Reviewed, UniProtKB/Swiss-Prot Q9GZN1 (ARP6_HUMAN)

Names and origin

Protein names

Recommended name:
    Actin-related protein 6
      Short name=hArp6
      Short name=hARPX

Gene names

Name:	ACTR6
ORF Names:	CDA12

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Cytoplasm › cytoskeleton By similarity.
Sequence similarities	Belongs to the actin family. ARP6 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Actin-related protein 6		PRO_0000089105
Amino acid modifications
	Modified residue	260	1	N6-acetyllysine Ref.6
Experimental info
	Sequence conflict	226	1	K → E in AAK14934. Ref.2
	Sequence conflict	237	1	V → A in AAK14934. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9GZN1-1 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: E7F77190F60D1700	FASTA	396	45,810
	10 20 30 40 50 60 MTTLVLDNGA YNAKIGYSHE NVSVIPNCQF RSKTARLKTF TANQIDEIKD PSGLFYILPF 70 80 90 100 110 120 QKGYLVNWDV QRQVWDYLFG KEMYQVDFLD TNIIITEPYF NFTSIQESMN EILFEEYQFQ 130 140 150 160 170 180 AVLRVNAGAL SAHRYFRDNP SELCCIIVDS GYSFTHIVPY CRSKKKKEAI IRINVGGKLL 190 200 210 220 230 240 TNHLKEIISY RQLHVMDETH VINQVKEDVC YVSQDFYRDM DIAKLKGEEN TVMIDYVLPD 250 260 270 280 290 300 FSTIKKGFCK PREEMVLSGK YKSGEQILRL ANERFAVPEI LFNPSDIGIQ EMGIPEAIVY 310 320 330 340 350 360 SIQNLPEEMQ PHFFKNIVLT GGNSLFPGFR DRVYSEVRCL TPTDYDVSVV LPENPITYAW 370 380 390 EGGKLISEND DFEDMVVTRE DYEENGHSVC EEKFDI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel actin-related proteins in vertebrates: similarities of structure and expression pattern to Arp6 localized on Drosophila heterochromatin." Kato M., Sasaki M., Mizuno S., Harata M. Gene 268:133-140(2001) [PubMed: 11368909] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"A novel gene expressed in human pheochromocytoma." Li Y., Huang Q., Peng Y., Song H., Yu Y., Xu S., Ren S., Chen Z., Han Z. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pheochromocytoma.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland and Placenta.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Urinary bladder.
[6]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-260, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB038229 mRNA. Translation: BAB20762.1. AF212251 mRNA. Translation: AAK14934.1. AK023495 mRNA. Translation: BAB14588.1. AK023684 mRNA. Translation: BAB14640.1. AK124075 mRNA. Translation: BAG53999.1. CH471054 Genomic DNA. Translation: EAW97623.1. BC015107 mRNA. Translation: AAH15107.1.
IPI	IPI00171779.
RefSeq	NP_071941.1.
UniGene	Hs.115088
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9GZN1. 20 interactions.
STRING	Q9GZN1.
Proteomic databases
PRIDE	Q9GZN1.
Genome annotation databases
Ensembl	ENST00000188312; ENSP00000188312; ENSG00000075089; Homo sapiens. [Genome view]
GeneID	64431.
KEGG	hsa:64431.
UCSC	uc001thb.1. human.
Organism-specific databases
CTD	64431.
GeneCards	GC12P099096.
H-InvDB	HIX0010916.
HGNC	HGNC:24025. ACTR6.
PharmGKB	PA134984466.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9GZN1.
HOVERGEN	Q9GZN1.
OMA	FPGFRER
OrthoDB	EOG9RZ1KS
Gene expression databases
ArrayExpress	Q9GZN1.
Bgee	Q9GZN1.
CleanEx	HS_ACTR6.
Genevestigator	Q9GZN1.
GermOnline	ENSG00000075089. Homo sapiens.
Family and domain databases
InterPro	IPR004000. Actin-like. [Graphical view]
PANTHER	PTHR11937. Actin_like. 1 hit.
Pfam	PF00022. Actin. 1 hit. [Graphical view]
SMART	SM00268. ACTIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	66449.

Entry information

Entry name

ARP6_HUMAN

Accession

Primary (citable) accession number: Q9GZN1
Secondary accession number(s): B3KW37, Q9BY39, Q9H8H6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 27, 2003
Last sequence update:	March 1, 2001
Last modified:	November 24, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.