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Protein

Actin-related protein 6

Gene

ACTR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9GZN1.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 6
Short name:
hArp6
Alternative name(s):
hARPX
Gene namesi
Name:ACTR6
ORF Names:CDA12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:24025. ACTR6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134984466.

Polymorphism and mutation databases

BioMutaiACTR6.
DMDMi27923737.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 396395Actin-related protein 6PRO_0000089105Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineCombined sources
Modified residuei260 – 2601N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9GZN1.
MaxQBiQ9GZN1.
PaxDbiQ9GZN1.
PRIDEiQ9GZN1.

PTM databases

iPTMnetiQ9GZN1.
PhosphoSiteiQ9GZN1.

Expressioni

Gene expression databases

BgeeiQ9GZN1.
CleanExiHS_ACTR6.
ExpressionAtlasiQ9GZN1. baseline and differential.
GenevisibleiQ9GZN1. HS.

Organism-specific databases

HPAiHPA038587.
HPA038588.

Interactioni

Subunit structurei

Interacts with CBX1, CBX3 and CBX5.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ZNHIT1O432574EBI-769329,EBI-347522

Protein-protein interaction databases

BioGridi122179. 21 interactions.
IntActiQ9GZN1. 8 interactions.
MINTiMINT-3065065.
STRINGi9606.ENSP00000188312.

Structurei

3D structure databases

ProteinModelPortaliQ9GZN1.
SMRiQ9GZN1. Positions 2-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP6 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0680. Eukaryota.
ENOG410XPT5. LUCA.
GeneTreeiENSGT00720000108833.
HOGENOMiHOG000170496.
HOVERGENiHBG097980.
InParanoidiQ9GZN1.
KOiK11662.
OMAiWNMMDET.
PhylomeDBiQ9GZN1.
TreeFamiTF105780.

Family and domain databases

InterProiIPR004000. Actin.
IPR030054. Arp6.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 2 hits.
PTHR11937:SF47. PTHR11937:SF47. 2 hits.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9GZN1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTLVLDNGA YNAKIGYSHE NVSVIPNCQF RSKTARLKTF TANQIDEIKD
60 70 80 90 100
PSGLFYILPF QKGYLVNWDV QRQVWDYLFG KEMYQVDFLD TNIIITEPYF
110 120 130 140 150
NFTSIQESMN EILFEEYQFQ AVLRVNAGAL SAHRYFRDNP SELCCIIVDS
160 170 180 190 200
GYSFTHIVPY CRSKKKKEAI IRINVGGKLL TNHLKEIISY RQLHVMDETH
210 220 230 240 250
VINQVKEDVC YVSQDFYRDM DIAKLKGEEN TVMIDYVLPD FSTIKKGFCK
260 270 280 290 300
PREEMVLSGK YKSGEQILRL ANERFAVPEI LFNPSDIGIQ EMGIPEAIVY
310 320 330 340 350
SIQNLPEEMQ PHFFKNIVLT GGNSLFPGFR DRVYSEVRCL TPTDYDVSVV
360 370 380 390
LPENPITYAW EGGKLISEND DFEDMVVTRE DYEENGHSVC EEKFDI
Length:396
Mass (Da):45,810
Last modified:March 1, 2001 - v1
Checksum:iE7F77190F60D1700
GO
Isoform 2 (identifier: Q9GZN1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     127-182: AGALSAHRYF...INVGGKLLTN → GEFKFSLKLS...AEASRSLEFR
     183-395: Missing.

Note: No experimental confirmation available.
Show »
Length:183
Mass (Da):21,628
Checksum:i9587D94A1EF4499A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti218 – 2181R → G in BAD96679 (Ref. 4) Curated
Sequence conflicti226 – 2261K → E in AAK14934 (Ref. 2) Curated
Sequence conflicti237 – 2371V → A in AAK14934 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei127 – 18256AGALS…KLLTN → GEFKFSLKLSYMTMDMNRVI LIKSQNIKWHSWLAQWLTPV TPSVWEAEASRSLEFR in isoform 2. 1 PublicationVSP_054637Add
BLAST
Alternative sequencei183 – 395213Missing in isoform 2. 1 PublicationVSP_054638Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038229 mRNA. Translation: BAB20762.1.
AF212251 mRNA. Translation: AAK14934.1.
AK023495 mRNA. Translation: BAB14588.1.
AK023684 mRNA. Translation: BAB14640.1.
AK124075 mRNA. Translation: BAG53999.1.
AK296991 mRNA. Translation: BAG59531.1.
AK222959 mRNA. Translation: BAD96679.1.
CH471054 Genomic DNA. Translation: EAW97623.1.
BC015107 mRNA. Translation: AAH15107.1.
CCDSiCCDS9074.1. [Q9GZN1-1]
RefSeqiNP_071941.1. NM_022496.4. [Q9GZN1-1]
UniGeneiHs.115088.

