 51621Helical; Name=8Sequence analysisAdd
BLAST
Transmembranei534 – 55421Helical; Name=9Sequence analysisAdd
BLAST
Transmembranei568 – 58821Helical; Name=10Sequence analysisAdd
BLAST
Transmembranei609 – 62921Helical; Name=11Sequence analysisAdd
BLAST
Transmembranei659 – 67921Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini680 – 73657CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • intracellular Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37800.

Polymorphism and mutation databases

BioMutaiSLC6A16.
DMDMi18202928.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 736736Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5PRO_0000214801Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9GZN6.
PRIDEiQ9GZN6.

PTM databases

iPTMnetiQ9GZN6.
PhosphoSiteiQ9GZN6.

Expressioni

Tissue specificityi

Highly expressed in peripheral tissues, particularly in testis, pancreas, and prostate.

Gene expression databases

BgeeiQ9GZN6.
CleanExiHS_SLC6A16.
ExpressionAtlasiQ9GZN6. baseline and differential.
GenevisibleiQ9GZN6. HS.

Organism-specific databases

HPAiHPA049128.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000338627.

Structurei

3D structure databases

ProteinModelPortaliQ9GZN6.
SMRiQ9GZN6. Positions 103-406, 473-680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000116406.
HOVERGENiHBG098140.
InParanoidiQ9GZN6.
KOiK05048.
OMAiFFTRPSG.
OrthoDBiEOG77HDDJ.
PhylomeDBiQ9GZN6.
TreeFamiTF352709.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9GZN6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTEAQPSTS LLANTSWTGT VISDSVPGSQ TWEDKGSLTR SATSWTSEAQ
60 70 80 90 100
VSAARVAEAQ ARTSQPKQIS VLEALTASAL NQKPTHEKVQ MTEKKESEVL
110 120 130 140 150
LARPFWSSKT EYILAQVGFS MKPSCLWRFA YLWLNSGGCS FAAIYIFMLF
160 170 180 190 200
LVGVPLLFLE MAAGQSMRQG GMGVWKIIAP WIGGVGYSSF MVCFILGLYF
210 220 230 240 250
NVVNSWIIFY MSQSFQFPVP WEKCPLTMNS SGFDPECERT TPSIYFWYQQ
260 270 280 290 300
ALKASDRIED GGSPVYSLVL PFFLCWCLVG AFMINGLKST GKVIYVLVLL
310 320 330 340 350
PCFIIVGFFI RTLLLEGAKF GLQQLVVAKI SDVYNMSVWS LAGGQVLSNT
360 370 380 390 400
GIGLGSVASL ASYMPQSNNC LSDAFLVSVI NLLTLLVFTS FNFCVLGFWA
410 420 430 440 450
TVITHRCCER NAEILLKLIN LGKLPPDAKP PVNLLYNPTS IYNAWLSGLP
460 470 480 490 500
QHIKSMVLRE VTECNIETQF LKASEGPKFA FLSFVEAMSF LPPSVFWSFI
510 520 530 540 550
FFLMLLAMGL SSAIGIMQGI ITPLQDTFSF FRKHTKLLIV GVFLLMFVCG
560 570 580 590 600
LFFTRPSGSY FIRLLSDYWI VFPIIVVVVF ETMAVSWAYG ARRFLADLTI
610 620 630 640 650
LLGHPISPIF GWLWPHLCPV VLLIIFVTMM VHLCMKPITY MSWDSSTSKE
660 670 680 690 700
VLRPYPPWAL LLMITLFAIV ILPIPAYFVY CRIHRIPFRP KSGDGPMTAS
710 720 730
TSLPLSHQLT PSKEVQKEEI LQVDETKYPS TCNVTS
Length:736
Mass (Da):82,200
Last modified:March 1, 2001 - v1
Checksum:iE21EA16515446C35
GO
Isoform 2 (identifier: Q9GZN6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     648-736: SKEVLRPYPP...KYPSTCNVTS → VSLPQDPEPLWE

Note: No experimental confirmation available.
Show »
Length:659
Mass (Da):73,539
Checksum:i11C801151E9BAA07
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti181 – 1811W → R in AAD38044 (Ref. 1) Curated
Sequence conflicti307 – 3071G → GG in AAD38044 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti108 – 1081S → R.
Corresponds to variant rs35860981 [ dbSNP | Ensembl ].
VAR_052067
Natural varianti236 – 2361E → K Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064753