Genome annotation databases

EnsembliENST00000188312; ENSP00000188312; ENSG00000075089. [Q9GZN1-1]
GeneIDi64431.
KEGGihsa:64431.
UCSCiuc001thb.3. human. [Q9GZN1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038229 mRNA. Translation: BAB20762.1.
AF212251 mRNA. Translation: AAK14934.1.
AK023495 mRNA. Translation: BAB14588.1.
AK023684 mRNA. Translation: BAB14640.1.
AK124075 mRNA. Translation: BAG53999.1.
AK296991 mRNA. Translation: BAG59531.1.
AK222959 mRNA. Translation: BAD96679.1.
CH471054 Genomic DNA. Translation: EAW97623.1.
BC015107 mRNA. Translation: AAH15107.1.
CCDSiCCDS9074.1. [Q9GZN1-1]
RefSeqiNP_071941.1. NM_022496.4. [Q9GZN1-1]
UniGeneiHs.115088.

3D structure databases

ProteinModelPortaliQ9GZN1.
SMRiQ9GZN1. Positions 2-393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122179. 21 interactions.
IntActiQ9GZN1. 8 interactions.
MINTiMINT-3065065.
STRINGi9606.ENSP00000188312.

PTM databases

iPTMnetiQ9GZN1.
PhosphoSiteiQ9GZN1.

Polymorphism and mutation databases

BioMutaiACTR6.
DMDMi27923737.

Proteomic databases

EPDiQ9GZN1.
MaxQBiQ9GZN1.
PaxDbiQ9GZN1.
PRIDEiQ9GZN1.

Protocols and materials databases

DNASUi64431.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000188312; ENSP00000188312; ENSG00000075089. [Q9GZN1-1]
GeneIDi64431.
KEGGihsa:64431.
UCSCiuc001thb.3. human. [Q9GZN1-1]

Organism-specific databases

CTDi64431.
GeneCardsiACTR6.
HGNCiHGNC:24025. ACTR6.
HPAiHPA038587.
HPA038588.
neXtProtiNX_Q9GZN1.
PharmGKBiPA134984466.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0680. Eukaryota.
ENOG410XPT5. LUCA.
GeneTreeiENSGT00720000108833.
HOGENOMiHOG000170496.
HOVERGENiHBG097980.
InParanoidiQ9GZN1.
KOiK11662.
OMAiWNMMDET.
PhylomeDBiQ9GZN1.
TreeFamiTF105780.

Enzyme and pathway databases

SignaLinkiQ9GZN1.

Miscellaneous databases

ChiTaRSiACTR6. human.
GenomeRNAii64431.
PROiQ9GZN1.

Gene expression databases

BgeeiQ9GZN1.
CleanExiHS_ACTR6.
ExpressionAtlasiQ9GZN1. baseline and differential.
GenevisibleiQ9GZN1. HS.

Family and domain databases

InterProiIPR004000. Actin.
IPR030054. Arp6.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 2 hits.
PTHR11937:SF47. PTHR11937:SF47. 2 hits.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel actin-related proteins in vertebrates: similarities of structure and expression pattern to Arp6 localized on Drosophila heterochromatin."
    Kato M., Sasaki M., Mizuno S., Harata M.
    Gene 268:133-140(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "A novel gene expressed in human pheochromocytoma."
    Li Y., Huang Q., Peng Y., Song H., Yu Y., Xu S., Ren S., Chen Z., Han Z.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pheochromocytoma.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Mammary gland, Placenta and Tongue.
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Small intestine.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Urinary bladder.
  7. "Vertebrate Arp6, a novel nuclear actin-related protein, interacts with heterochromatin protein 1."
    Ohfuchi E., Kato M., Sasaki M., Sugimoto K., Oma Y., Harata M.
    Eur. J. Cell Biol. 85:411-421(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH CBX1; CBX3 AND CBX5.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-260, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARP6_HUMAN
AccessioniPrimary (citable) accession number: Q9GZN1
Secondary accession number(s): B3KW37
, B4DLG9, Q53GH2, Q9BY39, Q9H8H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.