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei648 – 73689SKEVL…CNVTS → VSLPQDPEPLWE in isoform 2. 1 PublicationVSP_056317Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151977 mRNA. Translation: AAD38044.1.
AF265578 mRNA. Translation: AAG41362.1.
AL136856 mRNA. Translation: CAB66790.1.
AC011450 Genomic DNA. No translation available.
BC034948 mRNA. Translation: AAH34948.1.
CCDSiCCDS42590.1. [Q9GZN6-1]
RefSeqiNP_054756.2. NM_014037.2. [Q9GZN6-1]
XP_005258877.1. XM_005258820.1. [Q9GZN6-1]
XP_006723231.1. XM_006723168.2. [Q9GZN6-1]
UniGeneiHs.130949.

Genome annotation databases

EnsembliENST00000335875; ENSP00000338627; ENSG00000063127. [Q9GZN6-1]
ENST00000454748; ENSP00000404022; ENSG00000063127. [Q9GZN6-2]
GeneIDi28968.
KEGGihsa:28968.
UCSCiuc002pmz.4. human. [Q9GZN6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151977 mRNA. Translation: AAD38044.1.
AF265578 mRNA. Translation: AAG41362.1.
AL136856 mRNA. Translation: CAB66790.1.
AC011450 Genomic DNA. No translation available.
BC034948 mRNA. Translation: AAH34948.1.
CCDSiCCDS42590.1. [Q9GZN6-1]
RefSeqiNP_054756.2. NM_014037.2. [Q9GZN6-1]
XP_005258877.1. XM_005258820.1. [Q9GZN6-1]
XP_006723231.1. XM_006723168.2. [Q9GZN6-1]
UniGeneiHs.130949.

3D structure databases

ProteinModelPortaliQ9GZN6.
SMRiQ9GZN6. Positions 103-406, 473-680.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000338627.

Protein family/group databases

TCDBi2.A.22.6.5. the neurotransmitter:sodium symporter (nss) family.

PTM databases

iPTMnetiQ9GZN6.
PhosphoSiteiQ9GZN6.

Polymorphism and mutation databases

BioMutaiSLC6A16.
DMDMi18202928.

Proteomic databases

PaxDbiQ9GZN6.
PRIDEiQ9GZN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335875; ENSP00000338627; ENSG00000063127. [Q9GZN6-1]
ENST00000454748; ENSP00000404022; ENSG00000063127. [Q9GZN6-2]
GeneIDi28968.
KEGGihsa:28968.
UCSCiuc002pmz.4. human. [Q9GZN6-1]

Organism-specific databases

CTDi28968.
GeneCardsiSLC6A16.
HGNCiHGNC:13622. SLC6A16.
HPAiHPA049128.
MIMi607972. gene.
neXtProtiNX_Q9GZN6.
PharmGKBiPA37800.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000116406.
HOVERGENiHBG098140.
InParanoidiQ9GZN6.
KOiK05048.
OMAiFFTRPSG.
OrthoDBiEOG77HDDJ.
PhylomeDBiQ9GZN6.
TreeFamiTF352709.

Miscellaneous databases

GenomeRNAii28968.
PROiQ9GZN6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9GZN6.
CleanExiHS_SLC6A16.
ExpressionAtlasiQ9GZN6. baseline and differential.
GenevisibleiQ9GZN6. HS.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a new member of the neurotransmitter transporter family."
    Sloan J.L., Mager S.
    Abstr. - Soc. Neurosci. 24:1606-1606(1998)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  2. "Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na(+)/Cl(-)-dependent neurotransmitter transporter gene family."
    Farmer M.K., Robbins M.J., Medhurst A.D., Campbell D.A., Ellington K., Duckworth M., Brown A.M., Middlemiss D.N., Price G.W., Pangalos M.N.
    Genomics 70:241-252(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  6. Cited for: VARIANT LYS-236.

Entry informationi

Entry nameiS6A16_HUMAN
AccessioniPrimary (citable) accession number: Q9GZN6
Secondary accession number(s): Q8IYV4, Q9Y5I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.